Shop All Sequencing & Genetic Analyzer Instruments

Ion GeneStudio™ S5 Food Protection System Thermo Scientific™

Identify meat, fish or plant species present in all food types using the Ion Genestudio™ S5 Food Protection System - a semiconductor-based next-generation sequencing (NGS) system which, when used as part of the Thermo Scientific™ Next Generation Sequencing Food Authenticity Workflow allows identification of the species present in even the most challenging sample types.

The Ion GeneStudio S5 Food Protection System is optimized to provide flexibility and affordability for laboratories who have a food application focus and comes with a laptop suitable for use with the SGS™ All Species ID Software.

Ion Chef™ Food Protection Instrument Thermo Scientific™

Simplify your workflow with automated template preparation and chip loading, with the Ion Chef™ Food Protection Instrument - a part of the Thermo Scientific™ Next Generation Sequencing (NGS) Food Authenticity Workflow. 

The Thermo Scientific NGS Food Authenticity Workflow allows identification of meat, plant and fish species present in even the most challenging sample types; protecting your business from food fraud by verifying the authenticity of any sample type.

This simple, automated instrument makes your workflow suitable for users at any experience level.

Applied Biosystems™ RapidHIT™ ID System Upgrade Applied Biosystems™

The Applied Biosystems RapidHIT ID System Upgrade gives IntegenX RapidHIT ID System owners the ability to upgrade their system to the latest Applied Biosystems-branded version. The upgrade provides improved system reliability and performance, and enables the system to be sample/data accessioning workflow-capable.

Before upgrading, please consume your remaining IntegenX RapidHIT ID consumables as several legacy consumables, such as the primary cartridges, are not compatible with the Applied Biosystems-branded RapidHIT ID System.

For more details or questions, please contact your local sales representative or local distributor.

3500xL Dx Genetic Analyzer CS2 Applied Biosystems™

The 3500 Dx Genetic Analyzer CS2 is the latest addition to our family of Applied Biosystems® genetic analyzers based on capillary electrophoresis. The 3500 Dx Genetic Analyzer CS2 is an IVD-labeled instrument, making it the first Sanger sequencing platform cleared for sequencing analysis of DNA.

Confidence in Your Results
• The 3500 Dx Genetic Analyzer CS2 is an IVD-labeled platform for Sequencing-Based Typing using SeCore® HLA typing kits. Sanger sequencing is known as the 'gold-standard' for its accuracy, reliability, and ease of use. It is also used for confirmatory sequencing by clinical labs.
• High accuracy: 99% concordance as shown in clinical trials using SeCore® HLA typing kits
• Proven through decades of results—including sequencing of the first human genome—Applied Biosystems® genetic analysis systems are trusted standards for Sanger sequencing.

You can now feel even more comfortable adopting the 3500 Dx Genetic Analyzer CS2 platform for the development of assays for FDA submission.

Simplicity and Efficiency
• Reduced instrument hands-on time with simplified installation and removal of consumables and accessories
• Controlled and efficient run setup with intuitive user interface, preconfigured plate templates, and software-controlled functions (plate setup, data collection, analysis)
• Instrument run-times as short as 1 hour; sample-to-result in as little as 1.5 days
• Maintenance calendar with programmable prompts and service history
• Security and electronic signature, RFID (radio frequency identification) tracking of consumables, built-in quality controls, and real-time data quality evaluation

The 3500 Dx Genetic Analyzer CS2 is a partner in your laboratory, making it easy for you to comply with various industry standards and simplifying the training of new users.

Flexibility
• Collect data in either IVD (diagnostic for HLA typing) or RUO mode
• Develop other applications in RUO mode, including de novo sequencing and re-sequencing, as well as fragment analysis applications such as microsatellite analysis, MLPA®, LOH, MLST, and SNP confirmation or screening
• Partner with us to develop assays for FDA submission
• Different configurations to meet your throughput needs: 24-capillary (3500xL Dx) and 8-capillary (3500 Dx) versions

The 3500 Dx Genetic Analyzer CS2 is a trusted capillary electrophoresis-based sequencing platform for development of your new assays. Capillary electrophoresis-based applications are supported by a large number of publications over the many years that these applications have been used successfully in laboratory testing.

IVD-labeled Accessories and Consumables
The purchase of a 3500 Dx Genetic Analyzer CS2 includes a computer system and associated Data Collection software, as well as an installation kit containing the initial set of accessories and reagents needed to start using the instrument right away. The 3500 Dx Genetic Analyzer CS2 installation includes a full install qualification and operational qualification, as well as instrument training to introduce you to your new genetic analyzer.

The 3500 Dx is backed by a comprehensive Service & Support program with options to purchase additional services depending upon your laboratory maintenance and audit requirements.

