Shop All Kinases

MATK (Hyl) Recombinant Human Protein

MATK (Hyl) is a non-receptor CSK-type protein tyrosine kinase that is thought to function in signal transduction pathways important in megakaryocyte growth and⁄or differentiation.

MAPK14 (p38 α) Recombinant Human Protein

MAPK14 (p38 alpha) is a member of the stress-activated protein kinase class of MAPKs.

LATS2 Recombinant Human Protein

LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. LATS2 interacts with a negative regulator of p53 and function in a positive feedback loop with p53 that responds to cytoskeleton damage and this interaction provokes centrosome/mitotic apparatus dysfunction. LATS2 plays an essential role in the maintenance of mitotic fidelity and genomic integrity. Recombinant human LATS2 (480-1088) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay

CLK3 Recombinant Human Protein

CLK3 is a dual specificity kinase that can interact with and cause the nuclear redistribution of SR proteins.

INSR Recombinant Human Protein

INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake.

PIP5K1C Recombinant Human Protein (Invitrogen™)

This PIP5K1C recombinant human protein (full length) was expressed in insect cells. PIP5K1C lipid kinase or phosphatidylinositol-4-phosphate 5-kinase 1 gamma phosphorylates phosphatidylinositol-4-phosphate to form phosphatidylinositol 4,5-bisphosphate. PIP5K1C is found at synapses and has been found to play roles in endocytosis and cell migration. PIP5K1C directly associates with β-catenin and increases β-catenin activity downstream of growth factor stimulation. PIP5K1C expression and kinase activity enhance β-catenin phosphorylation on residues that promote nuclear importation and transcriptional activity. PIP5K1C deficiency impairs neutrophil recruitment as a result of defect in adhesion. PIP5K1C regulated the adhesion through facilitation of RhoA GTPase and integrin activation by chemoattractants. PIP5K1C recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Adapta™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

CSNK2A1 (CK2 α 1) Recombinant Human Protein

CSNK2A1 is a serine⁄threonine protein kinase that phosphorylates acidic proteins.

CLK4 Recombinant Human Protein

CLK4 belongs to the CDC2-like protein kinase (CLK) family. It can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus is thought to be involved in the regulation of alternative splicing.

INSRR (IRR) Recombinant Human Protein

INSRR, insulin receptor-related receptor, is a member of the insulin receptor (IR) family. INSRR does not bind insulin-like molecules, but is similar to INSR in tyrosine kinase activity.

SRC Recombinant Human Protein

SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in the regulation of embryonic development and cell growth.

EPHA1 Recombinant Human Protein

EPHA1 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system.

PLK1 Recombinant Human Protein

PLK1 is a serine⁄threonine kinase that is thought to function in cell mitosis and regarded as a marker of cell proliferation. It has been found to play a critical role in carcinogenesis.

AMPK A2/B1/G1 Recombinant Human Protein

AMP-activated protein kinase (AMPK) is a heterotrimeric complex that acts as a sensor of cellular energy levels. The signaling cascades initiated by activating AMPK are critical to regulating metabolic events in the liver, skeletal muscle, heart, adipose tissue, and pancreas. An impairment in fuel metabolism that occurs in obesity is a factor leading to Type 2 diabetes. The insulin resistance associated with type 2 diabetes is most profound at the level of skeletal muscle, the primary site of glucose and fatty acid utilization. Activation of AMPK is of interest for the treatment of type 2 diabetes.

NEK1 Recombinant Human Protein

NEK1 is a serine⁄threonine protein kinase, related to the NIMA cell cycle regulator, and is highly expressed in meiotic germ cells. The kinase may function early in the DNA damage response pathway. NEK1 may also participate in polycystic kidney disease and neural cell development.

TAOK2 (TAO1) Recombinant Human Protein

TAOK2 (TAO1) is a serine⁄threonine kinase that may be an important regulator of the stress-responsive p38 MAP kinase pathway.

ROCK2 Recombinant Human Protein

ROCK2, the predominant ROCK isoform in skeletal muscle, is an important regulator downstream of Rho GTPases.

