Shop All Serine⁄Threonine Kinases

TGFBR1 (ALK5) Human Protein

TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-b, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation leading to downstream phosphorylation of SMADs by TGFBR1.

PRKCE (PKC epsilon) Recombinant Human Protein (Invitrogen™)

The PKC family of serine/threonine kinases, including PRKCE (PKC epsilon), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent.

MKNK1 (MNK1) Human Protein

The Map kinase-interacting kinases (MKNK1 and MKNK2) are activated by Map kinases, regulate protein synthesis by phosphroylating eIF4E on Ser209, and may contribute to tumorigenesis.

MLK4 Recombinant Human Protein (Invitrogen™)

This MLK4 recombinant human protein (114–420) was expressed in insect cells. MLK4 or mixed lineage kinase 4 belongs to the superfamily of MAP kinase kinase kinases (MAP3K1) which contain both ser/thr and tyr kinases activity in their catalytic domains. The structure of this kinase family incorporates an N-terminal Src homology (SH3) domain, followed by the kinase domain, a leucine zipper region, and a CDC42 /RAC -interactive binding (CRIB) motif, but divergent C-terminal regions. MLK4 is highly expressed in kidney and pancreas. MLK4 is a negative regulator of TLR4. MLK4 recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

CAMK1D (CaMKI Delta) Recombinant Human Protein

CAMK1D (CaMK1 delta) is a serine⁄threonine kinase that is a member of the calcium⁄calmodulin-dependent protein kinase family. CAMK1D is expressed in polymorphonuclear leukocytes and may be part of the chemokine signal transduction pathway that regulates granulocyte function. It may also be involved in modulation of neuronal apoptosis.

LRRK2 [I2020T] Human Protein

LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in this gene have been associated with Parkinson's disease, including the I2020T mutation in the kinase catalytic domain.

Related Links:
LRRK2 tools for advancing Parkinson's disease research
Kinase protein portfolio
LanthaScreen® Eu Kinase Binding Assay
LanthaScreen® Activity Assay

CSNK1G3 (CK1 γ 3) Recombinant Human Protein

The casein kinase I (CKI) gene family encodes serine⁄threonine kinases that preferentially phosphorylate acidic substrates. CKI proteins are monomeric and range from 25 to 55 kD. They are ubiquitous, being found in the nuclei, cytoplasm, and membrane fractions of eukaryotic cells

MYLK4 Recombinant Human Protein (Invitrogen™)

This MYLK4 recombinant human protein (full length) was expressed in insect cells. MYLK4 serine/threonine kinase or myosin light chain kinase family member 4 is a member of the CAMK kinase family. It is one of four myosin light chain kinases noted in a comprehensive analysis of protein kinases encoded by the human genome. MYLK4 recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

RPS6KA1 (RSK1) Recombinant Human Protein

RPS6KA1 (RSK1) is a growth-factor regulated serine⁄threonine kinase that is involved in the MAPK cascade. It is thought to control cellular proliferation and differentiation through the phosphorylation of transcription factors.

CDK5/p35 Recombinant Human Protein

CDK5 is a cyclin-dependent kinase that plays a critical role in neuron development. The kinase is strongly activated when it complexes with neuron-specific activators, especially p35, but less strongly when it complexes with cyclins. This protein is coexpressed and copurified with p35.

GRK4 Recombinant Human Protein

GRK4 is a member of the G protein-coupled receptor kinase subfamily of the serine⁄threonine protein kinase family. GRK4 phosphorylates the activated forms of G protein-coupled receptors.

ACVR1 (ALK2) [R206H] Recombinant Human Protein

ACVR1 (ALK2) belongs to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins which encodes activin A type I receptor. ACVR1 signals a particular transcriptional response in concert with activin type II receptors. Mutations in ACVR1 are associated with fibrodysplasia ossificans progressiva (FOP) and the mutations are located in or adjacent to the GS regulatory region or active site of the kinase. The mutations in ACVR1 were predicted by protein structure homology modeling to activate the ACVR1 protein and enhance receptor signaling. Dysregulated ACVR1 kinase activity plays a role in the pathogenesis of FOP. Recombinant human ACVR1 (R206H) (147-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay

AKT2 (PKB β), Recombinant Human Protein, inactive

AKT2 is a phosphoinositide-dependent serine⁄threonine protein kinase that is enriched in insulin responsive tissues and has been implicated in the metabolic actions of the hormone.

CSNK1A1 (CK1 α 1) Recombinant Human Protein

CNSK1A1 (CK1 alpha 1) is a member of the casein kinase I (CKI) gene family, which encodes serine⁄threonine kinases that preferentially phosphorylate acidic substrates. CKI proteins are monomeric, ranging from 25 to 55 kD, and are found in the nuclei, cytoplasm, and membrane fractions of eukaryotic cells.

CSNK2A1 (CK2 α 1) Recombinant Human Protein

CSNK2A1 is a serine⁄threonine protein kinase that phosphorylates acidic proteins.