Shop All Sequencing & Genetic Analyzer Instruments

HID Ion GeneStudio™ S5 Plus System (Ion Torrent™)

The HID Ion GeneStudio S5 Plus System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows for forensic analysis. From targeted SNP panels to Precision ID STR workflows and mitochonidrial DNA sequencing, the HID Ion GeneStudio S5 Plus System is designed to enable flexibility to help labs manage small and large projects across multiple applications. With cartridge-based reagents, the system is simple to use and offers scalability and flexibility. It uses Ion 5 Series chips to support a broad range of high-throughput sequencing for forensic applications.

Features of the HID Ion GeneStudio S5 Plus System include:
• Select the chip (Ion 510–550 chip) that fits your application and throughput needs to achieve from 2–130 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments

The Ion GeneStudio S5 Series
The HID Ion GeneStudio S5 Series sequencers share the same foundational technology and fluidic architecture across all three instruments: the HID Ion GeneStudio S5 System, this HID Ion GeneStudio S5 Plus System, and the HID Ion GeneStudio S5 Prime System. The primary difference across the three instruments is on-sequencer analysis time.

Speed
The HID Ion GeneStudio S5 Series sequencers leverage the speed of semiconductor sequencing to enable the production of high-quality sequencing data in a few hours and enable you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time when paired with the HID Ion Chef System.

Simplicity
With single-day installation, a straightforward user interface, and cartridge-based reagents, the HID Ion GeneStudio S5 Series sequencers are easy to use. Combined with Precision ID library prep technology for target selection, the HID Ion Chef System for automated library and template preparation, and Converge Software for automated analysis, forensic sequencing is simpler than ever.

Small sample input
Low input DNA amounts from challenging sample types such as touch DNA or other forensic samples can be difficult to sequence on competitor next-generation sequencers. However, with Precision ID library preparation and sequencing technology and the HID Ion GeneStudio S5 Series sequencers, you can use as little as 100 pg of DNA input and achieve accurate, robust results.

Scalability
Why buy multiple systems for your lab when you can modulate your throughput by chip selection on a single next-generation sequencer? The Ion 5 Series chips that run on the HID Ion GeneStudio S5 Series systems provide several throughput options, so your lab has the flexibility to scale from small to large projects, enabling multiple forensic applications on a single system.

Simple analysis and storage solutions
Torrent Suite Software and Converge Software make NGS easy for beginners and experts alike. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Converge Software (Thermo Fisher Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and help ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

HID Ion GeneStudio™ S5 Prime System (Ion Torrent™)

The HID Ion GeneStudio S5 Prime System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows. For core and service labs requiring maximum throughput and rapid turnaround time from a benchtop NGS system, the HID Ion GeneStudio S5 Prime System enables unparalleled breadth and depth for large panels with the fastest turnaround time needs. With cartridge-based reagents, the system is simple to use and offers scalability and flexibility. It uses Ion 5 Series chips to support a broad range of forensic applications including mitochondria sequencing, STR analysis, and SNP genotyping.

Features of the HID Ion GeneStudio S5 Prime System include:
• Select the chip (Ion 510–550 chip) that fits your application and throughput needs to achieve from 2–130 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments

The Ion GeneStudio S5 Series
The HID Ion GeneStudio S5 Series sequencers share the same foundational technology and fluidic architecture across all three instruments: the HID Ion GeneStudio S5 System, the HID Ion GeneStudio S5 Plus System, and this HID Ion GeneStudio S5 Prime System. The primary difference across the three instruments is on-sequencer analysis time.

Speed
The HID Ion GeneStudio S5 Series sequencers leverage the speed of semiconductor sequencing to enable the production of high-quality sequencing data in a few hours and enable you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time when paired with the HID Ion Chef System.

Simplicity
With single-day installation, a straightforward user interface, and cartridge-based reagents, the HID Ion GeneStudio S5 Series sequencers are easy to use. Combined with Precision ID library prep technology for target selection, the HID Ion Chef System for automated library and template preparation, and Converge Software for automated analysis, forensic sequencing is simpler than ever.

Small sample input
Low input DNA amounts from challenging sample types such as touch DNA or other forensic samples can be difficult to sequence on competitor next-generation sequencers. However, with Precision ID library preparation and sequencing technology and the HID Ion GeneStudio S5 Series sequencers, you can use as little as 100 pg of DNA input and achieve accurate, robust results.

Scalability
Why buy multiple systems for your lab when you can modulate your throughput by chip selection on a single next-generation sequencer? The Ion 5 Series chips that run on the HID Ion GeneStudio S5 Series systems provide several throughput options, so your lab has the flexibility to scale from small to large projects, enabling multiple forensic applications on a single system.

