Your search for "runx1t1" returned 317 TaqMan® SNP Genotyping Assays
RUNX1 translocation partner 1
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
AML1-MTG8, AML1T1, CBFA2T1, CBFA2T1H, CDR, ETO, MTG8, RUNX1T1, ZMYND2
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