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Dionex™ Ion Standards Thermo Scientific™
Dionex™ Chloride Standard (1000 mg/L) Thermo Scientific™
UltiMate™ AFC-3000 Low Flow Rate Kit Thermo Scientific™
Dionex™ Sulfate Standard (1000 mg/L) Thermo Scientific™
Dionex™ ICS-6000 DP Dual Pumps Thermo Scientific™
Choose from a variety of Thermo Scientific™ Dionex™ ICS-6000 DP Dual Pump configurations for your applications on the Thermo Scientific™ Dionex™ ICS-6000 HPIC™ system. Dionex ICS-6000 DP Dual Pumps include analytical, capillary, or hybrid (analytical and capillary) versions to support capillary, microbore, standard bore, semipreparative, and IC x IC (2D-IC) ion chromatography applications. Designed for continuous operation at up to 5000 psi, the pumps feature a variable-speed, serial-piston design that delivers consistent flow rates and quite detector baselines.
TRACE™ 1310 GC Analyzers for Permanent Gases & Trace Impurities Thermo Scientific™
UltiMate™ WPS-3000SL/TSL Standard Well Plate Autosamplers Thermo Scientific™
Enjoy wide application flexibility in a cost-effective, dependable autosampler. The Thermo Scientific™ Dionex™ UltiMate™ Standard Well Plate Autosampler is highly versatile in sample format and injection volume. It can rapidly, accurately and precisely inject from 1 to 100µL for conventional LC and up to 62 MPa (9000 psi) for UHPLC applications. The in-line split-loop (flow-through) injection design puts the needle and sample loop directly in the high-pressure fluid path. Combined with an external needle wash option, carryover is essentially eliminated.
Dionex™ Chelation Chromatography Reagents Thermo Scientific™
UltiMate™ AFC-3000 Collector Normal Phase Kit Thermo Scientific™
Bottom-of-the-Bottle™ Solvent Filters Thermo Scientific™
Dionex™ DRS 600 Dynamically Regenerated Suppressor Thermo Scientific™
Use the Thermo Scientific™ Dionex™ DRS 600 Dynamically Regenerated Suppressor for electrolytically regenerated suppression in ion chromatography (IC) applications requiring high capacity, low noise, high backpressure resiliency, and fast startup. The Dionex DRS 600 Suppressor operates in constant voltage mode as well as the traditional constant current mode. By operating in constant voltage mode, the Dionex DRS 600 Suppressor self-governs electrical current as long as a constant voltage is applied. This suppressor is a fundamental component of a reagent-free ion chromatography (RFIC™) system.
Vanquish™ Variable Wavelength Detectors Thermo Scientific™
Achieve excellent linearity and noise performance across a wide operating range with Thermo Scientific™ Vanquish™ variable wavelength detectors. These detectors can be integrated into Thermo Scientific™ Vanquish™ HPLC and UHPLC systems when you need more versatile, robust, high-performance UV-Vis absorption detection to measure your sample. With up to 250 Hz data acquisition, the detector keeps pace with any current and future HPLC and UHPLC detection challenges. Select from a wide flow-cell portfolio to match your application related requirements.
Employ a ready-to-dilute concentrate for the IonPac™ AS4 column with the Thermo Scientific™ Dionex™ AS4 Eluent Concentrate; Sodium Carbonate/Bicarbonate Concentrate.
POROS™ MabCapture™ G Select Resin Thermo Scientific™
With POROS MabCapture G affinity chromatography resin you can:
• Maintain high dynamic binding capacity at liner flow rates over 700 cm/hr
• Design processes with greater flexibility (shorter bed heights, faster flow rates, or both) due to the improvements made to the antibody binding efficiency
• Obtain the highest dynamic binding capacity for antibodies vs. conventional agarose- or silica-based Protein G resins
• Purify polyclonal IgG from mouse, human, cow, goat, and sheep serum, including human IgG3 and mouse IgG1 isotypes
• Sanitize and depyrogenate with standard agents used for other chromatography products
• Recognize major increases to process productivity and reduce the downstream bottleneck
Protein G is a bacterial cell wall protein isolated from group G Streptococci. Recombinant Protein G has been modified to eliminate its binding to albumin. The Protein G molecule contains two binding domains. Although the tertiary structures of Protein A and Protein G are very similar, their amino acid compositions differ significantly, resulting in different binding characteristics. Protein G has greater affinity than Protein A for most mammalian IgGs, especially for certain subclasses, including human IgG3, mouse IgG1, and rat IgG2a. Unlike Protein A, Protein G does not bind to human IgM, IgD, and IgA.
The development of humanized monoclonal antibodies has continued to fuel the growth of the biotherapeutic market. Addressing the therapeutic demand for monoclonal antibodies has led to major improvements to the cell-based expression systems that are used to manufacture these proteins. Consequently, these improvements have moved the processing bottleneck from upstream cell expression to downstream purification. The introduction of POROS MabCapture G Select chromatography resin was aimed at cracking open the downstream bottleneck and providing the capacity, efficiency, and flexibility needed to make improvements to the downstream purification platform, resulting in major increases to process productivity and antibody manufacturing.