Mouse Pref-1/DLK-1/FA1 quantitates mouse Pref-1/DLK-1/FA1 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse Pref-1/DLK-1/FA1.
The Delta-like 1 homolog (DLK1) is a transmembrane protein containing six epidermal growth factor repeats. It is involved in the differentiation of several cell types, including adipocytes and is also thought to be a tumor suppressor. The DLK1 gene is one of several imprinted genes located in a region on chromosome 14q32; certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). DLK1 is expressed from the paternal allele; a polymorphism within this gene has been associated with child and adolescent obesity.
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