Shop All Affinity Ligands

CaptureSelect™ Biotin Anti-IgG-Fc (Multi-species) Conjugate (Thermo Scientific™)

CaptureSelect™ Biotin Anti-IgG-Fc (ms) Conjugate consists of a 13 kDa llama antibody fragment (affinity ligand) that specifically binds to the Fc part of IgG from multiple species. The affinity ligand is chemically conjugated to biotin via an appropriate spacer that retains the binding reactivity of the ligand when used in combination with streptavidin-based conjugates or streptavidin pre-coated surfaces.

The CaptureSelect™ Biotin Anti-IgG-Fc (ms) Conjugate allows you to:

Detect, quantitate, and characterize IgG antibodies from multiple species (all subclasses, IgG-specific), multi-species IgG-derived Fc fusion proteins, recombinant IgG antibodies, and total IgG in plasma and/or serum samples
Avoid cross-binding with other isotypes, such as IgA and IgM

Applications for CaptureSelect™ Biotin Anti-IgG-Fc (ms) Conjugate include ELISA, Western blot, Gyrolab™-based immunoassays, and label-free detection platforms such as those based on surface plasmon resonance (Biacore™ and IBIS-MX96 systems) and bio-layer interferometry (ForteBio™ Octet™ systems).

CaptureSelect™ Biotin Anti-C3 Conjugate (Thermo Scientific™)

CaptureSelect™ Biotin Anti-C3 Conjugate consists of a 13 kDa camelid antibody fragment (affinity ligand) that specifically binds with high affinity and selectivity to human complement component 3 (C3). The affinity ligand is chemically conjugated to biotin via an appropriate spacer that retains the binding reactivity of the ligand when used in combination with streptavidin-based conjugates or streptavidin pre-coated surfaces. This conjugate allows you to detect, quantitate, and characterize native and recombinant human C3.

Applications for CaptureSelect Biotin Anti-C3 Conjugate include ELISA, immunoprecipitation with streptavidin-coupled Dynabeads™, MSIA Streptavidin D.A.R.T.’S, Gyrolab™-based immunoassays, and label-free detection platforms such as those based on surface plasmon resonance (Biacore™ and IBIS-MX96 systems) and bio-layer interferometry (ForteBio™ Octet™ systems).

CaptureSelect™ Biotin Anti-AAT Conjugate (Thermo Scientific™)

CaptureSelect™ Biotin Anti-AAT Conjugate consists of a 13 kDa camelid antibody fragment (affinity ligand) that specifically binds with high affinity and selectivity to human alpha-1 antitrypsin (AAT). The affinity ligand is chemically conjugated to biotin via an appropriate spacer that retains the binding reactivity of the ligand when used in combination with streptavidin-based conjugates or streptavidin pre-coated surfaces. This conjugate allows you to detect, quantitate, and characterize native and recombinant human AAT.

Applications for CaptureSelect Biotin Anti-AAT Conjugate include ELISA, immunoprecipitation with streptavidin-coupled Dynabeads™, Gyrolab™-based immunoassays, and label-free detection using platforms such as those based on surface plasmon resonance (Biacore™ and IBIS-MX96 systems) and bio-layer interferometry (ForteBio™ Octet™ systems).

CaptureSelect™ Biotin Anti-FIX Conjugate (Thermo Scientific™)

CaptureSelect™ Biotin Anti-FIX Conjugate consists of a 13 kDa camelid antibody fragment (affinity ligand) with high affinity and selectivity for both recombinant and plasma derived human Factor IX (FIX). The affinity ligand is chemically conjugated to biotin via an appropriate spacer that retains the binding reactivity of the ligand when used in combination with streptavidin-based conjugates or streptavidin pre-coated surfaces.

The CaptureSelect™ Biotin Anti-FIX Conjugate allows you to:

Detect, quantitate, and characterize recombinant and plasma derived human FIX

Applications for CaptureSelect™ Biotin Anti-FIX Conjugate include ELISA, Western blot, Gyrolab™-based immunoassays, and label-free detection platforms such as those based on surface plasmon resonance (Biacore™ and IBIS-MX96 systems) and bio-layer interferometry (ForteBio™ Octet™ systems).

CaptureSelect™ Biotin Anti-IgM Conjugate (Thermo Scientific™)

CaptureSelect™ Biotin Anti-IgM Conjugate consists of a 14 kDa llama antibody fragment (affinity ligand) that specifically binds to the μ chain of human, rat, and mouse IgM antibodies. The affinity ligand is chemically conjugated to biotin via an appropriate spacer that retains the binding reactivity of the ligand when used in combination with streptavidin-based conjugates or streptavidin pre-coated surfaces.