Simple analysis and storage solutions
Torrent Suite Software and Converge Software make NGS easy for beginners and experts alike. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Converge Software (Thermo Fisher Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and help ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

3730xl DNA Analyzer (Applied Biosystems™)


See the latest version of the 3730xl DNA Analyzer ›

The 96-capillary 3730xl DNA Analyzer is the Gold Standard for high throughput genetic analysis. Use this for DNA fragment analysis applications such as microsatellites, AFLP, SNP analysis, mutation detection and traditional DNA sequencing. Get the highest quality data at a low cost per sample.
• Higher optical sensitivity and advanced polymers enable you to obtain higher-quality sequencing data for less.
• Multiple automation features decrease costly human errors.
• Optimized polymers increase your productivity without compromising your results.
• Perform a wide variety of sequencing and fragment analysis applications including resequencing, microsatellite analysis, AFLP, LOH, SSCP, SNP screening and SNP validation.

Large-Scale DNA Analysis on a Small-Scale Budget
By combining advances in automation with innovative optics and proprietary reagents to increase throughput, yield high-quality data, and minimize reagent consumption, the 3730xl Analyzer provides your laboratory and production facility with faster, better, cheaper analysis.

Streamline Your Workflow
The 3730xl DNA Analyzer system is engineered for highly reliable, unattended operation of up to 48 hours (applies to modules with run times longer than 30 minutes). To minimize the need for operator intervention and decrease the risk of human error, automation features include an integrated plate stacker, internal bar code reader, and onboard polymer delivery system.

Increase Productivity
The high signal-to-noise ratio ensures you get high-quality data – even when you use low-concentration samples and reagents. Labor-saving automation features minimize hands-on time and enable you to analyze more data more efficiently.

Get the Highest-Quality Sequencing and Genotyping Data
The enhanced optical design provides a higher signal-to-noise ratio and a more uniform signal profile across the array. This design, combined with our new, advanced polymer, enables the longest read lengths of any available system, and provides enhanced color balance for streamlined genotyping sample handling. In addition, exceptional sensitivity enables higher success rates across a wide range of sample template types and concentrations.

One Instrument, Multiple Applications
With the 3730xl DNA Analyzer, you get the highest-quality data from a wide array of applications. In addition to being ideal for high-throughput sequencing, the analyzer's optimized application assays, instrument, and analysis software also provide a complete solution for genotyping and resequencing.

Integrated Data Analysis Tools Reduce Time-to-Results
The 3730xl DNA Analyzer software suite allows you to generate more meaningful data with less work. This system's labor-saving software suite includes:
• Data Collection (supplied with the instrument) – Manages your instrument setup, controls instrument operations, allows real-time data visualization, and performs diagnostics.
• Sequencing Analysis Software – Designed to base-call; assign quality values; trim, display, edit and print DNA sequencing data using the KB basecaller
• Seqscape® – Provides everything you need to perform resequencing applications such as VariantSEQr™ Resequencing System
• GeneMapper® – Enables configurable, automated allele calling; a plus for high-throughput genotyping and includes tools for SNPlex™ data analysis

New features include:
• Auto-analysis with GeneMapper® and SeqScape®
• Flexibility to use any choice in dye set option
• Tools to assist with regulatory and compliance requirements (In the United States, this assists with FDA 21CFR part 11).
• Additional optimized run modules covering more applications
• Support for fragment analysis applications on the 96-capillary array

The instrument comes with a one year limited warranty on parts and labor.

For Research Use Only. Not for use in diagnostics procedures.

3500xL Dx Genetic Analyzer CS2 (Applied Biosystems™)

The 3500 Dx Genetic Analyzer CS2 is the latest addition to our family of Applied Biosystems® genetic analyzers based on capillary electrophoresis. The 3500 Dx Genetic Analyzer CS2 is an IVD-labeled instrument, making it the first Sanger sequencing platform cleared for sequencing analysis of DNA.

Confidence in Your Results
• The 3500 Dx Genetic Analyzer CS2 is an IVD-labeled platform for Sequencing-Based Typing using SeCore® HLA typing kits. Sanger sequencing is known as the "gold-standard" for its accuracy, reliability, and ease of use. It is also used for confirmatory sequencing by clinical labs.
• High accuracy: 99% concordance as shown in clinical trials using SeCore® HLA typing kits
• Proven through decades of results—including sequencing of the first human genome—Applied Biosystems® genetic analysis systems are trusted standards for Sanger sequencing.

You can now feel even more comfortable adopting the 3500 Dx Genetic Analyzer CS2 platform for the development of assays for FDA submission.