Intended Use
The Applied Biosystems® 3500 Dx and 3500xL Dx Genetic Analyzers CS2 with 3500 Dx Series Software 2011 (v1) are in vitro diagnostic devices intended for the sequencing (detection and identification) of fluorescently labeled DNA by capillary electrophoresis.

The Applied Biosystems® 3500 Dx/3500xL Dx Genetic Analyzers CS2 with 3500 Dx Series Software 2011 (v1) are indicated for use with FDA-cleared or approved sequencing assays specifying their use and only by technologists trained in laboratory techniques, procedures, and use of the analyzer.

Note: The 3500 Dx Genetic Analyzer CS2 data collection software uses Windows 7 SP0 operating system. This makes the currently available RUO secondary analysis software incompatible for use on the same system. A separate computer is required to do secondary analysis if operating in RUO mode.

3730 DNA Analyzer Applied Biosystems™

The 48-capillary 3730 DNA Analyzer is the Gold Standard in medium-to-high throughput genetic analysis. Use the 3730 DNA Analyzer for DNA fragment analysis applications such as microsatellites, AFLP, SNP analysis, mutation detection and traditional DNA sequencing. Get the highest quality data at a low cost per sample. This is upgradeable to 96 capillaries.

• Higher optical sensitivity and advanced polymers enable you to obtain higher-quality data at a lower cost.
• Multiple automation features decrease costly human errors.
• Optimized polymers increase your productivity without compromising your results.
• Perform a wide variety of sequencing and fragment analysis applications including resequencing, microsatellite analysis, AFLP, LOH, SSCP, SNP screening and SNP validation.

Expand Your Laboratory's Possibilities
By dramatically improving your data quality, significantly reducing your cost per sample, and enabling you to perform more runs per day, the fully automated 48-capillary 3730 system gives your laboratory a tremendous technological and financial advantage. Which means you can pursue an exciting diversity of projects (and you can always upgrade to 96 capillaries when you need to).

Streamline Your Workflow
The 3730 DNA Analyzer system is engineered for highly reliable, unattended operation of up to 48 hours (applies to modules with run times longer than 30 minutes). Automation features which minimize the need for operator intervention and decrease the risk of human error include an integrated plate stacker, internal bar code reader, and onboard polymer delivery system.

Increase Productivity
The high signal-to-noise ratio ensures you get high-quality data – even when you use low-concentration samples and reagents. Labor-saving automation features minimize hands-on time and enable you to analyze more data more efficiently.

Get the Highest-Quality Sequencing and Genotyping Data
The enhanced optical design provides a higher signal-to-noise ratio and a more uniform signal profile across the array. This design, combined with our new, advanced polymer, enables the longest read lengths of any available system, and provides enhanced color balance for streamlined genotyping sample handling. In addition, exceptional sensitivity enables higher success rates across a wider range of sample templates and concentrations than other currently available systems.

One Instrument, Multiple Applications
With the 3730 DNA Analyzer, you get the highest-quality data from a wide array of applications. In addition to being ideal for high-throughput sequencing, the analyzer's optimized application assays, instrument, and analysis software also provide a complete solution for genotyping and resequencing.

Integrated Data Analysis Tools Reduce Time-to-Results
The 3730 DNA Analyzer software suite allows you to generate more meaningful data with less work. This system's labor-saving software suite includes:
• Data Collection (supplied with the instrument): Manages your instrument setup, controls instrument operations, allows real-time data visualization, and performs diagnostics. New features include: Auto-analysis with GeneMapper® and SeqScape®
• Tools to assist with regulatory and compliance requirements (In the United States, this assists with FDA 21CFR part 11).
Flexibility to use any choice in dye set option.
• Additional optimized sequencing run modules covering more applications.
• Sequencing Analysis – Designed to base-call; assign quality values; trim, display, edit and print DNA sequencing data using the KB basecaller
• Seqscape® – Provides everything you need to perform resequencing applications such as VariantSEQr™ Resequencing System
• GeneMapper® – Enables configurable, automated allele calling – a plus for high-throughput genotyping and includes tools for SNPlex™ data analysis

The instrument comes with a one year limited warranty on parts and labor.

For Research Use Only. Not for use in diagnostics procedures.

3500 Dx Genetic Analyzer CS2 Applied Biosystems™

The 3500 Dx Genetic Analyzer CS2 is the latest addition to our family of Applied Biosystems® genetic analyzers based on capillary electrophoresis. The 3500 Dx Genetic Analyzer CS2 is an IVD-labeled instrument, making it the first Sanger sequencing platform cleared for sequencing analysis of DNA.

