activin A receptor type II-like 1, activin A receptor type IL, activin A receptor, type II-like kinase 1, Activin receptor-like kinase 1, ALK-1, Serine/threonine-protein kinase receptor R3, SKR3, TGF-B superfamily receptor type I, TSR-I
Human ALK-1 quantitates human ALK-1 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human ALK-1.
The TGF-beta superfamily of ligands exerts its biological activity by binding to heteromeric receptor complexes two types (I and II) of the serine/threonine kinases. ALK1, like the other type I receptors, contains a cysteine rich domain with conserved cysteine spacing in the extracellular region and a glycine and serine rich domain preceding the kinase domain. The reduced human ALK1 monomer has a calculated molecular mass of approximately 37.3 kDa. Due to glycoslyation, the recombinant human protein migrates as a 50-55 kDa protein in SDS-PAGE under reducing conditions. Human and mouse ALK1 share approximately 71% amino acid sequence identity in their extracellular domains. ALK1 is highly expressed in endothelial cells and other vascular tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.