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f31 Carrot

Whole Allergen
Code f31
LOINC 6061-6
Family Apiaceae
Genus Daucus
Species carota
Route of Exposure Ingestion
Source Material Raw from and Fresh frozen juice
Latin Name Daucus carota
Common Name Carrot
Other Names Bird's nest, Bishop's lace, Queen Anne's lace, Wild carrot
Categories Food Of Plant Origin, Vegetables


Carrot (Daucus carota) is one of the most important, widely cultivated root vegetables, belonging to Apiaceae family with a rank in the top 10 vegetables around the world. The most widely cultivated species of carrot include D. carota L. subsp. sativus with Central Asia to be considered as the origin. They are classified as eastern and western carrots based on the pigmentation of the roots with colors ranging from orange, yellow, purple, red and white. The fleshy edible taproots of carrots may be allergic to some individuals. Carrot sensitization was found wide across Europe and even in the USA, Mexico, and certain countries of Asia. Carrot is one of the prominent triggering vegetables for pollen-food-allergy-syndrome associated with birch and mugwort pollens. Ingestion can trigger oral allergy syndrome or pollen food allergy syndrome with symptoms ranging from swelling of lips, tongue and throat, nausea, dysphonia, itching of the nose and ear to even systemic reactions like anaphylaxis in some. Dau c 1 reported as a major allergen, out of the 4 allergens, which is homologous to Bet v 1, the birch pollen allergen. Carrot allergens are highly cross-reactive with especially birch tree pollens and celery. The allergy might be prevented in carrot sensitized people by avoiding any intentional or un-intentional consumption of carrot.



Carrot (Daucus carota) is one of the most important root vegetables in the Apiaceae family and is widely cultivated around the world with a rank in the top 10 vegetables (1, 2). It is a biennial erect herbaceous plant with 20-50 cm tall during the mature vegetative stage and 120-150 cm tall when flowering (3). The part of the plant that is mostly consumed is the roots due to its richness in carotenoids, anthocyanins, dietary fiber, vitamins and other nutrients (2). Carrot plants flowers in the second year of growth. Carrot flowers are flattened umbrella-shaped umbel and usually white in color. The leaves of the carrot plants are glabrous, green compound leaves growing in a rosette (2).


Carrot is found in both wild and cultivated types. Wild carrot is a weed and can spread very fast. The cultivated carrot is mostly used as a vegetable. Carrot grows in natural grasslands or cultivated lands (3).


The taxonomic classification of the genus Daucus is not clear. Earlier studies subdivided the genus into 5 sections of 20 species with Daucus L. as one having 12 species. D. carota subsp. carota is the best-known wild species among them. The most widely cultivated carrot includes D. carota L. subsp. sativus domesticated from wild species (4). Spooner et. al., performed a multivariate analysis among D. carota species and proposed to classify all of the known subspecies under two main subspecies as D. carota subsp. carota and subsp. gummifer (4, 5). The cultivated carrots are classified into eastern carrots and western carrots based on the pigmentation of roots. Eastern carrot roots are branched, purple or yellow in color due to the presence of anthocyanin with slightly dissected leaves. Western carrot roots are unbranched, orange-red or white in color due to the presence of carotene with highly dissected leaves (2).

Taxonomic tree of Carrot 
Domain Eukaryota
Kingdom Plantae
Phylum Spermatophyta
Subphylum Angiospermae
Class Dicotyledonae 
Order Apiales
Family Apiaceae
Genus Daucus
Species Daucus carota



Fleshy taproots of carrot plants are the edible parts that may be allergic to some individuals. The shape of the fleshy taproots is usually conical or cylindrical, 5-50 cm long and 2-5 cm in diameter at the top with varied colors like orange, yellow, purple, red and white. The top of the root is usually green (2).