Confidence in Your Results
• The 3500 Dx Genetic Analyzer CS2 is an IVD-labeled platform for Sequencing-Based Typing using SeCore® HLA typing kits. Sanger sequencing is known as the 'gold-standard' for its accuracy, reliability, and ease of use. It is also used for confirmatory sequencing by clinical labs.
• High accuracy: 99% concordance as shown in clinical trials using SeCore® HLA typing kits
• Proven through decades of results—including sequencing of the first human genome—Applied Biosystems® genetic analysis systems are trusted standards for Sanger sequencing.

You can now feel even more comfortable adopting the 3500 Dx Genetic Analyzer CS2 platform for the development of assays for FDA submission.

Simplicity and Efficiency
• Reduced instrument hands-on time with simplified installation and removal of consumables and accessories
• Controlled and efficient run setup with intuitive user interface, preconfigured plate templates, and software-controlled functions (plate setup, data collection, analysis)
• Instrument run-times as short as 1 hour; sample-to-result in as little as 1.5 days
• Maintenance calendar with programmable prompts and service history
• Security and electronic signature, RFID (radio frequency identification) tracking of consumables, built-in quality controls, and real-time data quality evaluation

The 3500 Dx Genetic Analyzer CS2 is a partner in your laboratory, making it easy for you to comply with various industry standards and simplifying the training of new users.

Flexibility
• Collect data in either IVD (diagnostic for HLA typing) or RUO mode
• Develop other applications in RUO mode, including de novo sequencing and re-sequencing, as well as fragment analysis applications such as microsatellite analysis, MLPA®, LOH, MLST, and SNP confirmation or screening
• Partner with us to develop assays for FDA submission
• Different configurations to meet your throughput needs: 8-capillary (3500 Dx) and 24-capillary (3500xL Dx) versions

The 3500 Dx Genetic Analyzer CS2 is a trusted capillary electrophoresis-based sequencing platform for development of your new assays. Capillary electrophoresis-based applications are supported by a large number of publications over the many years that these applications have been used successfully in laboratory testing.

IVD-labeled Accessories and Consumables
The purchase of a 3500 Dx Genetic Analyzer CS2 includes a computer system and associated Data Collection software, as well as an installation kit containing the initial set of accessories and reagents needed to start using the instrument right away. The 3500 Dx Genetic Analyzer CS2 installation includes a full install qualification and operational qualification, as well as instrument training to introduce you to your new genetic analyzer.

The 3500 Dx is backed by a comprehensive Service & Support program with options to purchase additional services depending upon your laboratory maintenance and audit requirements.

Intended Use
The Applied Biosystems® 3500 Dx and 3500xL Dx Genetic Analyzers CS2 with 3500 Dx Series Software 2011 (v1) are in vitro diagnostic devices intended for the sequencing (detection and identification) of fluorescently labeled DNA by capillary electrophoresis.

The Applied Biosystems® 3500 Dx/3500xL Dx Genetic Analyzers CS2 with 3500 Dx Series Software 2011 (v1) are indicated for use with FDA-cleared or approved sequencing assays specifying their use and only by technologists trained in laboratory techniques, procedures, and use of the analyzer.

Note: The 3500 Dx Genetic Analyzer CS2 data collection software uses Windows 7 SP0 operating system. This makes the currently available RUO secondary analysis software incompatible for use on the same system. A separate computer is required to do secondary analysis if operating in RUO mode.

Ion GeneStudio™ S5 Plus System Extended Warranty Package Ion Torrent™

The Ion GeneStudio S5 Plus System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows. From genes to exomes, the Ion GeneStudio S5 Plus System is designed to enable flexibility to help labs manage small and large projects across multiple applications. Combining an extended warranty with your system purchase helps extend the life of your investment.

This package includes the Ion GeneStudio S5 Plus System, SmartStart orientation, and an extended warranty. Key features include:
• Select the chip (Ion 510–550 chip) that fits your application and throughput needs to achieve from 2–130 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments
• Increase efficiency and become operational faster with SmartStart orientation
• Receive fast repair from certified service engineers
• Minimize instrument downtime by troubleshooting with experienced Technical Support teams

For detailed instrument information and specifications, see the Ion GeneStudio S5 Plus System.

Get up and running quickly with SmartStart
SmartStart orientation is carried out by a Field Application Scientist (FAS) to get you up and running quickly in your lab and reduce downtime. SmartStart is the first step of your education journey and is designed to help you work smarter and with greater efficiency. It includes:
• 1-day technology overview and instrument workflow
• 1-day hands-on application workflow training
• 10 hours bioinformatics consultancy

Content will vary depending on your level of knowledge and experience.

Extended warranty plan
Add coverage to your existing manufacturer’s limited warranty with an extended warranty. Each extended warranty includes a planned maintenance visit. Should your instrument require a repair, the extended warranty coverage includes parts, labor, and travel at no additional cost. In addition, you’ll receive:
• On-site guaranteed 2-day response time*
• Scheduled on-site planned maintenance (PM)
• Priority access to Remote Service Engineers

Certain exclusions apply. Contact your Services and Support Representative for details at service.sales@thermofisher.com.