The CaptureSelect™ Biotin Anti-IgM Conjugate allows you to:

Detect, quantitate, and characterize all human, rat, and mouse IgM antibodies (independent of the type of light chain), recombinant IgM monoclonal antibodies, and total IgM in human plasma and/or serum samples
Avoid cross-binding with other isotypes such as IgG, IgA, IgD, and IgE, free light chains, or with IgM from bovine sources such as FCS

Applications for CaptureSelect™ Biotin Anti-IgM Conjugate include ELISA, Western blot, Gyrolab™-based immunoassays, and label-free detection platforms such as those based on surface plasmon resonance (Biacore™ and IBIS-MX96 systems) and bio-layer interferometry (ForteBio™ Octet™ systems).

CaptureSelect™ Biotin Anti-AAVX Conjugate (Thermo Scientific™)

CaptureSelect Biotin Anti-AAVX Conjugate consists of a 14 kDa camelid antibody fragment (affinity ligand) that specifically binds with high affinity and selectivity to native and recombinant adeno-associated virus (AAV) particles of various serotypes. The anti-AAVX affinity ligand has demonstrated binding reactivity towards a large set of different AAV serotypes including AAV1 to AAV8, and AAVrh10, indicating that an even broader range of AAV serotypes could potentially be recognized and detected. The affinity ligand is chemically conjugated to biotin via a spacer that retains the binding reactivity of the ligand when used in combination with streptavidin-based conjugates or streptavidin pre-coated surfaces.

This conjugate enables the detection, quantitation, and characterization of native and recombinant AAV virus particles. Applications for CaptureSelect Biotin Anti-AAVX Conjugate include ELISA, immunoprecipitation with streptavidin-coupled Dynabeads, Gyrolab™-based immunoassays, and use with label-free detection platforms such as those based on surface plasmon resonance (Biacore™ and IBIS-MX96 systems) and bio-layer interferometry (ForteBio™ Octet™ systems).

CaptureSelect™ Biotin Anti-LC-kappa (Human) Conjugate (Thermo Scientific™)

CaptureSelect™ Biotin Anti-LC-kappa (Hu) Conjugate consists of a 13 kDa llama antibody fragment (affinity ligand) that specifically binds to the constant domain of human kappa light chains. The affinity ligand is chemically conjugated to biotin via an appropriate spacer that retains the binding reactivity of the ligand when used in combination with streptavidin-based conjugates or streptavidin pre-coated surfaces.

The CaptureSelect™ Biotin Anti-LC-kappa (Hu) Conjugate allows you to:

Detect, quantitate, and characterize all human antibody isotypes and subclasses (for example, IgG1 to 4, IgM, IgA, IgD, and IgE), and Fab fragments thereof, that contain a kappa light chain; as well as recombinant human Fab fragments and/or Fab and Fab2 fragments obtained after papain or pepsin digestion
Avoid cross-binding with human antibodies that possess a lambda light chain or IgG from bovine sources such as FCS
Screen antibody-antigen interactions—biotin anti-LC-kappa (Hu) forms a stable [low k(diss)] complex with, for example, human IgG antibodies through bivalent binding

Applications for CaptureSelect™ Biotin Anti-LC-kappa (Hu) Conjugate include ELISA, Western blot, Gyrolab™-based immunoassays, and label-free detection platforms such as those based on surface plasmon resonance (Biacore™ and IBIS-MX96 systems) and bio-layer interferometry (ForteBio™ Octet™ systems).

CaptureSelect™ Human Fab-kappa Kinetics Biotin Conjugate (Thermo Scientific™)

CaptureSelect™ Human Fab-kappa Kinetics Biotin Conjugate is a bi-functional ligand construct consisting of 2 different 13 kDa llama antibody fragments (affinity ligands). The CaptureSelect™ anti-LC-kappa (Hu) ligand that specifically binds to the constant domain of human kappa light chains is genetically fused to the CaptureSelect™ anti-IgG-CH1 ligand that specifically binds to the CH1 domain of all four human IgG subclasses. The bi-functional affinity ligand is chemically conjugated to biotin via an appropriate spacer that retains the binding reactivity of the ligand when used in combination with streptavidin-based conjugates or streptavidin pre-coated surfaces.

