Shop All General Chemicals for Life Science

UltraPure™ Sucrose Invitrogen™

UltraPure™ Sucrose is suitable for forming density gradients for a variety of separation applications. It is used to separate RNAs, to prepare bacteriophage λ-DNA arms, and to separate proteins. UltraPure™ Sucrose gradients typically are formed by use of gradient formers or by layering two or more sucrose solutions in varying amounts in a centrifuge tube.

Performance and Quality Testing: No protease activity detected.

Glycerol Thermo Scientific™

Thermo Scientific Pierce Glycerol is high-purity glycerol (greater than 99% pure) for use in molecular biology methods.

2'-Fluoro-Ac-C Phosphoramidite, TheraPure™ grade, serum vial bottle Thermo Scientific™

2'-Fluoro-Ac-C CEP is a phosphoramidite containing 5' DMT and the nucleoside cytidine (C) with 2'-Fluoro protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, the highly electronegative fluorine (2'-Fluoro) modification adopts a more thermodynamically stable A-form helix on hybridization to its target. Showing improved affinity and some nuclease resistance (compared to 2'-OH), the 2'-F modification has been proven useful in antisense, siRNA, and aptamer applications. The TheraPure trademark denotes our highest level of phosphoramidite purity, developed with the greatest stringency of high definition analytics and tightly controlled impurity profiles and, therefore, ideal for any therapeutic application. This product is supplied in a 20-mL amber bottle with a serum vial neck style, which is compatible with most Applied Biosystems synthesizers and AKTA synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-fluorocytidine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C41H49N5FO8P
• Base—C
• Base Protection—Ac
• Formula weight—789.8 g/mol
• CAS number—159414-99-0
• HPLC purity—>98%
31P NMR purity—≥98%

2'-OMe-U Phosphoramidite, TheraPure™ grade, serum vial bottle Thermo Scientific™

2'-OMe-U CEP is a phosphoramidite containing 5' DMT and the nucleoside uridine (U) with 2'-O-methyl protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, 2'-O-methyl (OMe) oligo modifications display nuclease resistance, fewer off-target effects, and slightly increased hybridization affinities. These phosphoramidites are commonly used for oligos designed for antisense, siRNA, aptamer, or gRNA-based research. The TheraPure trademark denotes our highest level of phosphoramidite purity, developed with the greatest stringency of high definition analytics and tightly controlled impurity profiles and, therefore, ideal for any therapeutic application. This product is supplied in a 20-mL amber bottle with a serum vial neck style, which is compatible with most Applied Biosystems synthesizers and AKTA synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-uridine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C40H56N7O9P
• Base—U
• Formula weight—760.8 g/mol
• CAS number—110764-79-9
• HPLC purity—≥99%; M-11 Impurity: ≤0.01%; Single critical impurity ≤0.3%
31P NMR purity—>99%; Sum of non-primary peaks at 140-152ppm ≤0.5%

rU Phosphoramidite, TheraPure™ grade, 20-400 finish bottle Thermo Scientific™

rU CEP is a phosphoramidite containing 5' DMT and the nucleoside uridine (U) for use in oligonucleotide synthesis. RNA phosphoramidites contain a 2'-OH protecting group, tBDMS (tert-butyl dimethylsilyl). Each base has unique protecting groups (except T and U) designed specifically to protect the RNA during the chemical synthesis process, and produce the highest amount of full length product. Alternate base protection options are also available to allow for faster deprotection and longer oligonucleotide synthesis. The TheraPure trademark denotes our highest level of phosphoramidite purity, developed with the greatest stringency of high definition analytics and tightly controlled impurity profiles and, therefore, ideal for any therapeutic application. This product is supplied in a 30 mL Amber bottle with a 20-400 Finish neck style, which is compatible with most Expedite Systems of oligonucleotide synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]-uridine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C45H61N4O9PSi
• Base—rU
• Formula weight—861.1 g/mol
• CAS number—118362-03-1
• HPLC Purity—≥99%; M-11 Impurity: ≤0.01%
• 31P NMR Purity—≥99%; Sum of non-primary peaks in 140-152 ppm range: ≤0.5%; No single PIII impurity >0.3%

L-Isoleucine, USP/EP/JP Gibco™

L-Isoleucine, USP/EP/JP, also known as (2S, 3S)-2-Amino-3-methylpentanoic Acid, is a multi-compendial amino acid for your manufacturing needs and part of our Gibco Chemicals family of products.

Gibco Chemicals is a line of raw materials that fulfill needs throughout the drug development process to commercial production. Standard features include cGMP manufacturing, custom specifications, and a variety of package sizes, as well as a portfolio of cGMP supply chain services to help meet your requirements.

