Shop All Hydrophobic Interaction Chromatography Reagents and Supplies

POROS™ GoPure™ Benzyl Ultra Pre-packed Column, 0.8 x 10 cm, 5 mL Thermo Scientific™

POROS GoPure 0.8 cmD pre-packed columns are intended for the screening of POROS affinity, ion exchange, and hydrophobic interaction chromatography (HIC) and hydrophobic interaction chromatography (HIC) resins or for small-scale purification. These pre-packed columns are ready to connect and have the following features:

• Dimensions of 0.8 cmD x 10 cmL, with a nominal bed volume of 5 mL, providing a uniform screening platform
• Direct connection to standard chromatography systems
>• Convenient—ready-to-run columns simplify and speed POROS resin evaluations
• The 10-cm bed height and 5-mL bed volume allow initial process development at a bench scale
• Packed with POROS high performance resins that offer high dynamic binding capacity and high resolution over a wide range of flow rates

The POROS Benzyl Ultra HIC resin in this GoPure column has an aromatic hydrophobic benzyl ligand, well suited for hydrophobic interaction chromatography (HIC) for aggregate removal from monoclonal antibody monomer in flow-through mode at low salt concentrations.

Other POROS hydrophobic interaction and ion exchange resins are also available in this column format. All POROS High Performance Chromatography resins have a unique pore structure that provides excellent mass transport for high capacity and resolution over a wide range of flow rates.

POROS™ Ethyl Hydrophobic Interaction Chromatography (HIC) Resin Thermo Scientific™

POROS Ethyl Hydrophobic Interaction Chromatography (HIC) Resin is a bioprocess high-performance resin engineered for improved impurity removal during large-scale downstream purification of biomolecules. This unique resin provides high resolution and capacity while maintaining excellent pressure flow characteristics, helping increase productivity.

POROS Ethyl HIC Resin is designed on the well-established cross‐linked poly(styrene-divinylbenzene) POROS base bead with an attached novel hydrophobic ethyl ligand, a resin that is primarily suited for bind/elute purifications.

Features of POROS Ethyl HIC Resin include:
• Superior resolution capability while maintaining excellent pressure-flow properties, achieved by combining the high-flow characteristics of a POROS base bead with a 50 micron particle size. Higher flow rates help improve productivity.
• Unique selectivity due to the novel hydrophobic ligand, allowing for purification of a wide range of biomolecules, including therapeutic proteins, antibody fragments, antibody drug conjugates, and enzymes
• High capacity, reducing the process volume significantly for subsequent steps
• A rigid polymeric bead with covalent surface chemistry for easier handling and packing with superior physical and chemical stability, allowing cleaning with various clean-in-place (CIP) solutions such as sodium hydroxide and enabling a more robust downstream purification process

These features of POROS Ethyl HIC Resin are a major improvement to the performance of traditional HIC resins, setting the standard for hydrophobic interaction chromatography. POROS Ethyl HIC Resin combines superior and consistent performance, exceptional customer support, strong operational excellence, and a strong legacy based on proven technology from a well-established chromatography resin supplier. This resin comes with complete technical and regulatory support. POROS Ethyl HIC Resin is available in various bulk package sizes for large-scale purification, as well as pre-packed columns for initial process development.

Main characteristics

Support matrix: cross-linked poly(styrene-divinylbenzene)
Average particle size: 50 µm
Ligand: novel ethyl
pH range: 1–14
Ionic strength range: 0 to 5 M, all common salts
Mechanical resistance: 100 bar (1,450 psi; 10 MPa)
Shipping solution: 18% (v/v) ethanol

POROS™ Benzyl Ultra Hydrophobic Interaction Chromatography (HIC) Resin Thermo Scientific™

POROS Benzyl Ultra Hydrophobic Interaction Chromatography (HIC) Resin is a bioprocess high-performance resin engineered for improved impurity removal during large-scale downstream purification of biomolecules. This unique resin provides high resolution and capacity while maintaining excellent pressure flow characteristics, helping increase productivity.

POROS Benzyl Ultra HIC Resin is designed on the well-established cross‐linked poly(styrene-divinylbenzene) POROS base bead with an aromatic hydrophobic benzyl ligand. This resin is well suited for aggregate removal from monoclonal antibody monomer in flow-through mode at low salt concentrations.