*Availability limited in some geographical areas.

3500xL Genetic Analyzer for Fragment Analysis Applied Biosystems™

The 3500xL Genetic Analyzer is an 24-capillary sequencing instrument specifically designed to support the demanding performance needs of validated and process-controlled environments, while retaining the unsurpassed application versatility that life science researchers expect. The analyzer supports a wide variety of applications, including de novo sequencing and re-sequencing (mutational profiling), as well as microsatellite analysis, MLPA™, LOH, MLST, AFLP®, and SNP validation or screening. The majority of applications can be run on a single polymer and capillary array.

In addition to the 3500xL Genetic Analyzer, this fragment analysis package includes 3500 Series Data Collection Software, a Dell Workstation and monitor, reagent kits for system qualification, and secondary analysis software. 3500 Series Data Collection Software supports sequencing and fragment analysis, and integrates seamlessly with downstream software for secondary analysis of genetic data. GeneMapper™ secondary analysis software is included in this package.

Benefits and features of the 3500 Genetic Analyzer include:
Cost effective—lower running costs per sample and increased reagent life (14 days)
Easy setup—no special power outlets or external exhaust needed
Increased multiplexing—6-dye capability to interrogate more SNPs or markers
Easy-to-use software—integrated data collection and primary analysis software for real-time assessment of data quality
Consumables tracking—radio frequency identification (RFID) technology used for residual volume and expiry date tracking
Improved data uniformity—instrument-to-instrument, run-to-run, and capillary-to-capillary
More stable and precise fragment sizing due to improved oven temperature control
Smaller footprint versus 3130/3130xl instruments

Accurate and reliable data quality
The 3500 series systems significantly improve signal uniformity from instrument to instrument, run to run, and capillary to capillary. The combination of intelligent hardware and powerful algorithm and reagent combinations reduce the range of signal peak heights obtained across multiple 3500 series instruments.

Improved sizing precision
The thermal sub-system design provides enhanced performance during demanding fragment analysis applications, enabling improved sizing precision versus previous generations of capillary electrophoresis platforms.

Ready-to-use consumables with RFID tags
The 3500 series utilizes ready-to-use consumables with pre-packaged polymer pouches, cathode and anode buffer containers, and easy-to-install capillary arrays. Each of these consumables includes an integrated RFID tag that enables viewing, tracking, and reporting of critical information, including usage, lot number, part number, expiry date, and on-instrument lifetime, all within the 3500 Series Data Collection Software.

Easy-to-use data collection software
3500 Series Data Collection software features user-friendly navigation with an intuitive dashboard design, highly visible buttons for common operations, easy-to-read graphical displays to monitor the state of consumables, and a handy maintenance scheduling calendar. Additional features include simplified plate set-up and built-in primary analysis with quality control, so you can make decisions about the quality of data as it is produced on the instrument without the need to transfer output files into secondary analysis software packages.

3130 Genetic Analyzer to 3130xl Genetic Analyzer Upgrade Kit Applied Biosystems™

This is a system upgrade, from the 3130 Genetic Analyzer to the 3130xl Genetic Analyzer.

The 3130xl Genetic Analyzer is the latest generation of 16-capillary electrophoresis instruments for the medium throughput laboratories. The system offers industry-leading performance, plus sophisticated automation capabilities allowing researchers to save time, reduce costs and increase productivity.

Important Note: 3100 System Sequencers will be retired at the end of 2011. Take advantage of our limited time promotion to either TRADE-IN your 3100 for a brand new 3500 or UPGRADE to a 3130. Please contact your local Sales Representative to learn more.

For Research Use Only. Not for use in diagnostics procedures.

Ion GeneStudio™ S5 System Ion Torrent™

The Ion GeneStudio S5 System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows. The Ion GeneStudio S5 System is optimized to provide affordability for labs focused on smaller panels and lower sequencing throughput requirements. With cartridge-based reagents, the system is simple to use and offers scalability and flexibility. It uses Ion 5 Series chips to support a broad range of high-throughput sequencing for clinical research and research applications from microbial genomes and gene panels to exomes and transcriptomes.

Key features:
• Select the chip (Ion 510–540 chip) that fits your application and throughput needs to achieve from 2–80 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments

The Ion GeneStudio S5 Series
The Ion GeneStudio S5 Series sequencers share the same foundational technology and fluidic architecture across all three instruments: this Ion GeneStudio S5 System, the Ion GeneStudio S5 Plus System, and Ion GeneStudio S5 Prime System. The primary difference across the three instruments is on-sequencer analysis time.

Speed
The Ion GeneStudio S5 Series leverages the speed of semiconductor sequencing to enable the production of high quality sequencing data in a few hours and enables you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time when paired with the Ion Chef System.

