Shop All Single-Use BioProcess Containers

Thermo Scientific™ 5:1 Single-Use Bioreactor BioProcess Container, CX5-14 film, drilled-hole sparger, crossflow sparger, 2000 L (Thermo Scientific™)

This 2000 L Thermo Scientific 5:1 Single-Use Fermentor (SUF) BioProcess Container (BPC) is composed of CX5-14 film, a five-layer, animal-origin free film, and includes a drilled-hole sparger (DHS) and crossflow sparger.

All SUF BPCs are constructed in an ISO 7 (Class 10,000) cleanroom, which complies with cGMP standards.

Features:
• Manufactured with industry-leading CX5-14 film
• C-flex tubing that can be used with tubing welder and various connection options
• Configurable to meet your process needs, including options for single-use sensing (DO, pH, and pressure)

Customize standard BPC systems for optimized single-use technology
Choose from the industry’s largest component library, with over 2,000 unique components that include:
Fittings—straight, reducing, elbow, T-style, X-style, and cross-style
Connectors—quick connectors/disconnectors, aseptic connectors and disconnectors, steam-to and steam-through connectors
Filters—used for bioburden reduction; sterilization grade filters and gas filters
Tubing—thermoplastic elastomers, platinum-cured silicone
Sample ports—septum-style and needle-free ports
Clamps—sliders, pinch, and crimp bands

Productainer™ BioProcess Container (BPC), 200 L with 4 TopPorts and 1 Bottom Dispense, 3D Single-Use BPC (Thermo Scientific™)

The Thermo Scientific™ Productainer™ BioProcess Container (BPC), 200 L 3D system is composed of CX5-14 single web, multi-layer plastic film and includes 4 top ports and 1 bottom port. The 3D square tube design with bottom port dispense is for use with conical, bottom-drain drums.

Features:
• Use this system to eliminate post-use cleaning steps required with re-useable containers, and to reduce cross-contamination risks.
• All 3D BPCs are constructed in an ISO 7 cleanroom under cGMP conditions.
• All 3D BPCs are designed to fit the full range of support containers, both square and cylindrical – from 50 to 2000 L.

Applications of the Thermo Scientific 3D BPC include:
• Hydration and sterilization of process buffers, liquids, and culture media.
• Chromatography feed and fraction collection.
• Storage and transport of bulk drug product and bulk drug precursors.
• Harvest from and feed into bioreactors and fermentors.
• Dispensing, packaging, and storage of cell culture media, buffers and process liquids.

Customize standard BPC systems for optimized single-use technology. Choose from the industry’s largest component library – with over 20,000 unique components that include:
Fittings—straight, reducing, elbow, T-style, X-style, and cross-style.
Connectors—quick connectors/disconnectors, aseptic connectors and disconnectors, steam-to and steam-through connectors.
Filters—used for bioburden reduction; sterilization grade filters and vent filters.
Tubing—thermoplastic elastomers, platinum-cured silicone.
Sample ports—septum-style and needle-free ports.
Clamps—sliders, pinch, and crimp bands.

Bags and Liners for HyPerforma™ Single-Use Mixer DS 300, 50L Liner - Bottom drain, non-irradiated (Thermo Scientific™)

The 50L open-top, non-irradiated BioProcess Container (BPC) tank liner with bottom drain is composed of CX3-9 single web, multi-layer plastic film and that fit inside drums for Thermo Scientific™ HyPerforma Single-Use Mixer DS 300. Implement industry-proven BPCs and liners in the overall process of shipping and storing your liquid-liquid and powder-liquid bioprocess mixing applications. BPCs and liners come in open- and closed-top design and are manufactured using our proprietary CX5-14 and CX3-9 film that easily fit in every plastic drum size.

Key Features of HyPerforma Single-Use Mixer DS 300 BPCs and liners:
• All standard BPCs and liners are designed to fit “out-of-the-box“
• Available in volume options of 50, 100, and 200L
• Applicable to open- and closed-top mixing applications
• Powder-liquid and liquid-liquid mixing
• World class CX5-14 and CX3-9 film
• Adaptable to multiple upstream process applications in media and buffer prep

Required Accessories:
• HyPerforma Single-Use Mixer DS 300 docking station
• HyPerforma SIngle-Use Mixer DS 300 drums

Recommended for:
• Powder-liquid or liquid-liquid mixing applications in single use
• High-throughput mixing and storage
• Additional configurations are available to suit your application requirements.

2D Labtainer™ BioProcess Container (BPC), ASI™ 28 film, 1 port, Luer Lock body connector (Thermo Scientific™)

The 100 mL Thermo Scientific™ Labtainer™ BioProcess Container (BPC) 2D system is composed of Thermo Scientific™ ASI™ 28 film, a 4-layer, 12.5 mL, animal origin–free ethyl vinyl acetate film and includes 1 port (1 luer body + cap).

