Shop All Proteins and Derivatives

PIM3 Recombinant Human Protein Invitrogen™

This PIM3 recombinant human protein (full length) was expressed in insect cells. PIM3 serine/threonine kinase or PIM-3 oncogene belongs to a family of protooncogenes. PIM3 is expressed in hepatocellular carcinoma development and plays a main role in the proliferation of human hepatoma cell lines. PIM3 also expressed in human pancreatic cancer cells and phosphorylates BAD to block Bad-mediated apoptosis in human pancreatic cancer cell lines. PIM3 recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

RET S891A Recombinant Human Protein Invitrogen™

This RET S891A recombinant human protein (658–end) was expressed in insect cells. RET S891A receptor tyrosine kinase or ret proto-oncogene is a member of the cadherin superfamily which are cell-surface molecules that transduce signals for cell growth and differentiation. RET can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in the RET gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. RET signaling pathway, by regulating the development of both the nervous and lymphoid system in the gut, plays a key role in the molecular mechanisms that orchestrate intestine organogenesis. RET S891A recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

DNA-PK Human Protein

DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signalling cascades in response to DNA damage. DNA-PK is an atypical kinase, closely related to the PI3 kinases, and is often potently inhibited by small molecules designed to target PI3 kinases.

SBK1 Recombinant Human Protein Invitrogen™

This SBK1 recombinant human protein (full length) was expressed in insect cells. SBK1 novel serine/threonine kinase or SH3 domain binding kinase 1 is structurally related to a Xenopus gastrula-specific protein kinase, Pk9.7 which possessing a consensus sequence for an SH3-binding domain from developing rat brain. SBK1 plays an important role in signal-transduction pathways related to the control of brain development. SBK1 may predict a broad cellular function, and its dysregulated in certain cancers suggests an involvement of the protein in the pathogenesis of human cancers. SBK1 recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

Vascular Endothelial Growth Factor-121 (human) Recombinant Protein Invitrogen™

Human VEGF-121 Recombinant Protein for Ctrl

NEK8 Recombinant Human Protein Invitrogen™

This NEK8 recombinant human protein (1–322) was expressed in insect cells. NEK8 serine/threonine kinase or NIMA-related kinase 8 is related to NIMA (never in mitosis, gene A) of Aspergillus nidulans and may play a role in cell cycle progression from G2 to M phase. NEK8 is part of a complex of ciliary proteins required for renal and cardiovascular development. NEK8 interacts with polycystin signal transduction pathways and may control the targeting of these ciliary proteins. NEK8 recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

TEK (TIE2) Y897S Recombinant Human Protein Invitrogen™

This TEK (TIE2) Y897S recombinant human protein (771–end) was expressed in insect cells. TEK (TIE2) Y897S receptor tyrosine kinase is expressed principally on vascular endothelium. Disrupting TEK Y897S function in mice results in embryonic lethality with defects in embryonic vasculature, suggesting a role in blood vessel maturation and maintenance. Angiopoietin-1 is a secreted growth factor that binds to and activates the TEK receptor tyrosine kinase. SHP2 and GRB2 are recruited to the activated TEK kinase domain and are part of the cellular responses that mediate TEK function. TEK expression is upregulated in the endothelium of vascular 'hot spots' in human breast cancer specimens. However, TEK is also overexpressed in areas of active angiogenesis in normal tissues. TEK (TIE2) Y897S recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

Mouse IL-21 Carrier-Free Recombinant Protein, eBioscience™ Invitrogen™

Mouse IL-21 Carrier-Free Recombinant Protein for Ctrl, FN

Human CD257 (BAFF, BLyS) Recombinant Protein, eBioscience™ Invitrogen™

Human CD257 (BAFF, BLyS) Recombinant Protein for Ctrl, FN

IL5 Recombinant Human Protein Gibco™

Recombinant Human Interleukin-5 (IL5) is a bioactive protein intended for use in cell culture applications. IL5 promotes the growth and differentiation of eosinophils.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Human Interleukin-5 is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Interleukin-5 (IL5) specific activity is determined by measuring the IL5 dose dependent proliferation of TF-1 cells.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

Human CXCL10 Recombinant Protein Invitrogen™

Human CXCL10 Recombinant Protein for Ctrl

OXSR1 Recombinant Human Protein Invitrogen™

This OXSR1 recombinant human protein (full length) was expressed in insect cells. OXSR1 serine/threonine kinase or (OSR1) is activated by osmotic stresses and regulates downstream protein kinases such as PAK1 in order to establish the sensor/signaling modules that initiate the cellular response to environmental stress. OXSR1 can be phosphorylated by ATM or ATR during the DNA damage process. OXSR1 recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

TNK1 Recombinant Human Protein Invitrogen™

This TNK1 recombinant human protein (1–510) was expressed in insect cells. TNK1 tyrosine kinase, non-receptor 1 belongs to the tyrosine protein kinase family and as such is an important regulator of intracellular signal transduction pathways mediating cellular proliferation, survival, and development. TNK1 is highly expressed in fetal tissues and at lower levels in a few adult tissues. TNK1 may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. TNK1 plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. TNK1 recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

IL3 Recombinant Mouse Protein Gibco™

Recombinant Mouse Interleukin 3 (IL3) is a bioactive protein intended for use in cell culture applications. IL3 provides the cytokine connection between the immune system and the hematopoietic system. For example, IL3 supports the proliferation and development of almost all types of hematopoietic progenitor cells and can act as a chemoattractant for eosinophils.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Recombinant Mouse Interleukin 3 is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Mouse Interleukin 3 (IL3) specific activity is determined by the dose dependent proliferation of NFS-60 cells.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

Mouse M-CSF Recombinant Protein, eBioscience™ Invitrogen™

Mouse M-CSF Recombinant Protein for Ctrl, FN
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