Shop All Sequencing & Genetic Analyzer Instruments

3500 Genetic Analyzer for Resequencing & Fragment Analysis (Applied Biosystems™)

The 3500 Genetic Analyzer is an 8-capillary sequencing instrument specifically designed to support the demanding performance needs of validated and process controlled environments, while retaining the unsurpassed application versatility that life science researchers expect.

This package includes an 8-capillary instrument, 3500 Series Data Collection Software, a Dell Workstation and monitor, as well as reagent kits for system qualification and secondary analysis software. The 3500 Series Data Collection Software supports sequencing and fragment analysis, and integrates seamlessly with downstream software for secondary analysis of genetic data. This package includes such secondary software: GeneMapper® software for fragment analysis and software for resequencing applications.

Features include:

• An 8 capillary system that can easily be upgraded to a 24-capillary system when you’re ready.
• Single-line, 505 nm, solid-state, long-life laser that utilizes a standard power supply and requires no heat-removal ducting
• Powerful, integrated data collection and primary analysis software provides real-time assessment of data quality
• Radio frequency identification (RFID) technology tracks key consumables data and records administrative information
• Advanced multiplexing capabilities for DNA fragment analysis with up to six unique dyes
• Unrivaled application flexibility—one array and one polymer are used for most applications.
• Simple setup, operation and maintenance

Accurate Reliable Data Quality
The 3500 series systems significantly improves signal uniformity from instrument-to-instrument, run-to-run, and capillary-to-capillary. With a combination of intelligent hardware, powerful new algorithm and reagent combinations, these methods provide major reduction in the range of signal peak heights obtained across multiple 3500 series instruments (see figure).

Improved Sizing Precision
New thermal sub-system design gives enhanced performance in demanding fragment applications enabling improved sizing precision versus previous generations of capillary electrophoresis platforms.

Ready to Use Consumables With RFID Tags
The 3500 series introduces ready-to-use consumables with pre-packaged polymer pouches, cathode and anode buffer containers, and easy-to-install capillary arrays. Each of these consumables is integrated with RFID tags that enable viewing, tracking, and reporting of critical information about reagents and consumables including usage, lot number, part number, expiry date, and on-instrument lifetime within the 3500 Series Data Collection Software.

Easy to Use Data Collection Software
3500 Series Data Collection software breaks new ground in user-friendly navigation with an intuitive dashboard design, highly visible buttons for common operations, easy-to-read graphical displays to monitor the state of consumables and handy maintenance scheduling calendar functionality. New functionality includes simplified plate set-up and built-in primary analysis with quality control, so you can make decisions about the quality of data as it is produced on the instrument without the need to transfer output files into secondary analysis software packages.

3500xL Genetic Analyzer for Resequencing & Fragment Analysis (Applied Biosystems™)

The 3500xL 24-capillary platform can run a wide variety of applications, including de novo sequencing and resequencing (mutational profiling), as well as microsatellite analysis, MLPA™, LOH, MLST, AFLP® and SNP validation or screening. The majority of applications can be run on a single polymer and capillary array.

This package includes a 24-capillary instrument, 3500 Series Data Collection Software, a Dell Workstation and monitor, as well as reagent kits for system qualification and secondary analysis software. The 3500 Series Data Collection Software supports sequencing and fragment analysis, and integrates seamlessly with downstream software for secondary analysis of genetic data. This package includes such secondary software: GeneMapper® software for fragment analysis and software for resequencing applications.

Features include:

• An 8 capillary system that can easily be upgraded to a 24-capillary system when you’re ready.
• Single-line, 505 nm, solid-state, long-life laser that utilizes a standard power supply and requires no heat-removal ducting
• Powerful, integrated data collection and primary analysis software provides real-time assessment of data quality
• Radio frequency identification (RFID) technology tracks key consumables data and records administrative information
• Advanced multiplexing capabilities for DNA fragment analysis with up to six unique dyes
• Unrivaled application flexibility—one array and one polymer are used for most applications.
• Simple setup, operation and maintenance

Accurate Reliable Data Quality
The 3500 series systems significantly improves signal uniformity from instrument-to-instrument, run-to-run, and capillary-to-capillary. With a combination of intelligent hardware, powerful new algorithm and reagent combinations, these methods provide major reduction in the range of signal peak heights obtained across multiple 3500 series instruments (see figure).

Improved Sizing Precision
New thermal sub-system design gives enhanced performance in demanding fragment applications enabling improved sizing precision versus previous generations of capillary electrophoresis platforms.

Ready to Use Consumables With RFID Tags
The 3500 series introduces ready-to-use consumables with pre-packaged polymer pouches, cathode and anode buffer containers, and easy-to-install capillary arrays. Each of these consumables is integrated with RFID tags that enable viewing, tracking, and reporting of critical information about reagents and consumables including usage, lot number, part number, expiry date, and on-instrument lifetime within the 3500 Series Data Collection Software.