Simplicity
With single-day installation, a straightforward user interface, and cartridge-based reagents, the Ion GeneStudio S5 Series sequencers are easy to use. Combined with Ion AmpliSeq technology for target selection, the Ion Chef System for automated library and template preparation, and Ion Reporter Software for automated variant annotation, targeted sequencing is simpler than ever.

Small sample input
Low input DNA from challenging samples types such as formalin-fixed paraffin-embedded (FFPE) tissue, retrospective samples from fine needle aspirates, and cell-free DNA extracted from blood (cfDNA) can be difficult to sequence on competitor next-generation sequencers. However, with Ion AmpliSeq technology and the Ion GeneStudio S5 Series, you can use as little as 1 ng input DNA or RNA.

Scalability
Why buy multiple systems for your lab when you can run all of your targeted sequencing or microbial applications on a single next-generation sequencer? The Ion 5 Series chips that run on the Ion GeneStudio S5 Series provide several throughput options, so your lab has the flexibility to scale from small to large projects, enabling multiple targeted sequencing applications on a single system.

Simple analysis and storage solutions
Torrent Suite Software and Ion Reporter Software make NGS easy for beginners and experts alike. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Ion Reporter Software (Thermo Fisher Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

HID Ion GeneStudio™ S5 Prime System Ion Torrent™

The HID Ion GeneStudio S5 Prime System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows. For core and service labs requiring maximum throughput and rapid turnaround time from a benchtop NGS system, the HID Ion GeneStudio S5 Prime System enables unparalleled breadth and depth for large panels with the fastest turnaround time needs. With cartridge-based reagents, the system is simple to use and offers scalability and flexibility. It uses Ion 5 Series chips to support a broad range of forensic applications including mitochondria sequencing, STR analysis, and SNP genotyping.

Features of the HID Ion GeneStudio S5 Prime System include:
• Select the chip (Ion 510–550 chip) that fits your application and throughput needs to achieve from 2–130 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments

The Ion GeneStudio S5 Series
The HID Ion GeneStudio S5 Series sequencers share the same foundational technology and fluidic architecture across all three instruments: the HID Ion GeneStudio S5 System, the HID Ion GeneStudio S5 Plus System, and this HID Ion GeneStudio S5 Prime System. The primary difference across the three instruments is on-sequencer analysis time.

Speed
The HID Ion GeneStudio S5 Series sequencers leverage the speed of semiconductor sequencing to enable the production of high-quality sequencing data in a few hours and enable you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time when paired with the HID Ion Chef System.

Simplicity
With single-day installation, a straightforward user interface, and cartridge-based reagents, the HID Ion GeneStudio S5 Series sequencers are easy to use. Combined with Precision ID library prep technology for target selection, the HID Ion Chef System for automated library and template preparation, and Converge Software for automated analysis, forensic sequencing is simpler than ever.

Small sample input
Low input DNA amounts from challenging sample types such as touch DNA or other forensic samples can be difficult to sequence on competitor next-generation sequencers. However, with Precision ID library preparation and sequencing technology and the HID Ion GeneStudio S5 Series sequencers, you can use as little as 100 pg of DNA input and achieve accurate, robust results.

Scalability
Why buy multiple systems for your lab when you can modulate your throughput by chip selection on a single next-generation sequencer? The Ion 5 Series chips that run on the HID Ion GeneStudio S5 Series systems provide several throughput options, so your lab has the flexibility to scale from small to large projects, enabling multiple forensic applications on a single system.

Simple analysis and storage solutions
Torrent Suite Software and Converge Software make NGS easy for beginners and experts alike. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Converge Software (Thermo Fisher Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and help ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

5500xl Genetic Analyzer Applied Biosystems™

Never before has a next-generation sequencing platform provided the combination of accuracy, sensitivity, and cost effectiveness to support your large translational research studies–until now. The new 5500xl Genetic Analyzer (Figure 1) helps ensure optimal productivity with two flexible FlowChips, embedded quality controls, intuitive user workflows, and project scalability. With the 5500xl Genetic Analyzer, you are empowered to discover rare genetic events or sub-populations of somatic mutations at an unprecedented pace.

Key Benefits
• Sequencing right here, right now
• Cost-effective sequencing runs with individually configurable lanes
• Superior low frequency variant detection for whole exome sequencing or targeted resequencing
• Reproducibility, reliability, and quality for your RNA applications
• Confidence and uniformity in multiplexing with up to 96 barcodes
• Optimal analysis solutions for streamlined productivity and freedom to operate

When Coverage is Not Enough
Additional sequence coverage fails to compensate for poor accuracy in the detection of rare variants that may hold the key to a better understanding cancer progression, disease penetrance, or drug resistance. With a system accuracy of up to 99.99%, the 5500xl Genetic Analyzer enables you to perform 25% less sequencing to detect rare variants than a next-generation sequencing platform with 99.99% system accuracy in order to detect somatic variant present at 1% (Figure 2). The industry-leading accuracy of the 5500xl Genetic Analyzer enables detection of significant biological variation for applications like whole genome resequencing, targeted resequencing, and whole transcriptome analysis.

