Shop All Sequencing & Genetic Analyzer Instruments

Ion GeneStudio™ S5 Prime System for Agrigenomics (Ion Torrent™)

The Ion GeneStudio S5 Prime System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows. For core and service labs requiring maximum throughput and rapid turnaround time from a benchtop NGS system, the Ion GeneStudio S5 Prime System enables unparalleled breadth and depth, from large panels or exomes to clinical oncology research focused on low allele frequency applications. With cartridge-based reagents, the system is simple to use and offers scalability and flexibility. It uses Ion 5 Series chips to support a broad range of high-throughput sequencing for clinical research and research applications from microbial genomes and gene panels to exomes and transcriptomes.

Key features:
• Select the chip (Ion 510–550 chip) that fits your application and throughput needs to achieve from 2–130 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments

The Ion GeneStudio S5 Series
The Ion GeneStudio S5 Series sequencers share the same foundational technology and fluidic architecture across all three instruments: the Ion GeneStudio S5 System, the Ion GeneStudio S5 Plus System, and this Ion GeneStudio S5 Prime System. The primary difference across the three instruments is on-sequencer analysis time.

Speed
The Ion GeneStudio S5 Series leverages the speed of semiconductor sequencing to enable the production of high quality sequencing data in a few hours and enables you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time when paired with the Ion Chef System.

Simplicity
With single-day installation, a straightforward user interface, and cartridge-based reagents, the Ion GeneStudio S5 Series sequencers are easy to use. Combined with Ion AmpliSeq technology for target selection, the Ion Chef System for automated library and template preparation, and Ion Reporter Software for automated variant annotation, targeted sequencing is simpler than ever.

Small sample input
Low input DNA from challenging samples types such as formalin-fixed paraffin-embedded (FFPE) tissue, retrospective samples from fine needle aspirates, and cell-free DNA extracted from blood (cfDNA) can be difficult to sequence on competitor next-generation sequencers. However, with Ion AmpliSeq technology and the Ion GeneStudio S5 Series, you can use as little as 1 ng input DNA or RNA.

Scalability
Why buy multiple systems for your lab when you can run all of your targeted sequencing or microbial applications on a single next-generation sequencer? The Ion 5 Series chips that run on the Ion GeneStudio S5 Series provide several throughput options, so your lab has the flexibility to scale from small to large projects, enabling multiple targeted sequencing applications on a single system.

Simple analysis and storage solutions
Torrent Suite Software and Ion Reporter Software make NGS easy for beginners and experts alike. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Ion Reporter Software (Thermo Fisher Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

Ion GeneStudio™ S5 Plus System for Agrigenomics (Ion Torrent™)

The Ion GeneStudio S5 Plus System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows. From genes to exomes, the Ion GeneStudio S5 Plus System is designed to enable flexibility to help labs manage small and large projects across multiple applications. With cartridge-based reagents, the system is simple to use and offers scalability and flexibility. It uses Ion 5 Series chips to support a broad range of high-throughput sequencing for clinical research and research applications from microbial genomes and gene panels to exomes and transcriptomes.

Key features:
• Select the chip (Ion 510–550 chip) that fits your application and throughput needs to achieve from 2–130 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments

The Ion GeneStudio S5 Series
The Ion GeneStudio S5 Series sequencers share the same foundational technology and fluidic architecture across all three instruments: the Ion GeneStudio S5 System, this Ion GeneStudio S5 Plus System, and Ion GeneStudio S5 Prime System. The primary difference across the three instruments is on-sequencer analysis time.

Speed
The Ion GeneStudio S5 Series leverages the speed of semiconductor sequencing to enable the production of high quality sequencing data in a few hours and enables you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time when paired with the Ion Chef System.

Simplicity
With single-day installation, a straightforward user interface, and cartridge-based reagents, the Ion GeneStudio S5 Series sequencers are easy to use. Combined with Ion AmpliSeq technology for target selection, the Ion Chef System for automated library and template preparation, and Ion Reporter Software for automated variant annotation, targeted sequencing is simpler than ever.

Small sample input
Low input DNA from challenging samples types such as formalin-fixed paraffin-embedded (FFPE) tissue, retrospective samples from fine needle aspirates, and cell-free DNA extracted from blood (cfDNA) can be difficult to sequence on competitor next-generation sequencers. However, with Ion AmpliSeq technology and the Ion GeneStudio S5 Series, you can use as little as 1 ng input DNA or RNA.

Scalability
Why buy multiple systems for your lab when you can run all of your targeted sequencing or microbial applications on a single next-generation sequencer? The Ion 5 Series chips that run on the Ion GeneStudio S5 Series provide several throughput options, so your lab has the flexibility to scale from small to large projects, enabling multiple targeted sequencing applications on a single system.

Simple analysis and storage solutions
Torrent Suite Software and Ion Reporter Software make NGS easy for beginners and experts alike. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Ion Reporter Software (Thermo Fisher Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

3730 DNA Analyzer (factory refurbished) (Applied Biosystems™)

The Applied Biosystems 3730 (48-capillary) Genetic Analyzer was refurbished by the original manufacturer to meet both manufacturing and product specifications. Availability may be limited.

The 48-capillary 3730 DNA Analyzer is the Gold Standard in medium-to-high throughput genetic analysis. Use the 3730 DNA Analyzer for DNA fragment analysis applications such as microsatellites, AFLP, SNP analysis, mutation detection and traditional DNA sequencing. Get the highest quality data at a low cost per sample. This is upgradeable to 96 capillaries.

• Higher optical sensitivity and advanced polymers enable you to obtain higher-quality data at a lower cost.
• Multiple automation features decrease costly human errors.
• Optimized polymers increase your productivity without compromising your results.
• Perform a wide variety of sequencing and fragment analysis applications including resequencing, microsatellite analysis, AFLP, LOH, SSCP, SNP screening and SNP validation.

Expand Your Laboratory's Possibilities
By dramatically improving your data quality, significantly reducing your cost per sample, and enabling you to perform more runs per day, the fully automated 48-capillary 3730 system gives your laboratory a tremendous technological and financial advantage. Which means you can pursue an exciting diversity of projects (and you can always upgrade to 96 capillaries when you need to).

Streamline Your Workflow
The 3730 DNA Analyzer system is engineered for highly reliable, unattended operation of up to 48 hours (applies to modules with run times longer than 30 minutes). Automation features which minimize the need for operator intervention and decrease the risk of human error include an integrated plate stacker, internal bar code reader, and onboard polymer delivery system.

Increase Productivity
The high signal-to-noise ratio ensures you get high-quality data – even when you use low-concentration samples and reagents. Labor-saving automation features minimize hands-on time and enable you to analyze more data more efficiently.

Get the Highest-Quality Sequencing and Genotyping Data
The enhanced optical design provides a higher signal-to-noise ratio and a more uniform signal profile across the array. This design, combined with our new, advanced polymer, enables the longest read lengths of any available system, and provides enhanced color balance for streamlined genotyping sample handling. In addition, exceptional sensitivity enables higher success rates across a wider range of sample templates and concentrations than other currently available systems.

One Instrument, Multiple Applications
With the 3730 DNA Analyzer, you get the highest-quality data from a wide array of applications. In addition to being ideal for high-throughput sequencing, the analyzer's optimized application assays, instrument, and analysis software also provide a complete solution for genotyping and resequencing.

Integrated Data Analysis Tools Reduce Time-to-Results
The 3730 DNA Analyzer software suite allows you to generate more meaningful data with less work. This system's labor-saving software suite includes:
• Data Collection (supplied with the instrument): Manages your instrument setup, controls instrument operations, allows real-time data visualization, and performs diagnostics. New features include: Auto-analysis with GeneMapper® and SeqScape®
• Tools to assist with regulatory and compliance requirements (In the United States, this assists with FDA 21CFR part 11).
Flexibility to use any choice in dye set option.
• Additional optimized sequencing run modules covering more applications.
• Sequencing Analysis – Designed to base-call; assign quality values; trim, display, edit and print DNA sequencing data using the KB basecaller
• Seqscape® – Provides everything you need to perform resequencing applications such as VariantSEQr™ Resequencing System
• GeneMapper® – Enables configurable, automated allele calling – a plus for high-throughput genotyping and includes tools for SNPlex™ data analysis

The instrument comes with a one year limited warranty on parts and labor.

For Research Use Only. Not for use in diagnostics procedures.

Ion GeneStudio™ S5 System (Ion Torrent™)

The Ion GeneStudio S5 System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows. The Ion GeneStudio S5 System is optimized to provide affordability for labs focused on smaller panels and lower sequencing throughput requirements. With cartridge-based reagents, the system is simple to use and offers scalability and flexibility. It uses Ion 5 Series chips to support a broad range of high-throughput sequencing for clinical research and research applications from microbial genomes and gene panels to exomes and transcriptomes.

Key features:
• Select the chip (Ion 510–540 chip) that fits your application and throughput needs to achieve from 2–80 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments

The Ion GeneStudio S5 Series
The Ion GeneStudio S5 Series sequencers share the same foundational technology and fluidic architecture across all three instruments: this Ion GeneStudio S5 System, the Ion GeneStudio S5 Plus System, and Ion GeneStudio S5 Prime System. The primary difference across the three instruments is on-sequencer analysis time.

Speed
The Ion GeneStudio S5 Series leverages the speed of semiconductor sequencing to enable the production of high quality sequencing data in a few hours and enables you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time when paired with the Ion Chef System.

Simplicity
With single-day installation, a straightforward user interface, and cartridge-based reagents, the Ion GeneStudio S5 Series sequencers are easy to use. Combined with Ion AmpliSeq technology for target selection, the Ion Chef System for automated library and template preparation, and Ion Reporter Software for automated variant annotation, targeted sequencing is simpler than ever.

Small sample input
Low input DNA from challenging samples types such as formalin-fixed paraffin-embedded (FFPE) tissue, retrospective samples from fine needle aspirates, and cell-free DNA extracted from blood (cfDNA) can be difficult to sequence on competitor next-generation sequencers. However, with Ion AmpliSeq technology and the Ion GeneStudio S5 Series, you can use as little as 1 ng input DNA or RNA.

Scalability
Why buy multiple systems for your lab when you can run all of your targeted sequencing or microbial applications on a single next-generation sequencer? The Ion 5 Series chips that run on the Ion GeneStudio S5 Series provide several throughput options, so your lab has the flexibility to scale from small to large projects, enabling multiple targeted sequencing applications on a single system.

Simple analysis and storage solutions
Torrent Suite Software and Ion Reporter Software make NGS easy for beginners and experts alike. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Ion Reporter Software (Thermo Fisher Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

3730xl DNA Analyzer (latest version) (Applied Biosystems™)

This latest version of 3730xl DNA Analyzer has an upgraded solid-state laser, is 48- and 96-capillary compatible, and comes with Windows® 10 operating system and cloud connectivity. Like its predecessor, it is the gold standard for high-throughput genetic analysis. Use this analyzer for DNA fragment analysis applications such as microsatellites, AFLP, and SNP analysis, mutation detection, and traditional DNA sequencing. Get the highest quality data at a low cost per sample.

• Higher optical sensitivity and advanced polymers enable you to obtain higher-quality sequencing data for less
• Multiple automation features decrease costly human errors
• Optimized polymers increase your productivity without compromising your results
• Perform a wide variety of sequencing and fragment analysis applications including resequencing, microsatellite analysis, AFLP, LOH, SSCP, and SNP screening, and SNP validation

Large-scale DNA analysis on a small-scale budget
By combining advances in automation with innovative optics and proprietary reagents to increase throughput, yield high-quality data, and minimize reagent consumption, the 3730xl analyzer provides your laboratory and production facility with faster, better, and cheaper analysis.

Streamline your workflow
The 3730xl DNA Analyzer is engineered for highly reliable, unattended operation of up to 48 hours (applies to modules with run times longer than 30 minutes). To minimize the need for operator intervention and decrease the risk of human error, automation features include an integrated plate stacker, internal bar code reader, and onboard polymer delivery system.

Increase productivity
The high signal-to-noise ratio ensures you get high-quality data, even when you use low-concentration samples and reagents. Labor-saving automation features minimize hands-on time and enable you to analyze more data more efficiently.

Get the highest-quality sequencing and genotyping data
The enhanced optical design provides a higher signal-to-noise ratio and a more uniform signal profile across the array. This design, combined with our advanced polymer, enables the longest read lengths of any available system, and provides enhanced color balance for streamlined genotyping sample handling. In addition, exceptional sensitivity enables higher success rates across a wide range of sample template types and concentrations.

One instrument, multiple applications
With the 3730xl DNA Analyzer, you get the highest-quality data from a wide array of applications. In addition to being ideal for high-throughput sequencing, the analyzer's optimized application assays, instrument, and analysis software also provide a complete solution for genotyping and resequencing.

Integrated data analysis tools reduce time-to-results
The 3730xl DNA Analyzer software suite allows you to generate more meaningful data with less work. This system's labor-saving software suite includes:
• Data collection (supplied with the instrument)—manages your instrument setup, controls instrument operations, allows real-time data visualization, and performs diagnostics
• Sequencing analysis software—designed to base-call; assign quality values; trim, display, edit and print DNA sequencing data using the KB basecaller
• Seqscape Software—provides everything you need to perform resequencing applications such as VariantSEQr Resequencing System
• GeneMapper—enables configurable, automated allele calling; a plus for high-throughput genotyping and includes tools for SNPlex data analysis

Additional features include:
• Auto-analysis with GeneMapper and SeqScape software
• Flexibility to use any choice in dye set option
• Tools to assist with regulatory and compliance requirements (in the United States, this assists with FDA 21CFR part 11)
• Additional optimized run modules covering more applications
• Support for fragment analysis applications on the 96-capillary array

The instrument comes with a one year limited warranty on parts and labor.

3730xl DNA Analyzer (Applied Biosystems™)


See the latest version of the 3730xl DNA Analyzer ›

The 96-capillary 3730xl DNA Analyzer is the Gold Standard for high throughput genetic analysis. Use this for DNA fragment analysis applications such as microsatellites, AFLP, SNP analysis, mutation detection and traditional DNA sequencing. Get the highest quality data at a low cost per sample.
• Higher optical sensitivity and advanced polymers enable you to obtain higher-quality sequencing data for less.
• Multiple automation features decrease costly human errors.
• Optimized polymers increase your productivity without compromising your results.
• Perform a wide variety of sequencing and fragment analysis applications including resequencing, microsatellite analysis, AFLP, LOH, SSCP, SNP screening and SNP validation.

