Shop All SPE Columns

TurboFlow™ Columns for Automated Online LC-MS Sample Cleanup Thermo Scientific™

Use Thermo Scientific™ TurboFlow™ Columns for automated online matrix cleanup of complex matrices analyzed on the Thermo Scientific™ Aria™, Transcend™ TLX, and Prelude™ LC-MS systems. Placed before the analytical column, TurboFlow sample cleanup columns enable direct injection of complex matrices such as food, plasma, urine, and other biological matrices into the mass spectrometry (MS) system without prior sample pretreatment. The patented TurboFlow column design retains compounds of interest for subsequent analysis, while complex matrices quickly and completely elute to waste.

HyperSep™ Retain PEP Cartridges Thermo Scientific™

Get balanced retention for polar and nonpolar analytes with Thermo Scientific™ HyperSep™ Retain PEP Cartridges, packed with a high capacity, high purity, highly porous polystyrene DVB material modified with urea functional groups. With chemistry pH stable 0 to 14, the of these cartridges in SPE sample preparation can significantly enhance the robustness and reliability of many biological, pharmaceutical, forensic and environmental applications.

HyperSep™ Silica Cartridges Thermo Scientific™

The use of SPE sample preparation can significantly enhance the robustness and reliability of many biological, pharmaceutical, forensic and environmental applications.

Thermo Scientific™ HyperSep™ Silica Cartridges feature a polar sorbent primarily used to retain analytes in nonpolar matrices, and can effectively separate compounds of very similar structure. Typical applications include:

  • Extraction of polar compounds including aldehydes, amines, drugs, pesticides and herbicides
  • Extraction of carotenoids, fat-soluble vitamins, aflatoxins in food matrices
  • Extraction of fatty acids and phospholipids

HyperSep™ Retain CX Cartridges Thermo Scientific™

Achieve consistent, high recoveries for basic compounds with these Thermo Scientific™ HyperSep™ Retain CX Cartridges, packed with a high capacity, high purity, highly porous polystyrene DVB material partially modified with sulfonic acid functional groups to give superior recoveries for basic analytes. Used in SPE sample preparation, these cation exchange cartridges can significantly enhance the robustness and reliability of many biological, pharmaceutical, forensic and environmental applications.

HyperSep™ C8 Cartridges Thermo Scientific™

The use of SPE sample preparation can significantly enhance the robustness and reliability of many biological, pharmaceutical, forensic and environmental applications.

Thermo Scientific™ HyperSep™ C8 Cartridges offer a less retentive alternative to C18 for polar and nonpolar compounds, and are well-suited for methods requiring less retention than C18. The cartridges are ideally suited for the analysis of:

  • Drugs and their metabolites in biological samples
  • Peptides in biological samples

HyperSep™ Verify CX Cartridges Thermo Scientific™

The use of SPE sample preparation can significantly enhance the robustness and reliability of many biological, pharmaceutical, forensic and environmental applications.

Thermo Scientific™ HyperSep™ Verify CX Cartridges feature both nonpolar and ionic separation chemistries for improved sample preparation in the analysis of drugs of abuse. They are used in screening for wide range of drug compounds in biological matrices, including basic and neutral compounds.

HyperSep™ HPLC Columns for Online SPE Thermo Scientific™

Clean-up and concentrate target analytes in minutes with Thermo Scientific™ HyperSep™ Online SPE Products. Available in several convenient formats, the columns utilize popular HyperSep SPE chemistries. When used with conventional HPLC systems and appropriate switching valves, they provide:
  • Effective removal of contaminants, such as proteins, from samples
  • Fast, effective clean-up and concentration of target compounds

HyperSep HPLC Columns for Online SPE combine SPE chemistries with traditional HPLC column fittings and hardware.

HyperSep™ Phenyl Cartridges Thermo Scientific™

The use of SPE sample preparation can significantly enhance the robustness and reliability of many biological, pharmaceutical, forensic and environmental applications.


