Shop All Serine⁄Threonine Kinases

MAP2K1 (MEK1) Recombinant Human Protein

MAP2K1 (MEK1) kinse is a dual-specificity protein kinase that functions in mitogen-activated protein kinase (MAPK) cascades, controlling cell growth and differentiation. MAP2K1 is activated by a wide variety of growth factors and cytokines and also by membrane-dependent depolarization and calcium influx.

LATS1 Recombinant Human Protein

LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis which is phosphorylated in a cell-cycle dependent manner. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity which indicating a role as a negative regulator of CDC2/cyclin A and the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. LATS1 act as a tumor suppressor and play an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Recombinant human LATS1 (589-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay

CLK1 Recombinant Human Protein

CLK1 is a dual specificity kinase that phosphorylates PTP-1B and members of the SR family of splicing factors. It is thought to be involved in neuronal differentiation and mRNA splicing.

MAPK14 (p38 α) Recombinant Human Protein

MAPK14 (p38 alpha) is a member of the stress-activated protein kinase class of MAPKs.

LATS2 Recombinant Human Protein

LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. LATS2 interacts with a negative regulator of p53 and function in a positive feedback loop with p53 that responds to cytoskeleton damage and this interaction provokes centrosome/mitotic apparatus dysfunction. LATS2 plays an essential role in the maintenance of mitotic fidelity and genomic integrity. Recombinant human LATS2 (480-1088) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay

CLK3 Recombinant Human Protein

CLK3 is a dual specificity kinase that can interact with and cause the nuclear redistribution of SR proteins.

PIM1 Recombinant Human Protein

The proto-oncogene PIM1 is upregulated in prostate cancer.

AMPK A1/B1/G1 Recombinant Human Protein

AMP-activated protein kinase (AMPK) is a heterotrimeric complex that acts as sensor of cellular energy levels. The signaling cascades initiated by activating AMPK are critical to regulating metabolic events in the liver, skeletal muscle, heart, adipose tissue, and pancreas. An impairment in fuel metabolism that occurs in obesity is a factor leading to type 2 diabetes. The insulin resistance associated with type 2 diabetes is most profound at the level of skeletal muscle, the primary site of glucose and fatty acid utilization. Activation of AMPK is of interest for the treatment of type 2 diabetes.

MINK1 Recombinant Human Protein

MINK1 is a serine⁄threonine kinase belonging to the germinal center kinase (GCK) family.

AURKA (Aurora A) Recombinant Human Protein

AURKA (Aurora A) is a serine⁄threonine kinase that regulates mitosis by association in vivo with centrosomes. Overexpression of AURKA is observed in many types of cancer.

PRKD2 (PKD2) Recombinant Human Protein

PRKD2 (PKD2) is a member of the protein kinase D serine⁄threonine protein kinase family. PRKD2 is a component in the signal transduction pathway induced by phorbol esters and the CCK b gastrin receptor.

CSNK2A1 (CK2 α 1) Recombinant Human Protein

CSNK2A1 is a serine⁄threonine protein kinase that phosphorylates acidic proteins.

CLK4 Recombinant Human Protein

CLK4 belongs to the CDC2-like protein kinase (CLK) family. It can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus is thought to be involved in the regulation of alternative splicing.

PRKCA (PKC alpha) Recombinant Human Protein (Invitrogen™)

The PKC family of serine/threonine kinases, including PRKCA (PKC alpha), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent.

MAP4K5 (KHS1) Recombinant Human Protein

MAP4K5 (KHS1) is a serine⁄threonine kinase that belongs to the GCK family of kinases and has been implicated as an upstream regulator of MAP kinase signaling pathways.