When Flexibility, Speed, and Cost are Crucial
Multidisciplinary translational research programs often require processing of multiple samples across multiple applications like whole exome, RNA-seq, and structural variation. The 5500xl Genetic Analyzer provides you the flexibility to configure your sequencing runs to your project and throughput needs (Figure 3). The system’s two configurable microfluidic FlowChips process up to 12 independent samples and the intelligent barcoding kits multiplex up to hundreds of samples in a single run. Pay-Per-Lane Sequencing (PPL-Seq™) and independent run lanes tailor the system to any project scale. With the 5500xl Genetic Analyzer, avoid project delays by optimizing your run configurations to attain the lowest cost per sample.

When the Utmost Productivity and Efficiency are Essential
Ease of use, quality control, and speed are integral components of any next-generation sequencing workflow. Co-developed with Hitachi-Hi Technologies, the 5500xl Genetic Analyzer's elegant tabletop design (Figure 1) is built off “Six-Sigma" processes to streamline your research. The 5500xl Genetic Analyzer delivers streamlined fluidics and a simple, intuitive graphical user interface (GUI) for easy setup and run monitoring. Real-time analysis and 60% smaller data footprints expedite data export and analysis time. Additionally, with embedded sequencing controls and reagent usage tracking, the 5500xl Genetic Analyzer empowers you to obtain extremely high-quality and biologically meaningful data out of every sequencing run.

Take Comprehensive Research to New Heights
The superior accuracy, flexibility, and productivity of the 5500xl Genetic Analyzer accelerate comprehensive research. Larger translational medicine initiatives, genome consortiums, and disease-subtype stratification projects with resulting groundbreaking publications are now within your grasp. Catch them all with the new 5500xl Genetic Analyzer.

A Community of Support
With more than 2,000 field personnel, we have the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so that you can feel confident that we will be there when and where you need us most.

The 5500xl Genetic Analyzer is For Research Use Only. Not intended for any animal or human therapeutic or diagnostic use.

3730 DNA Analyzer (factory refurbished) Applied Biosystems™

The Applied Biosystems 3730 (48-capillary) Genetic Analyzer was refurbished by the original manufacturer to meet both manufacturing and product specifications. Availability may be limited.

The 48-capillary 3730 DNA Analyzer is the Gold Standard in medium-to-high throughput genetic analysis. Use the 3730 DNA Analyzer for DNA fragment analysis applications such as microsatellites, AFLP, SNP analysis, mutation detection and traditional DNA sequencing. Get the highest quality data at a low cost per sample. This is upgradeable to 96 capillaries.

• Higher optical sensitivity and advanced polymers enable you to obtain higher-quality data at a lower cost.
• Multiple automation features decrease costly human errors.
• Optimized polymers increase your productivity without compromising your results.
• Perform a wide variety of sequencing and fragment analysis applications including resequencing, microsatellite analysis, AFLP, LOH, SSCP, SNP screening and SNP validation.

Expand Your Laboratory's Possibilities
By dramatically improving your data quality, significantly reducing your cost per sample, and enabling you to perform more runs per day, the fully automated 48-capillary 3730 system gives your laboratory a tremendous technological and financial advantage. Which means you can pursue an exciting diversity of projects (and you can always upgrade to 96 capillaries when you need to).

Streamline Your Workflow
The 3730 DNA Analyzer system is engineered for highly reliable, unattended operation of up to 48 hours (applies to modules with run times longer than 30 minutes). Automation features which minimize the need for operator intervention and decrease the risk of human error include an integrated plate stacker, internal bar code reader, and onboard polymer delivery system.

Increase Productivity
The high signal-to-noise ratio ensures you get high-quality data – even when you use low-concentration samples and reagents. Labor-saving automation features minimize hands-on time and enable you to analyze more data more efficiently.

Get the Highest-Quality Sequencing and Genotyping Data
The enhanced optical design provides a higher signal-to-noise ratio and a more uniform signal profile across the array. This design, combined with our new, advanced polymer, enables the longest read lengths of any available system, and provides enhanced color balance for streamlined genotyping sample handling. In addition, exceptional sensitivity enables higher success rates across a wider range of sample templates and concentrations than other currently available systems.

One Instrument, Multiple Applications
With the 3730 DNA Analyzer, you get the highest-quality data from a wide array of applications. In addition to being ideal for high-throughput sequencing, the analyzer's optimized application assays, instrument, and analysis software also provide a complete solution for genotyping and resequencing.

