Shop All General Chemicals for Life Science

DMF-dG Phosphoramidite, standard grade, 20-400 finish bottle Thermo Scientific™

DMF-dG CEP is a phosphoramidite containing 5' DMT and the nucleoside deoxyguanosine (dG) with Dimethylaminoformamidine (DMF) base protection, for use in oligonucleotide synthesis. DNA phosphoramidites are the building blocks for synthesis of DNA or DNA containing oligonucleotides. Each base has unique protecting groups designed specifically to protect the DNA during the chemical synthesis process and produce the highest amount of full length product. Alternative protecting groups on dC (acetyl) and dG (DMF) allow for a faster deprotection of the oligonucleotide. By using Ac-dC, Bz-dA, and DMF-dG monomers, fast cleavage and deprotection can be effected by a 1:1 mixture of aqueous ammonium hydroxide and aqueous methylamine (or AMA) in 10 min. This product is supplied in a 30 mL Amber bottle with a 20-400 Finish neck style, which is compatible with most Expedite Systems of oligonucleotide synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-N2-(dimethylaminoformamidine)-2'-deoxyguanosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C43H53N8O7P
• Base—dG
• Base Protection—DMF
• Formula weight—824.9 g/mol
• CAS number—330628-04-1
• HPLC Purity—≥98.0%; M-11 Impurity ≤0.01%
• 31P NMR Purity—≥98.0%; Sum of non-primary peaks at 140-152 ppm (PIII impurities): ≤1.5%

Sodium Acetate (3 M), pH 5.5, RNase-free Invitrogen™

Ambion® Molecular biology grade, 3 M Sodium Acetate solution is supplied in one bottle containing 100 mL. The solution is certified RNase-free, economical, and ready-to-use. Due to the ubiquitous presence of RNases, manufacturing products for use with RNA is especially challenging. Ambion®'s nuclease-free reagents and buffers are manufactured in facilities specifically designed to prevent the introduction of nucleases. Highly sensitive RNase assays are performed at several different stages of the manufacturing process to ensure the highest quality. These reagents are rigorously tested for contaminating nonspecific endonuclease, exonuclease, and RNase activity.

Phosphalink™, for 3' and 5' Labeling, 70 mg Applied Biosystems™

Phosphalink® is used for 3’ or 5’ attachment of phosphorous group during oligonucleotide synthesis.

We offer several phosphoramidites that impart the means to add a phosphate during oligonucleotide synthesis.

• Specialty phosphoramidites allow online addition of linkers during synthesis, saving time in production of labeled probes and primers.
• Designed and optimized for use with ABI synthesizers, guaranteeing reliable nucleic acid synthesis.
• We offer a range of specialty linkers and phosphoramites to give you the flexibility demanded in oligonucleotide synthesis.

Phosphate linker:
Phosphalink® phosphoramidite can incorporate a phosphate group at either the 5' or the 3' end. A 5'-end phosphate permits ligation of an oligonucleotide to other DNA.

Note: See user's manual or package insert for limited label license, and trademark information. For Research Use Only. Not for use in diagnostics procedures.

DMF-dG Phosphoramidite, standard grade, 28-400 finish bottle Thermo Scientific™

DMF-dG CEP is a phosphoramidite containing 5' DMT and the nucleoside deoxyguanosine (dG) with Dimethylaminoformamidine (DMF) base protection, for use in oligonucleotide synthesis. DNA phosphoramidites are the building blocks for synthesis of DNA or DNA containing oligonucleotides. Each base has unique protecting groups designed specifically to protect the DNA during the chemical synthesis process and produce the highest amount of full length product. Alternative protecting groups on dC (acetyl) and dG (DMF) allow for a faster deprotection of the oligonucleotide. By using Ac-dC, Bz-dA, and DMF-dG monomers, fast cleavage and deprotection can be effected by a 1:1 mixture of aqueous ammonium hydroxide and aqueous methylamine (or AMA) in 10 min. This product is supplied in a 250 mL Amber bottle with a 28-400 Finish neck style, which is compatible with most MerMade Systems of oligonucleotide synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-N2-(dimethylaminoformamidine)-2'-deoxyguanosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C43H53N8O7P
• Base—dG
• Base Protection—DMF
• Formula weight—824.9 g/mol
• CAS number—330628-04-1
• HPLC Purity—≥98.0%; M-11 Impurity ≤0.01%
• 31P NMR Purity—≥98.0%; Sum of non-primary peaks at 140-152 ppm (PIII impurities): ≤1.5%

Beta Cyanoethyl Phosphoramidite, dG(iBu) Applied Biosystems™

The dG(iBu) Beta Cyanoethyl Phosphoramidite is used as a component of a deprotecting chemistry set including dA(Bz), dC(Bz) and T. Standard series of phosphoramidite deprotects in 6-8 hours at 55°C.