Benefits of Gibco Chemicals include:
Access the materials you need for your R&D and manufacturing processes
Realize manufacturing on a global scale with multi-compendial classifications
Maximize supply chain visibility with transparency of manufacturing and distribution
Eliminate need for re-validation with our comprehensive offering of technical documentation
Streamline supply chain operations by outsourcing key needs such as safety stock storage, custom labeling, and poly-palletization

A focus on quality
Gibco Chemicals are manufactured and distributed through ISO-certified, cGMP-compliant facilities to help meet your regulatory needs and mitigate risk.

Transparency of supply chain
Technical documentation, sales support, and technical service teams are available to provide full visibility into product specifications and journey from manufacturer to your hands.

Custom needs are a standard offering
Gibco Chemicals can be customized to meet your unique specifications including custom fill and weigh requirements, testing protocols, and tailgate samples.

2'-Fluoro-Ac-C Phosphoramidite, TheraPure™ grade, 20-400 finish bottle Thermo Scientific™

2'-Fluoro-Ac-C CEP is a phosphoramidite containing 5' DMT and the nucleoside cytidine (C) with 2'-Fluoro protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, the highly electronegative fluorine (2'-Fluoro) modification adopts a more thermodynamically stable A-form helix on hybridization to its target. Showing improved affinity and some nuclease resistance (compared to 2'-OH), the 2'-F modification has been proven useful in antisense, siRNA, and aptamer applications. The TheraPure trademark denotes our highest level of phosphoramidite purity, developed with the greatest stringency of high definition analytics and tightly controlled impurity profiles and, therefore, ideal for any therapeutic application. This product is supplied in a 30-mL amber bottle with a 20-400 finish neck style, which is compatible with most Expedite synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-fluorocytidine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C41H49N5FO8P
• Base—C
• Base Protection—Ac
• Formula weight—789.8 g/mol
• CAS number—159414-99-0
• HPLC purity—>98%
31P NMR purity—≥98%

2'-MOE-5mC Phosphoramidite, TheraPure™ grade, serum vial bottle Thermo Scientific™

2'-MOE-5mC CEP is a phosphoramidite containing 5' DMT and the nucleoside 5-methyl-cytidine (5mC) with 2'-O-methoxy-ethyl (MOE) protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, 2'-O-methoxy-ethyl (MOE) modifications display nuclease resistance, fewer off-target effects, and slightly increased hybridization affinities. These phosphoramidites are commonly used for oligos designed for antisense, siRNA, aptamer, or gRNA-based research. The TheraPure trademark denotes our highest level of phosphoramidite purity, developed with the greatest stringency of high definition analytics and tightly controlled impurity profiles and, therefore, ideal for any therapeutic application. This product is supplied in a 20-mL amber bottle with a serum vial neck style, which is compatible with most Applied Biosystems synthesizers and AKTA synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-2'-O-methoxyethyl-5-methyl-N4-benzoyl-cytidine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C50H60N5O10P
• Base—5mC
• Base Protection—Bz
• Formula weight—922.0 g/mol
• CAS number—163759-94-2
• HPLC purity—≥99%; M-11 Impurity ≤0.01%
31P NMR purity—≥99%

1- Methylimidazole/THF, Capping Formula B Applied Biosystems™

Contains 4 CapB filled Trap-Pak™ bags.

Cap B is a mix of NMI (N-methylimidazole) and THF (tetrahydrofuran).

For Research Use Only. Not for use in diagnostics procedures.

UltraPure™ Tris Buffer (powder format) Invitrogen™

UltraPure™ Tris Buffer is widely used because of its buffering range (pH 7.0 to 9.0) and compatibility with many enzymes, including restriction endonucleases and DNA-modifying enzymes.

Performance and quality testing
No DNase, RNase, or protease activity detected.

Tetrazole Acetonitrile Solution Applied Biosystems™

This Tetrazole⁄Acetonitrile solution comes in a convenient large volume for ABI 394 Nucleic Acid synthesizers, resulting in extended hands-free DNA synthesis. With these larger bottles attached your synthesizer can produce up to 40 average primer-length oligonucleotides with no bottle changes, reducing attended operation time by 50%.

• Reagent concentrations are within our strict specifications, guaranteeing consistent quality.
• Our performance specification of at least 98% stepwise coupling efficiency is assured, increasing oligonucleotide synthesis yields of full-length product.
• Reagent kits are available for your convenience, and save you time and money.

Our high-performance reagents begin with raw materials that must conform to strict specifications. Once the reagents are manufactured and packaged, we perform extensive testing to assure quality. Reagent lifetime on the instrument is two weeks for tetrazole, and six weeks for all other reagents.

For Research Use Only. Not for use in diagnostics procedures.