Simplicity and Efficiency
• Reduced instrument hands-on time with simplified installation and removal of consumables and accessories
• Controlled and efficient run setup with intuitive user interface, preconfigured plate templates, and software-controlled functions (plate setup, data collection, analysis)
• Instrument run-times as short as 1 hour; sample-to-result in as little as 1.5 days
• Maintenance calendar with programmable prompts and service history
• Security and electronic signature, RFID (radio frequency identification) tracking of consumables, built-in quality controls, and real-time data quality evaluation

The 3500 Dx Genetic Analyzer CS2 is a partner in your laboratory, making it easy for you to comply with various industry standards and simplifying the training of new users.

Flexibility
• Collect data in either IVD (diagnostic for HLA typing) or RUO mode
• Develop other applications in RUO mode, including de novo sequencing and re-sequencing, as well as fragment analysis applications such as microsatellite analysis, MLPA®, LOH, MLST, and SNP confirmation or screening
• Partner with us to develop assays for FDA submission
• Different configurations to meet your throughput needs: 24-capillary (3500xL Dx) and 8-capillary (3500 Dx) versions

The 3500 Dx Genetic Analyzer CS2 is a trusted capillary electrophoresis-based sequencing platform for development of your new assays. Capillary electrophoresis-based applications are supported by a large number of publications over the many years that these applications have been used successfully in laboratory testing.

IVD-labeled Accessories and Consumables
The purchase of a 3500 Dx Genetic Analyzer CS2 includes a computer system and associated Data Collection software, as well as an installation kit containing the initial set of accessories and reagents needed to start using the instrument right away. The 3500 Dx Genetic Analyzer CS2 installation includes a full install qualification and operational qualification, as well as instrument training to introduce you to your new genetic analyzer.

The 3500 Dx is backed by a comprehensive Service & Support program with options to purchase additional services depending upon your laboratory maintenance and audit requirements.

Intended Use
The Applied Biosystems® 3500 Dx and 3500xL Dx Genetic Analyzers CS2 with 3500 Dx Series Software 2011 (v1) are in vitro diagnostic devices intended for the sequencing (detection and identification) of fluorescently labeled DNA by capillary electrophoresis.

The Applied Biosystems® 3500 Dx/3500xL Dx Genetic Analyzers CS2 with 3500 Dx Series Software 2011 (v1) are indicated for use with FDA-cleared or approved sequencing assays specifying their use and only by technologists trained in laboratory techniques, procedures, and use of the analyzer.

Note: The 3500 Dx Genetic Analyzer CS2 data collection software uses Windows 7 SP0 operating system. This makes the currently available RUO secondary analysis software incompatible for use on the same system. A separate computer is required to do secondary analysis if operating in RUO mode.

3730xl DNA Analyzer (factory refurbished) (Applied Biosystems™)

The 96-capillary 3730xl DNA Analyzer is the Gold Standard for high throughput genetic analysis. Use this for DNA fragment analysis applications such as microsatellites, AFLP, SNP analysis, mutation detection and traditional DNA sequencing. Get the highest quality data at a low cost per sample. This instrument is refurbished by the original manufacturer to meet both manufacturing and product specifications. This system includes the refurbished instrument, new Windows computer, Data Collection software, choice of one analysis software package, installation by an Applied Biosystems “5-Step Certified" Field Service Engineer, chemistry kit, training, new parts and a one year warranty. Availability may be limited.

• Higher optical sensitivity and advanced polymers enable you to obtain higher-quality sequencing data for less.
• Multiple automation features decrease costly human errors.
• Optimized polymers increase your productivity without compromising your results.
• Perform a wide variety of sequencing and fragment analysis applications including resequencing, microsatellite analysis, AFLP, LOH, SSCP, SNP screening and SNP validation.

Large-Scale DNA Analysis on a Small-Scale Budget
By combining advances in automation with innovative optics and proprietary reagents to increase throughput, yield high-quality data, and minimize reagent consumption, the 3730xl Analyzer provides your laboratory and production facility with faster, better, cheaper analysis.

Streamline Your Workflow
The 3730xl DNA Analyzer system is engineered for highly reliable, unattended operation of up to 48 hours (applies to modules with run times longer than 30 minutes). To minimize the need for operator intervention and decrease the risk of human error, automation features include an integrated plate stacker, internal bar code reader, and onboard polymer delivery system.

Increase Productivity
The high signal-to-noise ratio ensures you get high-quality data – even when you use low-concentration samples and reagents. Labor-saving automation features minimize hands-on time and enable you to analyze more data more efficiently.

Get the Highest-Quality Sequencing and Genotyping Data
The enhanced optical design provides a higher signal-to-noise ratio and a more uniform signal profile across the array. This design, combined with our new, advanced polymer, enables the longest read lengths of any available system, and provides enhanced color balance for streamlined genotyping sample handling. In addition, exceptional sensitivity enables higher success rates across a wide range of sample template types and concentrations.

