Shop All General Chemicals for Life Science

2'-OMe-U Phosphoramidite, standard grade, 20-400 finish bottle (Thermo Scientific™)

2'-OMe-U CEP is a phosphoramidite containing 5' DMT and the nucleoside uridine (U) with 2'-O-methyl protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, 2'-O-methyl (OMe) oligo modifications display nuclease resistance, fewer off-target effects, and slightly increased hybridization affinities. These phosphoramidites are commonly used for oligos designed for antisense, siRNA, aptamer, or gRNA-based research. The "standard grade" marking denotes a baseline level of purity verified with analytical methods, and proven to be suitable for most oligo synthesis requirements. This product is supplied in a 30-mL amber bottle with a 20-400 finish neck style, which is compatible with most Expedite synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-uridine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C40H56N7O9P
• Base—U
• Formula weight—760.8 g/mol
• CAS number—110764-79-9
• HPLC purity—≥98.0%; Sum of non-primary peaks at 140-152ppm: ≤0.5%
31P NMR purity—≥98.0%

2'-OMe-U Phosphoramidite, standard grade, 28-400 finish bottle (Thermo Scientific™)

2'-OMe-U CEP is a phosphoramidite containing 5' DMT and the nucleoside uridine (U) with 2'-O-methyl protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, 2'-O-methyl (OMe) oligo modifications display nuclease resistance, fewer off-target effects, and slightly increased hybridization affinities. These phosphoramidites are commonly used for oligos designed for antisense, siRNA, aptamer, or gRNA-based research. The "standard grade" marking denotes a baseline level of purity verified with analytical methods, and proven to be suitable for most oligo synthesis requirements. This product is supplied in a 30-mL amber bottle with a 28-400 finish neck style, which is compatible with most MerMade synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-uridine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C40H56N7O9P
• Base—U
• Formula weight—760.8 g/mol
• CAS number—110764-79-9
• HPLC purity—≥98.0%; Sum of non-primary peaks at 140-152ppm: ≤0.5%
31P NMR purity—≥98.0%

UltraPure™ Phenol:Water (3.75:1, v/v) (Invitrogen™)

UltraPure™ Phenol:Water (3.75:1, v/v) is used in the purification of nucleic acids. This liquid reagent consists of UltraPure™ Phenol and highly pure deionized water. The reagent can be used to prepare different types of buffer-saturated phenol. When mixtures are extracted with buffer-saturated phenol, proteins are denatured and collect in the organic phase or at the interphase, while nucleic acids remain in the aqueous phase. UltraPure™ Phenol:Water (3.75:1, v/v) contains no preservatives. It is packaged under an inert gas in shatter-resistant, plastic-coated amber bottles.

Performance and Quality Testing: The appearance of the solution is evaluated at room temperature. No RNase or DNase activity detected.

2'-OMe-iPrPAC-G Phosphoramidite, standard grade, serum vial bottle (Thermo Scientific™)

2'-OMe-iPrPAC-G CEP is a phosphoramidite containing 5' DMT and the nucleoside guanosine (G) with 2'-O-methyl protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, 2'-O-methyl (OMe) oligo modifications display nuclease resistance, fewer off-target effects, and slightly increased hybridization affinities. These phosphoramidites are commonly used for oligos designed for antisense, siRNA, aptamer, or gRNA-based research. The "standard grade" marking denotes a baseline level of purity verified with analytical methods, and proven to be suitable for most oligo synthesis requirements. This product is supplied in a 20-mL amber bottle with a serum vial neck style, which is compatible with most Applied Biosystems synthesizers and AKTA synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-N2-isopropylphenoxyacetyl-2'-O-methyl-guanosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C52H62N7O10P
• Base—G
• Base Protection—iPrPAC
• Formula weight—976.1 g/mol
• CAS number—NA!!
• HPLC purity—≥98.0%
31P NMR purity—≥98.0%

HEG Phosphoramidite, standard grade, serum vial bottle (Thermo Scientific™)

HEG CEP (Spacer 18) is a hexaethyleneglycol-based phosphoramidite for use in oligonucleotide synthesis. This unique property creates a hydrophilic spacer, which can be useful for building flexibility within an oligo sequence. It has proven useful for probes requiring minimal steric hindrance (usually when conjugated to an antibody or enzyme), multiple binding sites, and polymerase activity at the 3' terminus to be eliminated. This product is supplied in a 20 mL amber bottle with a serum vial neck style, which is compatible with most Applied Biosystems synthesizers and AKTA synthesizers of oligonucleotide synthesizers.