Easy to Use Data Collection Software
3500 Series Data Collection software breaks new ground in user-friendly navigation with an intuitive dashboard design, highly visible buttons for common operations, easy-to-read graphical displays to monitor the state of consumables and handy maintenance scheduling calendar functionality. New functionality includes simplified plate set-up and built-in primary analysis with quality control, so you can make decisions about the quality of data as it is produced on the instrument without the need to transfer output files into secondary analysis software packages.

Ion GeneStudio™ S5 Prime System (Ion Torrent™)

The Ion GeneStudio S5 Prime System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows. For core and service labs requiring maximum throughput and rapid turnaround time from a benchtop NGS system, the Ion GeneStudio S5 Prime System enables unparalleled breadth and depth, from large panels or exomes to clinical oncology research focused on low allele frequency applications. With cartridge-based reagents, the system is simple to use and offers scalability and flexibility. It uses Ion 5 Series chips to support a broad range of high-throughput sequencing for clinical research and research applications from microbial genomes and gene panels to exomes and transcriptomes.

Key features:
• Select the chip (Ion 510–550 chip) that fits your application and throughput needs to achieve from 2–130 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments

The Ion GeneStudio S5 Series
The Ion GeneStudio S5 Series sequencers share the same foundational technology and fluidic architecture across all three instruments: the Ion GeneStudio S5 System, the Ion GeneStudio S5 Plus System, and this Ion GeneStudio S5 Prime System. The primary difference across the three instruments is on-sequencer analysis time.

Speed
The Ion GeneStudio S5 Series leverages the speed of semiconductor sequencing to enable the production of high quality sequencing data in a few hours and enables you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time when paired with the Ion Chef System.

Simplicity
With single-day installation, a straightforward user interface, and cartridge-based reagents, the Ion GeneStudio S5 Series sequencers are easy to use. Combined with Ion AmpliSeq technology for target selection, the Ion Chef System for automated library and template preparation, and Ion Reporter Software for automated variant annotation, targeted sequencing is simpler than ever.

Small sample input
Low input DNA from challenging samples types such as formalin-fixed paraffin-embedded (FFPE) tissue, retrospective samples from fine needle aspirates, and cell-free DNA extracted from blood (cfDNA) can be difficult to sequence on competitor next-generation sequencers. However, with Ion AmpliSeq technology and the Ion GeneStudio S5 Series, you can use as little as 1 ng input DNA or RNA.

Scalability
Why buy multiple systems for your lab when you can run all of your targeted sequencing or microbial applications on a single next-generation sequencer? The Ion 5 Series chips that run on the Ion GeneStudio S5 Series provide several throughput options, so your lab has the flexibility to scale from small to large projects, enabling multiple targeted sequencing applications on a single system.

Simple analysis and storage solutions
Torrent Suite Software and Ion Reporter Software make NGS easy for beginners and experts alike. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Ion Reporter Software (Thermo Fisher Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

Ion GeneStudio™ S5 System Extended Warranty Package (Ion Torrent™)

The Ion GeneStudio S5 System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows. It is optimized to provide affordability for labs focused on smaller panels and lower sequencing throughput requirements. Combining an extended warranty with your system purchase helps extend the life of your investment.

This package includes the Ion GeneStudio S5 System, SmartStart orientation, and an extended warranty. Key features include:
• Select the chip (Ion 510–540 chip) that fits your application and throughput needs to achieve from 2–80 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments
• Increase efficiency and become operational faster with SmartStart orientation
• Receive fast repair from certified service engineers
• Minimize instrument downtime by troubleshooting with experienced Technical Support teams

For detailed instrument information and specifications, see the Ion GeneStudio S5 System.

Get up and running quickly with SmartStart
SmartStart orientation is carried out by a Field Application Scientist (FAS) to get you up and running quickly in your lab and reduce downtime. SmartStart is the first step of your education journey and is designed to help you work smarter and with greater efficiency. It includes:
• 1-day technology overview and instrument workflow
• 1-day hands-on application workflow training
• 10 hours bioinformatics consultancy

Content will vary depending on your level of knowledge and experience.

Extended warranty plan
Add coverage to your existing manufacturer’s limited warranty with an extended warranty. Each extended warranty includes a planned maintenance visit. Should your instrument require a repair, the extended warranty coverage includes parts, labor, and travel at no additional cost. In addition, you’ll receive:
• On-site guaranteed 2-day response time*
• Scheduled on-site planned maintenance (PM)
• Priority access to Remote Service Engineers

Certain exclusions apply. Contact your Services and Support Representative for details at service.sales@thermofisher.com.

*Availability limited in some geographical areas.

3500 Genetic Analyzer for Human Identification (Applied Biosystems™)

The 8-capillary 3500 Genetic Analyzer sets the standard in capillary electrophoresis. The 3500-series instruments are the first genetic analyzers designed with a specific feature set and workflow for the Human Identification application. The complete product combines the instrument with Applied Biosystems™ reagents, consumables and software, as well as industry leading support, to provide an integrated HID system solution that significantly improves ease-of-use and application efficiencies.

