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          System Message

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          LOADING ...
          See other SNCA SIRNA Assays ›
          Gene Symbol:
          SNCA
          Gene Name:
          synuclein alpha
          Gene Aliases:
          NACP, PARK1, PARK4, PD1
          Chromosome Location:
          Chr.4: 89724099 - 89838324 on Build GRCh38
          UniGene ID:
          Hs.21374
          Species:
          Human
          Species Specific ID (Flybase ID):
          -
          siRNA ID HSS144006
          Size 20 nmol
          Availability Made To Order
          Catalog # 1299001
          Price Contact Us
          Your Price
          Online offer:
          3062.0
          Check your price ›
          • Genomic Map
          • siRNA Details
          • More Information

          Genomic Map

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          siRNA Details

          Gene Symbol: SNCA
          Interrogated Sequence Translated Protein Targeted Exon(s) siRNA Location IMAGE Clone ID
          RefSeq NM_000345.3 NP_000336.1 2 312
          NM_001146054.1 NP_001139526.1 2 308
          NM_001146055.1 NP_001139527.1 2 119
          NM_007308.2 NP_009292.1 2 308
          XM_011532203.1 XP_011530505.1 2 341
          XM_011532204.2 XP_011530506.1 2 445
          XM_011532205.2 XP_011530507.1 2 147
          XM_011532206.1 XP_011530508.1 2 169
          XM_011532207.1 XP_011530509.1 2 156
          XM_011532208.2 XP_011530510.1 2 189
          XM_017008562.1 XP_016864051.1 2 183
          XM_017008563.1 XP_016864052.1 2 209
          GenBank mRNA AI815523.1 - 2 312
          AK290169.1 - 2 133
          AY049786.1 - 1 51
          BC013293.2 - 2 472 3604532
          BC108275.1 - 2 266 6147966
          CR457058.1 - 1 49
          CR541653.1 - 1 49
          CR736451.1 - 2 308
          D31839.1 - 1 62
          DA391115.1 - 2 119
          HQ830267.1 - 2 321
          HQ830268.1 - 2 484
          HQ830269.1 - 2 174
          JN709859.1 - 2 308
          JN709860.1 - 2 308
          JN709861.1 - 2 312
          JN709862.1 - 2 312
          JN709863.1 - 2 312
          JN709864.1 - 2 119
          JN709865.1 - 2 119
          JN709866.1 - 2 119
          JN709867.1 - 2 161
          JN709868.1 - 2 161
          JN709869.1 - 2 161
          L08850.1 - 2 101
          L36674.1 - 1 67
          L36675.1 - 1 67

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          More Information


          Other Species Targeted

          This siRNA also targets the following transcripts in Rat: NM_019169, XM_006236591, AF007758, AY550005, BC087682, and others.
          This siRNA also targets the following transcripts in Mouse: NM_009221, NM_001042451, AK014472, BY099071, BC046764, and others.

          Panther Classification:

          Molecular Function -

          membrane trafficking regulatory protein

          Gene Ontology Categories:

          Function(s) Process(es)

          negative regulation of transcription from RNA polymerase II promoter
          microglial cell activation
          positive regulation of receptor recycling
          negative regulation of protein phosphorylation
          positive regulation of neurotransmitter secretion
          fatty acid metabolic process
          neutral lipid metabolic process
          phospholipid metabolic process
          apoptotic process
          activation of cysteine-type endopeptidase activity involved in apoptotic process
          mitochondrial membrane organization
          aging
          adult locomotory behavior
          response to iron(II) ion
          regulation of phospholipase activity
          negative regulation of platelet-derived growth factor receptor signaling pathway
          regulation of glutamate secretion
          regulation of dopamine secretion
          negative regulation of microtubule polymerization
          receptor internalization
          protein destabilization
          response to magnesium ion
          negative regulation of transporter activity
          response to lipopolysaccharide
          negative regulation of monooxygenase activity
          positive regulation of peptidyl-serine phosphorylation
          response to interferon-gamma
          cellular response to oxidative stress
          negative regulation of histone acetylation
          regulation of locomotion
          dopamine biosynthetic process
          response to drug
          mitochondrial ATP synthesis coupled electron transport
          regulation of macrophage activation
          positive regulation of apoptotic process
          negative regulation of apoptotic process
          negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
          extracellular fibril organization
          negative regulation of neuron apoptotic process
          cellular protein metabolic process
          cellular response to fibroblast growth factor stimulus
          positive regulation of endocytosis
          negative regulation of exocytosis
          negative regulation of dopamine metabolic process
          behavioral response to cocaine
          regulation of long-term neuronal synaptic plasticity
          synaptic vesicle endocytosis
          synapse organization
          regulation of acyl-CoA biosynthetic process
          positive regulation of release of sequestered calcium ion into cytosol
          dopamine uptake involved in synaptic transmission
          negative regulation of dopamine uptake involved in synaptic transmission
          negative regulation of serotonin uptake
          negative regulation of norepinephrine uptake
          calcium ion homeostasis
          oxidation-reduction process
          excitatory postsynaptic potential
          long-term synaptic potentiation
          positive regulation of inositol phosphate biosynthetic process
          negative regulation of thrombin receptor signaling pathway
          response to interleukin-1
          cellular response to copper ion
          cellular response to epinephrine stimulus
          positive regulation of protein serine/threonine kinase activity
          negative regulation of neuron death
          negative regulation of mitochondrial electron transport, NADH to ubiquinone
          positive regulation of glutathione peroxidase activity
          positive regulation of hydrogen peroxide catabolic process
          regulation of synaptic vesicle recycling
          regulation of reactive oxygen species biosynthetic process
          negative regulation of chaperone-mediated autophagy
          magnesium ion binding
          fatty acid binding
          copper ion binding
          calcium ion binding
          protein binding
          phospholipid binding
          microtubule binding
          ferrous iron binding
          zinc ion binding
          oxidoreductase activity
          kinesin binding
          protein domain specific binding
          histone binding
          identical protein binding
          alpha-tubulin binding
          cysteine-type endopeptidase inhibitor activity involved in apoptotic process
          phospholipase binding
          transcription regulatory region DNA binding
          dynein binding
          protein N-terminus binding
          tau protein binding
          beta-tubulin binding
          phosphoprotein binding
          phospholipase D inhibitor activity

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