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PA1-21148 detects TNF receptor II in human, mouse and rat samples.
PA1-21148 has been successfully used in immunohistochemistry (paraffin), Immunoprecipitation and Western blot procedures.
The PA1-21148 immunogen is a synthetic peptide to the C-terminal region of mouse TNF receptor II protein.
TNFR2 (tumor necrosis factor receptor superfamily member 1B) is a receptor with high affinity for TNFSF2/TNF-alpha. It has a much lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. TNFR2 mediates most of the metabolic effects of TNF-alpha.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD120b; Etanercept; p75; p75 TNF receptor; p75 TNFR; p80 TNF-alpha receptor; sCD120b; soluble CD120b; soluble TNFR1B variant 1; soluble TNFR2; sTNF R2; sTNFR 2; sTNFR2; TBP-2; TBPII; TNF receptor beta chain; TNF-R2; TNF-RII; TNFR; TNFR II; TNFR-II; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; Tumor necrosis factor receptor; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor superfamily member 1b, membrane form; tumor necrosis factor receptor superfamily, member 1B; Tumor necrosis factor receptor type II; Tumor necrosis factor-binding protein 2
Gene Aliases: TNFBR; Tnfr-2; TNFR2; TNFRSF1B
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