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LRRK2 G2019S Full Length Protein Thermo Scientific™
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multidomain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease. This full-length, purified and active LRRK2 G2019S mutant protein may be useful in research to better understand the most common Parkinson's disease-relevant mutant, as well as to explore the mechanisms underlying the disease.
• Increase disease relevance by interrogating a purified and active full-length LRRK2 protein
• Uncover novel compounds or hits specific to the full-length form
• Advance Parkinson's research using the full-length protein and validated assays
Related Links:
• LRRK2 tools for advancing Parkinson's disease research
• Kinase protein portfolio
• LanthaScreen® Eu Kinase Binding Assay
• LanthaScreen® TR-FRET Kinase Activity Assay
• Increase disease relevance by interrogating a purified and active full-length LRRK2 protein
• Uncover novel compounds or hits specific to the full-length form
• Advance Parkinson's research using the full-length protein and validated assays
Related Links:
• LRRK2 tools for advancing Parkinson's disease research
• Kinase protein portfolio
• LanthaScreen® Eu Kinase Binding Assay
• LanthaScreen® TR-FRET Kinase Activity Assay
Rat GM-CSF (aa 18-144) Recombinant Protein Invitrogen™
Rat GM-CSF (aa 18-144) Recombinant Protein for Western Blot, ELISA, Ctrl
FGF4 Recombinant Human Protein Gibco™
Recombinant Human Fibroblast Growth Factor 4 (FGF4) is a bioactive protein intended for use in cell culture applications. FGF4 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. Studies on the mouse homolog suggest a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.
• High purity—no interference from other proteins or contaminants
• High biological activity—more results with less protein
• Proven compatibility—Gibco® proteins bioassayed with Gibco® media
High Purity Recombinant Bioactive Protein
Recombinant Human Fibroblast Growth Factor 4 is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.
High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Fibroblast Growth Factor 4 (FGF4) specific activity is determined by the dose dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors.
Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.
See our selection of recombinant Gibco® growth factors.
For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.
• High purity—no interference from other proteins or contaminants
• High biological activity—more results with less protein
• Proven compatibility—Gibco® proteins bioassayed with Gibco® media
High Purity Recombinant Bioactive Protein
Recombinant Human Fibroblast Growth Factor 4 is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.
High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Fibroblast Growth Factor 4 (FGF4) specific activity is determined by the dose dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors.
Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.
See our selection of recombinant Gibco® growth factors.
For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.
Lipofectamine™ CRISPRMAX™ Cas9 Transfection Reagent Invitrogen™
Lipofectamine CRISPRMAX Cas9 Transfection Reagent is the first optimized lipid nanoparticle transfection reagent for CRISPR-Cas9 protein delivery. It is a high-throughput-friendly, cost-effective alternative to electroporation.
Working together with our TrueCut Cas9 Protein v2 and TrueGuide Synthetic gRNA, it provides:
• Demonstrated cleavage efficiency—tested in over 20 cell types including iPSC, mESC, N2A, CHO, A549, HCT116, HeLa, HEK293, and several others
• Low cell toxicity—less cells needed to initiate your experiment
• High throughput friendly—an ideal delivery solution for 96-well format
• Cost savings—whether cost-per-reaction or initial investment
Achieve high transfection efficiency in novel genome editing applications
Lipofectamine CRISPRMAX transfection reagent increases the likelihood of successful cleavage and recombination, especially when combined with our TrueCut Cas9 Protein v2 and TrueGuide Synthetic gRNA. This ultimately maximizes the efficiency of performing genetic modifications.
Improve experimental outcomes using TrueCut Cas9 Protein v2
Unlike CRISPR plasmid or Cas9 mRNA, using Cas9 protein provides superior cleavage efficiency in primary cells and stem cells. It eliminates the need for transcription or translation of the payload, removes the risk of genomic integration, and is cell cycle independent.
Working together with our TrueCut Cas9 Protein v2 and TrueGuide Synthetic gRNA, it provides:
• Demonstrated cleavage efficiency—tested in over 20 cell types including iPSC, mESC, N2A, CHO, A549, HCT116, HeLa, HEK293, and several others
• Low cell toxicity—less cells needed to initiate your experiment
• High throughput friendly—an ideal delivery solution for 96-well format
• Cost savings—whether cost-per-reaction or initial investment
Achieve high transfection efficiency in novel genome editing applications
Lipofectamine CRISPRMAX transfection reagent increases the likelihood of successful cleavage and recombination, especially when combined with our TrueCut Cas9 Protein v2 and TrueGuide Synthetic gRNA. This ultimately maximizes the efficiency of performing genetic modifications.
Improve experimental outcomes using TrueCut Cas9 Protein v2
Unlike CRISPR plasmid or Cas9 mRNA, using Cas9 protein provides superior cleavage efficiency in primary cells and stem cells. It eliminates the need for transcription or translation of the payload, removes the risk of genomic integration, and is cell cycle independent.
MicroSEQ™ ID Microbial Identification Software v3.0 Bundle for 3500 Instrument Applied Biosystems™
MicroSEQ® ID Microbial Identification Software allows you to easily identify and classify unidentified bacterial or fungal sequences by comparing them to a validated microbial library. This bundled version includes the bacterial and fungal sequence libraries.