Worldwide distribution

Most of the carrot allergic persons are reported to be sensitive to birch or mugwort pollens (6). A survey regarding triggers and symptoms of food allergy was conducted in Germany on 73 patients with a history of birch pollen associated food allergy. The results reported that the carrot was responsible for eliciting allergic reactions in 52% of patients (7). According to a EuroPrevall analysis (the study about the basis and prevalence of food allergy across Europe), 3.6% prevalence of sensitization to carrot was observed in a study on 4522 adults (aged 20-39 years) from 13 countries across Europe (8). Apple, banana and carrot were triggering foods for 5% of pollen food allergy syndrome (PFAS) due to birch and ragweed pollens in 122 children (0-18 year) in the USA (9), whereas, apple, peach and carrot were triggering foods for 26.7% of PFAS due to birch, grass and ragweed pollens in Croatia including 120 patients (10). A total of 2633 Mexican subjects were tested for food allergy through immunoglobulin E (IgE) positivity and carrot was found as food with high positivity in 37.5% of subjects although less than 50 samples tested (11).

A prevalence study of self-reported food allergy (FA), food sensitization (FS) and probable FA (individuals having symptoms plus IgE sensitization) to 24 Europrevall priority foods in adults (12) and in school-age children across Europe (13) was conducted to analyze geographical variation. Probable FA to carrot was markedly common among adults in Zurich, Switzerland (1.0 %) than in other countries of Europe (12). Carrot constituted 1.1% of 16,935 children (7-10 years old) for self-reported FA. Carrot along with hazelnut, apple and celery were important sources of FA in children in Central and Northern Europe. Carrot was among the most common sensitizing food in children causing probable FA in birch-endemic countries, Switzerland, Netherlands, Poland and Lithuania, maybe due to cross-reactivity with birch PR-10 protein (13). The prevalence of FS for carrot in the total study population (2196 patients) with available food serology was found to be 12.4% in Zurich, 8.3% in Madrid, 4.8% in Athens, 7.2% in Utrecht, 4.5% in Vilnius, 5.0% in Lodz and 2.1% in Reykjavik. Carrot was the cause of self-reported FA and matching FS in 30.3% of the total of 1989 subjects with available food serology (13).  

A similar study was conducted in South India for the 24 Europrevall priority foods in 11,791 adults (20-54 years), however, the South-Indian population was not found to be allergic to carrot as compared to high sensitization in Europe (14). According to a study conducted in China, India and Russia for 24 Europrevall priority foods in 35,549 school children (6-11 years), 1.5% subjects in Hongkong, 0% in Guangzhou, 2.0% in Shaoguan, 2.5% in Tomsk and 6.7% in India depicted positive serum specific IgE to carrot. However, only 0.15% of subjects in Russia reported symptoms with positive IgE, while others countries were not found to have a probable food allergy to carrot (15).

Risk factors

Carrot is considered to be one of the prominent triggering vegetables for pollen-food-allergy-syndrome (PFAS) associated with birch and mugwort pollens (10).

Environmental Characteristics

Living environment

Carrot adapts and grows in a cool climate and can be sown in spring in temperate zones or in winter in subtropical zones (2). It grows well at altitudes of 700 m in tropical regions with an optimum temperature of 16-24ºC and grows best in well-drained fertile soil with sandy texture and pH of 6.0 to 6.5 (3).

Worldwide distribution

Central Asia is considered to be one of the origins of cultivated carrot with Afghanistan to be thought as the first center of diversity and Turkey as the second center (2). Its cultivation has spread throughout the world and is now native to temperate regions of Europe, Southwestern Asia, and North Africa. It is also grown in North America, Japan, New Zealand and Australia (3). 

Route of Exposure Section


Ingestion of carrot can trigger food related allergic response as Oral Allergy Syndrome (OAS) or Pollen food allergy syndrome (PFAS) (16-19).

Clinical Relevance

Food Allergy

Carrot is normally associated with food allergy and OAS or PFAS (Sánchez-Guerrero et al, 2020). Allergic symptoms in OAS mostly include the oropharyngeal regions such as swelling of lips, tongue, and throat, nausea, dysphonia, and itching of the nose and ear (17, 20). About 50% of carrot allergic patients develop systemic reactions (6). In a study on 55 patients with airborne allergy, food hypersensitivity (mainly OAS) was reported in 15 patients especially with apples, carrots, cherry, peach, hazelnut, walnut, celery and nectarines (21). Systemic allergic reactions are reported after the ingestion of carrot in pollen allergic patients due to cross-reactivity (22). PFAS was found to be significantly correlated with root vegetables including carrot in a study conducted on 54 seasonal allergic rhinitis patients (23).