One Instrument, Multiple Applications
With the 3730xl DNA Analyzer, you get the highest-quality data from a wide array of applications. In addition to being ideal for high-throughput sequencing, the analyzer's optimized application assays, instrument, and analysis software also provide a complete solution for genotyping and resequencing.

Integrated Data Analysis Tools Reduce Time-to-Results
The 3730xl DNA Analyzer software suite allows you to generate more meaningful data with less work. This system's labor-saving software suite includes:
• Data Collection (supplied with the instrument): Manages your instrument setup, controls instrument operations, allows real-time data visualization, and performs diagnostics.
• Sequencing Analysis Software: Designed to base-call; assign quality values; trim, display, edit and print DNA sequencing data using the KB basecaller.
• Seqscape®: Provides everything you need to perform resequencing applications such as VariantSEQr™ Resequencing System.
• GeneMapper®: Enables configurable, automated allele calling – a plus for high-throughput genotyping and includes tools for SNPlex™ data analysis

New features include:
• Auto-analysis with GeneMapper® and SeqScape®
• Flexibility to use any choice in dye set option
• Tools to assist with regulatory and compliance requirements (In the United States, this assists with FDA 21CFR part 11).
• Additional optimized run modules covering more applications
• Support for fragment analysis applications on the 96-capillary array

The instrument comes with a one year limited warranty on parts and labor.

For Research Use Only. Not for use in diagnostics procedures.

3500 Genetic Analyzer for Resequencing (Applied Biosystems™)

This 8-capillary Genetic Analyzer is specifically configured with software for resequencing applications.

We set a new standard in capillary electrophoresis with the 8-capillary 3500 Genetic Analyzer. These instruments are specifically designed to support the demanding performance needs of validated and process controlled environments, while retaining the unsurpassed application versatility that life science researchers expect from us.

• An 8 capillary system that can easily be upgraded to a 24-capillary system when you’re ready.
• New single-line 505 nm, solid-state long-life laser – utilizes a standard power supply; requires no heat-removal ducting.
• Powerful, integrated data collection and primary analysis software provides real-time assessment of data quality.
• Radio Frequency Identification (RFID) technology tracks key consumables data and records administrative information.
• Advanced multiplexing capabilities for DNA fragment analysis with up to six unique dyes.
• Unrivaled application flexibility – one array and one polymer are used for most applications.
• Simple setup, operation and maintenance – the easiest-to-run, easiest-to-own DNA sequencer to date.

Accurate Reliable Data Quality
The 3500 series systems significantly improves signal uniformity from instrument-to-instrument, run-to-run, and capillary-to-capillary. With a combination of intelligent hardware, powerful new algorithm and reagent combinations, these methods provide major reduction in the range of signal peak heights obtained across multiple 3500 series instruments (see figure 1).

Improved Sizing Precision
New thermal sub-system design gives enhanced performance in demanding fragment applications enabling improved sizing precision versus previous generations of capillary electrophoresis platforms (see figure 2).

Ready to Use Consumables With RFID Tags
The 3500 series introduces ready-to-use consumables with pre-packaged polymer pouches, cathode and anode buffer containers and easy-to-install capillary arrays. Each of these consumables is integrated with RFID tags that enable viewing, tracking and reporting of critical information about reagents and consumables including usage, lot number, part number, expiry date and on-instrument lifetime within the 3500 Series Data Collection Software (see figures 3 and 4).

Easy to Use New Data Collection Software
3500 Series Data Collection software breaks new ground in user-friendly navigation with an intuitive dashboard design, highly visible buttons for common operations, easy-to-read graphical displays to monitor the state of consumables and handy maintenance scheduling calendar functionality. New functionality includes simplified plate set-up, built-in primary analysis with quality control, so you can make decisions about the quality of data as it is produced on the instrument without the need to transfer output files into secondary analysis software packages (see figures 4 & 5).

For Research Use Only. Not for use in diagnostics procedures.

5500 Genetic Analyzer (Applied Biosystems™)

Built on three decades of sequencing expertise and powered by the proven accuracy of ligation-based sequencing, the new 5500 Genetic Analyzer provides a robust, affordable next-generation sequencing platform for every lab. Designed to give you the choice to optimize for turnaround time or throughput, the 5500 Genetic Analyzer is a highly accurate, cost-effective solution for analyzing one or many samples.

Key Benefits
• Sequencing right here, right now
• Cost-effective sequencing runs with individually configurable lanes
• Superior low frequency variant detection for whole exome sequencing or targeted resequencing
• Reproducibility, reliability, and quality for your RNA applications
• Confidence and uniformity in multiplexing with up to 96 barcodes
• Optimal analysis solutions for streamlined productivity and freedom to operate

Explore the Depths of Translational Research
With Exact Call Chemistry, the industry-leading accuracy of the 5500 Genetic Analyzer helps you get definitive answers about biological variation for applications like whole exome, RNA-seq, and structural variation.