β-cyanoethyl phosphoramidites are for use on ABI synthesizers to guarantee you high quality nucleic acid synthesis.

• Proprietary manufacturing processes yield high-purity β-cyanoethyl phosphoramidites, which in turn guarantee production of high-quality DNA at all scales.
• β-cyanoethyl phosphoramidites are use-tested and optimized for use on the ABI synthesizers to guarantee you high-quality nucleic acid synthesis.

High Quality
Our phosphoramidites benefit from proprietary manufacturing processes that yield high-purity products. In synthesis they perform at a correspondingly high level, producing pure, high quality DNA at all scales. We guarantee that 5'-dimethoxytrityl nucleoside β-cyanoethyl phosphoramidites, monomer intermediates for licensed β-cyanoethyl phosphoramidite chemistry, will produce DNA that is at least 99.8% chemically authentic when used with recommended synthesis cycles.

Dry phosphoroamidites (powder form) are guaranteed for one year from the date of shipment. Lifetime of diluted phosphoramidites in residence on the instrument is two weeks when used with CPG synthesis supports, and three weeks when used with polystyrene supports.

For Research Use Only. Not for use in diagnostics procedures.

NaCl (5 M), RNase-free Invitrogen™

Ambion® Molecular biology grade, 5 M NaCl solution is supplied in one bottle containing 100 mL. The solution is certified RNase-free, economical, and ready-to-use. Due to the ubiquitous presence of RNases, manufacturing products for use with RNA is especially challenging. Ambion®'s nuclease-free reagents and buffers are manufactured in facilities specifically designed to prevent the introduction of nucleases. Highly sensitive RNase assays are performed at several different stages of the manufacturing process to ensure the highest quality. These reagents are rigorously tested for contaminating nonspecific endonuclease, exonuclease, and RNase activity.

Iodine-Water-Pyridine-Tetrahydrofuran Oxidizer Solution (0.02 M) Applied Biosystems™

This Iodine⁄Water⁄Pyridine⁄Tetrahydrofuran (oxidizer) solution comes in a convenient large volume for ABI 394 Nucleic Acid synthesizers, resulting in extended hands-free DNA synthesis. With these larger bottles attached your synthesizer can produce up to 40 average primer-length oligonucleotides with no bottle changes, reducing attended operation time by 50%.

• Reagent concentrations are within our strict specifications, guaranteeing consistent quality.
• Our performance specification of at least 98% stepwise coupling efficiency is assured, increasing oligonucleotide synthesis yields of full-length product.
• Reagent kits are available for your convenience, and save you time and money.

Our high-performance reagents begin with raw materials that must conform to strict specifications. Once the reagents are manufactured and packaged, we perform extensive testing to assure quality. Reagent lifetime on the instrument is two weeks for tetrazole, and six weeks for all other reagents.

For Research Use Only. Not for use in diagnostics procedures.

Ac-dC Phosphoramidite, standard grade, serum vial bottle Thermo Scientific™

Ac-dC CEP is a phosphoramidite containing 5' DMT and the nucleoside deoxycytidine (dC) with Acetyl (Ac) base protection, for use in oligonucleotide synthesis. DNA phosphoramidites are the building blocks for synthesis of DNA or DNA containing oligonucleotides. Each base has unique protecting groups designed specifically to protect the DNA during the chemical synthesis process and produce the highest amount of full length product. Alternative protecting groups on dC (acetyl) and dG (DMF) allow for a faster deprotection of the oligonucleotide. By using Ac-dC, Bz-dA, and DMF-dG monomers, fast cleavage and deprotection can be effected by a 1:1 mixture of aqueous ammonium hydroxide and aqueous methylamine (or AMA) in 10 min. This product is supplied in a 60 mL Amber bottle with a Serum Vial neck style, which is compatible with most ABI Systems|AKTA Systems of oligonucleotide synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-N4-Acetyl-2'-deoxycytidine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite
• Molecular formula—C41H50N5O8P
• Base—dC
• Base Protection—Ac
• Formula weight—771.8 g/mol
• CAS number—154110-40-4
• HPLC Purity—≥98%
• 31P NMR Purity—≥98%

Beta Cyanoethyl Phosphoramidite, T Applied Biosystems™

The T Beta Cyanoethyl Phosphoramidite is used as a component of a deprotecting chemistry set including dA(Bz), dC(Bz) and dG(iBu). Standard series of phosphoramidite deprotects in 6-8 hours at 55°C.