Allergic rhinitis

A study on 2305 representative samples of the Korean population found that more carrot consumption (OR - 2.01; CI, 1.01–1.43; p - 0.10) was associated with increased risk of allergic rhinitis (24). A study enrolled 54 patients with seasonal allergic rhinitis and subjected to skin prick tests and microarray analysis to determine the incidence of PFAS and food tolerance. Carrot showed a positive skin prick test in 29 patients (23).


Some patients presented asthma due to handling or ingesting raw carrots which were due to major carrot allergen Dau c 1 according to a small study. 2 patients were found to be sensitized to carrots directly without pollens involved while 1 patient has pollen-related carrot allergy (25).

Atopic Dermatitis

Allergic contact dermatitis by Apiaceae root vegetables is rare, however; few cases of dermatitis have been reported due to carrots (26-28).

Other diseases

Anaphylactic shock has been reported in some case studies in carrot allergic patients (17, 29, 30).

Other topics

As per a study, carrot was the food trigger for PFAS in 15.5% of adults with eosinophilic esophagitis (31).

Prevention and Therapy

Prevention strategies


The major management of carrot allergy in pollen sensitized individuals is to avoid eating the food which poses a positive challenge (22). 


Molecular Aspects

Allergenic molecules

A total of 3 allergens have been formally named from carrot by WHO/IUIS Allergen Nomenclature Sub-committee (32), however, Dau c cyclophilin has also been reported in the literature (33, 34).


Biochemical Name

Molecular Weight


Dau c 1

Pathogenesis-related protein, PR-10, Bet v 1 family member

16 kDa

85% of 26 carrot allergics were sensitized to Dau c 1 (35). 98% of 40 carrot allergic patients were allergic to isoallergen Dau c 1.0104 variant while 65% to Dau c 1.0201 (36, 37).

Dau c 4


14 kDa

A relatively smaller number of patients (20%) are sensitive to Dau c 4 (35).

Dau c 5

Isoflavone reductase-like protein (IFR)

33 kDa

 IFR-1 and IFR-2 were found in 6% and 20% of 49 carrot allergics respectively (34).

Dau c

Cyclophilin protein

20 kDa



The major carrot allergen is Dau c 1, homologous to Bet v 1, the birch pollen allergen belonging to the class of pathogenesis-related class 10 (PR-10) (6). Profilin was considered as a minor allergen in carrots (38). Carrot cyclophilin (Dau c Cyc) showed IgE antibody binding in carrot allergic patients in Japan. However, the study on 49 carrot allergic patients conducted to evaluate the carrot allergens found sensitization to Dau c Cyc in only one carrot allergic patient (34).  Lipid like transfer protein (LTP) was not found to be a concern for carrot allergic individuals (6). Dau c 1 does not change its structure until higher temperatures are reached (39). As per the study conducted by Jacob, et al., the heat sensitivity of Dau c 1 differs with specific isoallergen and pH. The natural Dau c 1 in carrots is heat stable as cooked carrot extract could generate mediator release. Different isoallergens (nDau c 1, Dau c 1.0301, Dau c 1.0201, Dau c 1.0105 and Dau c 1.0104) were found heat resistant and stable at pH 3 (stomach conditions). Further, Dau c 1.0301 at pH 3 and Dau c 1.0201 at pH 7 unfolds but were able to trigger the mediator response (36).

Dau c 1 can induce allergic responses independent from Bet v1. This was proved as Dau c 1 was able to trigger Bet v 1 independent T-cell response in 31 birch pollen-allergic patients showing allergic symptoms after ingestion of raw carrots (40).


A number of studies have reported cross-reactivity between pollens (especially Birch and mugwort) and carrot (17, 41, 42) leading to oral allergy syndrome.

Cross-reactivity is also found between the species of Apiaceae family too. The major allergen in carrot (Dau c 1) is homologous to Bet v 1 – the major birch pollen allergen. A study has shown that 70% of patients allergic to birch pollen may also be allergic to apples, nuts, celery, soybeans in addition to carrots (43).

Carrot-celery-mugwort spice syndrome is quite known in Europe. Carrot, celery and spices were found to be highly cross-reactive along with sensitivity to birch pollens (44). 

Compiled By

Author: Turacoz Healthcare Solutions

Reviewer: Dr. Fabio Iachetti


Last reviewed: November  2020

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