Shop All Serine⁄Threonine Kinases

CDC42 BPG (MRCKG) Recombinant Human Protein (Invitrogen™)

This CDC42 BPG (MRCKG) recombinant human protein (1–475) was expressed in insect cells. CDC42 BPG serine/threonine kinase is encoded by the CDC42BPG gene. It acts as a downstream effector of CDC42 in cytoskeletal reorganization, and contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and MLC2 phosphorylation. It belongs to the AGC protein kinase family, DMPK subfamily. It contains an N-terminal kinase domain, followed by a coiled-coil domain, a second coiled-coil domain containing a kinase inhibitory motif (KIM), a variable region, a cysteine-rich domain, a pleckstrin (PLEK; 173570) homology (PH) domain, a citron (605629) homology (CNH) domain, and a C-terminal CDC42 (116952)/RAC (602048) interactive binding (CRIB) domain. CDC42 BPG (MRCKG) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

CDK17/cyclin Y Recombinant Human Protein (Invitrogen™)

This CDK17/cyclin Y recombinant human protein (CDK17: full length, cyclin Y: 2–end) was expressed in insect cells. CDK17/cyclin Y serine/threonine kinase or cyclin-dependent kinase 17 belongs to the cdc2/cdkx subfamily of kinases. CDK17/cyclin Y has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. The identification of a large family of cdc2-related kinases opens the possibility of combinatorial regulation of the cell cycle together with the emerging large family of cyclins. CDK17/cyclin Y recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

CDK18/cyclin Y Recombinant Human Protein (Invitrogen™)

This CDK18/cyclin Y recombinant human protein (CDK18: full length, cyclin Y: 2–end) was expressed in insect cells. CDK18/cyclin Y serine/threonine kinase or cyclin-dependent kinase 18 belongs to the cdc2/cdkx subfamily of kinases. CDK18/cyclin Y is thought to play a role in terminally differentiated neurons and it contains an N-terminal extension relative to CDC2. CDK18/cyclin Y is expressed in a variety of human cell lines and tissues. Elevation in the protein levels of CDK18/cyclin Y in the temporal cortex of Alzheimer's disease relative to control brains has been observed. It is proposed that CDK18/cyclin Y is a paired helical filaments-associated kinase that modulates tau phosphorylation. CDK18/cyclin Y recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

CDKL5 Recombinant Human Protein (Invitrogen™)

This CDKL5 recombinant human protein (1–498) was expressed in insect cells. CDKL5 serine/threonine kinase (STK9) is associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome and Rett syndrome (RTT). CDKL5 can control nuclear speckle morphology by regulating the phosphorylation state of splicing regulatory proteins, and may be involved indirectly in pre-mRNA processing by controlling splicing factor dynamics. The mutations in CDKL5 are major cause of infantile spasms and early epileptic seizures in female patients, and of a later intractable seizure disorder. CDKL5 recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

ADCK3 Recombinant Human Protein (Invitrogen™)

This ADCK3 recombinant human protein (156–end) was expressed in insect cells. ADCK3 serine/threonine kinase is a mitochondrial protein similar to yeast ABC1 that is a member of the ADCK family. The purified catalytic domain (135-end) of ADCK3 can be used in a number of different applications, but has been specifically validated for use with our LanthaScreen™ Kinase binding assay technology to identify novel kinase inhibitors. ADCK3 recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

IRAK1 Recombinant Human Protein

IL-1 receptor associated kinases (IRAKs) are serine⁄threonine kinases involved in signaling via Toll⁄IL-1 pathways.

CAMK4 (CaMKIV) Recombinant Human Protein

CAMK4 (CaMKIV) is a serine⁄threonine protein kinase that phosphoryates CREB, oncoprotein 18, and SRF. It has limited tissue distribution, and has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells.

DYRK4 Recombinant Human Protein

Dual-specificity kinases, such as DYRK4, play key roles in cell proliferation, survival, and development.

CSNK1A1L Recombinant Human Protein (Invitrogen™)

This CSNK1A1L recombinant human protein (full length) was expressed in insect cells. CSNK1A1L serine/threonine kinase or CK1-alpha dynamically associates with the CBM complex upon T cell receptor engagement to participate in cytokine production and lymphocyte proliferation which has a contrasting role by subsequently promoting the phosphorylation and inactivation of CARMA1. It governs antigen-receptor-induced NF-kappa-B activation and human lymphoma cell survival. CSNK1A1L recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

LRRK2 [G2019S] Recombinant Human Protein

LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in this gene have been associated with Parkinson's disease. The G2019S mutation of LRRK2 is associated with an increase in catalytic activity.

Related Links:
LRRK2 tools for advancing Parkinson's disease research
Kinase protein portfolio
LanthaScreen® Eu Kinase Binding Assay
LanthaScreen® Activity Assay

ANKK1 Recombinant Human Protein (Invitrogen™)

This ANKK1 recombinant human protein (full length) was expressed in insect cells. ANKK1 serine/threonine kinase is a member of the RIPK family and is closely linked to the DRD2 gene. The recombinant full length ANKK1 can be used in a number of different applications, but has been specifically validated for use with our LanthaScreen™ Kinase binding assay technology to identify novel kinase inhibitors. ANKK1 recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

PAK7 (KIAA1264) Recombinant Human Protein

PAK7 (KIAA1264) is implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling.

MAPK3 (ERK1) Recombinant Human Protein

MAPK3 (ERK1) is a serine⁄threonine kinase that is an important activator of p90, RSK, MSK, ELK1, and Stat3, and is involved in the MAPK pathway.

DCAMKL1 (DCLK1) Recombinant Human Protein (Invitrogen™)

This DCAMKL1 (DCLK1) recombinant human protein (full length) was expressed in insect cells. DCAMKL1 (DCLK1) serine/threonine kinase or DCLK1 or doublecortin-like kinase 1 contains two N-terminal doublecortin domains (which bind microtubules and regulate microtubule polymerization), a C-terminal serine/threonine protein kinase domain (which shows substantial homology to Ca2+/calmodulin-dependent protein kinase), and a serine/proline-rich domain in between the doublecortin and the protein kinase domains (which mediates multiple protein-protein interactions). DCAMKL1 is a microtubule-associated kinase that can undergo autophosphorylation. DCAMKL1 has microtubule-polymerizing activity that is independent of its protein kinase activity. DCAMKL1 is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. DCAMKL1 (DCLK1) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

MAPK13 (p38 δ) Recombinant Human Protein

MAPK13 (p38 delta) is a serine⁄threonine kinase that transduces a variety of extracellular signals, including cytokine and environmental stress responses. MAPK13 also regulates the differentiation of keratinocytes.