Customize the System for Your Projects
The 5500 Genetic Analyzer allows you to tailor your sequencing runs precisely for your research. The six independent FlowChip lanes and Pay-Per-Lane Sequencing (PPL-Seq™) allow you to configure the instrument to different project scales and application types. Additionally, the system’s intelligent barcode kits can accommodate from one to hundreds of samples in a single run.

Don’t Wait
With the 5500 Genetic Analyzer, the unique capability to run each FlowChip lane independently allows you to turn around results in the shortest time possible. Now you can explore the genome, transcriptome, and epigenome with a hypothesis-neutral platform that combines powerful sequence data generation with premium accuracy. Whether you're running whole exome, RNA-seq, or a structural variation experiment, the 5500 Genetic Analyzer is designed to deliver high-quality results in a time-sensitive and cost-effective manner.

Perform Sequencing with Ease
Designed in collaboration with core facilities and principal investigators, the integrated 5500 Genetic Analyzer provides an intuitive and user-friendly workflow from sample preparation to data analysis.

Workflow Benefits Include:
• Embedded sequencing controls to enable real-time monitoring of data quality throughout the entire workflow
• System alerts to help maximize data quality and system performance, and to track reagent usage during the course of the sequencing run
• Easy-to-use software, 60% smaller data footprints, workstation computing, and standard base sequence file formats to facilitate setup, daily operations, and seamless integration with data analysis tools

Join the Era of Genomic Medicine
The throughput, broad range of applications, system flexibility, and intuitive design of the 5500 Genetic Analyzer address the needs of core and services laboratories, and basic and clinical research labs, to take sequencing into every scientific discipline.

A Community of Support
With more than 2,000 field personnel, we have the most extensive network of dedicated Field Application Specialists and Service Engineers in the industry. You can feel confident that we will be there when and where you need us most.

The 5500 Genetic Analyzer is For Research Use Only. Not intended for any animal or human therapeutic or diagnostic use.

3500 Dx Genetic Analyzer CS2 (Applied Biosystems™)

The 3500 Dx Genetic Analyzer CS2 is the latest addition to our family of Applied Biosystems® genetic analyzers based on capillary electrophoresis. The 3500 Dx Genetic Analyzer CS2 is an IVD-labeled instrument, making it the first Sanger sequencing platform cleared for sequencing analysis of DNA.

Confidence in Your Results
• The 3500 Dx Genetic Analyzer CS2 is an IVD-labeled platform for Sequencing-Based Typing using SeCore® HLA typing kits. Sanger sequencing is known as the "gold-standard" for its accuracy, reliability, and ease of use. It is also used for confirmatory sequencing by clinical labs.
• High accuracy: 99% concordance as shown in clinical trials using SeCore® HLA typing kits
• Proven through decades of results—including sequencing of the first human genome—Applied Biosystems® genetic analysis systems are trusted standards for Sanger sequencing.

You can now feel even more comfortable adopting the 3500 Dx Genetic Analyzer CS2 platform for the development of assays for FDA submission.

Simplicity and Efficiency
• Reduced instrument hands-on time with simplified installation and removal of consumables and accessories
• Controlled and efficient run setup with intuitive user interface, preconfigured plate templates, and software-controlled functions (plate setup, data collection, analysis)
• Instrument run-times as short as 1 hour; sample-to-result in as little as 1.5 days
• Maintenance calendar with programmable prompts and service history
• Security and electronic signature, RFID (radio frequency identification) tracking of consumables, built-in quality controls, and real-time data quality evaluation

The 3500 Dx Genetic Analyzer CS2 is a partner in your laboratory, making it easy for you to comply with various industry standards and simplifying the training of new users.

Flexibility
• Collect data in either IVD (diagnostic for HLA typing) or RUO mode
• Develop other applications in RUO mode, including de novo sequencing and re-sequencing, as well as fragment analysis applications such as microsatellite analysis, MLPA®, LOH, MLST, and SNP confirmation or screening
• Partner with us to develop assays for FDA submission
• Different configurations to meet your throughput needs: 8-capillary (3500 Dx) and 24-capillary (3500xL Dx) versions

The 3500 Dx Genetic Analyzer CS2 is a trusted capillary electrophoresis-based sequencing platform for development of your new assays. Capillary electrophoresis-based applications are supported by a large number of publications over the many years that these applications have been used successfully in laboratory testing.