Features of the system include:
• Helps to eliminate post-use cleaning steps required with reusable containers, and to reduce cross-contamination risks
• All Labtainers constructed in an ISO 7 cleanroom environment under cGMP conditions

Applications include:
• Harvesting from, feeding into, and collecting samples from bioreactors and fermenters
• Preparing and storing buffer, culture media, and process liquid
• Collecting chromatography feed and fraction
• Harvesting, storing, and transporting bulk drug product and drug precursors

Customize standard BPC systems for optimized single-use technology
Choose from the industry’s largest component library, with over 2,000 unique components that include:
• Fittings—straight, reducing, elbow, T-style, X-style, and cross-style
• Connectors—quick connectors/disconnectors, aseptic connectors and disconnectors, and steam-to and steam-through connectors
• Filters (used for bioburden reduction)—sterilization grade filters and vent filters
• Tubing—thermoplastic elastomers and platinum-cured silicone
• Sample ports—septum-style and needle-free ports
• Clamps—sliders, pinch, and crimp bands

Standard Fluid Transfer Assembly Extension Set, 1/2 in. ID, 5 m long (Thermo Scientific™)

Thermo Scientific™ Standard Fluid Transfer Assembly products increase single-use product flexibility. They connect to our standard Labtainer BPCs, Productainer BPCs, single-use bioreactors, mixers, and fermentors right on the shop floor. And they deliver simplified connectivity and enable greater process efficiency for most upstream and downstream process operations.

• One set of stocked products reduces the number of customized stock keeping units (SKUs), simplifies the ordering process, and reduces product storage requirements
• Multiple manufacturing sites ensure security in product supply
• Produced under cGMP conditions in ISO 7 clean areas to ensure a high level of quality
• Characterized using ISO, USP, EP, and ASTM test methods to validate performance

Standard Fluid Transfer Assembly products interconnect with Thermo Scientific standard BPC products to deliver a comprehensive and complete set of single-use products to meet the needs of your facility or process. Designed to aid many common shop floor processes such as sampling, transfer, and filling, a fit-for-purpose solution in the required tubing size and length can be easily selected from these designs.

All Standard Fluid Transfer Assembly products are constructed of capped-end connectors and thermoplastic elastomer (TPE) tubing for use with welders. The Extension Set is available in a variety of tubing sizes and lengths to meet your fluid transfer needs.

These Standard Fluid Transfer Assembly products provide a common set of products that addresses an expansive set of needs while decreasing the number of customized stock keeping units (SKUs), simplifying the ordering process and reducing storage requirements. They are manufactured at multiple sites globally to minimize concerns of production shutdown from supply shortages. These products are built to contribute to the performance and quality of your process at the highest level.

Standard Fluid Transfer Assembly Y Set, 3 x 3/8 in. ID (Thermo Scientific™)

Thermo Scientific™ Standard Fluid Transfer Assembly products increase single-use product flexibility. They connect to our standard Labtainer BPCs, Productainer BPCs, single-use bioreactors, mixers, and fermentors right on the shop floor. And they deliver simplified connectivity and enable greater process efficiency for most upstream and downstream process operations.

• One set of stocked products reduces the number of customized stock keeping units (SKUs), simplifies the ordering process, and reduces product storage requirements
• Multiple manufacturing sites ensure security in product supply
• Produced under cGMP conditions in ISO 7 clean areas to ensure a high level of quality
• Characterized using ISO, USP, EP, and ASTM test methods to validate performance

Standard Fluid Transfer Assembly products interconnect with Thermo Scientific standard BPC products to deliver a comprehensive and complete set of single-use products to meet the needs of your facility or process. Designed to aid many common shop floor processes such as sampling, transfer, and filling, a fit-for-purpose solution in the required tubing size and length can be easily selected from these designs.

All Standard Fluid Transfer Assembly products are constructed of capped-end connectors and thermoplastic elastomer (TPE) tubing for use with welders. The Y Set enables the user to split one connection into two branches or combine two connections into one. Users can also join individual Y sets to create multiple branches.

These Standard Fluid Transfer Assembly products provide a common set of products that addresses an expansive set of needs while decreasing the number of customized stock keeping units (SKUs), simplifying the ordering process and reducing storage requirements. They are manufactured at multiple sites globally to minimize concerns of production shutdown from supply shortages. These products are built to contribute to the performance and quality of your process at the highest level.