• Increased Consistency – Reduced signal variation with factory standardization and optional in-lane normalization
• Real-Time Data Quality Assessment – On instrument data evaluation features provide rapid identification and re-injection of samples requiring additional processing
• Improved Thermal Control – Smaller oven design and improved door seal for more consistent data migration
• HID Specific Workflow – Pre-configured for Applied Biosystems® amplification kits to simplify run setup and software navigation
• Effortless Consumable Installation – Convenient one-time use consumable packaging
• Consumable Tracking with RFID Technology – On-instrument, real-time monitoring of consumable consumption and expiration
• Enhanced Throughput – Faster data generation with 8 or 24 capillary arrays and shorter run times
• Improved Polymer Pump Design – Reduced waste and fewer bubbles for better data quality
• Simplified Instrument Installation & Operation – New solid-state laser eliminates need for high voltage wiring and external venting
• Streamlined Instrument Maintenance – HID specific performance check and maintenance scheduling tools
• Data Chain of Custody – Controlled access and tracking through Security, Audit and eSig features

For more information, please contact your local Sales Representative.

For Research Use Only. Not for use in diagnostics procedures.

HID Ion GeneStudio™ S5 Plus System (Ion Torrent™)

The HID Ion GeneStudio S5 Plus System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows for forensic analysis. From targeted SNP panels to Precision ID STR workflows and mitochonidrial DNA sequencing, the HID Ion GeneStudio S5 Plus System is designed to enable flexibility to help labs manage small and large projects across multiple applications. With cartridge-based reagents, the system is simple to use and offers scalability and flexibility. It uses Ion 5 Series chips to support a broad range of high-throughput sequencing for forensic applications.

Features of the HID Ion GeneStudio S5 Plus System include:
• Select the chip (Ion 510–550 chip) that fits your application and throughput needs to achieve from 2–130 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments

The Ion GeneStudio S5 Series
The HID Ion GeneStudio S5 Series sequencers share the same foundational technology and fluidic architecture across all three instruments: the HID Ion GeneStudio S5 System, this HID Ion GeneStudio S5 Plus System, and the HID Ion GeneStudio S5 Prime System. The primary difference across the three instruments is on-sequencer analysis time.

Speed
The HID Ion GeneStudio S5 Series sequencers leverage the speed of semiconductor sequencing to enable the production of high-quality sequencing data in a few hours and enable you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time when paired with the HID Ion Chef System.

Simplicity
With single-day installation, a straightforward user interface, and cartridge-based reagents, the HID Ion GeneStudio S5 Series sequencers are easy to use. Combined with Precision ID library prep technology for target selection, the HID Ion Chef System for automated library and template preparation, and Converge Software for automated analysis, forensic sequencing is simpler than ever.

Small sample input
Low input DNA amounts from challenging sample types such as touch DNA or other forensic samples can be difficult to sequence on competitor next-generation sequencers. However, with Precision ID library preparation and sequencing technology and the HID Ion GeneStudio S5 Series sequencers, you can use as little as 100 pg of DNA input and achieve accurate, robust results.

Scalability
Why buy multiple systems for your lab when you can modulate your throughput by chip selection on a single next-generation sequencer? The Ion 5 Series chips that run on the HID Ion GeneStudio S5 Series systems provide several throughput options, so your lab has the flexibility to scale from small to large projects, enabling multiple forensic applications on a single system.

Simple analysis and storage solutions
Torrent Suite Software and Converge Software make NGS easy for beginners and experts alike. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Converge Software (Thermo Fisher Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and help ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

3500 Dx Genetic Analyzer CS2 (Applied Biosystems™)

The 3500 Dx Genetic Analyzer CS2 is the latest addition to our family of Applied Biosystems® genetic analyzers based on capillary electrophoresis. The 3500 Dx Genetic Analyzer CS2 is an IVD-labeled instrument, making it the first Sanger sequencing platform cleared for sequencing analysis of DNA.

Confidence in Your Results
• The 3500 Dx Genetic Analyzer CS2 is an IVD-labeled platform for Sequencing-Based Typing using SeCore® HLA typing kits. Sanger sequencing is known as the "gold-standard" for its accuracy, reliability, and ease of use. It is also used for confirmatory sequencing by clinical labs.
• High accuracy: 99% concordance as shown in clinical trials using SeCore® HLA typing kits
• Proven through decades of results—including sequencing of the first human genome—Applied Biosystems® genetic analysis systems are trusted standards for Sanger sequencing.

You can now feel even more comfortable adopting the 3500 Dx Genetic Analyzer CS2 platform for the development of assays for FDA submission.