β-cyanoethyl phosphoramidites are for use on ABI synthesizers to guarantee you high quality nucleic acid synthesis.

• Proprietary manufacturing processes yield high-purity β-cyanoethyl phosphoramidites, which in turn guarantee production of high-quality DNA at all scales.
• β-cyanoethyl phosphoramidites are use-tested and optimized for use on the ABI synthesizers to guarantee you high-quality nucleic acid synthesis.

High Quality
Our phosphoramidites benefit from proprietary manufacturing processes that yield high-purity products. In synthesis they perform at a correspondingly high level, producing pure, high quality DNA at all scales. We guarantee that 5'-dimethoxytrityl nucleoside β-cyanoethyl phosphoramidites, monomer intermediates for licensed β-cyanoethyl phosphoramidite chemistry, will produce DNA that is at least 99.8% chemically authentic when used with recommended synthesis cycles.

Dry phosphoroamidites (powder form) are guaranteed for one year from the date of shipment. Lifetime of diluted phosphoramidites in residence on the instrument is two weeks when used with CPG synthesis supports, and three weeks when used with polystyrene supports.

For Research Use Only. Not for use in diagnostics procedures.

Ac-rC Phosphoramidite, TheraPure™ grade, 28-400 finish bottle Thermo Scientific™

Ac-rC CEP is a phosphoramidite containing 5' DMT and the nucleoside cytidine (C) with Acetyl (Ac) base protection, for use in oligonucleotide synthesis. RNA phosphoramidites contain a 2'-OH protecting group, tBDMS (tert-butyl dimethylsilyl). Each base has unique protecting groups designed specifically to protect the RNA during the chemical synthesis process, and produce the highest amount of full length product. Alternate base protection options are also available to allow for faster deprotection and longer oligonucleotide synthesis. The TheraPure trademark denotes our highest level of phosphoramidite purity, developed with the greatest stringency of high definition analytics and tightly controlled impurity profiles and, therefore, ideal for any therapeutic application. This product is supplied in a 30 mL Amber bottle with a 28-400 Finish neck style, which is compatible with most MerMade Systems of oligonucleotide synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-O-[(tert-butyl)dimethylsilyl]-cytidine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C47H64N5O9PSi
• Base—rC
• Base Protection—Ac
• Formula weight—902.1 g/mol
• CAS number—121058-88-6
• HPLC Purity—≥99%; M-11 Impurity: ≤0.01%
• 31P NMR Purity—≥99%; Sum of non-primary peaks in 140-152 ppm range: ≤0.5%; No single PIII impurity >0.3%

Bz-dA Phosphoramidite, TheraPure™ grade, 20-400 finish bottle Thermo Scientific™

Bz-dA CEP is a phosphoramidite containing 5' DMT and the nucleoside deoxyadenosine (dA) with Benzoyl (Bz) base protection, for use in oligonucleotide synthesis. DNA phosphoramidites are the building blocks for synthesis of DNA or DNA containing oligonucleotides. Each base has unique protecting groups designed specifically to protect the DNA during the chemical synthesis process, and produce the highest amount of full length product. Alternative protecting groups on dC (acetyl) and dG (DMF) allow for a faster deprotection of the oligonucleotide. The TheraPure trademark denotes a highest level of phosphoramidite purity, developed with the highest stringency of of high definiteion analytics and tightly controlled impurity profiles. Ideal for any therapeutic application. This product is supplied in a 60 mL Amber bottle with a 20-400 Finish neck style, which is compatible with most Expedite Systems of oligonucleotide synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C47H52N7O7P
• Base—dA
• Base Protection—Bz
• Formula weight—857.95 g/mol
• CAS number—98796-53-3
• HPLC Purity—≥99%; M-11 Impurity ≤0.01%; Single critical impurity ≤0.3%; Presence of dC, dG, or T impurity ≤0.03%
• 31P NMR Purity—≥99%; Sum of non-primary peaks at 140-152 ppm: ≤0.3%; No peak(s) above 170 ppm; HMT impurity (~146ppm): ≤0.10%

