Shop All Receptor Tyrosine Kinases

TEK (TIE2) Recombinant Human Protein

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations.

MERTK (cMER) Recombinant Human Protein

MERTK (cMER) is a tyrosine kinase proto-oncogene and is involved in the retinal pigment epithelium (RPE) phagocytosis pathway, which is implicated in human retinal disease.

EPHB2 Recombinant Human Protein

EPHB2 is a receptor tyrosine kinase that belongs to the ephrin receptor family. Members of the Eph family of kinases play important roles in diverse biological processes including nervous system development, angiogenesis and neural synapsis formation and maturation.

KIT [D816H] Recombinant Human Protein

Human KIT, C-terminal fragment, amino acids T544-V976 (as in NCBI/Protein entry NP_000213.1) with a D816H mutation, N-terminal GST-HIS6 fusion protein with a 3C cleavage site, expressed in Sf9 insect cells.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay

EGFR (ErbB1) [L858R] Recombinant Human Protein

The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The EGFR L858R mutation is implicated in epithelial tumor formation.

FLT4 (VEGFR3) Recombinant Human Protein

FLT4 (VEGFR3), a receptor tyrosine kinase, is a key regulator of embryonic blood vessel development and adult angiogenesis. This kinase has been implicated in juvenile hemangioma, kaposi sarcoma, lymphangiomas, and hereditary lymphedemia.

KDR (VEGFR2) Recombinant Human Protein

KDR (VEGFR2) is a type III receptor tyrosine kinase. It binds vascular endothelial growth factor with high affinity in vitro, and is expressed early in development by endothelial cell precursors.

KIT [D816V] Recombinant Human Protein

Human KIT, C-terminal fragment, amino acids T544-V976 (as in NCBI/Protein entry NP_000213.1) with a D816V mutation, N-terminal GST-HIS6 fusion protein with a 3C cleavage site, expressed in Sf9 insect cells.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay

KIT [V654A] Recombinant Human Protein

KIT is a proto-oncogene encoding a transmembrane tyrosine kinase receptor for stem cell factor required for normal hematopoiesis, melangenesis and gametogenesis. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. The clinically observed V654A mutant has been demonstrated to be resistant to inhibition with imatinib.

NTRK2 (TRKB) Recombinant Human Protein

NTRK2 (TRKB) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses.

TEK (TIE2) [Y1108F] Recombinant Human Protein

Human TEK (TIE2) Y1108F, C-terminal fragment, amino acids Q771-A1124 (as in NCBI/Protein entry NP_000450.2) with a Y1108F mutation, N-terminal GST-HIS6 fusion protein with a 3C cleavage site, expressed in Sf9 insect cells.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay

PDGFRA [D842V] Recombinant Human Protein

PDGFRA is a cell surface receptor tyrosine kinase which binds members of the platelet-derived growth factor family. PDGFRA D842V is expressed in a high percentage of epithelial ovarian cancers and is implicated in the pathogenesis of acute myelogenous leukemia.

DDR2 [N456S] Recombinant Human Protein

Human DDR2, C-terminal fragment, amino acids R422-E855 (as in NCBI/Protein entry NP_006173.2), with a N456S mutation, activated, N-terminal GST-HIS6 fusion protein with a 3C cleavage site, expressed in Sf9 insect cells.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay

EPHA2 Recombinant Human Protein

EPHA2 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. EPHA2 is overexpressed in many types of human cancers.

FGFR3 [K650M] Recombinant Human Protein

Human FGFR3, C-terminal fragment, amino acids R397-T806 (as in NCBI/Protein entry NP_000133.1) with a K650M mutation, N-terminal GST-HIS6 fusion protein with a 3C cleavage site, expressed in Sf9 insect cells.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay
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