Features of POROS Benzyl Ultra HIC Resin include:
• Superior resolution capability while maintaining excellent pressure-flow properties, achieved by combining the high-flow characteristics of a POROS base bead with a 50 micron particle size. Higher flow rates help improve productivity.
• Unique selectivity due to the aromatic hydrophobic ligand, allowing for purification of a wide range of biomolecules, including therapeutic proteins, antibody fragments, antibody drug conjugates, and enzymes
• High capacity, reducing the process volume significantly for subsequent steps
• Utilized at low salt concentrations and/or with weaker lyotropic salts in flow-through mode operations for aggregate removal to simplify processes and increase process design flexibility
• A rigid polymeric bead with covalent surface chemistry for easier handling and packing with superior physical and chemical stability, allowing cleaning with various clean-in-place (CIP) solutions such as sodium hydroxide and enabling a more robust downstream purification process

These features of POROS Benzyl Ultra HIC Resin are a major improvement to the performance of traditional HIC resins, setting the standard for hydrophobic interaction chromatography. POROS Benzyl Ultra HIC Resin combines superior and consistent performance, exceptional customer support, strong operational excellence, and a strong legacy based on proven technology from a well-established chromatography resin supplier. This resin comes with complete technical and regulatory support. POROS Benzyl Ultra HIC Resin is available in various bulk package sizes for large-scale purification, as well as pre-packed columns for initial process development.

Main characteristics

Support matrix: cross-linked poly(styrene-divinylbenzene)
Average particle size: 50 µm
Ligand: benzyl/aromatic
pH range: 1–14
Ionic strength range: 0 to 5 M, all common salts
Mechanical resistance: 100 bar (1,450 psi; 10 MPa)
Shipping solution: 18% (v/v) ethanol

POROS™ Ethyl RoboColumn Thermo Scientific™

This RoboColumn product is pre-packed with POROS Ethyl Hydrophobic Interaction Chromatography (HIC) Resin and suitable for impurity removal during large-scale downstream purification of biomolecules, primarily for bind/elute operations.

RoboColumn products are small chromatography columns that are provided in 8-column strips. They are useful for fully automated and parallel chromatographic separations using robotic liquid handling platforms.Features of POROS Ethyl HIC Resin include:

• Superior resolution capability while maintaining excellent pressure-flow properties, achieved by combining the high-flow characteristics of a POROS base bead with a 50-micron particle size. Higher flow rates help improve productivity.
• Unique selectivity due to the novel hydrophobic ligand, allowing for purification of a wide range of biomolecules, including therapeutic proteins, antibody fragments, antibody drug conjugates, and enzymes
• High capacity, reducing the process volume significantly for subsequent steps
• A rigid polymeric bead with covalent surface chemistry for easier handling and packing with superior physical and chemical stability, allowing cleaning with various clean-in-place (CIP) solutions such as sodium hydroxide and enabling a more robust downstream purification process

These features of POROS Ethyl HIC Resin are a major improvement to the performance of traditional HIC resins, setting the standard for hydrophobic interaction chromatography.

RoboColumn is a registered trademark of ATOLL GmbH.

POROS™ Benzyl RoboColumn Thermo Scientific™

This RoboColumn product is pre-packed with POROS Benzyl Hydrophobic Interaction Chromatography (HIC) Resin that is suitable for impurity removal in the large scale downstream purification of biomolecules, for both bind/elute and flow-through operations.

RoboColumn products are small chromatography columns that are provided in 8-column strips. They are useful for fully automated and parallel chromatographic separations using robotic liquid handling platforms.Features of POROS Benzyl HIC Resin include:

• Superior resolution capability while maintaining excellent pressure-flow properties, achieved by combining the high-flow characteristics of a POROS base bead with a 50-micron particle size. Higher flow rates help improve productivity.
• Unique selectivity due to the novel hydrophobic ligand, allowing for purification of a wide range of biomolecules, including therapeutic proteins, antibody fragments, antibody drug conjugates, and enzymes
• High capacity, reducing the process volume significantly for subsequent steps
• A rigid polymeric bead with covalent surface chemistry for easier handling and packing with superior physical and chemical stability, allowing cleaning with various clean-in-place (CIP) solutions such as sodium hydroxide and enabling a more robust downstream purification process

These features of POROS Benzyl HIC Resin are a major improvement to the performance of traditional HIC resins, setting the standard for hydrophobic interaction chromatography.