CDK18/cyclin Y Recombinant Human Protein (Invitrogen™)

This CDK18/cyclin Y recombinant human protein (CDK18: full length, cyclin Y: 2–end) was expressed in insect cells. CDK18/cyclin Y serine/threonine kinase or cyclin-dependent kinase 18 belongs to the cdc2/cdkx subfamily of kinases. CDK18/cyclin Y is thought to play a role in terminally differentiated neurons and it contains an N-terminal extension relative to CDC2. CDK18/cyclin Y is expressed in a variety of human cell lines and tissues. Elevation in the protein levels of CDK18/cyclin Y in the temporal cortex of Alzheimer's disease relative to control brains has been observed. It is proposed that CDK18/cyclin Y is a paired helical filaments-associated kinase that modulates tau phosphorylation. CDK18/cyclin Y recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

CSF1R (FMS) Recombinant Human Protein

CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias.

CSNK1D (CK1 δ) Recombinant Human Protein

CSNK1D (CK1 delta), a serine/threonine kinase, plays a critical role in Wnt/beta-catenin signaling pathway. This pathway is important in both development and cancer.

PRKCB1 (PKC beta I) Recombinant Human Protein (Invitrogen™)

The PKC family of serine/threonine kinases, including PRKCB1 (PKC beta I), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent.

MERTK (cMER) Recombinant Human Protein

MERTK (cMER) is a tyrosine kinase proto-oncogene and is involved in the retinal pigment epithelium (RPE) phagocytosis pathway, which is implicated in human retinal disease.

ABL1 Recombinant Human Protein

The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response.

PRKCH (PKC eta) Recombinant Human Protein

The PKC family of serine⁄threonine kinases, including PRKCH (PKC eta), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent.

MAPKAPK3 Recombinant Human Protein

MAPKAPK3 functions as an integrative element of signaling in both mitogen and stress responses.

IRAK3 Recombinant Human Protein (Invitrogen™)

This IRAK3 recombinant human protein (full length) was expressed in insect cells. IRAK3 serine/threonine kinase or interleukin-1 receptor-associated kinase 3 is a member of the interleukin-1 receptor-associated kinase protein family which are essential components of the Toll/IL-R immune signal transduction pathways. IRAK3 is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. IRAK3 mediates critical aspects of innate immunity that result in an immunocompromised state during sepsis. Mutations in IRAK3 are associated with a susceptibility to asthma. IRAK3 recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

JAK3 Recombinant Human Protein

Janus kinase 3 (JAK3) phosphorylates members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to activation of interleukin receptors.

ZAP-70 Recombinant Human Protein

ZAP-70 is a cytosolic protein tyrosine kinase that is a member of the Syk family of proteins. ZAP-70 is expressed exclusively in T-cells and natural killer cells and is required for T-cell receptor activation.

MAP2K6 (MKK6) Recombinant Human Protein

MAP2K6 (MKK6) is a serine⁄threonine kinase that functions as an activator of p38 in the MAPK pathway.

OXSR1 Recombinant Human Protein (Invitrogen™)

This OXSR1 recombinant human protein (full length) was expressed in insect cells. OXSR1 serine/threonine kinase or (OSR1) is activated by osmotic stresses and regulates downstream protein kinases such as PAK1 in order to establish the sensor/signaling modules that initiate the cellular response to environmental stress. OXSR1 can be phosphorylated by ATM or ATR during the DNA damage process. OXSR1 recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

PAK6 Recombinant Human Protein

PAK6 is a serine⁄threonine kinase expressed in the testis and prostate. It associates with both the estrogen and androgen receptors.

MAP2K2 (MEK2) Recombinant Human Protein

MAP2K2 (MEK2) is a dual specificity serine⁄threonine kinase that is known to play a critical role in mitogen growth factor signal transduction.

PIK3CG (p110 gamma) Recombinant Human Protein

PIK3CG (p110 gamma) is the sole class IB phosphatidylinositol 3-kinase family member, which along with the class IA family members, generates the important second messenger PIP2. However, unlike the class IA enzymes which signal downstream of receptor tyrosine kinases, PIK3CG primarily signals downstream of GPCRs.

PRKX Recombinant Human Protein

PRKX is a serine⁄threonine kinase related to the catalytic subunit of the cAMP-dependent protein kinases.