The CaptureSelect™ Human Fab-kappa Kinetics Biotin Conjugate allows you to:

Screen Fab-antigen interactions—the Human Fab-kappa Kinetics Biotin Conjugate allows high affinity capture of human IgG Fab fragments that possess a kappa light chain. Extreme low off-rates [k(diss)] are achieved through avidity by targeting the CL-kappa domain of the Fab (light chain) and its IgG CH1 domain (heavy chain) simultaneously, thereby enabling Fab screening on target binding kinetics.

Applications for CaptureSelect™ Human Fab-kappa Kinetics Biotin Conjugate include ELISA, Western blot, Gyrolab™-based immunoassays, and label-free detection platforms such as those based on surface plasmon resonance (Biacore™ and IBIS-MX96 systems) and bio-layer interferometry (ForteBio™ Octet™ systems).

CaptureSelect™ Biotin Anti-IgG-CH1 Conjugate (Thermo Scientific™)

CaptureSelect™ Biotin Anti-IgG-CH1 Conjugate consists of a 14 kDa llama antibody fragment (affinity ligand) that specifically binds to the CH1 domain of all four human IgG subclasses. The affinity ligand is chemically conjugated to biotin via an appropriate spacer that retains the binding reactivity of the ligand when used in combination with streptavidin-based conjugates or streptavidin pre-coated surfaces.

The CaptureSelect™ Biotin Anti-IgG-CH1 Conjugate allows you to:

Detect, quantitate, and characterize all human IgG antibodies (subclasses 1 to 4) and Fab fragments thereof, independent of light chain type, and total IgG in human plasma and/or serum samples
Avoid cross-binding with other isotypes, such as IgA, IgM, IgD, and IgE, free light chains, or IgG from mouse sources or bovine sources such as FCS
Screen antibody-antigen interactions—biotin anti-IgG-CH1 forms a stable [low k(diss)] complex with human IgG antibodies through bivalent binding

Applications for CaptureSelect™ Biotin Anti-IgG-CH1 Conjugate include ELISA, Western blot, Gyrolab™-based immunoassays, and label-free detection platforms such as those based on surface plasmon resonance (Biacore™ and IBIS-MX96 systems) and bio-layer interferometry (ForteBio™ Octet™ systems).

CaptureSelect™ Biotin Anti-IgG4 (Human) Conjugate (Thermo Scientific™)

CaptureSelect™ Biotin Anti-IgG4 (Hu) Conjugate consists of a 12 kDa llama antibody fragment (affinity ligand) that specifically binds to the Fc part of the human IgG4 subclass. The affinity ligand is chemically conjugated to biotin via an appropriate spacer that retains the binding reactivity of the ligand when used in combination with streptavidin-based conjugates or streptavidin pre-coated surfaces.

The CaptureSelect™ Biotin Anti-IgG4 (Hu) Conjugate allows you to:

Detect, quantitate, and characterize human IgG4 antibodies
Avoid cross-binding with other IgG subclasses like IgG1, 2 and 3 and isotypes like IgM and IgA including IgG from bovine sources such as FCS

Applications for CaptureSelect™ Biotin Anti-IgG4 (Hu) Conjugate include ELISA, Western blot, Gyrolab™-based immunoassays, and label-free detection platforms such as those based on surface plasmon resonance (Biacore™ and IBIS-MX96 systems) and bio-layer interferometry (ForteBio™ Octet™ systems).

CaptureSelect™ Biotin Anti-IgG3 (Human) Conjugate (Thermo Scientific™)

CaptureSelect™ Biotin Anti-IgG3 (Hu) Conjugate consists of a 13 kDa llama antibody fragment (affinity ligand) that specifically binds to the Fc part of the human IgG3 subclass, most likely the hinge region. The affinity ligand is chemically conjugated to biotin via an appropriate spacer that retains the binding reactivity of the ligand when used in combination with streptavidin-based conjugates or streptavidin pre-coated surfaces.

The CaptureSelect™ Biotin Anti-IgG3 (Hu) Conjugate allows you to:

Detect, quantitate, and characterize human IgG3 antibodies
Avoid cross-binding with other human IgG subclasses like IgG1, 2 and 4 and isotypes like IgM and IgA including IgG from bovine sources such as FCS

Applications for CaptureSelect™ Biotin Anti-IgG3 (Hu) Conjugate include ELISA, Western blot, Gyrolab™-based immunoassays, and label-free detection platforms such as those based on surface plasmon resonance (Biacore™ and IBIS-MX96 systems) and bio-layer interferometry (ForteBio™ Octet™ systems).