IVD-labeled Accessories and Consumables
The purchase of a 3500 Dx Genetic Analyzer CS2 includes a computer system and associated Data Collection software, as well as an installation kit containing the initial set of accessories and reagents needed to start using the instrument right away. The 3500 Dx Genetic Analyzer CS2 installation includes a full install qualification and operational qualification, as well as instrument training to introduce you to your new genetic analyzer.

The 3500 Dx is backed by a comprehensive Service & Support program with options to purchase additional services depending upon your laboratory maintenance and audit requirements.

Intended Use
The Applied Biosystems® 3500 Dx and 3500xL Dx Genetic Analyzers CS2 with 3500 Dx Series Software 2011 (v1) are in vitro diagnostic devices intended for the sequencing (detection and identification) of fluorescently labeled DNA by capillary electrophoresis.

The Applied Biosystems® 3500 Dx/3500xL Dx Genetic Analyzers CS2 with 3500 Dx Series Software 2011 (v1) are indicated for use with FDA-cleared or approved sequencing assays specifying their use and only by technologists trained in laboratory techniques, procedures, and use of the analyzer.

Note: The 3500 Dx Genetic Analyzer CS2 data collection software uses Windows 7 SP0 operating system. This makes the currently available RUO secondary analysis software incompatible for use on the same system. A separate computer is required to do secondary analysis if operating in RUO mode.

Ion GeneStudio™ S5 Plus System (Ion Torrent™)

The Ion GeneStudio S5 Plus System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows. From genes to exomes, the Ion GeneStudio S5 Plus System is designed to enable flexibility to help labs manage small and large projects across multiple applications. With cartridge-based reagents, the system is simple to use and offers scalability and flexibility. It uses Ion 5 Series chips to support a broad range of high-throughput sequencing for clinical research and research applications from microbial genomes and gene panels to exomes and transcriptomes.

Key features:
• Select the chip (Ion 510–550 chip) that fits your application and throughput needs to achieve from 2–130 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments

The Ion GeneStudio S5 Series
The Ion GeneStudio S5 Series sequencers share the same foundational technology and fluidic architecture across all three instruments: the Ion GeneStudio S5 System, this Ion GeneStudio S5 Plus System, and Ion GeneStudio S5 Prime System. The primary difference across the three instruments is on-sequencer analysis time.

Speed
The Ion GeneStudio S5 Series leverages the speed of semiconductor sequencing to enable the production of high quality sequencing data in a few hours and enables you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time when paired with the Ion Chef System.

Simplicity
With single-day installation, a straightforward user interface, and cartridge-based reagents, the Ion GeneStudio S5 Series sequencers are easy to use. Combined with Ion AmpliSeq technology for target selection, the Ion Chef System for automated library and template preparation, and Ion Reporter Software for automated variant annotation, targeted sequencing is simpler than ever.

Small sample input
Low input DNA from challenging samples types such as formalin-fixed paraffin-embedded (FFPE) tissue, retrospective samples from fine needle aspirates, and cell-free DNA extracted from blood (cfDNA) can be difficult to sequence on competitor next-generation sequencers. However, with Ion AmpliSeq technology and the Ion GeneStudio S5 Series, you can use as little as 1 ng input DNA or RNA.

Scalability
Why buy multiple systems for your lab when you can run all of your targeted sequencing or microbial applications on a single next-generation sequencer? The Ion 5 Series chips that run on the Ion GeneStudio S5 Series provide several throughput options, so your lab has the flexibility to scale from small to large projects, enabling multiple targeted sequencing applications on a single system.

Simple analysis and storage solutions
Torrent Suite Software and Ion Reporter Software make NGS easy for beginners and experts alike. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Ion Reporter Software (Thermo Fisher Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

3500xL Genetic Analyzer for Resequencing (Applied Biosystems™)

This 24-capillary Genetic Analyzer is specifically configured with software for resequencing applications.

The 3500xL 24-capillary platform can run a wide variety of applications, including de novo sequencing and resequencing (mutational profiling), as well as microsatellite analysis, MLPA™, LOH, MLST, AFLP® and SNP validation or screening. The majority of applications can be run on a single polymer and capillary array.

This package includes a 24 capillary instrument, the 3500 Data Collection Software, a Dell Workstation and monitor as well as reagent kits for system qualification. The product package also includes software for resequencing. The 3500 Series Data Collection Software integrates seamlessly with several downstream software packages to provide comprehensive analysis of genetic data.

Important Note: Do you still have a 3100? 3100 Systems will be retired at the end of 2011. Take advantage of our limited time promotions to TRADE-IN your 3100 to get a brand new 3500. Please contact your local Sales Representative to learn more.

For Research Use Only. Not for use in diagnostics procedures.