Accent™ Plastic Outer Container 3D BioProcess Container (BPC), ASI™ 26/77 film, 3 ports, MPX inserts and Kleenpak connector (Thermo Scientific™)

The 500 L Thermo Scientific™ Single-Use 3D BioProcess Container (BPC) is a 3D BPC designed for use within the Thermo Scientific™ Accent™ Plastic Outer Container. It is composed of Thermo Scientific™ ASI™ 26/77 Polyethylene Film, with interconnecting C-Flex tubing and three ports (2 MPX insert + cap, 1 Kleenpak body connector with ½-inch barb). The plastic outer container provides support for the BPC, eliminating the need for complicated on-site sterilizing and cleaning procedures. Large volumes of cell culture media, buffers, or other liquids remain clean and ready to use directly from the outer container. Together, the Accent outer container and BPC form a system for collecting, storing, and dispensing fluids used in bioprocessing operations. Not intended for shipping applications.

BPC port specifications:
• Line 1: MPX insert with cap and pinch clamp
   Tubing: Silicone, length: 50.8 cm (20 in.)
   ID x OD: 12.7 x 19.1 mm (0.5 x 0.75 in.)
• Line 2: Kleenpak body connector with 12.7 cm (0.5 in) barb and pinch clamp
   Tubing: Silicone, length: 91.4 cm (36 in.)
   ID x OD: 12.7 x 19.1 mm (0.5 x 0.75 in.)
• Line 3: MPX insert with cap and pinch clamp
   Tubing: Silicone, length: 50.8 cm (20 in.)
   ID x OD: 12.7 x 19.1 mm (0.5 x 0.75 in.)

Applications
• Storing and transporting sterile media and buffers within facility
• Feeding sterile media into bioreactors and buffers into purification systems
• Receiving and storing harvest from bioreactors

HyPerforma™ Rocker BioProcess Container (BPC) (Thermo Scientific™)

The Thermo Scientific Rocker Bioprocess Container (BPC) is manufactured for use with the Thermo Scientific Rocker Bioreactor and is available in three volumes: 10, 20, and 50 L. Rocker BPCs are manufactured using a multi-layer, polyolefin-based, slip agent-free film. This film provides superior extractables and leachables profiles, water vapor and oxygen barriers, and complete fluid integrity. Each lot is routinely tested for bacterial endotoxins.

Rocker BPC features include:
• Shipped gamma-irradiated (25 to 40 kGy) and ready for use
• Routinely monitored for particulates per USP <788>
• Lot release requires endotoxin levels to test below 0.25 EU/mL
• All wetted materials are USP class VI-compliant and animal derived component-free (ADCF)

Applications
• Suspension and adherent cell culture processes

BioProcess Containers (BPC), 500L, for HyPerforma™ Single-Use Mixer and docking tank, powder-to-liquid w/probe ports (Thermo Scientific™)

The 500L Thermo Scientific™ Bioprocess Container (BPC) with probe ports is for use with the Thermo Scientific™ HyPerforma™ Single-Use Mixer and docking tank for powder-to-liquid mixing.

Single Use Mixer (S.U.M.) BPC options include:
• Open top liner for media/buffer hydration
• Closed BPC with powder port for contained media/buffer hydration
• Closed BPC with powder port and monitoring probe capability
• Closed BPC for liquid-liquid mixing of critical sterile solutions such as pooling of fractions or processing of intermediate solutions
• Closed BPC for liquid-liquid mixing with monitoring probe capability

Productainer™ BioProcess Container (BPC), 200 L with 2 Top and 1 Bottom Ports, 3D Single-Use BPC (Thermo Scientific™)

The Thermo Scientific™ Productainer™ BioProcess Container (BPC), 200 L 3D system is composed of CX5-14 single web, multi-layer plastic film and includes 2 top ports and 1 bottom port. The 3D square tube design with bottom port dispense is for use with conical, bottom-drain drums.

Features:
• Use this system to eliminate post-use cleaning steps required with re-useable containers, and to reduce cross-contamination risks.
• All 3D BPCs are constructed in an ISO 7 cleanroom under cGMP conditions.
• All 3D BPCs are designed to fit the full range of support containers, both square and cylindrical – from 50 to 2000 L.

Applications of the Thermo Scientific 3D BPC include:
• Hydration and sterilization of process buffers, liquids, and culture media.
• Chromatography feed and fraction collection.
• Storage and transport of bulk drug product and bulk drug precursors.
• Harvest from and feed into bioreactors and fermentors.
• Dispensing, packaging, and storage of cell culture media, buffers and process liquids.

Customize standard BPC systems for optimized single-use technology. Choose from the industry’s largest component library – with over 20,000 unique components that include:
Fittings—straight, reducing, elbow, T-style, X-style, and cross-style.
Connectors—quick connectors/disconnectors, aseptic connectors and disconnectors, steam-to and steam-through connectors.
Filters—used for bioburden reduction; sterilization grade filters and vent filters.
Tubing—thermoplastic elastomers, platinum-cured silicone.
Sample ports—septum-style and needle-free ports.
Clamps—sliders, pinch, and crimp bands.