2'-OMe-U Phosphoramidite, TheraPure™ grade, 20-400 finish bottle Thermo Scientific™

2'-OMe-U CEP is a phosphoramidite containing 5' DMT and the nucleoside uridine (U) with 2'-O-methyl protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, 2'-O-methyl (OMe) oligo modifications display nuclease resistance, fewer off-target effects, and slightly increased hybridization affinities. These phosphoramidites are commonly used for oligos designed for antisense, siRNA, aptamer, or gRNA-based research. The TheraPure trademark denotes our highest level of phosphoramidite purity, developed with the greatest stringency of high definition analytics and tightly controlled impurity profiles and, therefore, ideal for any therapeutic application. This product is supplied in a 30-mL amber bottle with a 20-400 finish neck style, which is compatible with most Expedite synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-uridine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C40H56N7O9P
• Base—U
• Formula weight—760.8 g/mol
• CAS number—110764-79-9
• HPLC purity—≥99%; M-11 Impurity: ≤0.01%; Single critical impurity ≤0.3%
31P NMR purity—>99%; Sum of non-primary peaks at 140-152ppm ≤0.5%

Ac-rC Phosphoramidite, standard grade, serum vial bottle Thermo Scientific™

Ac-rC CEP is a phosphoramidite containing 5' DMT and the nucleoside cytidine (C) with Acetyl (Ac) base protection, for use in oligonucleotide synthesis. RNA phosphoramidites contain a 2'-OH protecting group, tBDMS (tert-butyl dimethylsilyl). Each base has unique protecting groups designed specifically to protect the RNA during the chemical synthesis process, and produce the highest amount of full length product. Alternate base protection options are also available to allow for faster deprotection and longer oligonucleotide synthesis. The 'Standard Grade' marking denotes a baseline level of purity verified with analytical methods, and proven to be suitable for most oligo synthesis requirements. This product is supplied in a 60 mL Amber bottle with a Serum Vial neck style, which is compatible with most ABI Systems|AKTA Systems of oligonucleotide synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-O-TBDMSi-cytidine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C47H64N5O9PSi
• Base—rC
• Base Protection—Ac
• Formula weight—902.1 g/mol
• CAS number—121058-88-6
• HPLC Purity—≥98.0%
• 31P NMR Purity—≥98.0%; Sum of non-primary peaks in 140-152 ppm range: ≤0.5%

rU Phosphoramidite, TheraPure™ grade, 28-400 finish bottle Thermo Scientific™

rU CEP is a phosphoramidite containing 5' DMT and the nucleoside uridine (U) for use in oligonucleotide synthesis. RNA phosphoramidites contain a 2'-OH protecting group, tBDMS (tert-butyl dimethylsilyl). Each base has unique protecting groups (except T and U) designed specifically to protect the RNA during the chemical synthesis process, and produce the highest amount of full length product. Alternate base protection options are also available to allow for faster deprotection and longer oligonucleotide synthesis. The TheraPure trademark denotes our highest level of phosphoramidite purity, developed with the greatest stringency of high definition analytics and tightly controlled impurity profiles and, therefore, ideal for any therapeutic application. This product is supplied in a 30 mL Amber bottle with a 28-400 Finish neck style, which is compatible with most MerMade Systems of oligonucleotide synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]-uridine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C45H61N4O9PSi
• Base—rU
• Formula weight—861.1 g/mol
• CAS number—118362-03-1
• HPLC Purity—≥99%; M-11 Impurity: ≤0.01%
• 31P NMR Purity—≥99%; Sum of non-primary peaks in 140-152 ppm range: ≤0.5%; No single PIII impurity >0.3%

2'-Fluoro-Ac-C Phosphoramidite, TheraPure™ grade, 28-400 finish bottle Thermo Scientific™

2'-Fluoro-Ac-C CEP is a phosphoramidite containing 5' DMT and the nucleoside cytidine (C) with 2'-Fluoro protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, the highly electronegative fluorine (2'-Fluoro) modification adopts a more thermodynamically stable A-form helix on hybridization to its target. Showing improved affinity and some nuclease resistance (compared to 2'-OH), the 2'-F modification has been proven useful in antisense, siRNA, and aptamer applications. The TheraPure trademark denotes our highest level of phosphoramidite purity, developed with the greatest stringency of high definition analytics and tightly controlled impurity profiles and, therefore, ideal for any therapeutic application. This product is supplied in a 30-mL amber bottle with a 28-400 finish neck style, which is compatible with most MerMade synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-fluorocytidine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C41H49N5FO8P
• Base—C
• Base Protection—Ac
• Formula weight—789.8 g/mol
• CAS number—159414-99-0
• HPLC purity—>98%
31P NMR purity—≥98%

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