HIPK1 (Myak) Recombinant Human Protein

HIPK1 phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors.

MAP2K5 (MEK5) Recombinant Human Protein (Invitrogen™)

This MAP2K5 (MEK5) recombinant human protein (full length) was expressed in insect cells. MAP2K5 (MEK5) serine/threonine kinase (mitogen-activated protein kinase kinase 5) or MEK5 is a dual specificity protein kinase that belongs to the MAP kinase kinase family which specifically interacts with and activates MAPK7/ERK5. MAP2K5 itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by MAP2K5 is involved in growth factor stimulated cell proliferation and muscle cell differentiation. The rs3743354 polymorphism in the MAP2K5 promoter may affect the risk of developing colorectal cancer (CRC). MAP2K5 (MEK5) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

TAOK3 (JIK) Recombinant Human Protein

TAOK3 (JIK) is a serine⁄threonine kinase that is a member of the GCK-like subfamily of the STE20 kinase family. JIK is ubiquitously expressed in human tissues, inhibits JNK and has been implicated in cancer.

BRSK1 (SAD1) Recombinant Human Protein

BRSK1 (SAD1) is a serine⁄threonine kinase, and is a UV-induced DNA damage checkpoint kinase

ABL1 [E255K] Recombinant Human Protein

The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. The E255K mutant is a Gleevec resistant form of ABL1.

PAK7 (KIAA1264) Recombinant Human Protein

PAK7 (KIAA1264) is implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling.

RPS6KB2 (p70S6K Beta) Recombinant Human Protein

RPS6KB2 (p70S6K beta) is a serine⁄threonine kinase with 2 non-identical kinase catalytic domains which phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.

MYO3B (MYO3 beta) Recombinant Human Protein

MYO3B (MYO3 beta) is a member of the Class III myosins that are actin-dependent motor proteins containing an amino-terminal kinase domain. MYO3B contains a N-terminal kinase domain, followed by motor, neck, and tail domains. The MYO3B gene generates a variety of splice variants that contain 1 or 2 calmodulin-binding (IQ) motifs in the neck domain and 1 of 3 domains in the tail domain. Northern blot analysis shows expression of a 7-kb MYO3B transcript in the human retina but not in a RPE cell line. The MYO3B gene transcript is also detected in the kidney, intestine and testis. The MYO3B gene maps to chromosome 2q31.1-q31.2 by genomic sequence alignment. Recombinant human MYO3B (1-326) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay

MAPK3 (ERK1) Recombinant Human Protein, Inactive

MAPK3 (ERK1) is a serine⁄threonine kinase that is an important activator of p90, RSK, MSK, ELK1, and Stat3, and is involved in the MAPK pathway.

CDK14 (PFTK1)/cyclin Y Recombinant Human Protein

CDK14 (PFTK1)/cyclin Y is a member of the CDC2-related protein kinase family which is expressed primarily in the postnatal and adult nervous system. CDK14 is expressed at high levels in brain, pancreas, kidney, heart, testis, and ovary. CDK14 amino acid residue ser119 is required for its interaction with all four 14-3-3 isoforms, while ser120 may contribute slightly to CDK14 binding. CDK14 acts as a cyclin-dependent kinase that regulates cell cycle progression and cell proliferation. Overexpression of CDK14 predicts resistance to chemotherapy in patients with oesophageal squamous cell carcinoma. Recombinant human full-length CDK14 and Cyclin Y (2-end) were co-expressed by baculovirus in Sf9 insect cells using N-terminal GST tags.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay

PI4KB (PI4K beta) Recombinant Human Protein

PI4KB and PI4KA are the two human type III PI4 kinases, which share sequence similarly with PI3 kinases and phosphorylate the 4 position of phosphotidyl inositol.

IGF1R Recombinant Human Protein

IGF1R, also known as Insulin-like Growth Factor 1 (IGF-1) Receptor, is a receptor tyrosine kinase activated by IGF-1 and IGF-2. IGFR has been implicated in a variety of cancers.

IRAK4 Recombinant Human Protein

IL-1 receptor associated kinases (IRAKs) are serine⁄threonine kinases involved in signaling via Toll⁄IL-1 pathways.