Integrated Data Analysis Tools Reduce Time-to-Results
The 3730 DNA Analyzer software suite allows you to generate more meaningful data with less work. This system's labor-saving software suite includes:
• Data Collection (supplied with the instrument): Manages your instrument setup, controls instrument operations, allows real-time data visualization, and performs diagnostics. New features include: Auto-analysis with GeneMapper® and SeqScape®
• Tools to assist with regulatory and compliance requirements (In the United States, this assists with FDA 21CFR part 11).
Flexibility to use any choice in dye set option.
• Additional optimized sequencing run modules covering more applications.
• Sequencing Analysis – Designed to base-call; assign quality values; trim, display, edit and print DNA sequencing data using the KB basecaller
• Seqscape® – Provides everything you need to perform resequencing applications such as VariantSEQr™ Resequencing System
• GeneMapper® – Enables configurable, automated allele calling – a plus for high-throughput genotyping and includes tools for SNPlex™ data analysis

The instrument comes with a one year limited warranty on parts and labor.

For Research Use Only. Not for use in diagnostics procedures.

Genexus™ Integrated Sequencer Ion Torrent™

The Ion Torrent Genexus Integrated Sequencer is part of the Ion Torrent Genexus System, the first turnkey next-generation sequencing (NGS) solution that automates the specimen-to-report workflow and can deliver results in a single day.

The Genexus Integrated Sequencer automates all steps of the targeted NGS workflow starting from purified and quantified nucleic acid. With a single touchpoint and five minutes of hands-on time, the Genexus sequencer automates NGS library preparation (including cDNA synthesis), template preparation, sequencing, primary data analysis, and variant reporting for DNA, RNA, and cfTNA applications. Sequencing on the Genexus sequencer is done on a four-lane semiconductor chip: the Ion Torrent GX5 Chip. Each of the four lanes of the GX5 Chip supports the output of 12–15 million reads, and they can be used individually or all at once depending on throughput needs. Ion Torrent Genexus Software streamlines the NGS workflow by integrating the setup-to-report workflow within a single software ecosystem.

• Rapidly go from nucleic acid to report in a single day
• Simplify the NGS workflow with a single instrument that can automate library prep, sequencing, and analysis, including variant calling
• Modulate run setup as samples come in with the flexibility of multiplexing up to 32 library reactions per run in increments of four
• Simultaneously create libraries and sequence up to four different assays using the four-lane GX5 Chip
• Reduce NGS operating costs with simplified setup using pre-filled reagents, a single touchpoint, and five minutes of total hands-on time
• Prevent user error by allowing the Genexus sequencer’s onboard vision system to verify reagent placement and detect errors in real time
• Ease the burden of assay adoption and test new software versions while retaining previous versions with Genexus Software

Experience in-house NGS refined
Many labs performing NGS in-house today or considering the adoption of in-house NGS in the future face significant challenges and barriers. Existing NGS workflows can be slow, complex, and costly for many clinical research labs. These workflows, as well as the outsourcing of samples to external laboratories, can take weeks to get results, which may delay answers. The complexity of the workflows, high operating costs, and lengthy turnaround times are roadblocks for labs considering in-house NGS and limit the way labs can utilize the power of next-generation sequencing.

The Genexus Integrated Sequencer helps create a paradigm shift in the way labs implement NGS in-house. Library preparation using Ion AmpliSeq and Ion AmpliSeq HD technologies, template preparation via isothermal amplification, and semiconductor sequencing are all automated on the Genexus Integrated Sequencer, enabling a hands-off nucleic acid-to-report workflow in a single day. Users of the Genexus sequencer have the power to generate and deliver a comprehensive molecular profile for sequenced samples every day of the week.

Complexity reduction is accomplished through several key innovations of the Genexus Integrated Sequencer. The hands-off, automated workflow from nucleic acid to variant report begins with run planning using Genexus Software. During run planning the user can select their desired sample(s) and assay(s) and use the setup wizard to create a run plan for the sequencer. During sequencer setup, which takes five minutes of hands-on time, the onboard vision system verifies consumable installation in real-time using barcode and RFID detection, ensuring proper setup before the run begins. After the run is completed, the user can view an integrated variant report for each sample, sample-level quality control metrics, and a list of reagents that were used.

A new way to think about assay adoption
In addition to streamlining the NGS workflow by integrating all steps from run planning to variant reporting into a single software ecosystem, Genexus Software helps reduce the burden of assay implementation by containerizing assay design files, algorithms, and UI features into a self-sufficient package. Multiple assays can be supported simultaneously by the same version of the software, allowing users to retain previously implemented workflows while optimizing new assay workflows. Software updates will be less frequent since new assays can be installed as a self-contained app. Genexus Software provides users the flexibility of optimizing a new assay while running an already implemented assay on a single Genexus Integrated Sequencer, eliminating the need for multiple instruments in a testing environment.

