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    GRK1 Recombinant Human Protein Thermo Scientific™

    GRK1 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinases. GRK1 mediates rapid desensitization of rod photoreceptors to light by catalyzing phosphorylation of the visual pigment rhodopsin which leads to its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). GRK1 can be phosphorylated by PKA and this reduces the ability of GRK1 to phosphorylate rhodopsin in vitro. It is speculated that phosphorylation of GRK1 by PKA in vivo occurs in the dark when cAMP levels in photoreceptor cells are elevated. Full-length recombinant human GRK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

    • Validated in LanthaScreen® Kinase Binding Assay
    • Protocols available for simple use and optimized performance
    • Multiple pack sizes available for convenient use

    Related Product:
    LanthaScreen® Eu Kinase Binding Assay

    MAP4K1 (HPK1) Recombinant Human Protein

    MAP4K1 (also known as HPK1) or Hematopoietic progenitor kinase 1 is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase super family. MAP4K1 is a tissue-specific upstream activator of the MEKK/JNK/SAPK signaling pathway. MAP4K1 diminishes T cell receptor (TCR) signaling activity and T cell proliferation by phosphorylating the adaptor protein SLP-76. Recombinant human MAP4K1 (1-346) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

    • Validated in LanthaScreen® Kinase Binding Assay
    • Protocols available for simple use and optimized performance
    • Multiple pack sizes available for convenient use

    Related Product:
    LanthaScreen® Eu Kinase Binding Assay

    Converge™ Software v1.0 Case Management License and Kinship & Paternity Analysis License Applied Biosystems™

    These two licenses are for the Case Management and Kinship & Paternity Analysis applications of Converge Software v1.0. The software is obtained through purchase of the Converge Software documentation and server computer. Converge Software is an all-in-one, modular, enterprise platform from Thermo Fisher Scientific that provides integrated DNA data management and analysis software for forensic laboratories. The software simplifies the daily complexities of forensic case management and kinship/paternity analysis and centralizes all case data under one powerful solution.

    Case Management application
    Converge Software is designed to increase the efficiency of forensic and relationship DNA testing laboratories through the centralization of data creation, analysis, and storage to a single access point. The Case Management software application supports case, subject, genotype profile, and laboratory data management, and allows for automated data transfer and integration with various forensic DNA laboratory systems. The software is highly configurable to fit specific laboratory workflows, not only for analysis parameters, but also for data fields per the laboratory SOPs. In addition, it allows for configuration of the user interface and output reports, and provides features that help ensure data security and integrity. These features are easily accessible through a secured web browser interface under the protection of a laboratory’s own IT department. A variety of software modules can be readily built on the Converge platform to support various forensic applications.

    Converge Kinship and Paternity application
    Kinship and paternity testing can provide challenges in both the sheer volume of cases to be analyzed, as well as the complexity of laboratory workflows and statistical analyses being performed. Thermo Fisher Scientific offers an integrated and streamlined solution for kinship and paternity testing on the Converge platform with its Converge Kinship and Paternity application. The application integrates with Converge Software and GeneMapper™ ID-X genotyping software to help enable automated analysis, reporting of routine paternity and other relationship testing cases, and allows for genetic likelihood ratio calculation, as well as reports for any complex relationship. Licenses for this module may be purchased in addition to the Case Management license.

    Learn more about Case Management License (without Kinship & Paternity Analysis License) >

    Human HRK Synthetic Peptide Invitrogen™

    Human HRK Synthetic Peptide for BLOCK, Ctrl

    AMPK (A1/B2/G3) Recombinant Human Protein Invitrogen™

    This AMPK (A1/B2/G3) recombinant human protein (full length) was expressed in insect cells. AMPK (AMP-activated protein kinase) serine/threonine kinase is a heterotrimeric complex, which acts as sensor of cellular energy levels. The signaling cascades initiated by activating AMPK are critical to regulation of metabolic events in the liver, skeletal muscle, heart, adipose tissue, and pancreas. This AMPK consists of the alpha1, beta2 and gamma3 subunits. While the purified AMPK (A1/B2/G3) complex can be used in a number of different applications, it has been specifically validated for use with our Z’-LYTE™ assay technology to identify novel kinase inhibitors. AMPK (A1/B2/G3) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

    • Validated for use with the Z’-LYTE™ assay
    • Available in multiple pack sizes for convenient use
    • Also available in our SelectScreen Kinase Profiling Service

    MAXIscript™ SP6 Transcription Kit Invitrogen™

    The Ambion® MAXIscript® SP6 In Vitro Transcription Kit synthesizes RNA probes in just 10 minutes for use in ribonuclease protection assays, in situ hybridization, and blot hybridizations. Each kit contains sufficient reagents for 100 reactions.


    • High yields of high specific activity, full-length RNA probes in just 10 minutes
    • Ideal probe synthesis kit for nuclease protection assays, northern and Southern blots, and in situ hybridization
    • Includes TURBO DNase™
    • All kits contain quality-tested DNase/RNase-free reagents

    The MAXIscript® In Vitro Transcription Kit synthesizes RNA probes with specific activities reaching 1 × 109 cpm/µg in just 10 minutes. MAXIscript® Kits are very efficient at synthesizing full-length probes, even at limiting nucleotide concentrations, making them the perfect companion to ribonuclease protection assays. MAXIscript® Kits are also an excellent choice for the synthesis of nonisotopically labeled probes. Labeling can be accomplished post-transcriptionally by using Ambion's BrightStar® Psoralen-Biotin Labeling Kit, or during transcription by incorporating modified nucleotides into the reaction. MAXIscript® Kits can also be used for the synthesis of modest amounts of unlabeled RNA (2–6 µg/20 µl reaction) of up to 2 kb.

    Human PAI1 Recombinant Protein Invitrogen™

    Human PAI1 Recombinant Protein for Western Blot, Ctrl

    AURKB (Aurora B) Recombinant Human Protein

    The Aurora kinases associate with microtubules during chromosome movement and segregation. AURKB (Aurora B) localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers.

    FGFR3 Recombinant Human Protein Thermo Scientific™

    FGFR3 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy.

    Richard-Allan Scientific™ May-Grunwald Stain, bottle Thermo Scientific™

    Produce very dense color saturation with Thermo Scientific™ Richard-Allan Scientific™ May-Grunwald Stain, a classical hematology stain

    LRRK2 G2019S Full Length Protein

    Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multidomain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease. This full-length, purified and active LRRK2 G2019S mutant protein may be useful in research to better understand the most common Parkinson's disease-relevant mutant, as well as to explore the mechanisms underlying the disease.

    Increase disease relevance by interrogating a purified and active full-length LRRK2 protein
    Uncover novel compounds or hits specific to the full-length form
    Advance Parkinson's research using the full-length protein and validated assays

    Related Links:
    LRRK2 tools for advancing Parkinson's disease research
    Kinase protein portfolio
    LanthaScreen® Eu Kinase Binding Assay
    LanthaScreen® TR-FRET Kinase Activity Assay

    Human Estrogen Receptor alpha (aa 21-32) Synthetic Peptide Invitrogen™

    Human Estrogen Receptor alpha (aa 21-32) Synthetic Peptide for Ctrl
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