Large-Scale DNA Analysis on a Small-Scale Budget
By combining advances in automation with innovative optics and proprietary reagents to increase throughput, yield high-quality data, and minimize reagent consumption, the 3730xl Analyzer provides your laboratory and production facility with faster, better, cheaper analysis.

Streamline Your Workflow
The 3730xl DNA Analyzer system is engineered for highly reliable, unattended operation of up to 48 hours (applies to modules with run times longer than 30 minutes). To minimize the need for operator intervention and decrease the risk of human error, automation features include an integrated plate stacker, internal bar code reader, and onboard polymer delivery system.

Increase Productivity
The high signal-to-noise ratio ensures you get high-quality data – even when you use low-concentration samples and reagents. Labor-saving automation features minimize hands-on time and enable you to analyze more data more efficiently.

Get the Highest-Quality Sequencing and Genotyping Data
The enhanced optical design provides a higher signal-to-noise ratio and a more uniform signal profile across the array. This design, combined with our new, advanced polymer, enables the longest read lengths of any available system, and provides enhanced color balance for streamlined genotyping sample handling. In addition, exceptional sensitivity enables higher success rates across a wide range of sample template types and concentrations.

One Instrument, Multiple Applications
With the 3730xl DNA Analyzer, you get the highest-quality data from a wide array of applications. In addition to being ideal for high-throughput sequencing, the analyzer's optimized application assays, instrument, and analysis software also provide a complete solution for genotyping and resequencing.

Integrated Data Analysis Tools Reduce Time-to-Results
The 3730xl DNA Analyzer software suite allows you to generate more meaningful data with less work. This system's labor-saving software suite includes:
• Data Collection (supplied with the instrument) – Manages your instrument setup, controls instrument operations, allows real-time data visualization, and performs diagnostics.
• Sequencing Analysis Software – Designed to base-call; assign quality values; trim, display, edit and print DNA sequencing data using the KB basecaller
• Seqscape® – Provides everything you need to perform resequencing applications such as VariantSEQr™ Resequencing System
• GeneMapper® – Enables configurable, automated allele calling; a plus for high-throughput genotyping and includes tools for SNPlex™ data analysis

New features include:
• Auto-analysis with GeneMapper® and SeqScape®
• Flexibility to use any choice in dye set option
• Tools to assist with regulatory and compliance requirements (In the United States, this assists with FDA 21CFR part 11).
• Additional optimized run modules covering more applications
• Support for fragment analysis applications on the 96-capillary array

The instrument comes with a one year limited warranty on parts and labor.

For Research Use Only. Not for use in diagnostics procedures.

Ion GeneStudio™ S5 Plus System (Ion Torrent™)

The Ion GeneStudio S5 Plus System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows. From genes to exomes, the Ion GeneStudio S5 Plus System is designed to enable flexibility to help labs manage small and large projects across multiple applications. With cartridge-based reagents, the system is simple to use and offers scalability and flexibility. It uses Ion 5 Series chips to support a broad range of high-throughput sequencing for clinical research and research applications from microbial genomes and gene panels to exomes and transcriptomes.

Key features:
• Select the chip (Ion 510–550 chip) that fits your application and throughput needs to achieve from 2–130 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments

The Ion GeneStudio S5 Series
The Ion GeneStudio S5 Series sequencers share the same foundational technology and fluidic architecture across all three instruments: the Ion GeneStudio S5 System, this Ion GeneStudio S5 Plus System, and Ion GeneStudio S5 Prime System. The primary difference across the three instruments is on-sequencer analysis time.

Speed
The Ion GeneStudio S5 Series leverages the speed of semiconductor sequencing to enable the production of high quality sequencing data in a few hours and enables you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time when paired with the Ion Chef System.

Simplicity
With single-day installation, a straightforward user interface, and cartridge-based reagents, the Ion GeneStudio S5 Series sequencers are easy to use. Combined with Ion AmpliSeq technology for target selection, the Ion Chef System for automated library and template preparation, and Ion Reporter Software for automated variant annotation, targeted sequencing is simpler than ever.

Small sample input
Low input DNA from challenging samples types such as formalin-fixed paraffin-embedded (FFPE) tissue, retrospective samples from fine needle aspirates, and cell-free DNA extracted from blood (cfDNA) can be difficult to sequence on competitor next-generation sequencers. However, with Ion AmpliSeq technology and the Ion GeneStudio S5 Series, you can use as little as 1 ng input DNA or RNA.

Scalability
Why buy multiple systems for your lab when you can run all of your targeted sequencing or microbial applications on a single next-generation sequencer? The Ion 5 Series chips that run on the Ion GeneStudio S5 Series provide several throughput options, so your lab has the flexibility to scale from small to large projects, enabling multiple targeted sequencing applications on a single system.

Simple analysis and storage solutions
Torrent Suite Software and Ion Reporter Software make NGS easy for beginners and experts alike. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Ion Reporter Software (Thermo Fisher Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

3500 Genetic Analyzer for Human Identification (Applied Biosystems™)

The 8-capillary 3500 Genetic Analyzer sets the standard in capillary electrophoresis. The 3500-series instruments are the first genetic analyzers designed with a specific feature set and workflow for the Human Identification application. The complete product combines the instrument with Applied Biosystems™ reagents, consumables and software, as well as industry leading support, to provide an integrated HID system solution that significantly improves ease-of-use and application efficiencies.

• Increased Consistency – Reduced signal variation with factory standardization and optional in-lane normalization
• Real-Time Data Quality Assessment – On instrument data evaluation features provide rapid identification and re-injection of samples requiring additional processing
• Improved Thermal Control – Smaller oven design and improved door seal for more consistent data migration
• HID Specific Workflow – Pre-configured for Applied Biosystems® amplification kits to simplify run setup and software navigation
• Effortless Consumable Installation – Convenient one-time use consumable packaging
• Consumable Tracking with RFID Technology – On-instrument, real-time monitoring of consumable consumption and expiration
• Enhanced Throughput – Faster data generation with 8 or 24 capillary arrays and shorter run times
• Improved Polymer Pump Design – Reduced waste and fewer bubbles for better data quality
• Simplified Instrument Installation & Operation – New solid-state laser eliminates need for high voltage wiring and external venting
• Streamlined Instrument Maintenance – HID specific performance check and maintenance scheduling tools
• Data Chain of Custody – Controlled access and tracking through Security, Audit and eSig features

For more information, please contact your local Sales Representative.

For Research Use Only. Not for use in diagnostics procedures.

3130 Genetic Analyzer (factory refurbished) (Applied Biosystems™)

With the Applied Biosystems 3130 Genetic Analyzer, you get the sophisticated automation and superior performance of the 3130 system, at acquisition and operating costs tailored to a growing research lab. This instrument is refurbished by the original manufacturer to meet both manufacturing and product specifications. This system includes the refurbished instrument, new Windows computer, Data Collection software, choice of one analysis software package, installation by an Applied Biosystems “5-Step Certified" Field Service Engineer, chemistry kit, training, new parts and a one year warranty. Availability may be limited.

• Run a wide variety of sequencing and fragment analysis applications including microsatellite analysis, AFLP, LOH, SNP validation, and SNP screening.
• Reduce maintenance time by eliminating manual syringe washing and filling with automated polymer delivery.
• Increase your data quality for sequencing and fragment analysis applications – longer read length, and higher resolution with shorter run times.
• Increase laboratory productivity and turnaround time by processing 96- or 384-well plates with a four-capillary array.

Perform a Wide Range of Applications
The Applied Biosystems 3130 Genetic Analyzer is more than just a DNA sequencer. You can run a wide variety of sequencing and fragment analysis applications including microsatellite analysis, AFLP, LOH, SNP validation, and SNP screening – as well as de novo sequencing and resequencing (mutational profiling). The full range of applications can be run on a single polymer and capillary array meaning you can run mixed applications on one plate. The software even includes tools to assist with regulatory and compliance requirements (In the United States, this assists with FDA 21CFR part 11).

Easy to Use
Reduce maintenance time by eliminating manual syringe washing and filling with the new automated polymer delivery system. No more handling of polymer syringes for set up and maintenance. Samples are automatically injected into the four-capillary arrays, and – unlike slab-gel systems – only minimal amounts of DNA are required for accurate analysis. Seamlessly switch between sequencing and fragment analysis runs, even in the same plate with the expanded one-polymer, one-array functionality for both sequencing and fragment analysis applications.

Superior Data Quality
Simply set up your sample and then sit back and watch as the analyzer's ultra-rapid sequencing gives you high-quality data (with Length of Read longer than 500 bp) in less than 35 minutes. Achieve accurate read lengths of 1,000 base pairs (bp) or longer in a single sequencing reaction using the 80 cm capillary array and the 3130 POP-7™ polymer.

Ideal for Growing Labs
The flexible, four-capillary 3130 system gives you all the advanced automation and superior performance of Applied Biosystems 3130xl platform, at acquisition and operating costs tailored to a growing research lab. And as your throughput needs increase, you can easily upgrade the system to 16 capillaries. It is the perfect way to get the capacity and savings you need today – without limiting your growth options. Researchers who own an ABI PRISM® 3100-Avant or 3100 Genetic Analyzer can upgrade to the new Applied Biosystems 3130 or 3130xl Genetic Analyzer.

3130 and 3130xl instruments are CE marked and compliant with the specifications and requirements as set in the EMC directive 89⁄336⁄EEC and the Low Voltage directive 73⁄23⁄EEC.

For Research Use Only. Not for use in diagnostics procedures.

3730xl DNA Analyzer (factory refurbished) (Applied Biosystems™)

The 96-capillary 3730xl DNA Analyzer is the Gold Standard for high throughput genetic analysis. Use this for DNA fragment analysis applications such as microsatellites, AFLP, SNP analysis, mutation detection and traditional DNA sequencing. Get the highest quality data at a low cost per sample. This instrument is refurbished by the original manufacturer to meet both manufacturing and product specifications. This system includes the refurbished instrument, new Windows computer, Data Collection software, choice of one analysis software package, installation by an Applied Biosystems “5-Step Certified" Field Service Engineer, chemistry kit, training, new parts and a one year warranty. Availability may be limited.

• Higher optical sensitivity and advanced polymers enable you to obtain higher-quality sequencing data for less.
• Multiple automation features decrease costly human errors.
• Optimized polymers increase your productivity without compromising your results.
• Perform a wide variety of sequencing and fragment analysis applications including resequencing, microsatellite analysis, AFLP, LOH, SSCP, SNP screening and SNP validation.

Large-Scale DNA Analysis on a Small-Scale Budget
By combining advances in automation with innovative optics and proprietary reagents to increase throughput, yield high-quality data, and minimize reagent consumption, the 3730xl Analyzer provides your laboratory and production facility with faster, better, cheaper analysis.

Streamline Your Workflow
The 3730xl DNA Analyzer system is engineered for highly reliable, unattended operation of up to 48 hours (applies to modules with run times longer than 30 minutes). To minimize the need for operator intervention and decrease the risk of human error, automation features include an integrated plate stacker, internal bar code reader, and onboard polymer delivery system.

Increase Productivity
The high signal-to-noise ratio ensures you get high-quality data – even when you use low-concentration samples and reagents. Labor-saving automation features minimize hands-on time and enable you to analyze more data more efficiently.

Get the Highest-Quality Sequencing and Genotyping Data
The enhanced optical design provides a higher signal-to-noise ratio and a more uniform signal profile across the array. This design, combined with our new, advanced polymer, enables the longest read lengths of any available system, and provides enhanced color balance for streamlined genotyping sample handling. In addition, exceptional sensitivity enables higher success rates across a wide range of sample template types and concentrations.

One Instrument, Multiple Applications
With the 3730xl DNA Analyzer, you get the highest-quality data from a wide array of applications. In addition to being ideal for high-throughput sequencing, the analyzer's optimized application assays, instrument, and analysis software also provide a complete solution for genotyping and resequencing.

Integrated Data Analysis Tools Reduce Time-to-Results
The 3730xl DNA Analyzer software suite allows you to generate more meaningful data with less work. This system's labor-saving software suite includes:
• Data Collection (supplied with the instrument): Manages your instrument setup, controls instrument operations, allows real-time data visualization, and performs diagnostics.
• Sequencing Analysis Software: Designed to base-call; assign quality values; trim, display, edit and print DNA sequencing data using the KB basecaller.
• Seqscape®: Provides everything you need to perform resequencing applications such as VariantSEQr™ Resequencing System.
• GeneMapper®: Enables configurable, automated allele calling – a plus for high-throughput genotyping and includes tools for SNPlex™ data analysis

New features include:
• Auto-analysis with GeneMapper® and SeqScape®
• Flexibility to use any choice in dye set option
• Tools to assist with regulatory and compliance requirements (In the United States, this assists with FDA 21CFR part 11).
• Additional optimized run modules covering more applications
• Support for fragment analysis applications on the 96-capillary array

The instrument comes with a one year limited warranty on parts and labor.

For Research Use Only. Not for use in diagnostics procedures.

3500xL Genetic Analyzer for Protein Quality Analysis, with software (Applied Biosystems™)

The 3500xL Genetic Analyzer for Protein Quality Analysis is a capillary electrophoresis instrument with a 24-capillary array specifically designed to support the demanding performance needs of biopharmaceutical screening and quality control environments, while retaining the unsurpassed application versatility appreciated by scientists working in analytical and process development environments. The instrument enables parallel analysis of 24 samples without compromising on the run time per sample, thereby enabling high throughput analysis with high quality data. This system includes a 24-capillary instrument, GlycanAssure™ Acquisition and Analysis Software, a Dell Workstation and monitor, as well as reagent kits for system qualification.

