The SULT1A1 gene exhibits copy number variation. Individuals may carry deletion alleles or extra copies of SULT1A1. SULT1A1 SNP genotyping assays run on samples having 2 or more gene copies that are homozygous for the SNP allele will cluster together, and samples having more than 2 gene copies that are heterozygous may run between the 2 copy heterozygous and homozygous clusters. For accurate SULT1A1 genotype analysis, copy number analysis must be done. For more information, refer to the PGx Experiments User Guide (Pub. # MAN0009612) Chapter 2 Copy Number Variation section.
For this assay, SNP(s) [rs35480621] are located under a probe and SNP(s) [rs56205284] are located under a primer sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the
1000 Genomes and NCBI
dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.
For this assay, SNP(s) [rs35480621] are located under a probe and SNP(s) [rs56205284] are located under a primer sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the
1000 Genomes and NCBI
dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.