Simplicity and Efficiency
• Reduced instrument hands-on time with simplified installation and removal of consumables and accessories
• Controlled and efficient run setup with intuitive user interface, preconfigured plate templates, and software-controlled functions (plate setup, data collection, analysis)
• Instrument run-times as short as 1 hour; sample-to-result in as little as 1.5 days
• Maintenance calendar with programmable prompts and service history
• Security and electronic signature, RFID (radio frequency identification) tracking of consumables, built-in quality controls, and real-time data quality evaluation

The 3500 Dx Genetic Analyzer CS2 is a partner in your laboratory, making it easy for you to comply with various industry standards and simplifying the training of new users.

Flexibility
• Collect data in either IVD (diagnostic for HLA typing) or RUO mode
• Develop other applications in RUO mode, including de novo sequencing and re-sequencing, as well as fragment analysis applications such as microsatellite analysis, MLPA®, LOH, MLST, and SNP confirmation or screening
• Partner with us to develop assays for FDA submission
• Different configurations to meet your throughput needs: 8-capillary (3500 Dx) and 24-capillary (3500xL Dx) versions

The 3500 Dx Genetic Analyzer CS2 is a trusted capillary electrophoresis-based sequencing platform for development of your new assays. Capillary electrophoresis-based applications are supported by a large number of publications over the many years that these applications have been used successfully in laboratory testing.

IVD-labeled Accessories and Consumables
The purchase of a 3500 Dx Genetic Analyzer CS2 includes a computer system and associated Data Collection software, as well as an installation kit containing the initial set of accessories and reagents needed to start using the instrument right away. The 3500 Dx Genetic Analyzer CS2 installation includes a full install qualification and operational qualification, as well as instrument training to introduce you to your new genetic analyzer.

The 3500 Dx is backed by a comprehensive Service & Support program with options to purchase additional services depending upon your laboratory maintenance and audit requirements.

Intended Use
The Applied Biosystems® 3500 Dx and 3500xL Dx Genetic Analyzers CS2 with 3500 Dx Series Software 2011 (v1) are in vitro diagnostic devices intended for the sequencing (detection and identification) of fluorescently labeled DNA by capillary electrophoresis.

The Applied Biosystems® 3500 Dx/3500xL Dx Genetic Analyzers CS2 with 3500 Dx Series Software 2011 (v1) are indicated for use with FDA-cleared or approved sequencing assays specifying their use and only by technologists trained in laboratory techniques, procedures, and use of the analyzer.

Note: The 3500 Dx Genetic Analyzer CS2 data collection software uses Windows 7 SP0 operating system. This makes the currently available RUO secondary analysis software incompatible for use on the same system. A separate computer is required to do secondary analysis if operating in RUO mode.

3500 Genetic Analyzer for Resequencing (Applied Biosystems™)

This 8-capillary Genetic Analyzer is specifically configured with software for resequencing applications.

We set a new standard in capillary electrophoresis with the 8-capillary 3500 Genetic Analyzer. These instruments are specifically designed to support the demanding performance needs of validated and process controlled environments, while retaining the unsurpassed application versatility that life science researchers expect from us.

• An 8 capillary system that can easily be upgraded to a 24-capillary system when you’re ready.
• New single-line 505 nm, solid-state long-life laser – utilizes a standard power supply; requires no heat-removal ducting.
• Powerful, integrated data collection and primary analysis software provides real-time assessment of data quality.
• Radio Frequency Identification (RFID) technology tracks key consumables data and records administrative information.
• Advanced multiplexing capabilities for DNA fragment analysis with up to six unique dyes.
• Unrivaled application flexibility – one array and one polymer are used for most applications.
• Simple setup, operation and maintenance – the easiest-to-run, easiest-to-own DNA sequencer to date.

Accurate Reliable Data Quality
The 3500 series systems significantly improves signal uniformity from instrument-to-instrument, run-to-run, and capillary-to-capillary. With a combination of intelligent hardware, powerful new algorithm and reagent combinations, these methods provide major reduction in the range of signal peak heights obtained across multiple 3500 series instruments (see figure 1).

Improved Sizing Precision
New thermal sub-system design gives enhanced performance in demanding fragment applications enabling improved sizing precision versus previous generations of capillary electrophoresis platforms (see figure 2).

Ready to Use Consumables With RFID Tags
The 3500 series introduces ready-to-use consumables with pre-packaged polymer pouches, cathode and anode buffer containers and easy-to-install capillary arrays. Each of these consumables is integrated with RFID tags that enable viewing, tracking and reporting of critical information about reagents and consumables including usage, lot number, part number, expiry date and on-instrument lifetime within the 3500 Series Data Collection Software (see figures 3 and 4).

Easy to Use New Data Collection Software
3500 Series Data Collection software breaks new ground in user-friendly navigation with an intuitive dashboard design, highly visible buttons for common operations, easy-to-read graphical displays to monitor the state of consumables and handy maintenance scheduling calendar functionality. New functionality includes simplified plate set-up, built-in primary analysis with quality control, so you can make decisions about the quality of data as it is produced on the instrument without the need to transfer output files into secondary analysis software packages (see figures 4 & 5).

For Research Use Only. Not for use in diagnostics procedures.

