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Recombinant


GRK1 Recombinant Human Protein Thermo Scientific™

GRK1 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinases. GRK1 mediates rapid desensitization of rod photoreceptors to light by catalyzing phosphorylation of the visual pigment rhodopsin which leads to its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). GRK1 can be phosphorylated by PKA and this reduces the ability of GRK1 to phosphorylate rhodopsin in vitro. It is speculated that phosphorylation of GRK1 by PKA in vivo occurs in the dark when cAMP levels in photoreceptor cells are elevated. Full-length recombinant human GRK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay

MAP4K1 (HPK1) Recombinant Human Protein

MAP4K1 (also known as HPK1) or Hematopoietic progenitor kinase 1 is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase super family. MAP4K1 is a tissue-specific upstream activator of the MEKK/JNK/SAPK signaling pathway. MAP4K1 diminishes T cell receptor (TCR) signaling activity and T cell proliferation by phosphorylating the adaptor protein SLP-76. Recombinant human MAP4K1 (1-346) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay

AMPK (A1/B2/G3) Recombinant Human Protein Invitrogen™

This AMPK (A1/B2/G3) recombinant human protein (full length) was expressed in insect cells. AMPK (AMP-activated protein kinase) serine/threonine kinase is a heterotrimeric complex, which acts as sensor of cellular energy levels. The signaling cascades initiated by activating AMPK are critical to regulation of metabolic events in the liver, skeletal muscle, heart, adipose tissue, and pancreas. This AMPK consists of the alpha1, beta2 and gamma3 subunits. While the purified AMPK (A1/B2/G3) complex can be used in a number of different applications, it has been specifically validated for use with our Z’-LYTE™ assay technology to identify novel kinase inhibitors. AMPK (A1/B2/G3) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

Human PAI1 Recombinant Protein Invitrogen™

Human PAI1 Recombinant Protein for Western Blot, Ctrl

AURKB (Aurora B) Recombinant Human Protein

The Aurora kinases associate with microtubules during chromosome movement and segregation. AURKB (Aurora B) localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers.

FGFR3 Recombinant Human Protein Thermo Scientific™

FGFR3 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy.

LRRK2 G2019S Full Length Protein

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multidomain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease. This full-length, purified and active LRRK2 G2019S mutant protein may be useful in research to better understand the most common Parkinson's disease-relevant mutant, as well as to explore the mechanisms underlying the disease.

Increase disease relevance by interrogating a purified and active full-length LRRK2 protein
Uncover novel compounds or hits specific to the full-length form
Advance Parkinson's research using the full-length protein and validated assays

Related Links:
LRRK2 tools for advancing Parkinson's disease research
Kinase protein portfolio
LanthaScreen® Eu Kinase Binding Assay
LanthaScreen® TR-FRET Kinase Activity Assay

STK38L (NDR2) Recombinant Human Protein Thermo Scientific™

STK38L (also known as NDR2) or Nuclear Dbf2-related protein is a serine/threonine kinase in the subgroup of the AGC kinase family. STK38L act as novel pro-apoptotic kinase that is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis. STK38L is mainly involved in the regulation of structural processes in differentiating and mature neuronal cells and it is highly expressed with highest levels observed in the thymus. Recombinant full-length human STK38L was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay

AMPK (A2/B1/G2) Recombinant Human Protein Invitrogen™

This AMPK (A2/B1/G2) recombinant human protein (full length) was expressed in insect cells. AMPK (AMP-activated protein kinase) serine/threonine kinase is a heterotrimeric complex, which acts as sensor of cellular energy levels. The signaling cascades initiated by activating AMPK are critical to regulation of metabolic events in the liver, skeletal muscle, heart, adipose tissue, and pancreas. This AMPK consists of the alpha2, beta1 and gamma2 subunits. While the purified AMPK (A2/B1/G2) complex can be used in a number of different applications, it has been specifically validated for use with our Z’-LYTE™ assay technology to identify novel kinase inhibitors. AMPK (A2/B1/G2) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

BDNF Recombinant Protein Invitrogen™

Human BDNF Recombinant Protein for Ctrl

KDR (VEGFR2) Recombinant Human Protein

KDR (VEGFR2) is a type III receptor tyrosine kinase. It binds vascular endothelial growth factor with high affinity in vitro, and is expressed early in development by endothelial cell precursors.

Mouse LIF Recombinant Protein, eBioscience™ Invitrogen™

Mouse LIF Recombinant Protein for Ctrl, FN

Human PAI1 Recombinant Protein Invitrogen™

Human PAI1 Recombinant Protein for Western Blot, Ctrl

IL13 Recombinant Human Protein Gibco™

Recombinant Human Interleukin 13 (IL13) is a bioactive protein intended for use in cell culture applications. IL13 down-regulates macrophage produced cytokines such as TNF-α, IL-1, IL-6, IL-8, and IL-12 in response to LPS challenge or IFN-γ. IL13 induces monocyte differentiation and also induces B cell differentiation and proliferation.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High purity recombinant bioactive protein
Recombinant Human Interleukin 13 is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High biological activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Interleukin 13 (IL13) specific activity is determined by the dose dependent proliferation of human TF-1 cells.

Proven compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

FLT3 Recombinant Human Protein Thermo Scientific™

FLT3 is a tyrosine protein kinase that is a member of the growth factor receptor tyrosine kinase family.
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