Features include:
• A 24-capillary system for high throughput analysis
• Single-line, 505 nm, solid-state, long-life laser that utilizes a standard power supply and requires no heat-removal
• Powerful, integrated data acquisition and analysis software that provides real-time assessment of data
• Radio frequency identification (RFID) technology that tracks key consumables data and records administrative information
• Advanced multiplexing capabilities for glycan analysis with up to six unique dyes
• Unrivaled application flexibility—one array and one polymer are used for most applications
• Simple setup, operation, and maintenance

Request more information >

Accurate, precise, and reliable data quality
The 3500 Series systems significantly improve signal uniformity from instrument-to-instrument, run-to-run, and capillary array-to-capillary array. The system provides accurate, reproducible, and precise relative quantitation of glycan levels.

Ready-to-use consumables with RFID tags
The 3500 Series systems introduce ready-to-use consumables with pre-packaged polymer pouches, cathode and anode buffer containers, and easy-to-install capillary arrays. Each of these consumables is integrated with RFID tags that enable viewing, tracking, and reporting of critical information about reagents and consumables, including usage, lot number, part number, expiry date, and on-instrument lifetime within the GlycanAssure data acquisition software.

Easy-to-use data acquisition and data analysis software
GlycanAssure data acquisition software breaks new ground in user-friendly navigation with an intuitive dashboard design, highly visible buttons for common operations, easy-to-read graphical displays to monitor the state of consumables, simplified plate setup, and a handy maintenance scheduling calendar functionality. GlycanAssure data analysis software allows quick viewing of analyzed and un-analyzed samples and quick comparison of different analysis methods. It includes built-in primary analysis with quality control, so you can make decisions about the quality of data as it is produced without the need to transfer output files to other software.

Additional products
The following products are required for use with this system:
A31278: Anode Buffer Container (ABC) for 3500 Series for Protein Quality Analysis
A31279: Cathode Buffer Container (CBC) for 3500 Series for Protein Quality Analysis
A30936: POP-7™ for Protein Quality Analysis (384 samples)
A31122: POP-7™ for Protein Quality Analysis (960 samples)



Ion GeneStudio™ S5 Prime System (Ion Torrent™)

The Ion GeneStudio S5 Prime System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows. For core and service labs requiring maximum throughput and rapid turnaround time from a benchtop NGS system, the Ion GeneStudio S5 Prime System enables unparalleled breadth and depth, from large panels or exomes to clinical oncology research focused on low allele frequency applications. With cartridge-based reagents, the system is simple to use and offers scalability and flexibility. It uses Ion 5 Series chips to support a broad range of high-throughput sequencing for clinical research and research applications from microbial genomes and gene panels to exomes and transcriptomes.

Key features:
• Select the chip (Ion 510–550 chip) that fits your application and throughput needs to achieve from 2–130 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments

The Ion GeneStudio S5 Series
The Ion GeneStudio S5 Series sequencers share the same foundational technology and fluidic architecture across all three instruments: the Ion GeneStudio S5 System, the Ion GeneStudio S5 Plus System, and this Ion GeneStudio S5 Prime System. The primary difference across the three instruments is on-sequencer analysis time.

Speed
The Ion GeneStudio S5 Series leverages the speed of semiconductor sequencing to enable the production of high quality sequencing data in a few hours and enables you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time when paired with the Ion Chef System.

Simplicity
With single-day installation, a straightforward user interface, and cartridge-based reagents, the Ion GeneStudio S5 Series sequencers are easy to use. Combined with Ion AmpliSeq technology for target selection, the Ion Chef System for automated library and template preparation, and Ion Reporter Software for automated variant annotation, targeted sequencing is simpler than ever.

Small sample input
Low input DNA from challenging samples types such as formalin-fixed paraffin-embedded (FFPE) tissue, retrospective samples from fine needle aspirates, and cell-free DNA extracted from blood (cfDNA) can be difficult to sequence on competitor next-generation sequencers. However, with Ion AmpliSeq technology and the Ion GeneStudio S5 Series, you can use as little as 1 ng input DNA or RNA.

Scalability
Why buy multiple systems for your lab when you can run all of your targeted sequencing or microbial applications on a single next-generation sequencer? The Ion 5 Series chips that run on the Ion GeneStudio S5 Series provide several throughput options, so your lab has the flexibility to scale from small to large projects, enabling multiple targeted sequencing applications on a single system.

Simple analysis and storage solutions
Torrent Suite Software and Ion Reporter Software make NGS easy for beginners and experts alike. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Ion Reporter Software (Thermo Fisher Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

SeqStudio™ Genetic Analyzer System with SmartStart (Applied Biosystems™)

The Applied Biosystems SeqStudio Genetic Analyzer is a 4-capillary, fluorescence-based capillary electrophoresis system designed to provide users with an integrated experience that is easy, efficient, and versatile for research in genetic analysis. The all-in-one reagent cartridge allows easy operation for multiple users with the flexibility to perform both sequencing and fragment analysis in a single run. The simplified SeqStudio Plate Manger software is well-suited for first-time and experienced users. Be more connected to your data than ever with intuitive browser-based software and cloud-based connectivity options for remote monitoring, and data transfer and analysis.

The SeqStudio system gives you the same data quality, reliability, and support you have come to expect from the Applied Biosystems brand with a modernized experience. Same workflow, same trusted data. Now with one-click convenience.

Key features
• Simplified instrument software with interactive touch screen for greater ease of use
• Minimized hands-on setup time with integrated reagents cartridge (SeqStudio Cartridge)
• Application flexibility to run Sanger sequencing and fragment analysis on the same run
• Connectivity: Wi-Fi or wired Ethernet connection
• Web-enabled remote monitoring capability
• Consumables usage tracking through radio frequency identification (RFID)

This package includes:
• 4-capillary SeqStudio Genetic Analyzer
• SeqStudio Analysis Software (GeneMapper, Sequencing Analysis, Minor Variant Finder, Variant Reporter, and SeqScape)
• SeqStudio Plate Manager Software
• 1Day SmartStart Orientation
Note: SeqStudio Cartridge and other system consumables and reagents sold separately

Just click. That's it.
Load up your samples, click in the cartridge, and go—no need for technical experts for setup or maintenance, no calibration before each run, and no installation of capillaries, polymer, and anode buffer. The cartridge is stable for 4 months on the instrument.

Access your data anytime, anywhere*
This system features Thermo Fisher Cloud connectivity so you can set up your run, check its progress, and access your data from wherever you have Internet access, all without the need to stay in the lab.* Get the same data quality, service, and support you’ve come to expect from Applied Biosystems technology with a modernized experience at a price any lab can afford.
* Internet connection and Thermo Fisher Cloud account required.

Service, support, and training
We offer a range of service options, plans, and warranties to improve productivity, increase instrument uptime, and lower the total cost of ownership. SmartStart orientation helps get you started with your new instrument more quickly.

Software
SeqStudio Genetic Analyzer Instrument Software, v 1.1Software update fileRelease notesEULA
SeqStudio Genetic Analyzer Plate Manager Software, v1.1Windows installerMac installer
Sequence Analysis Software patch for SeqStudio supportInstallerRelease notes 
SeqScape Software patch for SeqStudio supportInstallerRelease notes 
Variant Reporter Software patch for SeqStudio supportInstallerRelease notes 
GeneMapper Client Software patch for SeqStudio supportInstallerRelease notes 
GeneMapper Full Software patch for SeqStudio supportInstallerRelease notes 
Minor Variant Finder Software patch for SeqStudio supportInstaller 


3500 Genetic Analyzer for Protein Quality Analysis (Applied Biosystems™)

The 3500 Genetic Analyzer for Protein Quality Analysis is a capillary electrophoresis instrument with an 8-capillary array specifically designed to support the demanding performance needs of biopharmaceutical screening and quality control environments, while retaining the unsurpassed application versatility appreciated by scientists working in analytical and process development environments. The instrument enables parallel analysis of 8 samples without compromising on the run time per sample, thereby enabling high throughput analysis with high quality data.

This system includes an 8-capillary instrument and a Dell Workstation and monitor, as well as reagent kits for system qualification. For a system that includes GlycanAssure™ Acquisition and Analysis Software, please see Cat. No. A30886.

Features include:
• An 8-capillary system that can easily be upgraded to a 24-capillary system when you need higher throughput
• Single-line, 505 nm, solid-state, long-life laser that utilizes a standard power supply and requires no heat removal
• Radio frequency identification (RFID) technology that tracks key consumables data and records administrative information
• Advanced multiplexing capabilities for glycan analysis with up to six unique dyes
• Unrivaled application flexibility—one array and one polymer are used for most applications
• Simple setup, operation, and maintenance

Request more information >

Accurate, precise, and reliable data quality
The 3500 Series systems significantly improve signal uniformity from instrument-to-instrument, run-to-run, and capillary array-to-capillary array. The systems provide accurate, reproducible, and precise relative quantitation of glycan levels.

Ready-to-use consumables with RFID tags
The 3500 Series systems introduce ready-to-use consumables with pre-packaged polymer pouches, cathode and anode buffer containers, and easy-to-install capillary arrays. Each of these consumables is integrated with RFID tags that enable viewing, tracking, and reporting of critical information about reagents and consumables, including usage, lot number, part number, expiry date, and on-instrument lifetime within the GlycanAssure data acquisition software.

Additional products
The following products are required for use with this system:
A31278: Anode Buffer Container (ABC) for 3500 Series for Protein Quality Analysis
A31279: Cathode Buffer Container (CBC) for 3500 Series for Protein Quality Analysis
A30936: POP-7™ for Protein Quality Analysis (384 samples)

3500 Genetic Analyzer for Sequence Typing & Fragment Analysis (Applied Biosystems™)

This 8-capillary Genetic Analyzer is specifically configured with software for both fragment analysis and sequence typing applications.

We set a new standard in capillary electrophoresis with the 8-capillary 3500 Genetic Analyzer. These instruments are specifically designed to support the demanding performance needs of validated and process controlled environments, while retaining the unsurpassed application versatility that life science researchers expect from us.

• An 8 capillary system that can easily be upgraded to a 24-capillary system when you’re ready.
• New single-line 505 nm, solid-state long-life laser – utilizes a standard power supply; requires no heat-removal ducting.
• Powerful, integrated data collection and primary analysis software provides real-time assessment of data quality.
• Radio Frequency Identification (RFID) technology tracks key consumables data and records administrative information.
• Advanced multiplexing capabilities for DNA fragment analysis with up to six unique dyes.
• Unrivaled application flexibility – one array and one polymer are used for most applications.
• Simple setup, operation and maintenance – the easiest-to-run, easiest-to-own DNA sequencer to date.

Accurate Reliable Data Quality
The 3500 series systems significantly improves signal uniformity from instrument-to-instrument, run-to-run, and capillary-to-capillary. With a combination of intelligent hardware, powerful new algorithm and reagent combinations, these methods provide major reduction in the range of signal peak heights obtained across multiple 3500 series instruments (see figure 1).

Improved Sizing Precision
New thermal sub-system design gives enhanced performance in demanding fragment applications enabling improved sizing precision versus previous generations of capillary electrophoresis platforms (see figure 2).

Ready to Use Consumables With RFID Tags
The 3500 series introduces ready-to-use consumables with pre-packaged polymer pouches, cathode and anode buffer containers and easy-to-install capillary arrays. Each of these consumables is integrated with RFID tags that enable viewing, tracking and reporting of critical information about reagents and consumables including usage, lot number, part number, expiry date and on-instrument lifetime within the 3500 Series Data Collection Software (see figures 3 and 4).

Easy to Use New Data Collection Software
3500 Series Data Collection software breaks new ground in user-friendly navigation with an intuitive dashboard design, highly visible buttons for common operations, easy-to-read graphical displays to monitor the state of consumables and handy maintenance scheduling calendar functionality. New functionality includes simplified plate set-up, built-in primary analysis with quality control, so you can make decisions about the quality of data as it is produced on the instrument without the need to transfer output files into secondary analysis software packages (see figures 4 & 5).

For Research Use Only. Not for use in diagnostics procedures.

3500xL Dx Genetic Analyzer CS2 (Applied Biosystems™)

The 3500 Dx Genetic Analyzer CS2 is the latest addition to our family of Applied Biosystems® genetic analyzers based on capillary electrophoresis. The 3500 Dx Genetic Analyzer CS2 is an IVD-labeled instrument, making it the first Sanger sequencing platform cleared for sequencing analysis of DNA.

Confidence in Your Results
• The 3500 Dx Genetic Analyzer CS2 is an IVD-labeled platform for Sequencing-Based Typing using SeCore® HLA typing kits. Sanger sequencing is known as the "gold-standard" for its accuracy, reliability, and ease of use. It is also used for confirmatory sequencing by clinical labs.
• High accuracy: 99% concordance as shown in clinical trials using SeCore® HLA typing kits
• Proven through decades of results—including sequencing of the first human genome—Applied Biosystems® genetic analysis systems are trusted standards for Sanger sequencing.

You can now feel even more comfortable adopting the 3500 Dx Genetic Analyzer CS2 platform for the development of assays for FDA submission.

Simplicity and Efficiency
• Reduced instrument hands-on time with simplified installation and removal of consumables and accessories
• Controlled and efficient run setup with intuitive user interface, preconfigured plate templates, and software-controlled functions (plate setup, data collection, analysis)
• Instrument run-times as short as 1 hour; sample-to-result in as little as 1.5 days
• Maintenance calendar with programmable prompts and service history
• Security and electronic signature, RFID (radio frequency identification) tracking of consumables, built-in quality controls, and real-time data quality evaluation

The 3500 Dx Genetic Analyzer CS2 is a partner in your laboratory, making it easy for you to comply with various industry standards and simplifying the training of new users.

Flexibility
• Collect data in either IVD (diagnostic for HLA typing) or RUO mode
• Develop other applications in RUO mode, including de novo sequencing and re-sequencing, as well as fragment analysis applications such as microsatellite analysis, MLPA®, LOH, MLST, and SNP confirmation or screening
• Partner with us to develop assays for FDA submission
• Different configurations to meet your throughput needs: 24-capillary (3500xL Dx) and 8-capillary (3500 Dx) versions

The 3500 Dx Genetic Analyzer CS2 is a trusted capillary electrophoresis-based sequencing platform for development of your new assays. Capillary electrophoresis-based applications are supported by a large number of publications over the many years that these applications have been used successfully in laboratory testing.

IVD-labeled Accessories and Consumables
The purchase of a 3500 Dx Genetic Analyzer CS2 includes a computer system and associated Data Collection software, as well as an installation kit containing the initial set of accessories and reagents needed to start using the instrument right away. The 3500 Dx Genetic Analyzer CS2 installation includes a full install qualification and operational qualification, as well as instrument training to introduce you to your new genetic analyzer.