2D Labtainer™ BioProcess Container (BPC), ASI™ 28 film, 3 ports, Luer Lock insert and body connectors, injection site (Thermo Scientific™)

The 2 L Thermo Scientific™ Labtainer™ BioProcess Container (BPC) 2D system is composed of Thermo Scientific™ ASI™ 28 film, a 4-layer, 12.5 mL, animal origin–free ethyl vinyl acetate film and includes 3 ports (1 male Luer Lock + cap, 1 female Luer Lock + cap, 1 injection site).

Features of the system include:
• Helps to eliminate post-use cleaning steps required with reusable containers, and to reduce cross-contamination risks
• All Labtainers constructed in an ISO 7 cleanroom environment under cGMP conditions

Applications include:
• Harvesting from, feeding into, and collecting samples from bioreactors and fermenters
• Preparing and storing buffer, culture media, and process liquid
• Collecting chromatography feed and fraction
• Harvesting, storing, and transporting bulk drug product and drug precursors

Customize standard BPC systems for optimized single-use technology
Choose from the industry’s largest component library, with over 2,000 unique components that include:
• Fittings—straight, reducing, elbow, T-style, X-style, and cross-style
• Connectors—quick connectors/disconnectors, aseptic connectors and disconnectors, and steam-to and steam-through connectors
• Filters (used for bioburden reduction)—sterilization grade filters and vent filters
• Tubing—thermoplastic elastomers and platinum-cured silicone
• Sample ports—septum-style and needle-free ports
• Clamps—sliders, pinch, and crimp bands

Harvestainer™ Microcarrier Separation System (Thermo Scientific™)

The Thermo Scientific Harvestainer Microcarrier Separation System is the ideal solution for the separation of microcarrier beads during adherent cell culture production. The Harvestainer system is a closed, single-use system that helps to increase product yields versus traditional methods, while reducing clean-in-place and steam-in-place requirements and water for injection usage. It eliminates equipment maintenance and reduces process validations, cycle times, and manual final decanting processes.

For smaller-scale or larger-scale applications, the Harvestainer system is ideal for in-line microcarrier separation. The 3 L and 12 L Harvestainer systems consist of a pre-assembled bioprocess container (BPC) and tray in a single-use unit, where the tray acts as the secondary containment device. The 25 L and 50 L Harvestainer systems consist of a 3D BPC with a drum as the secondary containment device. The BPC features a dip tube with dipwell design for better drainage and minimal manipulation.

• Closed system
• Scalable for both smaller-scale and larger-scale applications
• Helps deliver high recovery rates
• Inline microcarrier separation

Applications
• Adherent cell culture production

BioProcess Containers (BPC), 500L, for HyPerforma™ Single-Use Mixer and docking tank, liquid-to-liquid w/probe ports (Thermo Scientific™)

The 500L Thermo Scientific™ Bioprocess Container (BPC) with probe ports is for use with the Thermo Scientific™ HyPerforma™ Single-Use Mixer and docking tank for liquid-to-liquid mixing.

Single Use Mixer (S.U.M.) BPC options include:
• Open top liner for media/buffer hydration
• Closed BPC with powder port for contained media/buffer hydration
• Closed BPC with powder port and monitoring probe capability
• Closed BPC for liquid-liquid mixing of critical sterile solutions such as pooling of fractions or processing of intermediate solutions
• Closed BPC for liquid-liquid mixing with monitoring probe capability

PowderTainer™ II 1 to 25kg Single-Use BPC for powder applications, 5 kg (Thermo Scientific™)

The 5 kg Thermo Scientific™ Powdertainer™ II BioProcess Container (BPC) is a 2D powder handling system composed of CX3-9 film that includes 1 port (1 powder port). The Powdertainer BPC is specifically designed for powder containment and discharge applications, and maintains a closed system for maximum recovery of powder while minimizing the risk of cross contamination.

Features:
• Three-inch tri-clamp port designed for secure connection to, and easy integration, with existing formulation vessels.
• Powdertainer BPC features suspensor handle for support during discharge, as well as neck clamp to retain powder prior to discharge.
• Use this system to eliminate post-use cleaning steps required with re-useable containers.

Applications of the Thermo Scientific Powdertainer BPC include:
• Storage and delivery of powder culture media and buffers.
• Storage and dispensing of pre-weighed chemicals and other process powders.

Accent™ Plastic Outer Container (Thermo Scientific™)

The 500 L Thermo Scientific™ Accent™ Plastic Outer Container is designed for safe intra-family fluid handling and storage. These containers give the customer the flexibility to add custom-configured options to the standard product line without extensive lead times or cost.

Features
• Standard sizes ranging from 100 L to 1,000 L
• 1,000 L wide configuration option
• Ease of use and operation
• Clean room–grade swivel casters (available up to 500 L)

Applications
• Buffer and media storage and distribution
• Bulk feed and harvest
• Bulk intermediate hold
• Bulk drug substance
• Final product transport