Features:
• Full chemical name—18-O-(4,4'-Dimethoxytrityl)-Hexaethyleneglycol-1-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C42H61N2O10P
• Formula weight—784.9 g/mol
• CAS number—NA!!
• HPLC Purity—≥95.0%; Bis impurity ≤0.3%; Penta impurity ≤1.6%; Hepta impurity ≤0.9%
• 31P NMR Purity—≥98%; Sum of non-primary peaks in 140-152 ppm range: ≤0.5%

Bz-rA Phosphoramidite, TheraPure™ grade, serum vial bottle (Thermo Scientific™)

Bz-rA CEP is a phosphoramidite containing 5' DMT and the nucleoside adenosine (A) with Benzoyl (Bz) base protection, for use in oligonucleotide synthesis. RNA phosphoramidites contain a 2'-OH protecting group, tBDMS (tert-butyl dimethylsilyl). Each base has unique protecting groups designed specifically to protect the RNA during the chemical synthesis process, and produce the highest amount of full length product. Alternate base protection options are also available to allow for faster deprotection and longer oligonucleotide synthesis. The TheraPure trademark denotes our highest level of phosphoramidite purity, developed with the greatest stringency of high definition analytics and tightly controlled impurity profiles and, therefore, ideal for any therapeutic application. This product is supplied in a 20 mL Amber bottle with a Serum Vial neck style, which is compatible with most ABI Systems|AKTA Systems of oligonucleotide synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-O-[(tert-butyl)dimethylsilyl]-adenosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C53H66N7O8PSi
• Base—rA
• Base Protection—Bz
• Formula weight—988.2 g/mol
• CAS number—104992-55-4
• HPLC Purity—≥99%; M-11 Impurity: ≤0.01%
• 31P NMR Purity—≥99%; Sum of non-primary peaks in 140-152 ppm range: ≤0.5%; No single PIII impurity >0.3%

L-Alanine, USP/EP/JP (Gibco™)

L-Alanine, USP/EP/JP, also known as 2-Aminopropanoic Acid, is a multi-compendial amino acid for your manufacturing needs and part of our Gibco Chemicals family of products.

Gibco Chemicals is a line of raw materials that fulfill needs throughout the drug development process to commercial production. Standard features include cGMP manufacturing, custom specifications, and a variety of package sizes, as well as a portfolio of cGMP supply chain services to help meet your requirements.

Benefits of Gibco Chemicals include:
Access the materials you need for your R&D and manufacturing processes
Realize manufacturing on a global scale with multi-compendial classifications
Maximize supply chain visibility with transparency of manufacturing and distribution
Eliminate need for re-validation with our comprehensive offering of technical documentation
Streamline supply chain operations by outsourcing key needs such as safety stock storage, custom labeling, and poly-palletization

A focus on quality
Gibco Chemicals are manufactured and distributed through ISO-certified, cGMP-compliant facilities to help meet your regulatory needs and mitigate risk.

Transparency of supply chain
Technical documentation, sales support, and technical service teams are available to provide full visibility into product specifications and journey from manufacturer to your hands.

Custom needs are a standard offering
Gibco Chemicals can be customized to meet your unique specifications including custom fill and weigh requirements, testing protocols, and tailgate samples.

2'-MOE-5mC Phosphoramidite, TheraPure™ grade, 28-400 finish bottle (Thermo Scientific™)

2'-MOE-5mC CEP is a phosphoramidite containing 5' DMT and the nucleoside 5-methyl-cytidine (5mC) with 2'-O-methoxy-ethyl (MOE) protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, 2'-O-methoxy-ethyl (MOE) modifications display nuclease resistance, fewer off-target effects, and slightly increased hybridization affinities. These phosphoramidites are commonly used for oligos designed for antisense, siRNA, aptamer, or gRNA-based research. The TheraPure trademark denotes our highest level of phosphoramidite purity, developed with the greatest stringency of high definition analytics and tightly controlled impurity profiles and, therefore, ideal for any therapeutic application. This product is supplied in a 30-mL amber bottle with a 28-400 finish neck style, which is compatible with most MerMade synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-2'-O-methoxyethyl-5-methyl-N4-benzoyl-cytidine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C50H60N5O10P
• Base—5mC
• Base Protection—Bz
• Formula weight—922.0 g/mol
• CAS number—163759-94-2
• HPLC purity—≥99%; M-11 Impurity ≤0.01%
31P NMR purity—≥99%

L-Isoleucine, USP/EP/JP (Gibco™)

L-Isoleucine, USP/EP/JP, also known as (2S, 3S)-2-Amino-3-methylpentanoic Acid, is a multi-compendial amino acid for your manufacturing needs and part of our Gibco Chemicals family of products.