The 3500 Dx is backed by a comprehensive Service & Support program with options to purchase additional services depending upon your laboratory maintenance and audit requirements.

Intended Use
The Applied Biosystems® 3500 Dx and 3500xL Dx Genetic Analyzers CS2 with 3500 Dx Series Software 2011 (v1) are in vitro diagnostic devices intended for the sequencing (detection and identification) of fluorescently labeled DNA by capillary electrophoresis.

The Applied Biosystems® 3500 Dx/3500xL Dx Genetic Analyzers CS2 with 3500 Dx Series Software 2011 (v1) are indicated for use with FDA-cleared or approved sequencing assays specifying their use and only by technologists trained in laboratory techniques, procedures, and use of the analyzer.

Note: The 3500 Dx Genetic Analyzer CS2 data collection software uses Windows 7 SP0 operating system. This makes the currently available RUO secondary analysis software incompatible for use on the same system. A separate computer is required to do secondary analysis if operating in RUO mode.

Ion Proton™ System (Ion Torrent™)

The Ion Proton™ System is the first benchtop sequencing system capable of human-scale genome, exome, or transcriptome sequencing in a few hours—with DNA-to-variants called in a single day.

The system combines semiconductor sequencing technology with natural biochemistry to directly translate chemical information into digital data. By leveraging the exponential improvements in the semiconductor industry (known as Moore’s Law), the Ion Proton™ Sequencing System provides an unprecedented level of scalability and flexibility to support a broad range of high throughput sequencing applications, ranging from human-scale genome to exome to transcriptome sequencing. The system’s use of the simplest natural sequencing chemistry eliminates the need for expensive optics and complex sequencing chemistries, resulting in a highly affordable sequencing system to own and operate. Real-time, direct, electrical detection of sequencing, combined with the enormous amount of computing power in both the Ion Proton™ Sequencer and Ion Proton™ Torrent Server, enables generation of high quality sequencing results from DNA library to variants in a single day.

Features of the Ion Proton™ System:

Fastest high-throughput next-generation sequencing workflow with the fastest sequencing run-times of 2–4 hours on the Ion PI™ Chip
Highest number of complete sequencing runs per week, with a simple and automated workflow (when used with the Ion OneTouch™ 2 System)
Simple semiconductor sequencing workflows with robust and simple hardware that can be relied upon—no cameras, no optics, and no lasers
Scalable, high throughput sequencing capabilities enabling up to 200-base single reads and flexible library options (e.g., fragment gDNA, targeted/exome, RNA)
Small benchtop footprint and mounting capability (with optional rack) (two Ion Proton™ systems per rack), to deliver the only benchtop genome center
Low-cost platform and attractively priced semiconductor chips and reagents for a range of applications
Proven Ion semiconductor sequencing requires no complex optics and employs natural nucleotides to deliver highly accurate variant detection, uniformity of coverage, and sensitivity to detect low frequency variants
Range of fast and simple library solutions and kits with low-input requirements for a variety of applications, such as genomic sequencing, exome sequencing, sequencing sets of genes, and RNA sequencing
Complete end-to-end solution from base calls to variants with the Proton™ Torrent Server and Torrent Suite Software v3.0
Simple and integrated tools for tertiary data analysis with Ion Reporter™ Software for DNA variation analysis across single, paired, or trio samples

With the availability of the groundbreaking Ion Proton™ System, rapid, high throughput sequencing is finally accessible by all laboratories.

Affordable Sequencing For Nearly Every Lab
Previous sequencing technologies have relied upon optical systems as bridges between the chemical and digital forms of sequence information. These systems have added tremendous costs to sequencers, relegating them to only the largest laboratories. By eliminating the need for the optical system, the Ion Proton™ System provides high throughput sequencing that is simpler, faster, more cost effective, and more scalable than any other technology available. With a benchtop footprint, low-cost sequencing reagents, and a simple touchscreen user interface, the Ion Proton™ System brings high throughput, next generation sequencing to nearly every lab.

Ion Power: PostLight™ Sequencing Produces Bits From Bases
The sequencing technology underlying the Ion Proton™ System exploits a well-characterized biochemical process: When a nucleotide is incorporated into a strand of DNA by a polymerase, a hydrogen ion (H+) is released as a byproduct. This hydrogen ion carries a charge that the Proton™ System’s ion sensor—essentially the world's smallest solid-state pH meter—can detect. As the sequencer floods the chip with one nucleotide after another, any nucleotide added to a DNA template will be detected as a voltage change, and the Ion Proton™ System will call the base. If a nucleotide is not a match for a particular template, no voltage change will be detected and no base will be called for that template.

Massively Parallel Sequencing On Your Bench
A principal component of the Ion Proton™ System is the sequencing chip. The Ion PI™ Chip incorporates an extremely dense array of >165 million micro-machined wells married to our proprietary ion sensor. Each well contains a different DNA template, allowing massively parallel sequencing. With the Ion PI™ Chip (165 million wells), the Ion Proton™ System enables a range of high throughput genomic applications from human-scale exome sequencing to whole transcriptome sequencing.

The Right Tool To Get Results Easily, Reliably, and Quickly
Because it detects nucleotide incorporation without the use of light, the Ion Proton™ System uses the simplest sequencing chemistry possible: natural nucleotides. There is no need for expensive and error-prone modified bases, enzymatic cascades, chemiluminescence, or fluorescence. Direct detection also means the incorporation of each nucleotide is recorded in seconds. As a result, you can do an entire sequencing run typically in a few hours.

Services and Support
Service and support plans—comprehensive plans to maximize instrument performance and ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

Ion PGM™ Dx System (Ion Torrent™)

The Ion PGM™ Dx System is a reliable and robust in vitro diagnostic (IVD) next-generation sequencing (NGS) platform that is designed to deliver the proven performance and simplicity of the Ion Torrent™ PGM system, while empowering clinical laboratories with the flexibility to develop molecular diagnostic assays to help meet their evolving needs.

The Ion PGM™ Dx System:
• Offers a complete, simple, and cost-effective IVD NGS instrument system solution
• Enables highly reproducible and accurate genetic variant analysis with as little as 10 ng of input DNA
• Provides rapid turnaround time from sample to variant analysis in <2 days
• Enables molecular diagnostic assay developers the flexibility to publish protocols in a locked workflow environment
• Helps increase laboratory efficiency with integrated software that supports sample and reagent tracking, auditing, and traceability compliance
• Supports role-based workflows to help ensure a higher level of results integrity

Proven technology and performance
The Ion PGM™ Dx System is built on proven Ion Torrent™ Post-Light™ Ion Semiconductor Sequencing technology that is well-established and adopted globally in life sciences and clinical research. With this system, the technology has been refined and designed specifically to help meet the increasing needs of the diagnostic laboratory environment. The system provides a comprehensive set of instruments, reagents & consumables, and integrated software developed under stringent design control with a complete design history file, and manufactured under GMP to help ensure performance and quality standards are met.

Results generated using the Ion PGM™ Dx System proved highly reproducible in a validation study across multiple sites, operators, and reagent kits. Overall system performance was excellent with an average SNV sensitivity of >99.5%. The system was validated using challenging germline variants, with library generation based on proven Ion AmpliSeq™ technology, enabling accurate and reliable genetic analysis even with input DNA amounts as low as 10 ng.

Flexibility & scalability
The Ion PGM™ Dx platform empowers clinical laboratories with the flexibility and scalability to reliably develop and implement their own molecular diagnostic assays using the Ion PGM™ Dx System and GMP manufactured reagent sets combined with their choice of targeted analyte specific reagents. Leveraging Ion Ampliseq™ ultrahigh-multiplex PCR targeted library generation technology, the system enables assay developers to define and customize their assay primer sets of any panel size, and to validate, lock, and publish protocols in a role-based workflow environment for implementation into routine use.

Simple & efficient workflow to help maximize throughput
The Ion PGM™ Dx System delivers the speed and simplicity of the Ion Torrent™ platform, combined with key workflow advantages designed specifically for regulated laboratory environments and in vitro diagnostic applications. A simplified instrument and assay workflow, as well as intuitive software, further automate the testing turnaround time, providing rapid sample-to-variant analysis results in as little as 2 days. Additionally, the validated workflow enables multiplexing of up to 16 samples within a single sequencing run, making it a cost-effective and flexible approach.

Integrated secure software helps ensure high integrity results
Ion PGM™ Dx Torrent Suite™ software is an integrated software system that manages and tracks the entire run process from sample definition to variant analysis, providing full data traceability and auditable run analysis—a necessary part of 21CFR Part 11 compliance. With a user-friendly intuitive software interface, multi-tier role-based workflows, and a suite of parameter controls, the software aids clinical laboratories in maintaining high performance standards and helps ensure a higher level of results integrity.

The unique capabilities and features of the Ion PGM™ Dx System designed specifically for regulated laboratory environments make it a suitable next-generation sequencing platform-of-choice for nearly every clinical diagnostic laboratory.

Services and support
Service and support plans—comprehensive plans to maximize instrument performance and ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

Intended use
The Ion PGM™ Dx Instrument System is composed of a sequencing instrument that measures the hydrogen ions that are generated during the incorporation of nucleotides in the DNA sequencing reaction and the ancillary instrumentation necessary for sample processing. This instrument system is used in conjunction with the instrument-specific Ion PGM™ Dx Library Kit, Ion OneTouch™ Dx Template Kit, Ion PGM™ Dx Sequencing Kit, and Ion 318™ Dx Chip Kit, and data analysis software. The Ion PGM™ Dx Instrument System is intended for targeted sequencing of human genomic DNA from peripheral whole-blood samples. The Ion PGM™ Dx Instrument System is not intended for whole genome or de novo sequencing.

HID Ion GeneStudio™ S5 System (Ion Torrent™)

The HID Ion GeneStudio S5 System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows. The system is optimized to provide affordability for labs focused on smaller panels and with lower sequencing throughput requirements. With cartridge-based reagents, the system is simple to use and offers scalability and flexibility. It uses Ion 5 Series chips to support a broad range of forensic sequencing applications, including mitochondria sequencing, STR analysis, and SNP genotyping.

Features of the HID Ion GeneStudio S5 System include:
• Select the chip (Ion 510–540 chip) that fits your application and throughput needs to achieve from 2–80 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments

The Ion GeneStudio S5 Series
The HID Ion GeneStudio S5 Series sequencers share the same foundational technology and fluidic architecture across all three instruments: this HID Ion GeneStudio S5 System, the HID Ion GeneStudio S5 Plus System, and the HID Ion GeneStudio S5 Prime System. The primary difference across the three instruments is on-sequencer analysis time.

Speed
The HID Ion GeneStudio S5 Series sequencers leverage the speed of semiconductor sequencing to enable the production of high-quality sequencing data in a few hours and enable you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time when paired with the HID Ion Chef System.

Simplicity
With single-day installation, a straightforward user interface, and cartridge-based reagents, the HID Ion GeneStudio S5 Series sequencers are easy to use. Combined with Precision ID library prep technology for target selection, the HID Ion Chef System for automated library and template preparation, and Converge Software for automated analysis, forensic sequencing is simpler than ever.

Small sample input
Low input DNA amounts from challenging sample types such as touch DNA or other forensic samples can be difficult to sequence on competitor next-generation sequencers. However, with Precision ID library preparation and sequencing technology and the HID Ion GeneStudio S5 Series sequencers, you can use as little as 100 pg of DNA input and achieve accurate, robust results.

Scalability
Why buy multiple systems for your lab when you can modulate your throughput by chip selection on a single next-generation sequencer? The Ion 5 Series chips that run on the HID Ion GeneStudio S5 Series systems provide several throughput options, so your lab has the flexibility to scale from small to large projects, enabling multiple forensic applications on a single system.

Simple analysis and storage solutions
Torrent Suite Software and Converge Software make NGS easy for beginners and experts alike. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Converge Software (Thermo Fisher Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and help ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

3500xL Genetic Analyzer for Resequencing & Fragment Analysis (Applied Biosystems™)

The 3500xL 24-capillary platform can run a wide variety of applications, including de novo sequencing and resequencing (mutational profiling), as well as microsatellite analysis, MLPA™, LOH, MLST, AFLP® and SNP validation or screening. The majority of applications can be run on a single polymer and capillary array.

This package includes a 24-capillary instrument, 3500 Series Data Collection Software, a Dell Workstation and monitor, as well as reagent kits for system qualification and secondary analysis software. The 3500 Series Data Collection Software supports sequencing and fragment analysis, and integrates seamlessly with downstream software for secondary analysis of genetic data. This package includes such secondary software: GeneMapper® software for fragment analysis and software for resequencing applications.

Features include:

• An 8 capillary system that can easily be upgraded to a 24-capillary system when you’re ready.
• Single-line, 505 nm, solid-state, long-life laser that utilizes a standard power supply and requires no heat-removal ducting
• Powerful, integrated data collection and primary analysis software provides real-time assessment of data quality
• Radio frequency identification (RFID) technology tracks key consumables data and records administrative information
• Advanced multiplexing capabilities for DNA fragment analysis with up to six unique dyes
• Unrivaled application flexibility—one array and one polymer are used for most applications.
• Simple setup, operation and maintenance

Accurate Reliable Data Quality
The 3500 series systems significantly improves signal uniformity from instrument-to-instrument, run-to-run, and capillary-to-capillary. With a combination of intelligent hardware, powerful new algorithm and reagent combinations, these methods provide major reduction in the range of signal peak heights obtained across multiple 3500 series instruments (see figure).

Improved Sizing Precision
New thermal sub-system design gives enhanced performance in demanding fragment applications enabling improved sizing precision versus previous generations of capillary electrophoresis platforms.

Ready to Use Consumables With RFID Tags
The 3500 series introduces ready-to-use consumables with pre-packaged polymer pouches, cathode and anode buffer containers, and easy-to-install capillary arrays. Each of these consumables is integrated with RFID tags that enable viewing, tracking, and reporting of critical information about reagents and consumables including usage, lot number, part number, expiry date, and on-instrument lifetime within the 3500 Series Data Collection Software.

