Critical Care Medicine Physician
New York, USA
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Bacterial co-infection and secondary bacterial infections are relatively infrequent (< 10%) in hospitalized patients with COVID-19, yet over 70% of patients receive antibiotics on hospital admission and often for several days.1
Majority of these patients may not require empiric IV antibiotics. Procalcitonin has a high negative-predictive value at ≤ 0.25 μg/L for determining need for antibiotics in patients with community-acquired pneumonia, including those who have underlying malignancy.
PCT levels also have a high negative predictive value when compared to blood cultures.2,3 Serial PCTs can assist with confirming the initial negative result and indicate that antibiotics are no longer necessary.