Invitrogen
Analytical sensitivity
0.2 ng/mL
Assay range
0.2-50 ng/mL
Sample type/volume
Plasma
50 µL
Serum
50 µL
Supernatant
50 µL
Hands-on time
1 hr 20 min
Time-to-result
4 hr 45 min
Homogenous (no wash)
No
Interassay CV
<12%
Intraassay CV
<10%
Instrument
Colorimetric Microplate Reader
Product size
96 Tests
Contents
Pre-coated 96 well plate
Standard
Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
Wash Buffer
Chromogen
Stop Solution
Adhesive Plate Covers
Shipping condition
Wet or Dry Ice
Storage
2-8°C
Protein name
DAND5
Protein aliases
cerberus 2, cerberus-like 2, Cerberus-like protein 2, Cerl-2, Cysteine knot superfamily 1, BMP antagonist 3, DAN domain family member 5, BMP antagonist, DAN domain family, member 5, Gremlin-3
Species (tested)
Human
Assay kit format
Sandwich ELISA Kit
Detector antibody conjugate
Biotin
Label or dye
HRP
Gene aliases
CER2, CERL2, CKTSF1B3, COCO, CRL2, DAND5, DANTE, GREM3, SP1
Gene ID
Gene symbol
DAND5
UniProt ID
Human COCO quantitates human COCO in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human COCO.
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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