Easy to Use Data Collection Software
3500 Series Data Collection software breaks new ground in user-friendly navigation with an intuitive dashboard design, highly visible buttons for common operations, easy-to-read graphical displays to monitor the state of consumables and handy maintenance scheduling calendar functionality. New functionality includes simplified plate set-up and built-in primary analysis with quality control, so you can make decisions about the quality of data as it is produced on the instrument without the need to transfer output files into secondary analysis software packages.

Ion GeneStudio™ S5 for Agrigenomics (Ion Torrent™)

The Ion GeneStudio S5 System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows. The Ion GeneStudio S5 System is optimized to provide affordability for labs focused on smaller panels and lower sequencing throughput requirements. With cartridge-based reagents, the system is simple to use and offers scalability and flexibility. It uses Ion 5 Series chips to support a broad range of high-throughput sequencing for clinical research and research applications from microbial genomes and gene panels to exomes and transcriptomes.

Key features:
• Select the chip (Ion 510–540 chip) that fits your application and throughput needs to achieve from 2–80 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments

The Ion GeneStudio S5 Series
The Ion GeneStudio S5 Series sequencers share the same foundational technology and fluidic architecture across all three instruments: this Ion GeneStudio S5 System, the Ion GeneStudio S5 Plus System, and Ion GeneStudio S5 Prime System. The primary difference across the three instruments is on-sequencer analysis time.

Speed
The Ion GeneStudio S5 Series leverages the speed of semiconductor sequencing to enable the production of high quality sequencing data in a few hours and enables you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time when paired with the Ion Chef System.

Simplicity
With single-day installation, a straightforward user interface, and cartridge-based reagents, the Ion GeneStudio S5 Series sequencers are easy to use. Combined with Ion AmpliSeq technology for target selection, the Ion Chef System for automated library and template preparation, and Ion Reporter Software for automated variant annotation, targeted sequencing is simpler than ever.

Small sample input
Low input DNA from challenging samples types such as formalin-fixed paraffin-embedded (FFPE) tissue, retrospective samples from fine needle aspirates, and cell-free DNA extracted from blood (cfDNA) can be difficult to sequence on competitor next-generation sequencers. However, with Ion AmpliSeq technology and the Ion GeneStudio S5 Series, you can use as little as 1 ng input DNA or RNA.

Scalability
Why buy multiple systems for your lab when you can run all of your targeted sequencing or microbial applications on a single next-generation sequencer? The Ion 5 Series chips that run on the Ion GeneStudio S5 Series provide several throughput options, so your lab has the flexibility to scale from small to large projects, enabling multiple targeted sequencing applications on a single system.

Simple analysis and storage solutions
Torrent Suite Software and Ion Reporter Software make NGS easy for beginners and experts alike. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Ion Reporter Software (Thermo Fisher Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

3500xL Genetic Analyzer for Fragment Analysis (Applied Biosystems™)

The 3500xL Genetic Analyzer is an 24-capillary sequencing instrument specifically designed to support the demanding performance needs of validated and process-controlled environments, while retaining the unsurpassed application versatility that life science researchers expect. The analyzer supports a wide variety of applications, including de novo sequencing and re-sequencing (mutational profiling), as well as microsatellite analysis, MLPA™, LOH, MLST, AFLP®, and SNP validation or screening. The majority of applications can be run on a single polymer and capillary array.

In addition to the 3500xL Genetic Analyzer, this fragment analysis package includes 3500 Series Data Collection Software, a Dell Workstation and monitor, reagent kits for system qualification, and secondary analysis software. 3500 Series Data Collection Software supports sequencing and fragment analysis, and integrates seamlessly with downstream software for secondary analysis of genetic data. GeneMapper™ secondary analysis software is included in this package.

Benefits and features of the 3500 Genetic Analyzer include:
Cost effective—lower running costs per sample and increased reagent life (14 days)
Easy setup—no special power outlets or external exhaust needed
Increased multiplexing—6-dye capability to interrogate more SNPs or markers
Easy-to-use software—integrated data collection and primary analysis software for real-time assessment of data quality
Consumables tracking—radio frequency identification (RFID) technology used for residual volume and expiry date tracking
Improved data uniformity—instrument-to-instrument, run-to-run, and capillary-to-capillary
More stable and precise fragment sizing due to improved oven temperature control
Smaller footprint versus 3130/3130xl instruments

Accurate and reliable data quality
The 3500 series systems significantly improve signal uniformity from instrument to instrument, run to run, and capillary to capillary. The combination of intelligent hardware and powerful algorithm and reagent combinations reduce the range of signal peak heights obtained across multiple 3500 series instruments.

Improved sizing precision
The thermal sub-system design provides enhanced performance during demanding fragment analysis applications, enabling improved sizing precision versus previous generations of capillary electrophoresis platforms.

Ready-to-use consumables with RFID tags
The 3500 series utilizes ready-to-use consumables with pre-packaged polymer pouches, cathode and anode buffer containers, and easy-to-install capillary arrays. Each of these consumables includes an integrated RFID tag that enables viewing, tracking, and reporting of critical information, including usage, lot number, part number, expiry date, and on-instrument lifetime, all within the 3500 Series Data Collection Software.

Easy-to-use data collection software
3500 Series Data Collection software features user-friendly navigation with an intuitive dashboard design, highly visible buttons for common operations, easy-to-read graphical displays to monitor the state of consumables, and a handy maintenance scheduling calendar. Additional features include simplified plate set-up and built-in primary analysis with quality control, so you can make decisions about the quality of data as it is produced on the instrument without the need to transfer output files into secondary analysis software packages.

3130 Genetic Analyzer to 3130xl Genetic Analyzer Upgrade Kit (Applied Biosystems™)

This is a system upgrade, from the 3130 Genetic Analyzer to the 3130xl Genetic Analyzer.

The 3130xl Genetic Analyzer is the latest generation of 16-capillary electrophoresis instruments for the medium throughput laboratories. The system offers industry-leading performance, plus sophisticated automation capabilities allowing researchers to save time, reduce costs and increase productivity.

Important Note: 3100 System Sequencers will be retired at the end of 2011. Take advantage of our limited time promotion to either TRADE-IN your 3100 for a brand new 3500 or UPGRADE to a 3130. Please contact your local Sales Representative to learn more.

For Research Use Only. Not for use in diagnostics procedures.

5500 Genetic Analyzer (Applied Biosystems™)

Built on three decades of sequencing expertise and powered by the proven accuracy of ligation-based sequencing, the new 5500 Genetic Analyzer provides a robust, affordable next-generation sequencing platform for every lab. Designed to give you the choice to optimize for turnaround time or throughput, the 5500 Genetic Analyzer is a highly accurate, cost-effective solution for analyzing one or many samples.

Key Benefits
• Sequencing right here, right now
• Cost-effective sequencing runs with individually configurable lanes
• Superior low frequency variant detection for whole exome sequencing or targeted resequencing
• Reproducibility, reliability, and quality for your RNA applications
• Confidence and uniformity in multiplexing with up to 96 barcodes
• Optimal analysis solutions for streamlined productivity and freedom to operate

Explore the Depths of Translational Research
With Exact Call Chemistry, the industry-leading accuracy of the 5500 Genetic Analyzer helps you get definitive answers about biological variation for applications like whole exome, RNA-seq, and structural variation.

Customize the System for Your Projects
The 5500 Genetic Analyzer allows you to tailor your sequencing runs precisely for your research. The six independent FlowChip lanes and Pay-Per-Lane Sequencing (PPL-Seq™) allow you to configure the instrument to different project scales and application types. Additionally, the system’s intelligent barcode kits can accommodate from one to hundreds of samples in a single run.

Don’t Wait
With the 5500 Genetic Analyzer, the unique capability to run each FlowChip lane independently allows you to turn around results in the shortest time possible. Now you can explore the genome, transcriptome, and epigenome with a hypothesis-neutral platform that combines powerful sequence data generation with premium accuracy. Whether you're running whole exome, RNA-seq, or a structural variation experiment, the 5500 Genetic Analyzer is designed to deliver high-quality results in a time-sensitive and cost-effective manner.

Perform Sequencing with Ease
Designed in collaboration with core facilities and principal investigators, the integrated 5500 Genetic Analyzer provides an intuitive and user-friendly workflow from sample preparation to data analysis.

Workflow Benefits Include:
• Embedded sequencing controls to enable real-time monitoring of data quality throughout the entire workflow
• System alerts to help maximize data quality and system performance, and to track reagent usage during the course of the sequencing run
• Easy-to-use software, 60% smaller data footprints, workstation computing, and standard base sequence file formats to facilitate setup, daily operations, and seamless integration with data analysis tools

Join the Era of Genomic Medicine
The throughput, broad range of applications, system flexibility, and intuitive design of the 5500 Genetic Analyzer address the needs of core and services laboratories, and basic and clinical research labs, to take sequencing into every scientific discipline.

A Community of Support
With more than 2,000 field personnel, we have the most extensive network of dedicated Field Application Specialists and Service Engineers in the industry. You can feel confident that we will be there when and where you need us most.

The 5500 Genetic Analyzer is For Research Use Only. Not intended for any animal or human therapeutic or diagnostic use.

Applied Biosystems™ RapidHIT™ ID System (Applied Biosystems™)

The Applied Biosystems RapidHIT ID System is a fast and simple-to-use instrument that produces trusted lab-quality forensic DNA profiles in 90 minutes. The system integrates sample preparation and capillary electrophoresis to generate DNA profiles that are aggregated within Applied Biosystems RapidLINK Software for direct upload to the database of choice or for further review and analysis.

The RapidHIT ID System delivers the reliable, reproducible, high-quality data you have come to expect from the Applied Biosystems brand. This system is for use with Applied Biosystems RapidLINK Software v1.0 and its v1.0 applications.

Features of the Applied Biosystems RapidHIT ID System include:
• Fast 90-minute system run time
• 1-minute hands-on time with integrated sample cartridge
• Consumables tracking through radio frequency identification (RFID)
• Intuitive touchscreen interface
• Facial recognition and barcode camera
• Fingerprint reader
• Up to six months of on-instrument time for the primary cartridge with refrigeration mechanism
• Expert system-capable
• Sample/data accessioning workflow-capable

3730 DNA Analyzer (Applied Biosystems™)

The 48-capillary 3730 DNA Analyzer is the Gold Standard in medium-to-high throughput genetic analysis. Use the 3730 DNA Analyzer for DNA fragment analysis applications such as microsatellites, AFLP, SNP analysis, mutation detection and traditional DNA sequencing. Get the highest quality data at a low cost per sample. This is upgradeable to 96 capillaries.

• Higher optical sensitivity and advanced polymers enable you to obtain higher-quality data at a lower cost.
• Multiple automation features decrease costly human errors.
• Optimized polymers increase your productivity without compromising your results.
• Perform a wide variety of sequencing and fragment analysis applications including resequencing, microsatellite analysis, AFLP, LOH, SSCP, SNP screening and SNP validation.

Expand Your Laboratory's Possibilities
By dramatically improving your data quality, significantly reducing your cost per sample, and enabling you to perform more runs per day, the fully automated 48-capillary 3730 system gives your laboratory a tremendous technological and financial advantage. Which means you can pursue an exciting diversity of projects (and you can always upgrade to 96 capillaries when you need to).

Streamline Your Workflow
The 3730 DNA Analyzer system is engineered for highly reliable, unattended operation of up to 48 hours (applies to modules with run times longer than 30 minutes). Automation features which minimize the need for operator intervention and decrease the risk of human error include an integrated plate stacker, internal bar code reader, and onboard polymer delivery system.

Increase Productivity
The high signal-to-noise ratio ensures you get high-quality data – even when you use low-concentration samples and reagents. Labor-saving automation features minimize hands-on time and enable you to analyze more data more efficiently.

Get the Highest-Quality Sequencing and Genotyping Data
The enhanced optical design provides a higher signal-to-noise ratio and a more uniform signal profile across the array. This design, combined with our new, advanced polymer, enables the longest read lengths of any available system, and provides enhanced color balance for streamlined genotyping sample handling. In addition, exceptional sensitivity enables higher success rates across a wider range of sample templates and concentrations than other currently available systems.

One Instrument, Multiple Applications
With the 3730 DNA Analyzer, you get the highest-quality data from a wide array of applications. In addition to being ideal for high-throughput sequencing, the analyzer's optimized application assays, instrument, and analysis software also provide a complete solution for genotyping and resequencing.

Integrated Data Analysis Tools Reduce Time-to-Results
The 3730 DNA Analyzer software suite allows you to generate more meaningful data with less work. This system's labor-saving software suite includes:
• Data Collection (supplied with the instrument): Manages your instrument setup, controls instrument operations, allows real-time data visualization, and performs diagnostics. New features include: Auto-analysis with GeneMapper® and SeqScape®
• Tools to assist with regulatory and compliance requirements (In the United States, this assists with FDA 21CFR part 11).
Flexibility to use any choice in dye set option.
• Additional optimized sequencing run modules covering more applications.
• Sequencing Analysis – Designed to base-call; assign quality values; trim, display, edit and print DNA sequencing data using the KB basecaller
• Seqscape® – Provides everything you need to perform resequencing applications such as VariantSEQr™ Resequencing System
• GeneMapper® – Enables configurable, automated allele calling – a plus for high-throughput genotyping and includes tools for SNPlex™ data analysis

The instrument comes with a one year limited warranty on parts and labor.

For Research Use Only. Not for use in diagnostics procedures.

3500xL Genetic Analyzer for Human Identification (Applied Biosystems™)

The 24-capillary 3500xL Genetic Analyzer sets the standard in capillary electrophoresis. The 3500-series instruments are the first genetic analyzers designed with a specific feature set and workflow for the Human Identification application. The complete product combines the instrument with Applied Biosystems™ reagents, consumables and software, as well as industry leading support, to provide an integrated HID system solution that significantly improves ease-of-use and application efficiencies.