Ion GeneStudio™ S5 for Agrigenomics (Ion Torrent™)

The Ion GeneStudio S5 System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows. The Ion GeneStudio S5 System is optimized to provide affordability for labs focused on smaller panels and lower sequencing throughput requirements. With cartridge-based reagents, the system is simple to use and offers scalability and flexibility. It uses Ion 5 Series chips to support a broad range of high-throughput sequencing for clinical research and research applications from microbial genomes and gene panels to exomes and transcriptomes.

Key features:
• Select the chip (Ion 510–540 chip) that fits your application and throughput needs to achieve from 2–80 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments

The Ion GeneStudio S5 Series
The Ion GeneStudio S5 Series sequencers share the same foundational technology and fluidic architecture across all three instruments: this Ion GeneStudio S5 System, the Ion GeneStudio S5 Plus System, and Ion GeneStudio S5 Prime System. The primary difference across the three instruments is on-sequencer analysis time.

Speed
The Ion GeneStudio S5 Series leverages the speed of semiconductor sequencing to enable the production of high quality sequencing data in a few hours and enables you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time when paired with the Ion Chef System.

Simplicity
With single-day installation, a straightforward user interface, and cartridge-based reagents, the Ion GeneStudio S5 Series sequencers are easy to use. Combined with Ion AmpliSeq technology for target selection, the Ion Chef System for automated library and template preparation, and Ion Reporter Software for automated variant annotation, targeted sequencing is simpler than ever.

Small sample input
Low input DNA from challenging samples types such as formalin-fixed paraffin-embedded (FFPE) tissue, retrospective samples from fine needle aspirates, and cell-free DNA extracted from blood (cfDNA) can be difficult to sequence on competitor next-generation sequencers. However, with Ion AmpliSeq technology and the Ion GeneStudio S5 Series, you can use as little as 1 ng input DNA or RNA.

Scalability
Why buy multiple systems for your lab when you can run all of your targeted sequencing or microbial applications on a single next-generation sequencer? The Ion 5 Series chips that run on the Ion GeneStudio S5 Series provide several throughput options, so your lab has the flexibility to scale from small to large projects, enabling multiple targeted sequencing applications on a single system.

Simple analysis and storage solutions
Torrent Suite Software and Ion Reporter Software make NGS easy for beginners and experts alike. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Ion Reporter Software (Thermo Fisher Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

3500xL Genetic Analyzer for Protein Quality Analysis (Applied Biosystems™)

The 3500xL Genetic Analyzer for Protein Quality Analysis is a capillary electrophoresis instrument with a 24-capillary array specifically designed to support the demanding performance needs of biopharmaceutical screening and quality control environments, while retaining the unsurpassed application versatility appreciated by scientists working in analytical and process development environments. The instrument enables parallel analysis of 24 samples without compromising on the run time per sample, thereby enabling high throughput analysis with high quality data.

This system includes a 24-capillary instrument, a Dell Workstation and monitor, as well as reagent kits for system qualification. For a system that includes GlycanAssure™ Acquisition and Analysis Software, please see Cat. No. A30887.

Features include:
• A 24-capillary system for high throughput analysis
• Single-line, 505 nm, solid-state, long-life laser that utilizes a standard power supply and requires no heat-removal
• Radio frequency identification (RFID) technology that tracks key consumables data and records administrative information
• Advanced multiplexing capabilities for glycan analysis with up to six unique dyes
• Unrivaled application flexibility—one array and one polymer are used for most applications
• Simple setup, operation, and maintenance

Request more information >

Accurate, precise, and reliable data quality
The 3500 Series systems significantly improve signal uniformity from instrument-to-instrument, run-to-run, and capillary array-to-capillary array. The system provides accurate, reproducible, and precise relative quantitation of glycan levels.

Ready-to-use consumables with RFID tags
The 3500 Series systems introduce ready-to-use consumables with pre-packaged polymer pouches, cathode and anode buffer containers, and easy-to-install capillary arrays. Each of these consumables is integrated with RFID tags that enable viewing, tracking, and reporting of critical information about reagents and consumables, including usage, lot number, part number, expiry date, and on-instrument lifetime within the Glycan Assure data acquisition software.

Additional products
The following products are required for use with this system:
A31278: Anode Buffer Container (ABC) for 3500 Series for Protein Quality Analysis
A31279: Cathode Buffer Container (CBC) for 3500 Series for Protein Quality Analysis
A30936: POP-7™ for Protein Quality Analysis (384 samples)

3130 Genetic Analyzer (factory refurbished) (Applied Biosystems™)

Applied Biosystems® 3130 (4-capillary) Genetic Analyzer was refurbished by the original manufacturer to meet both manufacturing and product specifications. Availability may be limited.

Applied Biosystems® 3130 Genetic Analyzer is the latest generation of 4-capillary electrophoresis instruments for the low to medium throughput laboratories. The system offers industry-leading performance, plus sophisticated automation capabilities allowing you to save time, reduce costs and increase productivity.

