Shop All Kinases

MAPK1 (ERK2) Recombinant Human Protein

MAPK1 (ERK2) is a serine⁄threonine kinase that acts as an important activator of p90 RSK, MSK, ELK1, and Stat3, and is involved in the MAPK pathway.

PBK (TOPK) Recombinant Human Protein

PBK (TOPK) is a serine⁄threonine kinase that is related to the dual specific mitogen-activated protein kinase kinase (MAPKK). The kinase is up-regulated in a variety of hematological malignancies, participates in activating lymphoid cells, and supports testicular function (spermatogenesis).

MINK1 Recombinant Human Protein

MINK1 is a serine⁄threonine kinase belonging to the germinal center kinase (GCK) family.

STK38 (NDR) Recombinant Human Protein

STK38 (also known as NDR) or Nuclear Dbf2-related protein is a serine/threonine kinase in the subgroup of the AGC kinase family that is regulated by Mob proteins. Fas and TNFα receptor stimulation activates human STK38 by promoting phosphorylation at the hydrophobic motif. NDR acts as a novel pro-apoptotic kinase, and is a key member of the RASSF1A/MST1 signaling cascade. STK38 is crucial for the fidelity of mitotic chromosome alignment in mammalian cells. STK38 is incorporated into the HIV-1 particles and is cleaved by the HIV-1 protease. STK38-driven centrosome duplication requires Cdk2 activity, and Cdk2-induced centrosome amplification is affected upon reduction of STK38 activity. Full-length recombinant human STK38 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay

PLK3 Recombinant Human Protein

PLK3 is a member of the polo family of serine⁄threonine kinases. PLK3 is involved in the regulation of M phase in the cell cycle.

EEF2K Recombinant Human Protein

EEF2K is a highly conserved Serine⁄Threoning kinase in the calmodulin signaling pathway whose activity is increased in cancers including breast cancer.

CLK1 Recombinant Human Protein

CLK1 is a dual specificity kinase that phosphorylates PTP-1B and members of the SR family of splicing factors. It is thought to be involved in neuronal differentiation and mRNA splicing.

CDK9/Cyclin T1 Recombinant Human Protein

CDK9 is a serine⁄threonine kinase which when complexed with CyclinT1 forms an active holoenzyme complex. This complex plays a key role in regulating the eukaryotic cell cycle. CDK9 is coexpressed and copurified with CyclinT1.

PDGFRA (PDGFR α) Recombinant Human Protein

PDGFRA is a cell surface receptor tyrosine kinase which binds members of the platelet-derived growth factor family.

CDK18/cyclin Y Recombinant Human Protein (Invitrogen™)

This CDK18/cyclin Y recombinant human protein (CDK18: full length, cyclin Y: 2–end) was expressed in insect cells. CDK18/cyclin Y serine/threonine kinase or cyclin-dependent kinase 18 belongs to the cdc2/cdkx subfamily of kinases. CDK18/cyclin Y is thought to play a role in terminally differentiated neurons and it contains an N-terminal extension relative to CDC2. CDK18/cyclin Y is expressed in a variety of human cell lines and tissues. Elevation in the protein levels of CDK18/cyclin Y in the temporal cortex of Alzheimer's disease relative to control brains has been observed. It is proposed that CDK18/cyclin Y is a paired helical filaments-associated kinase that modulates tau phosphorylation. CDK18/cyclin Y recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

STK38L (NDR2) Recombinant Human Protein

STK38L (also known as NDR2) or Nuclear Dbf2-related protein is a serine/threonine kinase in the subgroup of the AGC kinase family. STK38L act as novel pro-apoptotic kinase that is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis. STK38L is mainly involved in the regulation of structural processes in differentiating and mature neuronal cells and it is highly expressed with highest levels observed in the thymus. Recombinant full-length human STK38L was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay

PRKACA (PKA) Recombinant Human Protein

PRKACA (PKA) is a serine⁄threonine protein kinase that phosphorylates a broad spectrum of substrates. PRKACA regulates many cellular processes including cell growth, cell differentiation, ion-channel conductivity, gene transcription, and synaptic release of neurotransmitters.

RIPK2 Recombinant Human Protein

RIPK2 is a serine⁄threonine kinase that is involved in cell activation, proliferation, differentiation, and apoptosis.

EPHA3 Recombinant Human Protein

EPHA3 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. EPHA3 encodes a protein that binds ephrin-A ligands.

KIT [V654A] Recombinant Human Protein

KIT is a proto-oncogene encoding a transmembrane tyrosine kinase receptor for stem cell factor required for normal hematopoiesis, melangenesis and gametogenesis. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. The clinically observed V654A mutant has been demonstrated to be resistant to inhibition with imatinib.