• Increased Consistency – Reduced signal variation with factory standardization and optional in-lane normalization
• Real-Time Data Quality Assessment – On instrument data evaluation features provide rapid identification and re-injection of samples requiring additional processing
• Improved Thermal Control – Smaller oven design and improved door seal for more consistent data migration
• HID Specific Workflow – Pre-configured for Applied Biosystems® amplification kits to simplify run setup and software navigation
• Effortless Consumable Installation – Convenient one-time use consumable packaging
• Consumable Tracking with RFID Technology – On-instrument, real-time monitoring of consumable consumption and expiration
• Enhanced Throughput – Faster data generation with 8 or 24 capillary arrays and shorter run times
• Improved Polymer Pump Design – Reduced waste and fewer bubbles for better data quality
• Simplified Instrument Installation & Operation – New solid-state laser eliminates need for high voltage wiring and external venting
• Streamlined Instrument Maintenance – HID specific performance check and maintenance scheduling tools
• Data Chain of Custody – Controlled access and tracking through Security, Audit and eSig features

For more information, please contact your Sales Representative.

3500 Genetic Analyzer for Protein Quality Analysis, with software (Applied Biosystems™)

The 3500 Genetic Analyzer for Protein Quality Analysis is a capillary electrophoresis instrument with an 8-capillary array specifically designed to support the demanding performance needs of biopharmaceutical screening and quality control environments, while retaining the unsurpassed application versatility appreciated by scientists working in analytical and process development environments. The instrument enables parallel analysis of 8 samples without compromising on the run time per sample, thereby enabling high throughput analysis with high quality data. This system includes an 8-capillary instrument, GlycanAssure™ Acquisition and Analysis Software, a Dell Workstation and monitor, as well as reagent kits for system qualification.

Features include:
• An 8-capillary system that can easily be upgraded to a 24-capillary system when you need higher throughput
• Single-line, 505 nm, solid-state, long-life laser that utilizes a standard power supply and requires no heat removal
• Powerful, integrated data acquisition and analysis software that provides real-time assessment of data
• Radio frequency identification (RFID) technology that tracks key consumables data and records administrative information
• Advanced multiplexing capabilities for glycan analysis with up to six unique dyes
• Unrivaled application flexibility—one array and one polymer are used for most applications
• Simple setup, operation, and maintenance

Request more information >

Accurate, precise, and reliable data quality
The 3500 Series systems significantly improve signal uniformity from instrument-to-instrument, run-to-run, and capillary array-to-capillary array. The systems provide accurate, reproducible, and precise relative quantitation of glycan levels.

Ready-to-use consumables with RFID tags
The 3500 Series systems introduce ready-to-use consumables with pre-packaged polymer pouches, cathode and anode buffer containers, and easy-to-install capillary arrays. Each of these consumables is integrated with RFID tags that enable viewing, tracking, and reporting of critical information about reagents and consumables, including usage, lot number, part number, expiry date, and on-instrument lifetime within the GlycanAssure data acquisition software.

Easy-to-Use data acquisition and data analysis software
GlycanAssure data acquisition software breaks new ground in user-friendly navigation with an intuitive dashboard design, highly visible buttons for common operations, easy-to-read graphical displays to monitor the state of consumables, simplified plate setup, and a handy maintenance scheduling calendar functionality. GlycanAssure data analysis software allows quick viewing of analyzed and un-analyzed samples and quick comparison of different analysis methods. It includes built-in primary analysis with quality control, so you can make decisions about the quality of data as it is produced without the need to transfer output files to other software.

Additional products
The following products are required for use with this system:
A31278: Anode Buffer Container (ABC) for 3500 Series for Protein Quality Analysis
A31279: Cathode Buffer Container (CBC) for 3500 Series for Protein Quality Analysis
A30936: POP-7™ for Protein Quality Analysis (384 samples)
A31122: POP-7™ for Protein Quality Analysis (960 samples)



Ion Personal Genome Machine™ (PGM™) System (Ion Torrent™)

The Ion Personal Genome Machine (PGM) System combines semiconductor sequencing technology with natural biochemistry to directly translate chemical information into digital data, democratizing sequencing and making it accessible to your lab. This established system leverages the exponential improvements in the semiconductor industry (known as Moore’s Law) to provide scalability and flexibility for various applications. The Ion PGM System uses natural sequencing chemistry, which eliminates the need for expensive optics and reduces complex chemistries to measure natural DNA extension. The system leverages direct, real-time sequencing detection, providing sequencing results typically in 3–7 hours.

Affordable sequencing for small genomes and targeted panels
Other sequencing technologies rely on optical systems as bridges between chemical and digital sequence information. These systems typically entail significant additional costs; the elimination of the optical system by the Ion PGM System reduces these costs. With its small benchtop footprint, weight of about 65 lbs (30 kg), low-cost sequencing reagents, and simple touchscreen user interface, the Ion PGM System brings next-generation sequencing to your lab. Coupled with the Torrent Suite Software, the Ion PGM System performs preliminary reference genome alignment and outputs data in BAM format for easy downstream analysis with optional third party analysis tools. It can also provide access to a web portal for data review and sharing.

More information on the Ion Torrent Server >

Ion power: PostLight sequencing produces bits from bases
The sequencing technology underlying the Ion PGM System exploits a well-characterized biochemical process: when a polymerase incorporates a nucleotide into the growing strand of DNA, a hydrogen ion (H+) is released as a byproduct. This hydrogen ion carries a charge which the Ion PGM chip—essentially the world's smallest solid-state pH meter—can detect. As the sequencer floods the chip with one nucleotide after another, any nucleotide added to a DNA template will be detected as a voltage change, and the Ion PGM System will call the base. If a nucleotide is not a match for a particular template, no voltage change will be detected and no base will be called for that template.

Next-generation sequencing on your bench
A principal component of the Ion PGM System is the sequencing chip. This microprocessor chip incorporates an extremely dense array of >1 million micro-machined wells married to our proprietary ion sensor. Each well contains a different DNA template, allowing massively parallel sequencing. The chips can scale in density for specific applications from targeted panels to small genomes.

The right tool to get results easily, reliably, and quickly
Since it detects nucleotide incorporation without the use of light, the Ion PGM System uses the simplest sequencing chemistry possible: natural nucleotides. There is no need for expensive and error-prone modified bases, enzymatic cascades, chemiluminescence, or fluorescence. Direct detection also means the incorporation of each nucleotide is recorded in seconds. As a result, the Ion PGM System runs finish within hours rather than days.

Services and support
Service and support plans—comprehensive plans to maximize instrument performance and ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

For a more simplified next-generation sequencing workflow, see the Ion S5 System.

Learn more about the Ion PGM sequencing chips >

3500xL Genetic Analyzer for Sequence Typing & Fragment Analysis (Applied Biosystems™)

This 24-capillary Genetic Analyzer is specifically configured with software for both fragment analysis and sequence typing applications.

The 3500xL 24-capillary platform can run a wide variety of applications, including de novo sequencing and resequencing (mutational profiling), as well as microsatellite analysis, MLPA™, LOH, MLST, AFLP® and SNP validation or screening. The majority of applications can be run on a single polymer and capillary array.

This package includes a 24 capillary instrument, the 3500 Data Collection Software, a Dell Workstation and monitor as well as reagent kits for system qualification. The product package also includes software for sequence typing and fragment analysis. The 3500 Series Data Collection Software integrates seamlessly with several downstream software packages to provide comprehensive analysis of genetic data.

Important Note: Do you still have a 3100? 3100 Systems will be retired at the end of 2011. Take advantage of our limited time promotions to TRADE-IN your 3100 to get a brand new 3500. Please contact your local Sales Representative to learn more.

For Research Use Only. Not for use in diagnostics procedures.

3500 Dx Genetic Analyzer CS2 (Applied Biosystems™)

The 3500 Dx Genetic Analyzer CS2 is the latest addition to our family of Applied Biosystems® genetic analyzers based on capillary electrophoresis. The 3500 Dx Genetic Analyzer CS2 is an IVD-labeled instrument, making it the first Sanger sequencing platform cleared for sequencing analysis of DNA.

Confidence in Your Results
• The 3500 Dx Genetic Analyzer CS2 is an IVD-labeled platform for Sequencing-Based Typing using SeCore® HLA typing kits. Sanger sequencing is known as the "gold-standard" for its accuracy, reliability, and ease of use. It is also used for confirmatory sequencing by clinical labs.
• High accuracy: 99% concordance as shown in clinical trials using SeCore® HLA typing kits
• Proven through decades of results—including sequencing of the first human genome—Applied Biosystems® genetic analysis systems are trusted standards for Sanger sequencing.

You can now feel even more comfortable adopting the 3500 Dx Genetic Analyzer CS2 platform for the development of assays for FDA submission.

Simplicity and Efficiency
• Reduced instrument hands-on time with simplified installation and removal of consumables and accessories
• Controlled and efficient run setup with intuitive user interface, preconfigured plate templates, and software-controlled functions (plate setup, data collection, analysis)
• Instrument run-times as short as 1 hour; sample-to-result in as little as 1.5 days
• Maintenance calendar with programmable prompts and service history
• Security and electronic signature, RFID (radio frequency identification) tracking of consumables, built-in quality controls, and real-time data quality evaluation

The 3500 Dx Genetic Analyzer CS2 is a partner in your laboratory, making it easy for you to comply with various industry standards and simplifying the training of new users.

Flexibility
• Collect data in either IVD (diagnostic for HLA typing) or RUO mode
• Develop other applications in RUO mode, including de novo sequencing and re-sequencing, as well as fragment analysis applications such as microsatellite analysis, MLPA®, LOH, MLST, and SNP confirmation or screening
• Partner with us to develop assays for FDA submission
• Different configurations to meet your throughput needs: 8-capillary (3500 Dx) and 24-capillary (3500xL Dx) versions

The 3500 Dx Genetic Analyzer CS2 is a trusted capillary electrophoresis-based sequencing platform for development of your new assays. Capillary electrophoresis-based applications are supported by a large number of publications over the many years that these applications have been used successfully in laboratory testing.

IVD-labeled Accessories and Consumables
The purchase of a 3500 Dx Genetic Analyzer CS2 includes a computer system and associated Data Collection software, as well as an installation kit containing the initial set of accessories and reagents needed to start using the instrument right away. The 3500 Dx Genetic Analyzer CS2 installation includes a full install qualification and operational qualification, as well as instrument training to introduce you to your new genetic analyzer.

The 3500 Dx is backed by a comprehensive Service & Support program with options to purchase additional services depending upon your laboratory maintenance and audit requirements.

Intended Use
The Applied Biosystems® 3500 Dx and 3500xL Dx Genetic Analyzers CS2 with 3500 Dx Series Software 2011 (v1) are in vitro diagnostic devices intended for the sequencing (detection and identification) of fluorescently labeled DNA by capillary electrophoresis.

The Applied Biosystems® 3500 Dx/3500xL Dx Genetic Analyzers CS2 with 3500 Dx Series Software 2011 (v1) are indicated for use with FDA-cleared or approved sequencing assays specifying their use and only by technologists trained in laboratory techniques, procedures, and use of the analyzer.

Note: The 3500 Dx Genetic Analyzer CS2 data collection software uses Windows 7 SP0 operating system. This makes the currently available RUO secondary analysis software incompatible for use on the same system. A separate computer is required to do secondary analysis if operating in RUO mode.

3500xL Genetic Analyzer for Resequencing (Applied Biosystems™)

This 24-capillary Genetic Analyzer is specifically configured with software for resequencing applications.

The 3500xL 24-capillary platform can run a wide variety of applications, including de novo sequencing and resequencing (mutational profiling), as well as microsatellite analysis, MLPA™, LOH, MLST, AFLP® and SNP validation or screening. The majority of applications can be run on a single polymer and capillary array.

This package includes a 24 capillary instrument, the 3500 Data Collection Software, a Dell Workstation and monitor as well as reagent kits for system qualification. The product package also includes software for resequencing. The 3500 Series Data Collection Software integrates seamlessly with several downstream software packages to provide comprehensive analysis of genetic data.

Important Note: Do you still have a 3100? 3100 Systems will be retired at the end of 2011. Take advantage of our limited time promotions to TRADE-IN your 3100 to get a brand new 3500. Please contact your local Sales Representative to learn more.

For Research Use Only. Not for use in diagnostics procedures.

Genetic Analyzer Upgrade Kit (3500 to 3500xL) (Applied Biosystems™)

This kit allows you to upgrade your 8 capillary 3500 Genetic Analyzer to a 24 capillary 3500xL expanding the capabilities of your instrument. You’ll be able to take advantage of a dramatic increase in throughput and in overall laboratory productivity. The upgrade is simple and completed within a day. It does not involve any changes to the computer or software so you will not need to re-verify these components of your system.

• 8 capillary system can easily be upgraded to a 24-capillary system
• New single-line 505 nm, solid-state long-life laser—utilizes a standard power supply; requires no heat-removal ducting
• Powerful, integrated data collection and primary analysis software provides real-time assessment of data quality
• Radio Frequency Identification (RFID) technology tracks key consumables data and records administrative information
• Advanced multiplexing capabilities for DNA fragment analysis with up to six unique dyes
• Unrivaled application flexibility—one array and one polymer are used for most applications
• Simple setup, operation and maintenance—the easiest-to-run, easiest-to-own DNA sequencer to date

For Research Use Only. Not for use in diagnostics procedures.

5500xl Genetic Analyzer (Applied Biosystems™)

Never before has a next-generation sequencing platform provided the combination of accuracy, sensitivity, and cost effectiveness to support your large translational research studies–until now. The new 5500xl Genetic Analyzer (Figure 1) helps ensure optimal productivity with two flexible FlowChips, embedded quality controls, intuitive user workflows, and project scalability. With the 5500xl Genetic Analyzer, you are empowered to discover rare genetic events or sub-populations of somatic mutations at an unprecedented pace.

Key Benefits
• Sequencing right here, right now
• Cost-effective sequencing runs with individually configurable lanes
• Superior low frequency variant detection for whole exome sequencing or targeted resequencing
• Reproducibility, reliability, and quality for your RNA applications
• Confidence and uniformity in multiplexing with up to 96 barcodes
• Optimal analysis solutions for streamlined productivity and freedom to operate

When Coverage is Not Enough
Additional sequence coverage fails to compensate for poor accuracy in the detection of rare variants that may hold the key to a better understanding cancer progression, disease penetrance, or drug resistance. With a system accuracy of up to 99.99%, the 5500xl Genetic Analyzer enables you to perform 25% less sequencing to detect rare variants than a next-generation sequencing platform with 99.99% system accuracy in order to detect somatic variant present at 1% (Figure 2). The industry-leading accuracy of the 5500xl Genetic Analyzer enables detection of significant biological variation for applications like whole genome resequencing, targeted resequencing, and whole transcriptome analysis.