Important Note: 3100 Systems will be retired at the end of 2011. Take advantage of our limited time promotions to either TRADE-IN your 3100 for a brand new 3500 or UPGRADE your 3100 to a 3130. Please contact your local Sales Representative to learn more.

With the Applied Biosystems 3130 Genetic Analyzer, you get the sophisticated automation and superior performance of the 3130 system, at acquisition and operating costs tailored to a growing research lab.
• Run a wide variety of sequencing and fragment analysis applications including microsatellite analysis, AFLP, LOH, SNP validation, and SNP screening.
• Reduce maintenance time by eliminating manual syringe washing and filling with automated polymer delivery.
• Increase your data quality for sequencing and fragment analysis applications – longer read length, and higher resolution with shorter run times.
• Increase laboratory productivity and turnaround time by processing 96- or 384-well plates with a four-capillary array.

Perform a Wide Range of Applications
The Applied Biosystems® 3130 Genetic Analyzer is more than just a DNA sequencer. You can run a wide variety of sequencing and fragment analysis applications including microsatellite analysis, AFLP, LOH, SNP validation, and SNP screening – as well as de novo sequencing and resequencing (mutational profiling). The full range of applications can be run on a single polymer and capillary array meaning you can run mixed applications on one plate. The software even includes tools to assist with regulatory and compliance requirements (In the United States, this assists with FDA 21CFR part 11).

Easy to Use
Reduce maintenance time by eliminating manual syringe washing and filling with the new automated polymer delivery system. No more handling of polymer syringes for set up and maintenance. Samples are automatically injected into the four-capillary arrays, and – unlike slab-gel systems – only minimal amounts of DNA are required for accurate analysis. Seamlessly switch between sequencing and fragment analysis runs, even in the same plate with the expanded one-polymer, one-array functionality for both sequencing and fragment analysis applications.
Superior Data Quality
Simply set up your sample and then sit back and watch as the analyzer's ultra-rapid sequencing gives you high-quality data (with Length of Read longer than 500 bp) in less than 35 minutes. Achieve accurate read lengths of 1,000 base pairs (bp) or longer in a single sequencing reaction using the 80 cm capillary array and the 3130 POP-7™ polymer.

Ideal for Growing Labs
The flexible, four-capillary 3130 system gives you all the advanced automation and superior performance of Applied Biosystems 3130xl platform, at acquisition and operating costs tailored to a growing research lab. And as your throughput needs increase, you can easily upgrade the system to 16 capillaries. It is the perfect way to get the capacity and savings you need today – without limiting your growth options. Researchers who own an ABI PRISM® 3100-Avant or 3100 Genetic Analyzer can upgrade to the new Applied Biosystems® 3130 or 3130xl Genetic Analyzer.

3130 and 3130xl instruments are CE marked and compliant with the specifications and requirements as set in the EMC directive 89⁄336⁄EEC and the Low Voltage directive 73⁄23⁄EEC.

For Research Use Only. Not for use in diagnostics procedures.

HID Ion GeneStudio™ S5 Prime System (Ion Torrent™)

The HID Ion GeneStudio S5 Prime System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows. For core and service labs requiring maximum throughput and rapid turnaround time from a benchtop NGS system, the HID Ion GeneStudio S5 Prime System enables unparalleled breadth and depth for large panels with the fastest turnaround time needs. With cartridge-based reagents, the system is simple to use and offers scalability and flexibility. It uses Ion 5 Series chips to support a broad range of forensic applications including mitochondria sequencing, STR analysis, and SNP genotyping.

Features of the HID Ion GeneStudio S5 Prime System include:
• Select the chip (Ion 510–550 chip) that fits your application and throughput needs to achieve from 2–130 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments

The Ion GeneStudio S5 Series
The HID Ion GeneStudio S5 Series sequencers share the same foundational technology and fluidic architecture across all three instruments: the HID Ion GeneStudio S5 System, the HID Ion GeneStudio S5 Plus System, and this HID Ion GeneStudio S5 Prime System. The primary difference across the three instruments is on-sequencer analysis time.

Speed
The HID Ion GeneStudio S5 Series sequencers leverage the speed of semiconductor sequencing to enable the production of high-quality sequencing data in a few hours and enable you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time when paired with the HID Ion Chef System.

Simplicity
With single-day installation, a straightforward user interface, and cartridge-based reagents, the HID Ion GeneStudio S5 Series sequencers are easy to use. Combined with Precision ID library prep technology for target selection, the HID Ion Chef System for automated library and template preparation, and Converge Software for automated analysis, forensic sequencing is simpler than ever.

Small sample input
Low input DNA amounts from challenging sample types such as touch DNA or other forensic samples can be difficult to sequence on competitor next-generation sequencers. However, with Precision ID library preparation and sequencing technology and the HID Ion GeneStudio S5 Series sequencers, you can use as little as 100 pg of DNA input and achieve accurate, robust results.