Ion GeneStudio™ S5 Prime System Extended Warranty Package (Ion Torrent™)

The Ion GeneStudio S5 Prime System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows. For core and service labs requiring maximum throughput and rapid turnaround time from a benchtop NGS system, the Ion GeneStudio S5 Prime System enables unparalleled breadth and depth, from large panels or exomes to clinical oncology research focused on low allele frequency applications. Combining an extended warranty with your system purchase helps extend the life of your investment.

This package includes the Ion GeneStudio S5 Prime System, SmartStart orientation, and an extended warranty. Key features include:
• Select the chip (Ion 510–550 chip) that fits your application and throughput needs to achieve from 2–130 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments
• Increase efficiency and become operational faster with SmartStart orientation
• Receive fast repair from certified service engineers
• Minimize instrument downtime by troubleshooting with experienced Technical Support teams

For detailed instrument information and specifications, see the Ion GeneStudio S5 Prime System.

Get up and running quickly with SmartStart
SmartStart orientation is carried out by a Field Application Scientist (FAS) to get you up and running quickly in your lab and reduce downtime. SmartStart is the first step of your education journey and is designed to help you work smarter and with greater efficiency. It includes:
• 1-day technology overview and instrument workflow
• 1-day hands-on application workflow training
• 10 hours bioinformatics consultancy

Content will vary depending on your level of knowledge and experience.

Extended warranty plan
Add coverage to your existing manufacturer’s limited warranty with an extended warranty. Each extended warranty includes a planned maintenance visit. Should your instrument require a repair, the extended warranty coverage includes parts, labor, and travel at no additional cost. In addition, you’ll receive:
• On-site guaranteed 2-day response time*
• Scheduled on-site planned maintenance (PM)
• Priority access to Remote Service Engineers

Certain exclusions apply. Contact your Services and Support Representative for details at service.sales@thermofisher.com.

*Availability limited in some geographical areas.

Applied Biosystems™ RapidHIT™ ID System Upgrade (Applied Biosystems™)

The Applied Biosystems RapidHIT ID System Upgrade gives IntegenX RapidHIT ID System owners the ability to upgrade their system to the latest Applied Biosystems-branded version. The upgrade provides improved system reliability and performance, and enables the system to be sample/data accessioning workflow-capable.

Before upgrading, please consume your remaining IntegenX RapidHIT ID consumables as several legacy consumables, such as the primary cartridges, are not compatible with the Applied Biosystems-branded RapidHIT ID System.

For more details or questions, please contact your local sales representative or local distributor.

3500 Genetic Analyzer for Sequence Typing & Fragment Analysis (Applied Biosystems™)

This 8-capillary Genetic Analyzer is specifically configured with software for both fragment analysis and sequence typing applications.

We set a new standard in capillary electrophoresis with the 8-capillary 3500 Genetic Analyzer. These instruments are specifically designed to support the demanding performance needs of validated and process controlled environments, while retaining the unsurpassed application versatility that life science researchers expect from us.

• An 8 capillary system that can easily be upgraded to a 24-capillary system when you’re ready.
• New single-line 505 nm, solid-state long-life laser – utilizes a standard power supply; requires no heat-removal ducting.
• Powerful, integrated data collection and primary analysis software provides real-time assessment of data quality.
• Radio Frequency Identification (RFID) technology tracks key consumables data and records administrative information.
• Advanced multiplexing capabilities for DNA fragment analysis with up to six unique dyes.
• Unrivaled application flexibility – one array and one polymer are used for most applications.
• Simple setup, operation and maintenance – the easiest-to-run, easiest-to-own DNA sequencer to date.

Accurate Reliable Data Quality
The 3500 series systems significantly improves signal uniformity from instrument-to-instrument, run-to-run, and capillary-to-capillary. With a combination of intelligent hardware, powerful new algorithm and reagent combinations, these methods provide major reduction in the range of signal peak heights obtained across multiple 3500 series instruments (see figure 1).

Improved Sizing Precision
New thermal sub-system design gives enhanced performance in demanding fragment applications enabling improved sizing precision versus previous generations of capillary electrophoresis platforms (see figure 2).

Ready to Use Consumables With RFID Tags
The 3500 series introduces ready-to-use consumables with pre-packaged polymer pouches, cathode and anode buffer containers and easy-to-install capillary arrays. Each of these consumables is integrated with RFID tags that enable viewing, tracking and reporting of critical information about reagents and consumables including usage, lot number, part number, expiry date and on-instrument lifetime within the 3500 Series Data Collection Software (see figures 3 and 4).

Easy to Use New Data Collection Software
3500 Series Data Collection software breaks new ground in user-friendly navigation with an intuitive dashboard design, highly visible buttons for common operations, easy-to-read graphical displays to monitor the state of consumables and handy maintenance scheduling calendar functionality. New functionality includes simplified plate set-up, built-in primary analysis with quality control, so you can make decisions about the quality of data as it is produced on the instrument without the need to transfer output files into secondary analysis software packages (see figures 4 & 5).