When Flexibility, Speed, and Cost are Crucial
Multidisciplinary translational research programs often require processing of multiple samples across multiple applications like whole exome, RNA-seq, and structural variation. The 5500xl Genetic Analyzer provides you the flexibility to configure your sequencing runs to your project and throughput needs (Figure 3). The system’s two configurable microfluidic FlowChips process up to 12 independent samples and the intelligent barcoding kits multiplex up to hundreds of samples in a single run. Pay-Per-Lane Sequencing (PPL-Seq™) and independent run lanes tailor the system to any project scale. With the 5500xl Genetic Analyzer, avoid project delays by optimizing your run configurations to attain the lowest cost per sample.

When the Utmost Productivity and Efficiency are Essential
Ease of use, quality control, and speed are integral components of any next-generation sequencing workflow. Co-developed with Hitachi-Hi Technologies, the 5500xl Genetic Analyzer's elegant tabletop design (Figure 1) is built off “Six-Sigma" processes to streamline your research. The 5500xl Genetic Analyzer delivers streamlined fluidics and a simple, intuitive graphical user interface (GUI) for easy setup and run monitoring. Real-time analysis and 60% smaller data footprints expedite data export and analysis time. Additionally, with embedded sequencing controls and reagent usage tracking, the 5500xl Genetic Analyzer empowers you to obtain extremely high-quality and biologically meaningful data out of every sequencing run.

Take Comprehensive Research to New Heights
The superior accuracy, flexibility, and productivity of the 5500xl Genetic Analyzer accelerate comprehensive research. Larger translational medicine initiatives, genome consortiums, and disease-subtype stratification projects with resulting groundbreaking publications are now within your grasp. Catch them all with the new 5500xl Genetic Analyzer.

A Community of Support
With more than 2,000 field personnel, we have the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so that you can feel confident that we will be there when and where you need us most.

The 5500xl Genetic Analyzer is For Research Use Only. Not intended for any animal or human therapeutic or diagnostic use.

3500 Genetic Analyzer for Resequencing & Fragment Analysis (Applied Biosystems™)

The 3500 Genetic Analyzer is an 8-capillary sequencing instrument specifically designed to support the demanding performance needs of validated and process controlled environments, while retaining the unsurpassed application versatility that life science researchers expect.

This package includes an 8-capillary instrument, 3500 Series Data Collection Software, a Dell Workstation and monitor, as well as reagent kits for system qualification and secondary analysis software. The 3500 Series Data Collection Software supports sequencing and fragment analysis, and integrates seamlessly with downstream software for secondary analysis of genetic data. This package includes such secondary software: GeneMapper® software for fragment analysis and software for resequencing applications.

Features include:

• An 8 capillary system that can easily be upgraded to a 24-capillary system when you’re ready.
• Single-line, 505 nm, solid-state, long-life laser that utilizes a standard power supply and requires no heat-removal ducting
• Powerful, integrated data collection and primary analysis software provides real-time assessment of data quality
• Radio frequency identification (RFID) technology tracks key consumables data and records administrative information
• Advanced multiplexing capabilities for DNA fragment analysis with up to six unique dyes
• Unrivaled application flexibility—one array and one polymer are used for most applications.
• Simple setup, operation and maintenance

Accurate Reliable Data Quality
The 3500 series systems significantly improves signal uniformity from instrument-to-instrument, run-to-run, and capillary-to-capillary. With a combination of intelligent hardware, powerful new algorithm and reagent combinations, these methods provide major reduction in the range of signal peak heights obtained across multiple 3500 series instruments (see figure).

Improved Sizing Precision
New thermal sub-system design gives enhanced performance in demanding fragment applications enabling improved sizing precision versus previous generations of capillary electrophoresis platforms.

Ready to Use Consumables With RFID Tags
The 3500 series introduces ready-to-use consumables with pre-packaged polymer pouches, cathode and anode buffer containers, and easy-to-install capillary arrays. Each of these consumables is integrated with RFID tags that enable viewing, tracking, and reporting of critical information about reagents and consumables including usage, lot number, part number, expiry date, and on-instrument lifetime within the 3500 Series Data Collection Software.

Easy to Use Data Collection Software
3500 Series Data Collection software breaks new ground in user-friendly navigation with an intuitive dashboard design, highly visible buttons for common operations, easy-to-read graphical displays to monitor the state of consumables and handy maintenance scheduling calendar functionality. New functionality includes simplified plate set-up and built-in primary analysis with quality control, so you can make decisions about the quality of data as it is produced on the instrument without the need to transfer output files into secondary analysis software packages.

Applied Biosystems™ RapidHIT™ ID System Upgrade (Applied Biosystems™)

The Applied Biosystems RapidHIT ID System Upgrade gives IntegenX RapidHIT ID System owners the ability to upgrade their system to the latest Applied Biosystems-branded version. The upgrade provides improved system reliability and performance, and enables the system to be sample/data accessioning workflow-capable.

Before upgrading, please consume your remaining IntegenX RapidHIT ID consumables as several legacy consumables, such as the primary cartridges, are not compatible with the Applied Biosystems-branded RapidHIT ID System.

For more details or questions, please contact your local sales representative or local distributor.

HID Ion GeneStudio™ S5 Prime System (Ion Torrent™)

The HID Ion GeneStudio S5 Prime System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows. For core and service labs requiring maximum throughput and rapid turnaround time from a benchtop NGS system, the HID Ion GeneStudio S5 Prime System enables unparalleled breadth and depth for large panels with the fastest turnaround time needs. With cartridge-based reagents, the system is simple to use and offers scalability and flexibility. It uses Ion 5 Series chips to support a broad range of forensic applications including mitochondria sequencing, STR analysis, and SNP genotyping.

Features of the HID Ion GeneStudio S5 Prime System include:
• Select the chip (Ion 510–550 chip) that fits your application and throughput needs to achieve from 2–130 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments

The Ion GeneStudio S5 Series
The HID Ion GeneStudio S5 Series sequencers share the same foundational technology and fluidic architecture across all three instruments: the HID Ion GeneStudio S5 System, the HID Ion GeneStudio S5 Plus System, and this HID Ion GeneStudio S5 Prime System. The primary difference across the three instruments is on-sequencer analysis time.

Speed
The HID Ion GeneStudio S5 Series sequencers leverage the speed of semiconductor sequencing to enable the production of high-quality sequencing data in a few hours and enable you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time when paired with the HID Ion Chef System.

Simplicity
With single-day installation, a straightforward user interface, and cartridge-based reagents, the HID Ion GeneStudio S5 Series sequencers are easy to use. Combined with Precision ID library prep technology for target selection, the HID Ion Chef System for automated library and template preparation, and Converge Software for automated analysis, forensic sequencing is simpler than ever.

Small sample input
Low input DNA amounts from challenging sample types such as touch DNA or other forensic samples can be difficult to sequence on competitor next-generation sequencers. However, with Precision ID library preparation and sequencing technology and the HID Ion GeneStudio S5 Series sequencers, you can use as little as 100 pg of DNA input and achieve accurate, robust results.

Scalability
Why buy multiple systems for your lab when you can modulate your throughput by chip selection on a single next-generation sequencer? The Ion 5 Series chips that run on the HID Ion GeneStudio S5 Series systems provide several throughput options, so your lab has the flexibility to scale from small to large projects, enabling multiple forensic applications on a single system.

Simple analysis and storage solutions
Torrent Suite Software and Converge Software make NGS easy for beginners and experts alike. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Converge Software (Thermo Fisher Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and help ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

3500 Genetic Analyzer for Resequencing (Applied Biosystems™)

This 8-capillary Genetic Analyzer is specifically configured with software for resequencing applications.

We set a new standard in capillary electrophoresis with the 8-capillary 3500 Genetic Analyzer. These instruments are specifically designed to support the demanding performance needs of validated and process controlled environments, while retaining the unsurpassed application versatility that life science researchers expect from us.

• An 8 capillary system that can easily be upgraded to a 24-capillary system when you’re ready.
• New single-line 505 nm, solid-state long-life laser – utilizes a standard power supply; requires no heat-removal ducting.
• Powerful, integrated data collection and primary analysis software provides real-time assessment of data quality.
• Radio Frequency Identification (RFID) technology tracks key consumables data and records administrative information.
• Advanced multiplexing capabilities for DNA fragment analysis with up to six unique dyes.
• Unrivaled application flexibility – one array and one polymer are used for most applications.
• Simple setup, operation and maintenance – the easiest-to-run, easiest-to-own DNA sequencer to date.

Accurate Reliable Data Quality
The 3500 series systems significantly improves signal uniformity from instrument-to-instrument, run-to-run, and capillary-to-capillary. With a combination of intelligent hardware, powerful new algorithm and reagent combinations, these methods provide major reduction in the range of signal peak heights obtained across multiple 3500 series instruments (see figure 1).

Improved Sizing Precision
New thermal sub-system design gives enhanced performance in demanding fragment applications enabling improved sizing precision versus previous generations of capillary electrophoresis platforms (see figure 2).

Ready to Use Consumables With RFID Tags
The 3500 series introduces ready-to-use consumables with pre-packaged polymer pouches, cathode and anode buffer containers and easy-to-install capillary arrays. Each of these consumables is integrated with RFID tags that enable viewing, tracking and reporting of critical information about reagents and consumables including usage, lot number, part number, expiry date and on-instrument lifetime within the 3500 Series Data Collection Software (see figures 3 and 4).

Easy to Use New Data Collection Software
3500 Series Data Collection software breaks new ground in user-friendly navigation with an intuitive dashboard design, highly visible buttons for common operations, easy-to-read graphical displays to monitor the state of consumables and handy maintenance scheduling calendar functionality. New functionality includes simplified plate set-up, built-in primary analysis with quality control, so you can make decisions about the quality of data as it is produced on the instrument without the need to transfer output files into secondary analysis software packages (see figures 4 & 5).

For Research Use Only. Not for use in diagnostics procedures.

Ion S5™ XL System (Ion Torrent™)

The Ion S5™ XL next-generation sequencing system enables a simple targeted sequencing workflow for your lab with reliable performance and industry-leading speed. The Ion S5 XL System leverages the speed of semiconductor sequencing with impressive computing power found both on-board and in the included Torrent Server, to produce high quality sequencing data in as little as 2.5 hours and enable you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time on the Ion Chef™ System and the Ion S5 XL System. The Ion S5 XL System is simple to use with cartridge-based reagents and offers superior scalability and flexibility to support a broad range of high throughput sequencing applications, from microbial genomes and gene panels to exomes and transcriptomes, using our 5 Series chips.

Speed
Some research decisions can’t wait. A few hours could make all the difference in your quest for the right answer.With other light-based sequencers you could wait almost 60 hours for results. With the Ion S5 XL System you get results in as little as 24 hours (with a 2.5-4 hour sequencer run time and overnight Ion Chef System run)—the fastest turnaround of any next-generation sequencer currently on the market.

Simplicity
With single-day installation, a straightforward user interface, and cartridge-loaded reagents, the Ion S5 XL System is easy to use. Beyond this, the system is part of a workflow that allows you to go from DNA to data with only 45 minutes of total hands-on time on the Ion Chef System and the Ion S5 XL System, significantly less than other targeted sequencing solutions that require as much as 2.5 hours of hands-on time. Combined with Ion AmpliSeq™ technology for target selection, the Ion Chef™ System for automated library and template preparation, and Ion Reporter™ Software for automated variant annotation, targeted sequencing becomes simpler than ever.

Small sample input
Low input DNA for challenging samples types, such as formalin-fixed paraffin-embedded (FFPE) tissue, retrospective samples from fine needle aspirates, and cell-free DNA extracted from blood (cfDNA) can be difficult to sequence on competitor next-generation sequencers. However, with Ion AmpliSeq technology and the Ion S5 XL Sequencer, you can use as little as 10 ng input DNA or RNA.

Scalability
Why buy multiple systems for your lab when you can run all your targeted sequencing or microbial research applications on a single next-generation sequencer? The Ion S5 XL System has a modular build, so your lab has the flexibility to do multiple targeted sequencing applications on a single system.

Simple analysis and storage solutions
Whether you are new to next-generation sequencing or an expert user, Torrent Suite™ Software and Ion Reporter™ Software make it easy for you to get started with next-generation sequencing. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Ion Reporter Software (Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

3500xL Genetic Analyzer for Protein Quality Analysis (Applied Biosystems™)

The 3500xL Genetic Analyzer for Protein Quality Analysis is a capillary electrophoresis instrument with a 24-capillary array specifically designed to support the demanding performance needs of biopharmaceutical screening and quality control environments, while retaining the unsurpassed application versatility appreciated by scientists working in analytical and process development environments. The instrument enables parallel analysis of 24 samples without compromising on the run time per sample, thereby enabling high throughput analysis with high quality data.

This system includes a 24-capillary instrument, a Dell Workstation and monitor, as well as reagent kits for system qualification. For a system that includes GlycanAssure™ Acquisition and Analysis Software, please see Cat. No. A30887.

Features include:
• A 24-capillary system for high throughput analysis
• Single-line, 505 nm, solid-state, long-life laser that utilizes a standard power supply and requires no heat-removal
• Radio frequency identification (RFID) technology that tracks key consumables data and records administrative information
• Advanced multiplexing capabilities for glycan analysis with up to six unique dyes
• Unrivaled application flexibility—one array and one polymer are used for most applications
• Simple setup, operation, and maintenance

Request more information >

Accurate, precise, and reliable data quality
The 3500 Series systems significantly improve signal uniformity from instrument-to-instrument, run-to-run, and capillary array-to-capillary array. The system provides accurate, reproducible, and precise relative quantitation of glycan levels.

Ready-to-use consumables with RFID tags
The 3500 Series systems introduce ready-to-use consumables with pre-packaged polymer pouches, cathode and anode buffer containers, and easy-to-install capillary arrays. Each of these consumables is integrated with RFID tags that enable viewing, tracking, and reporting of critical information about reagents and consumables, including usage, lot number, part number, expiry date, and on-instrument lifetime within the Glycan Assure data acquisition software.