CaptureSelect™ Biotin Anti-EPO Conjugate (Thermo Scientific™)

CaptureSelect™ Biotin Anti-EPO Conjugate consists of a 13 kDa camelid antibody fragment (affinity ligand) with high affinity and selectivity for both recombinant and natural-sourced human erythropoietin (EPO). The affinity ligand is chemically conjugated to biotin via an appropriate spacer that retains the binding reactivity of the ligand when used in combination with streptavidin-based conjugates or streptavidin pre-coated surfaces.

Applications for CaptureSelect™ Biotin Anti-EPO Conjugate include ELISA, western blot, Gyrolab™-based immunoassays, and use of label-free detection platforms such as those based on surface plasmon resonance (Biacore™ and IBIS-MX96 systems) and bio-layer interferometry (ForteBio™ Octet™ systems).

CaptureSelect™ Human IgG-Fc PK Biotin Conjugate (Thermo Scientific™)

CaptureSelect™ Human IgG-Fc PK Biotin Conjugate consists of a 13 kDa llama antibody fragment (affinity ligand) that specifically binds to the Fc part of all four human IgG subclasses without cross-binding to mouse, rat, rhesus, and cynomolgus monkey IgG. The affinity ligand is chemically conjugated to biotin via an appropriate spacer that retains the binding reactivity of the ligand when used in combination with streptavidin-based conjugates or streptavidin pre-coated surfaces.

The CaptureSelect™ Human IgG-Fc PK Biotin Conjugate allows you to:

Detect, quantitate, and characterize all human IgG antibodies (subclasses 1 to 4), recombinant human IgG antibodies, human IgG-derived Fc-fusion proteins in, for instance, non-human plasma and/or serum samples like mouse, rat , rhesus, and cynomolgus monkey, thereby making it extremely suitable for setting up pharmacokinetics (PK) assays

Applications for CaptureSelect™ Human IgG-Fc PK Biotin Conjugate include ELISA, Western blot, Gyrolab™-based immunoassays, and label-free detection platforms such as those based on surface plasmon resonance (Biacore™ and IBIS-MX96 systems) and bio-layer interferometry (ForteBio™ Octet™ systems).

CaptureSelect™ Biotin Anti-FVIII Conjugate (Thermo Scientific™)

CaptureSelect™ Biotin Anti-FVIII Conjugate consists of a 13 kDa camelid antibody fragment (affinity ligand) with high affinity and selectivity for both recombinant (full length and B-domain deleted) and plasma derived human Factor VIII (FVIII), through recognition of the human FVIII light chain. The affinity ligand is chemically conjugated to biotin via an appropriate spacer that retains the binding reactivity of the ligand when used in combination with streptavidin-based conjugates or streptavidin pre-coated surfaces.

The CaptureSelect™ Biotin Anti-FVIII Conjugate allows you to:

Detect, quantitate, and characterize recombinant and plasma derived human FVIII

Applications for CaptureSelect™ Biotin Anti-FVIII Conjugate include ELISA, Western blot, Gyrolab™-based immunoassays, and label-free detection platforms such as those based on surface plasmon resonance (Biacore™ and IBIS-MX96 systems) and bio-layer interferometry (ForteBio™ Octet™ systems).

CaptureSelect™ Biotin Anti-IgG-Fc (Human) Conjugate (Thermo Scientific™)

CaptureSelect™ Biotin Anti-IgG-Fc (Hu) Conjugate consists of a 13 kDa llama antibody fragment (affinity ligand) that specifically binds to the Fc part (CH3 domain) of all four human IgG subclasses. The affinity ligand is chemically conjugated to biotin via an appropriate spacer that retains the binding reactivity of the ligand when used in combination with streptavidin-based conjugates or streptavidin pre-coated surfaces.

The CaptureSelect™ Biotin Anti-IgG-Fc (Hu) Conjugate allows you to:

Detect, quantitate, and characterize all human IgG antibodies (subclasses 1 to 4), recombinant human IgG antibodies, human IgG-derived Fc-fusion proteins including CH2 deleted (or mutated) Fc formats, and total IgG in human plasma and/or serum samples
Avoid cross-binding with other isotypes, such as IgA, IgM, IgD, and IgE, free light chains, or IgG antibodies from non-primate species (for example, bovine, horse, and murine)

Applications for CaptureSelect™ Biotin Anti-IgG-Fc (Hu) Conjugate include ELISA, Western blot, Gyrolab™-based immunoassays, and label-free detection platforms such as those based on surface plasmon resonance (Biacore™ and IBIS-MX96 systems) and bio-layer interferometry (ForteBio™ Octet™ systems).