Gibco Chemicals is a line of raw materials that fulfill needs throughout the drug development process to commercial production. Standard features include cGMP manufacturing, custom specifications, and a variety of package sizes, as well as a portfolio of cGMP supply chain services to help meet your requirements.

Benefits of Gibco Chemicals include:
Access the materials you need for your R&D and manufacturing processes
Realize manufacturing on a global scale with multi-compendial classifications
Maximize supply chain visibility with transparency of manufacturing and distribution
Eliminate need for re-validation with our comprehensive offering of technical documentation
Streamline supply chain operations by outsourcing key needs such as safety stock storage, custom labeling, and poly-palletization

A focus on quality
Gibco Chemicals are manufactured and distributed through ISO-certified, cGMP-compliant facilities to help meet your regulatory needs and mitigate risk.

Transparency of supply chain
Technical documentation, sales support, and technical service teams are available to provide full visibility into product specifications and journey from manufacturer to your hands.

Custom needs are a standard offering
Gibco Chemicals can be customized to meet your unique specifications including custom fill and weigh requirements, testing protocols, and tailgate samples.

UltraPure™ Glycine (Invitrogen™)

UltraPure™ Glycine is an amino acid used in the preparation of some electrophoresis buffers. With a pKa1 of 2.3 and a pKa2 of 9.6, UltraPure™ Glycine is suitable for buffering at the extremes of the common buffering range.

Ac-dC Phosphoramidite, TheraPure™ grade, 28-400 finish bottle (Thermo Scientific™)

Ac-dC CEP is a phosphoramidite containing 5' DMT and the nucleoside deoxycytidine (dC) with Acetyl (Ac) base protection, for use in oligonucleotide synthesis. DNA phosphoramidites are the building blocks for synthesis of DNA or DNA containing oligonucleotides. Each base has unique protecting groups designed specifically to protect the DNA during the chemical synthesis process and produce the highest amount of full length product. Alternative protecting groups on dC (acetyl) and dG (DMF) allow for a faster deprotection of the oligonucleotide. By using Ac-dC, Bz-dA, and DMF-dG monomers, fast cleavage and deprotection can be effected by a 1:1 mixture of aqueous ammonium hydroxide and aqueous methylamine (or AMA) in 10 min. This product is supplied in a 250 mL Amber bottle with a 28-400 Finish neck style, which is compatible with most MerMade Systems of oligonucleotide synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-N4-Acetyl-2'-deoxycytidine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite
• Molecular formula—C41H50N5O8P
• Base—dC
• Base Protection—Ac
• Formula weight—771.8 g/mol
• CAS number—154110-40-4
• HPLC Purity—≥99%; M-11 Impurity ≤0.01%; No single impurity >0.5%
• 31P NMR Purity—≥99%; Sum of non-primary peaks at 140-152 ppm: ≤0.3%

dA(Bz) Phosphoramidite, 2.0 g (Applied Biosystems™)

This dA(Bz) Phosphoramidite is used for nucleic acid synthesis on the Expedite™ 8905, 8909, and 8909 with MOSS upgrade DNA synthesizers. Our β-cyanoethyl phosphoramidites guarantee you high-quality nucleic acid synthesis.

• Proprietary manufacturing processes guarantee high purity products
• Expedite™ system fast deprotecting amidites offer fast deprotection for primer-length oligonucleotides, shortening overall production time and costs
• Fast deprotecting amidites and standard deprotecting amidites are use-tested and optimized for use on the Expedite™ System for high-quality nucleic acid synthesis
• Phosphoramidite kits simplify ordering, saving you time and money

High purity
Our phosphoramidites benefit from proprietary manufacturing processes that yield products of high purity. In synthesis they perform at correspondingly high levels, producing pure, high quality DNA at all scales. We guarantee that 5'-dimethoxytrityl nucleoside β-cyanoethyl phosphoramidites, monomer intermediates for licensed β-cyanoethyl phosphoramidite chemistry, will produce DNA that is at least 99.8% chemically authentic when used with recommended synthesis cycles.