Applied Biosystems 3500xL Dx Genetic Analyzer Applied Biosystems™

The Applied Biosystems 3500xL Dx Genetic Analyzer is the first capillary electrophoresis platform for in vitro diagnostic (IVD) use for Sanger sequencing and fragment analysis of DNA. Sanger sequencing and fragment analysis are known as the 'gold-standard' for its accuracy, reliability, and ease of use.

Confidence in your results
You can now feel even more comfortable adopting the 3500xL Dx Genetic Analyzer platform for IVD use for Sanger sequencing and fragment analysis of DNA.
• The 3500xL Dx Genetic Analyzer is an IVD-labeled platform for Sequencing-Based Typing using SeCore HLA typing kits
• High accuracy: 99% concordance as shown in clinical trials using SeCore HLA typing kits
• The Applied Biosystems 3500 Dx Genetic Analyzer and the Applied Biosystems 3500xL Dx Genetic Analyzer are FDA-cleared for DNA fragment analysis with the AmplideX™ Fragile X Dx and Carrier Screen Kit from Asuragen, Inc.
• Direct injection of PCR products (no PCR clean up) into the Applied Biosystems 3500xL Dx Genetic Analyzer

Simplicity and efficiency
The 3500xL Dx Genetic Analyzer is a partner in your laboratory, making it easy for you to comply with various industry standards and simplifying the training of new users.
• Minimal instrument hands-on time with simplified installation and removal of consumables and accessories
• Controlled and efficient run setup with intuitive user interface, preconfigured plate templates, and software-controlled functions (plate setup, data collection, analysis)
• Instrument run-times as short as 1 hour; sample-to-result in as little as 1.5 days
• Maintenance calendar with programmable prompts and service history
• Security, audit, and electronic signature (SAE), radio frequency identification (RFID) tracking of consumables, built-in quality controls, and real-time data quality evaluation

Flexibility
• Collect data in IVD mode which is validated for sequencing using the SeCore HLA kit and validated for fragment analysis
• Different configurations to meet your throughput needs: 8-capillary (3500 Dx Genetic Analyzer) and 24-capillary (3500xL Dx Genetic Analyzer) versions
• Integrated, dual-mode software for instrument control, data collection, quality control, and auto-analysis of sample files

IVD-labeled accessories and consumables
The purchase of a 3500xL Dx Genetic Analyzer includes a computer system and associated data collection software, as well as an installation kit containing the initial set of accessories and reagents. Installation includes a full install qualification and operational qualification, as well as instrument training.

The 3500 Dx Genetic Analyzer is backed by a comprehensive service and support program with options to purchase additional services depending upon your laboratory maintenance and audit requirements.

Intended use—Applied Biosystems 3500 Dx Genetic Analyzer and the Applied Biosystems 3500xL Dx Genetic Analyzer
The Applied Biosystems 3500 Dx Genetic Analyzer and the Applied Biosystems 3500xL Dx Genetic Analyzer are in vitro diagnostic devices intended for detection of fluorescently-labeled human genomic deoxyribonucleic acid (DNA) nucleotides by capillary electrophoresis.

The Applied Biosystems 3500 Dx Genetic Analyzer and the Applied Biosystems 3500xL Dx Genetic Analyzer are indicated for sequencing and fragment analysis using FDA- cleared or approved assays.

Intended Use—AmplideX Fragile X Dx & Carrier Screen Kit
The AmplideX Fragile X Dx & Carrier Screen Kit is an in vitro diagnostic device that uses polymerase chain reaction (PCR) and capillary electrophoresis to detect and identify the number of cytosine-guanine-guanine (CGG) repeats in the fragile X mental retardation-1 (FMR1) gene using genomic DNA isolated from peripheral whole blood specimens. It is solely intended as an aid in the post-natal diagnosis of fragile X syndrome, and fragile X-associated disorders [i.e., fragile X-associated tremor/ataxia syndrome (FXTAS) or fragile X-associated primary ovarian insufficiency (FXPOI)], and for carrier testing in adults of reproductive age. Assay results are solely intended to be interpreted by healthcare professionals who are board certified in molecular genetics and to be used in conjunction with other clinical and diagnostic findings, consistent with professional standards of practice. Reflex testing, clinical genetic evaluation, and genetic counseling should be offered as appropriate. The test is for use on the Applied Biosystems 3500 Dx Series Genetic Analyzers.

This test is not indicated for use for fetal diagnostic testing, newborn screening, or for stand‐alone diagnostic purposes.

Note: The 3500xL Dx Genetic Analyzer data collection software uses the Windows 10 operating system.

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