Shop All Kinases

AURKA (Aurora A) Recombinant Human Protein

AURKA (Aurora A) is a serine⁄threonine kinase that regulates mitosis by association in vivo with centrosomes. Overexpression of AURKA is observed in many types of cancer.

PRKD2 (PKD2) Recombinant Human Protein

PRKD2 (PKD2) is a member of the protein kinase D serine⁄threonine protein kinase family. PRKD2 is a component in the signal transduction pathway induced by phorbol esters and the CCK b gastrin receptor.

CSNK2A1 (CK2 α 1) Recombinant Human Protein

CSNK2A1 is a serine⁄threonine protein kinase that phosphorylates acidic proteins.

CLK4 Recombinant Human Protein

CLK4 belongs to the CDC2-like protein kinase (CLK) family. It can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus is thought to be involved in the regulation of alternative splicing.

PRKCA (PKC alpha) Recombinant Human Protein (Invitrogen™)

The PKC family of serine/threonine kinases, including PRKCA (PKC alpha), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent.

INSRR (IRR) Recombinant Human Protein

INSRR, insulin receptor-related receptor, is a member of the insulin receptor (IR) family. INSRR does not bind insulin-like molecules, but is similar to INSR in tyrosine kinase activity.

MAP4K5 (KHS1) Recombinant Human Protein

MAP4K5 (KHS1) is a serine⁄threonine kinase that belongs to the GCK family of kinases and has been implicated as an upstream regulator of MAP kinase signaling pathways.

SRC Recombinant Human Protein

SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in the regulation of embryonic development and cell growth.

AXL Recombinant Human Protein (Invitrogen™)

AXL is a chronic myelogenous leukemia-associated oncogene that is also associated with colon cancer and melanoma. The AXL protein is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6, and is involved in the stimulation of cell proliferation.

The purified recombinant protein can be used in a number of different applications, but it has been specifically validated for use with both the LanthaScreen™ & Z'-LYTE™ assay technologies to identify novel kinase inhibitors. AXL is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the LanthaScreen & Z'-LYTE assay technology
• Available in multiple pack sizes for convenient use
• Also available in our SelectSceen Kinase Profiling Service

PRKCI (PKC iota) Recombinant Human Protein

The PKC family of serine⁄threonine kinases, including PRKCI (PKC iota), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent.

MAP2K6 (MKK6) [S207E] [T211E] Recombinant Human Protein

MAP2K6 (MKK6) is a serine⁄threonine kinase that functions as an activator of p38 in the MAPK pathway. The MAP2K6 S207E T211E mutant is constitutively active.

ERN1 Recombinant Human Protein (Invitrogen™)

This ERN1 recombinant human protein (468–end) was expressed in insect cells. ERN1 serine/threonine kinase or endoplasmic reticulum to nucleus signaling 1 is the ER to nucleus signaling 1 protein, a human homologue of the yeast Ire1 gene product which possesses intrinsic kinase activity and an endoribonuclease activity and it is important in endoplasmic reticulum-based stress signals. ERN1 controls IRE1 proteolysis in mammalian cells. ERN1 has a critical function in extraembryonic cells that is essential for fetal viability. ERN1 recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

EPHA1 Recombinant Human Protein

EPHA1 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system.

ZAP-70 Recombinant Human Protein

ZAP-70 is a cytosolic protein tyrosine kinase that is a member of the Syk family of proteins. ZAP-70 is expressed exclusively in T-cells and natural killer cells and is required for T-cell receptor activation.

MAP2K1 (MEK1) [S218D] [S222D] Recombinant Human Protein

MAP2K1 (MEK1) kinse is a dual-specific protein kinase that functions in mitogen-activated protein kinase (MAPK) cascades, controlling cell growth and differentiation. MAP2K1 is activated by a wide variety of growth factors and cytokines and also by membrane-dependent depolarization and calcium influx. This mutant has been activated by subsituting serines 218 and 222 with aspartic acid to mimic the phosphorylated state.