For Research Use Only. Not for use in diagnostics procedures.

Ion GeneStudio™ S5 System Extended Warranty Package (Ion Torrent™)

The Ion GeneStudio S5 System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows. It is optimized to provide affordability for labs focused on smaller panels and lower sequencing throughput requirements. Combining an extended warranty with your system purchase helps extend the life of your investment.

This package includes the Ion GeneStudio S5 System, SmartStart orientation, and an extended warranty. Key features include:
• Select the chip (Ion 510–540 chip) that fits your application and throughput needs to achieve from 2–80 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments
• Increase efficiency and become operational faster with SmartStart orientation
• Receive fast repair from certified service engineers
• Minimize instrument downtime by troubleshooting with experienced Technical Support teams

For detailed instrument information and specifications, see the Ion GeneStudio S5 System.

Get up and running quickly with SmartStart
SmartStart orientation is carried out by a Field Application Scientist (FAS) to get you up and running quickly in your lab and reduce downtime. SmartStart is the first step of your education journey and is designed to help you work smarter and with greater efficiency. It includes:
• 1-day technology overview and instrument workflow
• 1-day hands-on application workflow training
• 10 hours bioinformatics consultancy

Content will vary depending on your level of knowledge and experience.

Extended warranty plan
Add coverage to your existing manufacturer’s limited warranty with an extended warranty. Each extended warranty includes a planned maintenance visit. Should your instrument require a repair, the extended warranty coverage includes parts, labor, and travel at no additional cost. In addition, you’ll receive:
• On-site guaranteed 2-day response time*
• Scheduled on-site planned maintenance (PM)
• Priority access to Remote Service Engineers

Certain exclusions apply. Contact your Services and Support Representative for details at service.sales@thermofisher.com.

*Availability limited in some geographical areas.

3500xL Genetic Analyzer for Fragment Analysis (Applied Biosystems™)

The 3500xL Genetic Analyzer is an 24-capillary sequencing instrument specifically designed to support the demanding performance needs of validated and process-controlled environments, while retaining the unsurpassed application versatility that life science researchers expect. The analyzer supports a wide variety of applications, including de novo sequencing and re-sequencing (mutational profiling), as well as microsatellite analysis, MLPA™, LOH, MLST, AFLP®, and SNP validation or screening. The majority of applications can be run on a single polymer and capillary array.

In addition to the 3500xL Genetic Analyzer, this fragment analysis package includes 3500 Series Data Collection Software, a Dell Workstation and monitor, reagent kits for system qualification, and secondary analysis software. 3500 Series Data Collection Software supports sequencing and fragment analysis, and integrates seamlessly with downstream software for secondary analysis of genetic data. GeneMapper™ secondary analysis software is included in this package.

Benefits and features of the 3500 Genetic Analyzer include:
Cost effective—lower running costs per sample and increased reagent life (14 days)
Easy setup—no special power outlets or external exhaust needed
Increased multiplexing—6-dye capability to interrogate more SNPs or markers
Easy-to-use software—integrated data collection and primary analysis software for real-time assessment of data quality
Consumables tracking—radio frequency identification (RFID) technology used for residual volume and expiry date tracking
Improved data uniformity—instrument-to-instrument, run-to-run, and capillary-to-capillary
More stable and precise fragment sizing due to improved oven temperature control
Smaller footprint versus 3130/3130xl instruments

Accurate and reliable data quality
The 3500 series systems significantly improve signal uniformity from instrument to instrument, run to run, and capillary to capillary. The combination of intelligent hardware and powerful algorithm and reagent combinations reduce the range of signal peak heights obtained across multiple 3500 series instruments.

Improved sizing precision
The thermal sub-system design provides enhanced performance during demanding fragment analysis applications, enabling improved sizing precision versus previous generations of capillary electrophoresis platforms.

Ready-to-use consumables with RFID tags
The 3500 series utilizes ready-to-use consumables with pre-packaged polymer pouches, cathode and anode buffer containers, and easy-to-install capillary arrays. Each of these consumables includes an integrated RFID tag that enables viewing, tracking, and reporting of critical information, including usage, lot number, part number, expiry date, and on-instrument lifetime, all within the 3500 Series Data Collection Software.

Easy-to-use data collection software
3500 Series Data Collection software features user-friendly navigation with an intuitive dashboard design, highly visible buttons for common operations, easy-to-read graphical displays to monitor the state of consumables, and a handy maintenance scheduling calendar. Additional features include simplified plate set-up and built-in primary analysis with quality control, so you can make decisions about the quality of data as it is produced on the instrument without the need to transfer output files into secondary analysis software packages.