In Thermo Scientific™ HyperSep™ Phenyl Cartridges, the electron density of the aromatic ring provides different selectivity than other nonpolar sorbents for retention of basic compounds. The cartridges are commonly used for nonpolar interactions, such as:

  • Extraction of aromatic compounds
  • Extraction of basic analytes

HyperSep™ Florisil Cartridges Thermo Scientific™

The use of SPE sample preparation can significantly enhance the robustness and reliability of many biological, pharmaceutical, forensic and environmental applications.

Thermo Scientific™ HyperSep™ Florisil Cartridges are ideal for the isolation of polar compounds from nonpolar matrices. Typical applications include:

  • Extraction of pesticides using official methods
  • Extraction of polychlorinated biphenyls (PCBs) in transformer oil
  • Alcohol, aldehydes, amines and drugs

Extremely polar in nature, HyperSep Florisil SPE Cartridges are especially well-suited for extraction of chlorinated pesticides. The magnesia-loaded silica gel offers rapid flow rates for large sample volumes.

HyperSep™ Retain AX Cartridges Thermo Scientific™

Achieve superior recoveries for acidic analytes with Thermo Scientific™ HyperSep™ Retain AX Cartridges, packed with a high capacity, high purity, highly porous polystyrene DVB material partially modified with quaternary amine functional groups. Their use in SPE sample preparation can significantly enhance the robustness and reliability of many biological, pharmaceutical, forensic and environmental applications.

HyperSep™ Javelin Direct-Connect Online SPE Columns Thermo Scientific™

Clean-up and concentrate target analytes in minutes with Thermo Scientific™ HyperSep™ Online SPE Products. Available in several convenient formats, the columns utilize popular HyperSep SPE chemistries. When used with conventional HPLC systems, columns and appropriate switching valves, they provide:
  • Effective removal of contaminants, such as proteins, from samples
  • Fast, effective clean-up and concentration of target compounds

Thermo Scientific HyperSep Javelin Direct-Connect Online SPE Columns feature a unique fingertight design for convenience and efficiency.

HyperSep™ UniGuard Direct-Connect Online SPE Columns Thermo Scientific™

Clean-up and concentrate target analytes in minutes with Thermo Scientific™ HyperSep™ Online SPE Products. Available in several convenient formats, the columns utilize popular HyperSep SPE chemistries. When used with conventional HPLC systems, columns and appropriate switching valves, they provide: 
  • Effective removal of contaminants, such as proteins, from samples
  • Fast, effective clean-up and concentration of target compounds

Thermo Scientific HyperSep UniGuard Direct-Connect Online SPE Column offer quick, easy connection by means of a reusable drop-in guard cartridge holder.

HyperSep™ Cyano Cartridges Thermo Scientific™

The use of SPE sample preparation can significantly enhance the robustness and reliability of many biological, pharmaceutical, forensic and environmental applications.

A medium polarity sorbent, Thermo Scientific™ HyperSep™ Cyano cartridges are less retentive than silica or diol, and are optimized for the isolation of polar compounds from nonpolar matrices. Typical applications include:

  • Retention of polar compounds from hexane and oils
  • Reversed phase extraction of moderately polar compounds

HyperSep™ SCX Cartridges Thermo Scientific™

The use of SPE sample preparation can significantly enhance the robustness and reliability of many biological, pharmaceutical, forensic and environmental applications.


Thermo Scientific™ HyperSep™ SCX Cartridges feature a strong cation exchange sorbent for extraction of charged basic compounds. Typical applications include extraction of:

  • Antibiotics
  • Drug compounds
  • Organic bases
  • Amino acids
  • Catecholamines
  • Herbicides

HyperSep™ Aminopropyl Cartridges Thermo Scientific™

The use of SPE sample preparation can significantly enhance the robustness and reliability of many biological, pharmaceutical, forensic and environmental applications.

Thermo Scientific™ HyperSep™ Aminopropyl Cartridges feature a polar sorbent that allows both polar and anion exchange interactions. The chemistry offers excellent retention of drugs, metabolites and structural isomers. Typical applications include:

  • Separation of structural isomers
  • Drugs and metabolites in biological fluids
  • Saccharides, phenols and petroleum products
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