antibody-purification-showcase

CaptureSelect Antibody Toolbox products are designed to enhance the success of your antibody purification processes. The products offer specific advantages over purification using Proteins A, G, and L, including unique target specificity and simplified elution protocols. Each product has defined target specificity for distinct antibody types and regions, minimizing the need for you to test multiple media products to determine the optimal choice.

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CaptureSelect Antibody Toolbox products offer:

  • Unique selectivity
  • High purity in a single step
  • Increased yield
  • Flexible formats
  • Species specificity

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Single-step purification of many antibody formats

Many kinds of antibody formats can be purified with one of our Antibody Toolbox products. Unlike the common bacterial coat protein matrices, Proteins A, G, and L, CaptureSelect ligands are developed with defined specificity and high avidity to the target protein of interest. This results in affinity chromatography resins well suited for single-step protein purification.

CaptureSelect Antibody Toolbox resins for biomolecule purification

IgG all sublasses

Characteristics

Pre-packed column

RoboColumn®^

BioProcess

CaptureSelect IgG-CH1

Suitable for purification of human IgG and all Fab fragments

IgG-CH1

 

IgG-CH1

CaptureSelect CH1-XL Suitable for purification of human IgG and all Fab fragments, offering mild elution conditions

CH1-XL

CH1-XL CH1-XL

CaptureSelect FcXL

Specific for human IgG, recognizing all four subclasses, offering mild elution conditions

FcXL

FcXL

FcXL

CaptureSelect IgG-Fc (ms)

Designed to purify IgG from multiple species by high affinity binding to the Fc region of IgGs

CaptureSelect IgG-Fc (rabbit) Designed to purify rabbit IgG from recombinant and plasma sources.
Light chains Characteristics      
CaptureSelect KappaXP To purify all human kappa Ig light chain containing products, offering high binding capacity and mild elution conditions
CaptureSelect KappaXL To purify all human kappa Ig light chain containing products, offering mild elution conditions Pre-packed column RoboColumn BioProcess
CaptureSelect LC-kappa (mur) Murine Ig binder recognizing IgG, IgM, IgA, IgD, IgE, Fab fragments, Poly Ig from mouse, rat and guinea pig
CaptureSelect LC-lambda (Hu) To purify all human lambda Ig light chain containing products
CaptureSelect LC-lambda (ung) Suitable for Ig’s, Fab fragments and free light chains from ungulates (bovine, horse, donkey, sheep, goat, pig)
CaptureSelect LC-lambda (mouse) Mouse Ig binder recognizing IgG, IgM, IgA, IgD, IgE, Fab fragments containing a lambda light chain
CaptureSelect LC-lambda (rat) Ig binder recognizing IgG, IgM, IgA, IgD, IgE, Fab fragments containing a lambda light chain from Rat and Guinea Pig
Isotype specific Characteristics
POROS CaptureSelect IgM
IgM resin suitable for human, mouse and rat IgM's
CaptureSelect IgA For purification of human IgA, IgA-dimers and secretory IgA (sIgA)
CaptureSelect IgA-CH1 (Hu) For purification of human IgA, IgA-dimers and secretory IgA (sIgA) and Fab fragments thereof
CaptureSelect Bovine IgA For purification of bovine IgA from whey. The resin enables purification of monomeric, dimeric and secretory bovine IgA.
CaptureSelect IgE For the purification of human IgE (immunoglobuline E) from recombinant and plasma sources.
IgG subclass specific Characteristics
CaptureSelect IgG4 (Hu) Specific for human IgG4 without any crossbinding to other subclasses or species
CaptureSelect IgG1 (Hu) Specific for human IgG1 without any crossbinding to other subclasses or species
CaptureSelect IgG3 (Hu) Specific for human IgG3 without any crossbinding to other subclasses or species

IgG all sublasses

Characteristics

Pre-packed column

RoboColumn®^

BioProcess

CaptureSelect IgG-CH1

Suitable for purification of human IgG and all Fab fragments

IgG-CH1

 

IgG-CH1

CaptureSelect CH1-XL Suitable for purification of human IgG and all Fab fragments, offering mild elution conditions

CH1-XL

CH1-XL CH1-XL

CaptureSelect FcXL

Specific for human IgG, recognizing all four subclasses, offering mild elution conditions

FcXL

FcXL

FcXL

CaptureSelect IgG-Fc (ms)

Designed to purify IgG from multiple species by high affinity binding to the Fc region of IgGs

CaptureSelect IgG-Fc (rabbit) Designed to purify rabbit IgG from recombinant and plasma sources.
Light chains Characteristics      
CaptureSelect KappaXP To purify all human kappa Ig light chain containing products, offering high binding capacity and mild elution conditions
CaptureSelect KappaXL To purify all human kappa Ig light chain containing products, offering mild elution conditions Pre-packed column RoboColumn BioProcess
CaptureSelect LC-kappa (mur) Murine Ig binder recognizing IgG, IgM, IgA, IgD, IgE, Fab fragments, Poly Ig from mouse, rat and guinea pig
CaptureSelect LC-lambda (Hu) To purify all human lambda Ig light chain containing products
CaptureSelect LC-lambda (ung) Suitable for Ig’s, Fab fragments and free light chains from ungulates (bovine, horse, donkey, sheep, goat, pig)
CaptureSelect LC-lambda (mouse) Mouse Ig binder recognizing IgG, IgM, IgA, IgD, IgE, Fab fragments containing a lambda light chain
CaptureSelect LC-lambda (rat) Ig binder recognizing IgG, IgM, IgA, IgD, IgE, Fab fragments containing a lambda light chain from Rat and Guinea Pig
Isotype specific Characteristics
POROS CaptureSelect IgM
IgM resin suitable for human, mouse and rat IgM's
CaptureSelect IgA For purification of human IgA, IgA-dimers and secretory IgA (sIgA)
CaptureSelect IgA-CH1 (Hu) For purification of human IgA, IgA-dimers and secretory IgA (sIgA) and Fab fragments thereof
CaptureSelect Bovine IgA For purification of bovine IgA from whey. The resin enables purification of monomeric, dimeric and secretory bovine IgA.
CaptureSelect IgE For the purification of human IgE (immunoglobuline E) from recombinant and plasma sources.
IgG subclass specific Characteristics
CaptureSelect IgG4 (Hu) Specific for human IgG4 without any crossbinding to other subclasses or species
CaptureSelect IgG1 (Hu) Specific for human IgG1 without any crossbinding to other subclasses or species
CaptureSelect IgG3 (Hu) Specific for human IgG3 without any crossbinding to other subclasses or species

^RoboColumn is a product of Repligen Corp.

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