Scalability
Why buy multiple systems for your lab when you can modulate your throughput by chip selection on a single next-generation sequencer? The Ion 5 Series chips that run on the HID Ion GeneStudio S5 Series systems provide several throughput options, so your lab has the flexibility to scale from small to large projects, enabling multiple forensic applications on a single system.

Simple analysis and storage solutions
Torrent Suite Software and Converge Software make NGS easy for beginners and experts alike. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Converge Software (Thermo Fisher Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and help ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

Ion S5™ XL System (Ion Torrent™)

The Ion S5™ XL next-generation sequencing system enables a simple targeted sequencing workflow for your lab with reliable performance and industry-leading speed. The Ion S5 XL System leverages the speed of semiconductor sequencing with impressive computing power found both on-board and in the included Torrent Server, to produce high quality sequencing data in as little as 2.5 hours and enable you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time on the Ion Chef™ System and the Ion S5 XL System. The Ion S5 XL System is simple to use with cartridge-based reagents and offers superior scalability and flexibility to support a broad range of high throughput sequencing applications, from microbial genomes and gene panels to exomes and transcriptomes, using our 5 Series chips.

Speed
Some research decisions can’t wait. A few hours could make all the difference in your quest for the right answer.With other light-based sequencers you could wait almost 60 hours for results. With the Ion S5 XL System you get results in as little as 24 hours (with a 2.5-4 hour sequencer run time and overnight Ion Chef System run)—the fastest turnaround of any next-generation sequencer currently on the market.

Simplicity
With single-day installation, a straightforward user interface, and cartridge-loaded reagents, the Ion S5 XL System is easy to use. Beyond this, the system is part of a workflow that allows you to go from DNA to data with only 45 minutes of total hands-on time on the Ion Chef System and the Ion S5 XL System, significantly less than other targeted sequencing solutions that require as much as 2.5 hours of hands-on time. Combined with Ion AmpliSeq™ technology for target selection, the Ion Chef™ System for automated library and template preparation, and Ion Reporter™ Software for automated variant annotation, targeted sequencing becomes simpler than ever.

Small sample input
Low input DNA for challenging samples types, such as formalin-fixed paraffin-embedded (FFPE) tissue, retrospective samples from fine needle aspirates, and cell-free DNA extracted from blood (cfDNA) can be difficult to sequence on competitor next-generation sequencers. However, with Ion AmpliSeq technology and the Ion S5 XL Sequencer, you can use as little as 10 ng input DNA or RNA.

Scalability
Why buy multiple systems for your lab when you can run all your targeted sequencing or microbial research applications on a single next-generation sequencer? The Ion S5 XL System has a modular build, so your lab has the flexibility to do multiple targeted sequencing applications on a single system.

Simple analysis and storage solutions
Whether you are new to next-generation sequencing or an expert user, Torrent Suite™ Software and Ion Reporter™ Software make it easy for you to get started with next-generation sequencing. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Ion Reporter Software (Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

Ion GeneStudio™ S5 Prime System for Agrigenomics (Ion Torrent™)

The Ion GeneStudio S5 Prime System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows. For core and service labs requiring maximum throughput and rapid turnaround time from a benchtop NGS system, the Ion GeneStudio S5 Prime System enables unparalleled breadth and depth, from large panels or exomes to clinical oncology research focused on low allele frequency applications. With cartridge-based reagents, the system is simple to use and offers scalability and flexibility. It uses Ion 5 Series chips to support a broad range of high-throughput sequencing for clinical research and research applications from microbial genomes and gene panels to exomes and transcriptomes.

Key features:
• Select the chip (Ion 510–550 chip) that fits your application and throughput needs to achieve from 2–130 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments

The Ion GeneStudio S5 Series
The Ion GeneStudio S5 Series sequencers share the same foundational technology and fluidic architecture across all three instruments: the Ion GeneStudio S5 System, the Ion GeneStudio S5 Plus System, and this Ion GeneStudio S5 Prime System. The primary difference across the three instruments is on-sequencer analysis time.

Speed
The Ion GeneStudio S5 Series leverages the speed of semiconductor sequencing to enable the production of high quality sequencing data in a few hours and enables you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time when paired with the Ion Chef System.

Simplicity
With single-day installation, a straightforward user interface, and cartridge-based reagents, the Ion GeneStudio S5 Series sequencers are easy to use. Combined with Ion AmpliSeq technology for target selection, the Ion Chef System for automated library and template preparation, and Ion Reporter Software for automated variant annotation, targeted sequencing is simpler than ever.

Small sample input
Low input DNA from challenging samples types such as formalin-fixed paraffin-embedded (FFPE) tissue, retrospective samples from fine needle aspirates, and cell-free DNA extracted from blood (cfDNA) can be difficult to sequence on competitor next-generation sequencers. However, with Ion AmpliSeq technology and the Ion GeneStudio S5 Series, you can use as little as 1 ng input DNA or RNA.