For Research Use Only. Not for use in diagnostics procedures.

CE Phosphoramidite, dI, (deoxyinosine) (Applied Biosystems™)

The dI (deoxyinosine) CE Phosphoramidite is used for nucleic acid synthesis on the ABI DNA⁄RNA Synthesizers. Standard series of phosphoramidite deprotects in 6-8 hours at 55°C.

β-cyanoethyl phosphoramidites are for use on ABI synthesizers to guarantee you high quality nucleic acid synthesis.

• Proprietary manufacturing processes yield high-purity β-cyanoethyl phosphoramidites, which in turn guarantee production of high-quality RNA at all scales.
• β-cyanoethyl phosphoramidites are use-tested and optimized for use on the ABI synthesizers to guarantee you high-quality nucleic acid synthesis.

High Quality
Our phosphoramidites benefit from proprietary manufacturing processes that yield high-purity products. In synthesis they perform at a correspondingly high level, producing pure, high quality DNA at all scales. We guarantee that 5'-dimethoxytrityl nucleoside β-cyanoethyl phosphoramidites, monomer intermediates for licensed β-cyanoethyl phosphoramidite chemistry, will produce DNA that is at least 99.8% chemically authentic when used with recommended synthesis cycles.

Dry phosphoroamidites (powder form) are guaranteed for one year from the date of shipment. Lifetime of diluted phosphoramidites in residence on the instrument is two weeks when used with CPG synthesis supports, and three weeks when used with polystyrene supports.

For Research Use Only. Not for use in diagnostics procedures.

2'-OMe-iPrPAC-G Phosphoramidite, standard grade, 20-400 finish bottle (Thermo Scientific™)

2'-OMe-iPrPAC-G CEP is a phosphoramidite containing 5' DMT and the nucleoside guanosine (G) with 2'-O-methyl protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, 2'-O-methyl (OMe) oligo modifications display nuclease resistance, fewer off-target effects, and slightly increased hybridization affinities. These phosphoramidites are commonly used for oligos designed for antisense, siRNA, aptamer, or gRNA-based research. The "standard grade" marking denotes a baseline level of purity verified with analytical methods, and proven to be suitable for most oligo synthesis requirements. This product is supplied in a 30-mL amber bottle with a 20-400 finish neck style, which is compatible with most Expedite synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-N2-isopropylphenoxyacetyl-2'-O-methyl-guanosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C52H62N7O10P
• Base—G
• Base Protection—iPrPAC
• Formula weight—976.1 g/mol
• CAS number—NA!!
• HPLC purity—≥98.0%
31P NMR purity—≥98.0%

Beta Cyanoethyl Phosphoramidite, T (Applied Biosystems™)

The T Beta Cyanoethyl Phosphoramidite is used as a component of a deprotecting chemistry set including dA(Bz), dC(Bz) and dG(iBu). Standard series of phosphoramidite deprotects in 6-8 hours at 55°C.

β-cyanoethyl phosphoramidites are for use on ABI synthesizers to guarantee you high quality nucleic acid synthesis.

• Proprietary manufacturing processes yield high-purity β-cyanoethyl phosphoramidites, which in turn guarantee production of high-quality DNA at all scales.
• β-cyanoethyl phosphoramidites are use-tested and optimized for use on the ABI synthesizers to guarantee you high-quality nucleic acid synthesis.

High Quality
Our phosphoramidites benefit from proprietary manufacturing processes that yield high-purity products. In synthesis they perform at a correspondingly high level, producing pure, high quality DNA at all scales. We guarantee that 5'-dimethoxytrityl nucleoside β-cyanoethyl phosphoramidites, monomer intermediates for licensed β-cyanoethyl phosphoramidite chemistry, will produce DNA that is at least 99.8% chemically authentic when used with recommended synthesis cycles.

Dry phosphoroamidites (powder form) are guaranteed for one year from the date of shipment. Lifetime of diluted phosphoramidites in residence on the instrument is two weeks when used with CPG synthesis supports, and three weeks when used with polystyrene supports.

For Research Use Only. Not for use in diagnostics procedures.