CDK4/cyclin D3 Recombinant Human Protein (Invitrogen™)

This CDK4/cyclin D3 recombinant human protein (CDK4: full length, cyclin D3: full length) was expressed in insect cells. CDK4/cyclin D3 serine/threonine kinase is dimeric protein complex. CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of Rb protein leading to an active transcriptional repression of E2F complex. CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivities in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein. CDK4/cyclin D3 recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Adapta™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

CSNK1E (CK1 ε) Recombinant Human Protein

CSNK1E (CK1 epsilon) is a serine⁄threonine kinase implicated in a wide range of cellular functions, including vesicular trafficking, DNA damage repair, cell cycle progression, and cytokinesis.

ABL1 [T315I] Recombinant Human Protein

The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. The T315I mutant is a Gleevec resistant form of ABL1.

MUSK Recombinant Human Protein

MUSK plays an important and selective role in many aspects of skeletal muscle development and function through the initial step of postsynaptic differentiation and formation of end-plate bands in cooperation with Rapsyn.

STK25 (YSK1) Recombinant Human Protein

STK25 (YSK1) is a serine⁄threonine kinase that belongs to the GCK family of kinases. It has been implicated as an upstream regulator of MAP kinase signaling pathways.

AXL [R499C] Recombinant Human Protein

AXL, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase which is a member of the TAM (TYRO3/AXL/MER) receptor tyrosine kinase subfamily. AXL represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats and Axl transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. AXL is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Recombinant human AXL R499C (473-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay

ABL2 (Arg) Recombinant Human Protein

ABL2 (Arg) is an Abl-related non-receptor protein tyrosine kinase that links cell surface receptors to cell proliferation and⁄or cytoskeletal reorganization.

ROS1 Recombinant Human Protein

ROS1 is a tyrosine kinase that functions as a growth or differentiation factor receptor.

BRAF [V599E] Recombinant Human Protein

BRAF acts upstream of MEK in the MAP kinase pathway and is involved in cell division, differentiation, and secretion. The BRAF mutant V599E is oncogenic and found in a variety of cancers.

MAPKAPK3 Recombinant Human Protein, Inactive (Gibco™)

MAPKAPK3 functions as an integrative element of signaling in both mitogen and stress responses.

MAP2K4 (MEK4) Recombinant Human Protein (Invitrogen™)

This MAP2K4 (MEK4) recombinant human protein (full length) was expressed in insect cells. MAP2K4 (MEK4) serine/threonine kinase (mitogen-activated protein kinase kinase 4) MEK4 or MKK4 is a dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38. MAP2K4 preferentially phosphorylates the tyrosine residue of JNKs. MAP2K4 mediates a variety of physiological and pathophysiological processes such as responses to cellular stresses and inflammatory cytokines. MAP2K4 is important for carcinogenesis; a loss-off-function mutation in MAP2K4 was found in lung and pancreatic tumors. Conversely, a pro-oncogenic role was also found for MAP2K4. MAP2K4 (MEK4) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

CAMK1 (CaMK1) Recombinant Human Protein

CAMK1 (CaMK1) is a serine⁄threonine kinase that is a member of the calcium⁄calmodulin-dependent protein kinase family. It is involved in cell differentiation, nervous system development, and signal transduction.

AMPK (A1/B2/G3) Recombinant Human Protein (Invitrogen™)

This AMPK (A1/B2/G3) recombinant human protein (full length) was expressed in insect cells. AMPK (AMP-activated protein kinase) serine/threonine kinase is a heterotrimeric complex, which acts as sensor of cellular energy levels. The signaling cascades initiated by activating AMPK are critical to regulation of metabolic events in the liver, skeletal muscle, heart, adipose tissue, and pancreas. This AMPK consists of the alpha1, beta2 and gamma3 subunits. While the purified AMPK (A1/B2/G3) complex can be used in a number of different applications, it has been specifically validated for use with our Z’-LYTE™ assay technology to identify novel kinase inhibitors. AMPK (A1/B2/G3) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

HIPK2 Recombinant Human Protein

HIPK2 is a nuclear serine⁄threonine kinase that is linked to transcriptional regulation and apoptosis.