Scalability
Why buy multiple systems for your lab when you can run all of your targeted sequencing or microbial applications on a single next-generation sequencer? The Ion 5 Series chips that run on the Ion GeneStudio S5 Series provide several throughput options, so your lab has the flexibility to scale from small to large projects, enabling multiple targeted sequencing applications on a single system.

Simple analysis and storage solutions
Torrent Suite Software and Ion Reporter Software make NGS easy for beginners and experts alike. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Ion Reporter Software (Thermo Fisher Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

Ion Proton™ System (Ion Torrent™)

The Ion Proton™ System is the first benchtop sequencing system capable of human-scale genome, exome, or transcriptome sequencing in a few hours—with DNA-to-variants called in a single day.

The system combines semiconductor sequencing technology with natural biochemistry to directly translate chemical information into digital data. By leveraging the exponential improvements in the semiconductor industry (known as Moore’s Law), the Ion Proton™ Sequencing System provides an unprecedented level of scalability and flexibility to support a broad range of high throughput sequencing applications, ranging from human-scale genome to exome to transcriptome sequencing. The system’s use of the simplest natural sequencing chemistry eliminates the need for expensive optics and complex sequencing chemistries, resulting in a highly affordable sequencing system to own and operate. Real-time, direct, electrical detection of sequencing, combined with the enormous amount of computing power in both the Ion Proton™ Sequencer and Ion Proton™ Torrent Server, enables generation of high quality sequencing results from DNA library to variants in a single day.

Features of the Ion Proton™ System:

Fastest high-throughput next-generation sequencing workflow with the fastest sequencing run-times of 2–4 hours on the Ion PI™ Chip
Highest number of complete sequencing runs per week, with a simple and automated workflow (when used with the Ion OneTouch™ 2 System)
Simple semiconductor sequencing workflows with robust and simple hardware that can be relied upon—no cameras, no optics, and no lasers
Scalable, high throughput sequencing capabilities enabling up to 200-base single reads and flexible library options (e.g., fragment gDNA, targeted/exome, RNA)
Small benchtop footprint and mounting capability (with optional rack) (two Ion Proton™ systems per rack), to deliver the only benchtop genome center
Low-cost platform and attractively priced semiconductor chips and reagents for a range of applications
Proven Ion semiconductor sequencing requires no complex optics and employs natural nucleotides to deliver highly accurate variant detection, uniformity of coverage, and sensitivity to detect low frequency variants
Range of fast and simple library solutions and kits with low-input requirements for a variety of applications, such as genomic sequencing, exome sequencing, sequencing sets of genes, and RNA sequencing
Complete end-to-end solution from base calls to variants with the Proton™ Torrent Server and Torrent Suite Software v3.0
Simple and integrated tools for tertiary data analysis with Ion Reporter™ Software for DNA variation analysis across single, paired, or trio samples

With the availability of the groundbreaking Ion Proton™ System, rapid, high throughput sequencing is finally accessible by all laboratories.

Affordable Sequencing For Nearly Every Lab
Previous sequencing technologies have relied upon optical systems as bridges between the chemical and digital forms of sequence information. These systems have added tremendous costs to sequencers, relegating them to only the largest laboratories. By eliminating the need for the optical system, the Ion Proton™ System provides high throughput sequencing that is simpler, faster, more cost effective, and more scalable than any other technology available. With a benchtop footprint, low-cost sequencing reagents, and a simple touchscreen user interface, the Ion Proton™ System brings high throughput, next generation sequencing to nearly every lab.

Ion Power: PostLight™ Sequencing Produces Bits From Bases
The sequencing technology underlying the Ion Proton™ System exploits a well-characterized biochemical process: When a nucleotide is incorporated into a strand of DNA by a polymerase, a hydrogen ion (H+) is released as a byproduct. This hydrogen ion carries a charge that the Proton™ System’s ion sensor—essentially the world's smallest solid-state pH meter—can detect. As the sequencer floods the chip with one nucleotide after another, any nucleotide added to a DNA template will be detected as a voltage change, and the Ion Proton™ System will call the base. If a nucleotide is not a match for a particular template, no voltage change will be detected and no base will be called for that template.

Massively Parallel Sequencing On Your Bench
A principal component of the Ion Proton™ System is the sequencing chip. The Ion PI™ Chip incorporates an extremely dense array of >165 million micro-machined wells married to our proprietary ion sensor. Each well contains a different DNA template, allowing massively parallel sequencing. With the Ion PI™ Chip (165 million wells), the Ion Proton™ System enables a range of high throughput genomic applications from human-scale exome sequencing to whole transcriptome sequencing.

The Right Tool To Get Results Easily, Reliably, and Quickly
Because it detects nucleotide incorporation without the use of light, the Ion Proton™ System uses the simplest sequencing chemistry possible: natural nucleotides. There is no need for expensive and error-prone modified bases, enzymatic cascades, chemiluminescence, or fluorescence. Direct detection also means the incorporation of each nucleotide is recorded in seconds. As a result, you can do an entire sequencing run typically in a few hours.

Services and Support
Service and support plans—comprehensive plans to maximize instrument performance and ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data