rU Phosphoramidite, TheraPure™ grade, 20-400 finish bottle Thermo Scientific™

rU CEP is a phosphoramidite containing 5' DMT and the nucleoside uridine (U) for use in oligonucleotide synthesis. RNA phosphoramidites contain a 2'-OH protecting group, tBDMS (tert-butyl dimethylsilyl). Each base has unique protecting groups (except T and U) designed specifically to protect the RNA during the chemical synthesis process, and produce the highest amount of full length product. Alternate base protection options are also available to allow for faster deprotection and longer oligonucleotide synthesis. The TheraPure trademark denotes our highest level of phosphoramidite purity, developed with the greatest stringency of high definition analytics and tightly controlled impurity profiles and, therefore, ideal for any therapeutic application. This product is supplied in a 30 mL Amber bottle with a 20-400 Finish neck style, which is compatible with most Expedite Systems of oligonucleotide synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]-uridine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C45H61N4O9PSi
• Base—rU
• Formula weight—861.1 g/mol
• CAS number—118362-03-1
• HPLC Purity—≥99%; M-11 Impurity: ≤0.01%
• 31P NMR Purity—≥99%; Sum of non-primary peaks in 140-152 ppm range: ≤0.5%; No single PIII impurity >0.3%

dU Phosphoramidite, standard grade, serum vial bottle Thermo Scientific™

dU CEP is a phosphoramidite containing 5' DMT and the nucleoside deoxyuridine (dU) for use in oligonucleotide synthesis. The incorporation of a deoxyuridine base into a DNA sequence can be utilized to induce mutagenic effects. Enzymatically the uracil is removed, creating an abasic site at the dU position, and thus generating site-specific breaks in the oligo. This product is supplied in a 20 mL amber bottle with a serum vial neck style, which is compatible with most Applied Biosystems synthesizers and AKTA synthesizers of oligonucleotide synthesizers.

Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C39H47N4O8P
• Base—dU
• Formula weight—730.8 g/mol
• CAS number—144385-59-1
• HPLC Purity—≥98.0%; conforms to reference
• 31P NMR Purity—≥98.0%; conforms to reference

L-Serine, USP/EP/JP Gibco™

L-Serine, USP/EP/JP, also known as (S)-2-Amino-3-hydroxypropionic Acid, is a multi-compendial amino acid for your manufacturing needs and part of our Gibco Chemicals family of products.

Gibco Chemicals is a line of raw materials that fulfill needs throughout the drug development process to commercial production. Standard features include cGMP manufacturing, custom specifications, and a variety of package sizes, as well as a portfolio of cGMP supply chain services to help meet your requirements.

Benefits of Gibco Chemicals include:
Access the materials you need for your R&D and manufacturing processes
Realize manufacturing on a global scale with multi-compendial classifications
Maximize supply chain visibility with transparency of manufacturing and distribution
Eliminate need for re-validation with our comprehensive offering of technical documentation
Streamline supply chain operations by outsourcing key needs such as safety stock storage, custom labeling, and poly-palletization

A focus on quality
Gibco Chemicals are manufactured and distributed through ISO-certified, cGMP-compliant facilities to help meet your regulatory needs and mitigate risk.

Transparency of supply chain
Technical documentation, sales support, and technical service teams are available to provide full visibility into product specifications and journey from manufacturer to your hands.

Custom needs are a standard offering
Gibco Chemicals can be customized to meet your unique specifications including custom fill and weigh requirements, testing protocols, and tailgate samples.

dG(dmf) FastPhoramidite™ Reagent Applied Biosystems™

The dG(dmf) FastPhoramidite® is used for nucleic acid synthesis on the Expedite™ 8905, 8909, and 8909 with MOSS upgrade DNA synthesizers. Our β-cyanoethyl phosphoramidites guarantee you high-quality nucleic acid synthesis.

• Proprietary manufacturing processes guarantee high purity products.
• Expedite™ system fast deprotecting amidites offer fast deprotection for primer-length oligonucleotides, shortening overall production time and costs.
• Fast deprotecting amidites and standard deprotecting amidites are use-tested and optimized for use on the Expedite™ System for high-quality nucleic acid synthesis.
• Phosphoramidite® kits simplify ordering, saving you time and money.

High purity
Our phosphoramidites benefit from proprietary manufacturing processes that yield products of high purity. In synthesis they perform at correspondingly high levels, producing pure, high quality DNA at all scales. We guarantee that 5'-dimethoxytrityl nucleoside β-cyanoethyl phosphoramidites, monomer intermediates for licensed β-cyanoethyl phosphoramidite chemistry, will produce DNA that is at least 99.8% chemically authentic when used with recommended synthesis cycles.

For Research Use Only. Not for use in diagnostics procedures.
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