Additional products
The following products are required for use with this system:
A31278: Anode Buffer Container (ABC) for 3500 Series for Protein Quality Analysis
A31279: Cathode Buffer Container (CBC) for 3500 Series for Protein Quality Analysis
A30936: POP-7™ for Protein Quality Analysis (384 samples)

3500 Genetic Analyzer for Fragment Analysis (Applied Biosystems™)

The 3500 Genetic Analyzer is an 8-capillary sequencing instrument specifically designed to support the demanding performance needs of validated and process-controlled environments, while retaining the unsurpassed application versatility that life science researchers expect. The analyzer supports a wide variety of applications, including de novo sequencing and re-sequencing (mutational profiling), as well as microsatellite analysis, MLPA™, LOH, MLST, AFLP®, and SNP validation or screening. The majority of applications can be run on a single polymer and capillary array.

In addition to the 3500 Genetic Analyzer, this fragment analysis package includes 3500 Series Data Collection Software, a Dell Workstation and monitor, reagent kits for system qualification, and secondary analysis software. 3500 Series Data Collection Software supports sequencing and fragment analysis, and integrates seamlessly with downstream software for secondary analysis of genetic data. GeneMapper™ secondary analysis software is included in this package.

Benefits and features of the 3500 Genetic Analyzer include:
Cost effective—lower running costs per sample and increased reagent life (14 days)
Easy setup—no special power outlets or external exhaust needed
Increased multiplexing—6-dye capability to interrogate more SNPs or markers
Easy-to-use software—integrated data collection and primary analysis software for real-time assessment of data quality
Consumables tracking—radio frequency identification (RFID) technology used for residual volume and expiry date tracking
Improved data uniformity—instrument-to-instrument, run-to-run, and capillary-to-capillary
More stable and precise fragment sizing due to improved oven temperature control
Smaller footprint versus 3130/3130xl instruments

Accurate and reliable data quality
The 3500 series systems significantly improve signal uniformity from instrument to instrument, run to run, and capillary to capillary. The combination of intelligent hardware and powerful algorithm and reagent combinations reduce the range of signal peak heights obtained across multiple 3500 series instruments.

Improved sizing precision
The thermal sub-system design provides enhanced performance during demanding fragment analysis applications, enabling improved sizing precision versus previous generations of capillary electrophoresis platforms.

Ready-to-use consumables with RFID tags
The 3500 series utilizes ready-to-use consumables with pre-packaged polymer pouches, cathode and anode buffer containers, and easy-to-install capillary arrays. Each of these consumables includes an integrated RFID tag that enables viewing, tracking, and reporting of critical information, including usage, lot number, part number, expiry date, and on-instrument lifetime, all within the 3500 Series Data Collection Software.

Easy-to-use data collection software
3500 Series Data Collection software features user-friendly navigation with an intuitive dashboard design, highly visible buttons for common operations, easy-to-read graphical displays to monitor the state of consumables, and a handy maintenance scheduling calendar. Additional features include simplified plate set-up and built-in primary analysis with quality control, so you can make decisions about the quality of data as it is produced on the instrument without the need to transfer output files into secondary analysis software packages.

ABI PRISM 3100 Genetic Analyzer to 3130xl System Upgrade with computer (Applied Biosystems™)

This is a system upgrade, from the 3100 Genetic Analyzer to the Applied Biosystems® 3130xl System.

The 3130xl Genetic Analyzer is the latest generation of 16-capillary electrophoresis instruments for the medium throughput laboratories. The system offers industry-leading performance, plus sophisticated automation capabilities allowing researchers to save time, reduce costs and increase productivity.

Important Note: 3100 System Sequencers will be retired at the end of 2011. Take advantage of our limited time promotion to either TRADE-IN your 3100 for a brand new 3500 or UPGRADE to a 3130. Please contact your local Sales Representative to learn more.

For Research Use Only. Not for use in diagnostics procedures.

3130 Genetic Analyzer (factory refurbished) (Applied Biosystems™)

Applied Biosystems® 3130 (4-capillary) Genetic Analyzer was refurbished by the original manufacturer to meet both manufacturing and product specifications. Availability may be limited.

Applied Biosystems® 3130 Genetic Analyzer is the latest generation of 4-capillary electrophoresis instruments for the low to medium throughput laboratories. The system offers industry-leading performance, plus sophisticated automation capabilities allowing you to save time, reduce costs and increase productivity.

Important Note: 3100 Systems will be retired at the end of 2011. Take advantage of our limited time promotions to either TRADE-IN your 3100 for a brand new 3500 or UPGRADE your 3100 to a 3130. Please contact your local Sales Representative to learn more.

With the Applied Biosystems 3130 Genetic Analyzer, you get the sophisticated automation and superior performance of the 3130 system, at acquisition and operating costs tailored to a growing research lab.
• Run a wide variety of sequencing and fragment analysis applications including microsatellite analysis, AFLP, LOH, SNP validation, and SNP screening.
• Reduce maintenance time by eliminating manual syringe washing and filling with automated polymer delivery.
• Increase your data quality for sequencing and fragment analysis applications – longer read length, and higher resolution with shorter run times.
• Increase laboratory productivity and turnaround time by processing 96- or 384-well plates with a four-capillary array.

Perform a Wide Range of Applications
The Applied Biosystems® 3130 Genetic Analyzer is more than just a DNA sequencer. You can run a wide variety of sequencing and fragment analysis applications including microsatellite analysis, AFLP, LOH, SNP validation, and SNP screening – as well as de novo sequencing and resequencing (mutational profiling). The full range of applications can be run on a single polymer and capillary array meaning you can run mixed applications on one plate. The software even includes tools to assist with regulatory and compliance requirements (In the United States, this assists with FDA 21CFR part 11).

Easy to Use
Reduce maintenance time by eliminating manual syringe washing and filling with the new automated polymer delivery system. No more handling of polymer syringes for set up and maintenance. Samples are automatically injected into the four-capillary arrays, and – unlike slab-gel systems – only minimal amounts of DNA are required for accurate analysis. Seamlessly switch between sequencing and fragment analysis runs, even in the same plate with the expanded one-polymer, one-array functionality for both sequencing and fragment analysis applications.
Superior Data Quality
Simply set up your sample and then sit back and watch as the analyzer's ultra-rapid sequencing gives you high-quality data (with Length of Read longer than 500 bp) in less than 35 minutes. Achieve accurate read lengths of 1,000 base pairs (bp) or longer in a single sequencing reaction using the 80 cm capillary array and the 3130 POP-7™ polymer.

Ideal for Growing Labs
The flexible, four-capillary 3130 system gives you all the advanced automation and superior performance of Applied Biosystems 3130xl platform, at acquisition and operating costs tailored to a growing research lab. And as your throughput needs increase, you can easily upgrade the system to 16 capillaries. It is the perfect way to get the capacity and savings you need today – without limiting your growth options. Researchers who own an ABI PRISM® 3100-Avant or 3100 Genetic Analyzer can upgrade to the new Applied Biosystems® 3130 or 3130xl Genetic Analyzer.

3130 and 3130xl instruments are CE marked and compliant with the specifications and requirements as set in the EMC directive 89⁄336⁄EEC and the Low Voltage directive 73⁄23⁄EEC.

For Research Use Only. Not for use in diagnostics procedures.

HID Ion GeneStudio™ S5 Plus System (Ion Torrent™)

The HID Ion GeneStudio S5 Plus System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows for forensic analysis. From targeted SNP panels to Precision ID STR workflows and mitochonidrial DNA sequencing, the HID Ion GeneStudio S5 Plus System is designed to enable flexibility to help labs manage small and large projects across multiple applications. With cartridge-based reagents, the system is simple to use and offers scalability and flexibility. It uses Ion 5 Series chips to support a broad range of high-throughput sequencing for forensic applications.

Features of the HID Ion GeneStudio S5 Plus System include:
• Select the chip (Ion 510–550 chip) that fits your application and throughput needs to achieve from 2–130 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments

The Ion GeneStudio S5 Series
The HID Ion GeneStudio S5 Series sequencers share the same foundational technology and fluidic architecture across all three instruments: the HID Ion GeneStudio S5 System, this HID Ion GeneStudio S5 Plus System, and the HID Ion GeneStudio S5 Prime System. The primary difference across the three instruments is on-sequencer analysis time.

Speed
The HID Ion GeneStudio S5 Series sequencers leverage the speed of semiconductor sequencing to enable the production of high-quality sequencing data in a few hours and enable you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time when paired with the HID Ion Chef System.

Simplicity
With single-day installation, a straightforward user interface, and cartridge-based reagents, the HID Ion GeneStudio S5 Series sequencers are easy to use. Combined with Precision ID library prep technology for target selection, the HID Ion Chef System for automated library and template preparation, and Converge Software for automated analysis, forensic sequencing is simpler than ever.

Small sample input
Low input DNA amounts from challenging sample types such as touch DNA or other forensic samples can be difficult to sequence on competitor next-generation sequencers. However, with Precision ID library preparation and sequencing technology and the HID Ion GeneStudio S5 Series sequencers, you can use as little as 100 pg of DNA input and achieve accurate, robust results.

Scalability
Why buy multiple systems for your lab when you can modulate your throughput by chip selection on a single next-generation sequencer? The Ion 5 Series chips that run on the HID Ion GeneStudio S5 Series systems provide several throughput options, so your lab has the flexibility to scale from small to large projects, enabling multiple forensic applications on a single system.

Simple analysis and storage solutions
Torrent Suite Software and Converge Software make NGS easy for beginners and experts alike. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Converge Software (Thermo Fisher Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and help ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

Ion S5™ System (Ion Torrent™)

The Ion S5™ next-generation sequencing system enables a simple targeted sequencing workflow for your lab at an affordable price, without compromising on performance or reliability. The Ion S5 System leverages the speed of semiconductor sequencing with impressive on-board computing power, to enable the production of high quality sequencing data in as little as 2.5 hours and enable you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time on the Ion Chef™ System and the Ion S5 System. The Ion S5 System is simple to use with cartridge-based reagents and offers superior scalability and flexibility to support a broad range of high throughput sequencing applications, from microbial genomes and gene panels to exomes and transcriptomes, using our 5 Series chips.

Speed
Some research decisions can’t wait. A few hours could make all the difference in your quest for the right answer.With other light-based sequencers you could wait almost 60 hours for results. With the Ion S5 System you get results in as little as 24 hours (with a 2.5-4 hour sequencer run time and overnight Ion Chef System run).

Simplicity
With single-day installation, a straightforward user interface, and cartridge-loaded reagents, the Ion S5 System is easy to use. Beyond this, the system is part of a workflow that allows you to go from DNA to data with only 45 minutes of total hands-on time on the Ion Chef System and the Ion S5 System, significantly less than other targeted sequencing solutions that require as much as 2.5 hours of hands-on time. Combined with Ion AmpliSeq™ technology for target selection, the Ion Chef™ System for automated library and template preparation, and Ion Reporter™ Software for automated variant annotation, targeted sequencing becomes simpler than ever.

Small sample input
Low input DNA for challenging samples types, such as formalin-fixed paraffin-embedded (FFPE) tissue, retrospective samples from fine needle aspirates, and cell-free DNA extracted from blood (cfDNA) can be difficult to sequence on competititor next-generation sequencers. However, with Ion AmpliSeq technology and the Ion S5 Sequencer, you can use as little as 10 ng input DNA or RNA.

Scalability
Why buy multiple systems for your lab when you can run all of your targeted sequencing or microbial applications on a single next-generation sequencer? The Ion S5 System has a modular build, so your lab has the flexibility to do multiple targeted sequencing applications on a single system.

Simple analysis and storage solutions
Whether you are new to next-generation sequencing or an expert user, Torrent Suite™ Software and Ion Reporter™ Software make it easy for you to get started with next-generation sequencing. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Ion Reporter Software (Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

HID Ion Chef™ Instrument (Ion Torrent™)

The HID Ion Chef System is the next generation of workflow simplification products for the HID Ion GeneStudio S5 Series sequencers. The HID Ion Chef System provides automated library preparation, template preparation, and chip loading for users at any experience level. In less than 15 minutes of up-front hands-on time and with the use of pre-packaged library preparation reagent kits, the HID Ion Chef System provides a convenient walk-away workflow resulting in equalized, pooled libraries ready for templating. The automated workflow supports Precision ID panels for both one- and two-pool designs. After library preparation, less than 15 minutes of hands-on time is required to set up the HID Ion Chef System to perform fully automated template preparation, producing one or two chips ready for sequencing. Automating your sample preparation workflows on the HID Ion Chef System results in significantly higher productivity.

The HID Ion Chef System:
• Simplifies the workflow
• Minimizes sources of user-introduced variability
• Helps save time and labor
• Supports sequencing preparation for the HID Ion GeneStudio S5 Systems

The HID Ion Chef System features include:
• Automated Precision ID library preparation, template preparation, and chip loading
• Cartridge-based reagent system
• Sample- and reagent-tracking capability
• Intuitive user interface
• On-board diagnostics

Simplify the forensic NGS workflow
The HID Ion Chef System simplifies the forensic next-generation sequencing (NGS) workflow by integrating several manual and instrument steps into a single process. The HID Ion Chef System workflow now incorporates all steps of library preparation (targeted PCR amplification with respective primer panel, partial digestion of primer sequences, adapter/barcode ligation, purification, library equalization and pooling), as well as all steps of template preparation and chip loading. The simple, automated workflow provides easy access for users of any experience level.

Minimize variability and load chips reproducibly
The HID Ion Chef System provides reproducible chip loading by automating multiple manual chip-loading steps. The sophisticated visual system inside the HID Ion Chef System is designed to help reduce user-introduced error and variability by providing barcode reading and positive identification of samples, chips, and reagents. The visual system performs the setup check before the run, as well as the reagents and consumables load and unload check, calibration, and diagnostics.

Save time and labor
The HID Ion Chef System enables significant time and labor savings by offering quick and easy setup for both library preparation and templating that typically requires less than 15 minutes of hands-on time for each step.

Support for all Ion Torrent sequencing workflows
The flexible HID Ion Chef System is designed to provide automated and consistent Precision ID library preparation and template preparation for sequencing on the HID Ion GeneStudio S5 systems using any of the corresponding chips or template preparation and sequencing chemistries.

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and help ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data