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TNK2 (ACK) Recominant Human Protein

TNK2 (ACK) (activated Cdc42-associated kinase) is a non-receptor tyrosine kinase that signals downstream of Cdc42. TNK2 is known to be involved in tumorigenesis and metastasis, particularly in prostate cancer.

MAP2K6 (MKK6) Recombinant Human Protein

MAP2K6 (MKK6) is a serine⁄threonine kinase that functions as an activator of p38 in the MAPK pathway.

STK17A (DRAK1) Recombinant Human Protein

STK17A (DRAK1) is a serine⁄threonine kinase localized in the nucleus and involved in apoptosis.

GRK6 Recombinant Human Protein

GRK6 is a member of the guanine nucleotide-binding protein coupled receptor kinase subfamily of the serine⁄threonine protein kinase family. GRK6 phosphorylates the activated forms of G protein-coupled receptors to initiate their deactivation.

CDK9 Recombinant Human Protein, Inactive

CDK9 is a member of the cyclin-dependent protein kinase (CDK) family. CDK9 is closely related to cdc28 and cdc2 and is an important regulator of the cell cycle. CDK9 is a component of the multiprotein complex TAK/P-TEFβ. CDK9 can modulate RNA polymerase II-directed transcription by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. CDK9 forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. CDK9 also interacts with the HIV-1 Tat protein which suggested a possible involvement of this protein in AIDS. Recombinant full-length human CDK9 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay

ACVR1 (ALK2) Recombinant Human Protein

Activin A receptor, type I (ACVR1) belongs to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. ACVR1 signals a specific transcriptional response in concert with activin type II receptors

TLK2 Recombinant Human Protein

TLK2 or Tousled-like kinase 2, is a nuclear serine/threonine kinases that is thought to be involved in the regulation of chromatin assembly. In addition, TLK2 is also involved in other cellular processes such as intracellular signaling cascade, protein amino acid phosphorylation, cell cycle, chromatin modification and in response to DNA damage stimulus. TLK2 displays maximal activity during S phase of the cell cycle where it appears to be regulated by cell-cycle-dependent phosphorylation. Inhibition of DNA replication causes a rapid loss of TLK2 activity, indicating that TLK2 function is tightly linked to ongoing DNA replication. Recombinant human TLK2 (388-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay

CAMK1D (CaMKI Delta) Recombinant Human Protein

CAMK1D (CaMK1 delta) is a serine⁄threonine kinase that is a member of the calcium⁄calmodulin-dependent protein kinase family. CAMK1D is expressed in polymorphonuclear leukocytes and may be part of the chemokine signal transduction pathway that regulates granulocyte function. It may also be involved in modulation of neuronal apoptosis.

IRAK1 Recombinant Human Protein

IL-1 receptor associated kinases (IRAKs) are serine⁄threonine kinases involved in signaling via Toll⁄IL-1 pathways.

MAP2K6 (MKK6) [S207E] [T211E] Recombinant Human Protein

MAP2K6 (MKK6) is a serine⁄threonine kinase that functions as an activator of p38 in the MAPK pathway. The MAP2K6 S207E T211E mutant is constitutively active.

STK22B (TSSK2) Recombinant Human Protein

STK22B (TSSK2) is a serine⁄threonine kinase essential for the function and production of sperm (spermiogenesis). Deletions in the STK22B coding region correlate with numerous cardiovascular and glandular malformations.

MAP2K3 (MEK3) Recombinant Human Protein

MAP2K3 (MEK3) is a dual-specificity protein kinase which acts in cellular signal transduction pathways, and is necessary for the expression of glucose transporter.

EGFR (ErbB1) d747-749 A750P Recombinant Human Protein (Invitrogen™)

This EGFR (ErbB1) d747-749 A750P recombinant human protein (672–end) was expressed in insect cells. EGFR receptor tyrosine kinase is a transmembrane glycoprotein. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation. EGFR (ErbB1) d747-749 A750P recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

STK3 (MST2) Recombinant Human Protein

STK3 (MST2) is a STE kinase family member that acts upstream of the MAP kinase signaling pathways, and is known to be activated by the proapoptotic stimuli staurosporine and FAS ligand.

CAMK1G (CaMKI gamma) Recombinant Human Protein (Invitrogen™)

This CAMK1G (CaMKI gamma) recombinant human protein (full length) was expressed in insect cells. CAMK1G serine/threonine kinase is a member of CAMK family and is a novel membrane-anchored neuronal Ca2+ calmodulin-dependent protein kinase. Full activation of CAMK1G requires both Ca2+ and calmodulin and phosphorylation by CAMKK. CAMK1G transcripts are most abundant in neurons, with the highest levels in limited nuclei such as the central nucleus of the amygdala (CeA) and the ventromedial hypothalamus. CAMK1G (CaMKI gamma) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service