A validated library of over 2300 microbial 16S rDNA sequences help ensure you get the answers you need
• Automatically identify unknown specimens
• Run plates on Applied Biosystems® 3500 Series genetic analyzers directly via the MicroSEQ® ID Software
• MicroSEQ® system is a complete integrated solution, including security, audit, and e-signature features
• Qualification and validation support
Confidently Identify Microbes
The MicroSEQ® system comprises bacterial libraries of 500 bp 16S rDNA sequences and over 2300 validated entries--including extensive coverage of gram-negative nonfermenters, Bacillus, Coryneforms, Mycobacteria, and Staphylococcus. A fungal library containing more than 1100 entries is also included for fungal identification. To help ensure accurate identification of the species of your sequences, we rigorously validate all library entries. And unlike other widely available databases, MicroSEQ® libraries contain only correctly identified organisms and quality-controlled sequences derived from type strains of preeminent culture collections. The libraries also support sequence polymorphisms, and include bacterial Category A biothreat agents.
Automatically Identify Unknown Specimens
Reviewing each specimen in a project file to make a manual identification call can be tedious and time consuming. The new Auto-ID feature uses a set of editable parameters to automatically identify unknown specimens. The results table is displayed in the report, and an editable comments field allows additional information or manual identifications to be entered into the same table.
Run Plates on 3500/3500xL Instruments Directly via the MicroSEQ® ID Software
Applied Biosystems® 3500 Series Genetic Analyzer users are now able to run plates on these instruments directly via the MicroSEQ® ID Software user interface, without needing Autoanalysis Manager. A single software wizard enables you to set up projects, specimens, and plates; adjust the plate layout via drag and drop; start and monitor the run; and review results.
The MicroSEQ® System: A Complete, Integrated Solution
Streamlining every step in microbial identification, the Applied Biosystems® MicroSEQ® system combines the advantages of MicroSEQ® ID Software with easy to use PrepMan® Ultra sample preparation reagents and protocols, MicroSEQ® bacterial and fungal application kits, and industry-leading thermal cyclers and sequencing systems. To help ensure optimal performance and system-wide integration, we develop and test all components of the system together. The MicroSEQ® ID Software also includes security, audit, and electronic signature features enabling the software to smoothly integrate into your workflow.
Qualification and Validation Support
To help ensure seamless integration into your laboratory, from installation to routine operation, we offer comprehensive installation and operational qualification (IQ/OQ) and validation support services.
A validated library of over 2300 microbial 16S rDNA sequences help ensure you get the answers you need
• Automatically identify unknown specimens
• Run plates on Applied Biosystems® 3500 Series genetic analyzers directly via the MicroSEQ® ID Software
• MicroSEQ® system is a complete integrated solution, including security, audit, and e-signature features
• Qualification and validation support
Confidently Identify Microbes
The MicroSEQ® system comprises bacterial libraries of 500 bp 16S rDNA sequences and over 2300 validated entries--including extensive coverage of gram-negative nonfermenters, Bacillus, Coryneforms, Mycobacteria, and Staphylococcus. A fungal library containing more than 1100 entries is also included for fungal identification. To help ensure accurate identification of the species of your sequences, we rigorously validate all library entries. And unlike other widely available databases, MicroSEQ® libraries contain only correctly identified organisms and quality-controlled sequences derived from type strains of preeminent culture collections. The libraries also support sequence polymorphisms, and include bacterial Category A biothreat agents.
Automatically Identify Unknown Specimens
Reviewing each specimen in a project file to make a manual identification call can be tedious and time consuming. The new Auto-ID feature uses a set of editable parameters to automatically identify unknown specimens. The results table is displayed in the report, and an editable comments field allows additional information or manual identifications to be entered into the same table.
Run Plates on 3500/3500xL Instruments Directly via the MicroSEQ® ID Software
Applied Biosystems® 3500 Series Genetic Analyzer users are now able to run plates on these instruments directly via the MicroSEQ® ID Software user interface, without needing Autoanalysis Manager. A single software wizard enables you to set up projects, specimens, and plates; adjust the plate layout via drag and drop; start and monitor the run; and review results.
The MicroSEQ® System: A Complete, Integrated Solution
Streamlining every step in microbial identification, the Applied Biosystems® MicroSEQ® system combines the advantages of MicroSEQ® ID Software with easy to use PrepMan® Ultra sample preparation reagents and protocols, MicroSEQ® bacterial and fungal application kits, and industry-leading thermal cyclers and sequencing systems. To help ensure optimal performance and system-wide integration, we develop and test all components of the system together. The MicroSEQ® ID Software also includes security, audit, and electronic signature features enabling the software to smoothly integrate into your workflow.
Qualification and Validation Support
To help ensure seamless integration into your laboratory, from installation to routine operation, we offer comprehensive installation and operational qualification (IQ/OQ) and validation support services.
Human Dynamin 2 (aa 758-777) Synthetic Peptide Invitrogen™
Human Dynamin 2 (aa 758-777) Synthetic Peptide for Ctrl
Pharma KingFisher™ Flex Magnetic Head for 96 Deep-Well Plate Applied Biosystems™
Magnetic head for the Pharma KingFisher™ Flex Deep-Well Head Magnetic Particle Processor This magnetic head can serve as a replacement head for the 96 deep-well format system. Includes one magnetic head.
