The Human Big ET-1 Platinum ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human Big ET-1. Cell culture supernatant, serum, and plasma (EDTA, citrate, heparin) have been tested with this assay.
The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
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