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AutoMate Express™ Nucleic Acid Extraction System (Applied Biosystems™)

The AutoMate Express™ Nucleic Acid Extraction System is an easy-to-use benchtop instrument that enables hands-free automation of the nucleic acid extraction process for contaminant and impurity testing. The instrument uses the established PrepSEQ® nucleic acid extraction chemistry for quantitative recovery of DNA and RNA from diverse samples types, including cell culture, raw material (i.e., serum), and in-process downstream purification samples such as column purification or bulk drug substance (BDS) samples.

Key Product Features:

• Time-saving, cost-effective DNA extraction for mycoplasma, MMV, vesivirus, and residual DNA quantitation
• Quantitative and reproducible recovery of DNA from complex samples
• Out-of-the-box automation with prefilled PrepSEQ® Express™ cartridges and ready-to-run protocols
• Closed system minimizes the risk of contamination
• Ideal for in-process testing of contaminants and impurities

Three-in-One Extraction of Cell Culture Contaminants
The AutoMate Express™ system can be used to perform nucleic acid extraction of the common contaminants for mammalian cell culture manufacturing, i.e., mycoplasmas, MMV, and vesiviruses (Figure 1). Flexible protocols are available to isolate DNA and RNA from a single organism, or a 3-in-1 surveillance panel protocol can simultaneously extract mycoplasma, MMV, and vesivirus nucleic acid from a single sample.

Quantitative Recovery for Residual DNA Applications
The AutoMate Express™ system is also designed for highly efficient recovery of host cell residual DNA from complex samples typically recovered during biopharmaceutical purification processes. The system facilitates quantitative and consistent recovery of DNA from challenging matrices, including samples that have high protein concentration, low pH, or high salt (Figure 2).

Closed System with Walk-Away Automation
The AutoMate Express™ system automatically performs all steps for efficient nucleic acid extraction from contaminants and impurities in a closed environment. The system uses PrepSEQ® Express™ kits that contain sealed cartridges with extraction reagents, and plastics, including tips and sample, lysis, and elution tubes. The workflow has been designed for a completely hands-free operation enabling reproducible extraction efficiencies and reduced time-to-results.

For Research Use Only. Not for use in diagnostic procedures.

KingFisher™ Flex Purification System, KingFisher with 24 Deep-well Head (Thermo Scientific™)

Prepare samples efficiently from a variety of materials with Thermo Scientific™ KingFisher™ Flex Magnetic Particle Processors.

KingFisher™ Presto Purification System (Thermo Scientific™)

Automate the extraction of DNA, RNA and proteins with the Thermo Scientific™ KingFisher™ Presto Purification System.

KingFisher™ Flex™ Systems Consumables (Thermo Scientific™)

Optimize performance using consumables specifically designed for use with the KingFisher™ Flex™ System and ideal for magnetic particle processing.

KingFisher™ Duo Consumables (Thermo Scientific™)

Carry out magnetic particle processing with Thermo Scientific™ KingFisher™ Duo and KingFisher Duo Prime Consumables, specially designed combs and microplates optimized for performance.

AutoLys M Tube Locking Lid (Applied Biosystems™)

This is an extra locking lid for use with the AutoLys M Tube system. Note that two locking lids are included with the purchase of the AutoLys M TubeLifter. The locking lid is required to prevent the inner tube of the AutoLys M Tube from sliding into the outer tube during centrifugation.

KingFisher™ Flex Purification System, KingFisher with 96 PCR head (Thermo Scientific™)

Prepare samples efficiently from a variety of materials with Thermo Scientific™ KingFisher™ Flex Magnetic Particle Processors.

MagMAX™ Express-96 Deep Well Plates (Applied Biosystems™)

MagMAX™ Express-96 Deep Well Plates are designed for use with the MagMAX™ Express-96 Deep Well Magnetic Particle Processors, for automated magnetic bead separation and processing. The deep well configuration differs from the standard configuration in that the volume of sample input is from 100 to 1,000 µL per well (20–200 µL for the standard configuration).

KingFisher™ Flex Purification System (Thermo Scientific™)

Prepare samples efficiently from a variety of materials with Thermo Scientific™ KingFisher™ Flex Purification Systems.

iPrep™ Card: gDNA Blood (Invitrogen™)

The iPrep™ Protocol Card is a flash, 512 KB memory card. Each iPrep™ Protocol card is pre-programmed with the purification protocol that directs the volume of reagents used and incubation time.
The following iPrep™ Protocol Cards are available from Invitrogen:
- iPrep™ Forensic Card for use with the iPrep™ ChargeSwitch® Forensic Kit and the iPRep™ ChageSwitch® gDNA Buccal kit
-iPrep™ Tissue Card for use with the iPrep ChargeSwitch® Tissue Kit
- iPrep™ Blood Card for use with the iPrep PureLink Blood kit

96 Deep-Well Head for KingFisher™ Flex Magnetic Particle Processor (Thermo Scientific™)

This is a magnetic head for the KingFisher™ Flex Magnetic Particle Processor (Cat. Nos. 5400630 and 5400640). This magnetic head can serve as a replacement head for the 96 deep-well format system or a supplemental head for the 24 deep-well format system.

AutoLys M Tube Racks (Applied Biosystems™)

These AutoLys M Tube Racks hold 24 AutoLys M Tubes per rack. The racks are locked and unlocked using the AutoLys M TubeLifter.

AutoLys M Tube Pliers (Applied Biosystems™)

AutoLys M Tube Pliers can be used to separate the inner-tube from the outer-tube of AutoLys M Tubes. Centrifugation of the tubes in an AutoLys M Tube Rack is required when processing FFPE samples using the MagMAX FFPE DNA/RNA Ultra Kit. The outer-tube will contain the lysate that is processed further to recover the nucleic acids.

Consumables for KingFisher™ mL Systems (Thermo Scientific™)

Optimize system performance with Consumables for Thermo Scientific™ KingFisher™ mL Systems.

KingFisher™ Flex 24 Deep-Well Heating Block (Thermo Scientific™)

The KingFisher™ Flex 24 Deep-Well Heating Block is compatible with the KingFisher™ Flex 24 Deep-Well Plate when used on the KingFisher™ Flex Magnetic Particle Processor with 24 Deep-Well Head.