RoboColumn is a registered trademark of ATOLL GmbH.

POROS™ Benzyl Ultra RoboColumn Thermo Scientific™

This RoboColumn product is pre-packed with POROS Benzyl Ultra Hydrophobic Interaction Chromatography (HIC) Resin that is well suited for aggregate removal from monoclonal antibody monomer in flow-through mode at low salt concentrations in large scale downstream bioprocessing.

RoboColumn products are small chromatography columns that are provided in 8-column strips. They are useful for fully automated and parallel chromatographic separations using robotic liquid handling platforms.Features of POROS Benzyl Ultra HIC Resin include:

• Superior resolution capability while maintaining excellent pressure-flow properties, achieved by combining the high-flow characteristics of a POROS base bead with a 50-micron particle size. Higher flow rates help improve productivity.
• Unique selectivity due to the novel hydrophobic ligand, allowing for purification of a wide range of biomolecules, including therapeutic proteins, antibody fragments, antibody drug conjugates, and enzymes
• High capacity, reducing the process volume significantly for subsequent steps
• A rigid polymeric bead with covalent surface chemistry for easier handling and packing with superior physical and chemical stability, allowing cleaning with various clean-in-place (CIP) solutions such as sodium hydroxide and enabling a more robust downstream purification process

These features of POROS Benzyl Ultra HIC Resin are a major improvement to the performance of traditional HIC resins, setting the standard for hydrophobic interaction chromatography.

RoboColumn is a registered trademark of ATOLL GmbH.

POROS™ GoPure™ Ethyl Pre-packed Column, 0.8 x 10 cm, 5 mL Thermo Scientific™

POROS GoPure 0.8 cmD pre-packed columns are intended for the screening of POROS affinity, ion exchange, and hydrophobic interaction chromatography (HIC) and hydrophobic interaction chromatography (HIC) resins or for small-scale purification. These pre-packed columns are ready to connect and have the following features:

• Dimensions of 0.8 cmD x 10 cmL, with a nominal bed volume of 5 mL, providing a uniform screening platform
• Direct connection to standard chromatography systems
>• Convenient—ready-to-run columns simplify and speed POROS resin evaluations
• The 10-cm bed height and 5-mL bed volume allow initial process development at a bench scale
• Packed with POROS high performance resins that offer high dynamic binding capacity and high resolution over a wide range of flow rates

The POROS Ethyl HIC resin in this GoPure column has a novel hydrophobic ethyl ligand, making it suited primarily for bind/elute purifications.

Other POROS hydrophobic interaction and ion exchange resins are also available in this column format. All POROS High Performance Chromatography resins have a unique pore structure that provides excellent mass transport for high capacity and resolution over a wide range of flow rates.

POROS™ Benzyl Hydrophobic Interaction Chromatography (HIC) Resin Thermo Scientific™

POROS Benzyl Hydrophobic Interaction Chromatography (HIC) Resin is a bioprocess high-performance resin engineered for improved impurity removal during large-scale downstream purification of biomolecules. This unique resin provides high resolution and capacity while maintaining excellent pressure flow characteristics, helping increase productivity.

POROS Benzyl HIC Resin is designed on the well-established cross‐linked poly(styrene-divinylbenzene) POROS base bead with aromatic hydrophobic benzyl ligand, suited for both bind/elute and flow-through purifications.

Features of POROS Benzyl HIC Resin include:
• Superior resolution capability while maintaining excellent pressure-flow properties, achieved by combining the high-flow characteristics of a POROS base bead with a 50 micron particle size. Higher flow rates help improve productivity.
• Unique selectivity due to the aromatic hydrophobic ligand, allowing for purification of a wide range of biomolecules, including therapeutic proteins, antibody fragments, antibody drug conjugates, and enzymes
• High capacity, reducing the process volume significantly for subsequent steps
• A rigid polymeric bead with covalent surface chemistry for easier handling and packing with superior physical and chemical stability, allowing cleaning with various clean-in-place (CIP) solutions such as sodium hydroxide and enabling a more robust downstream purification process

These features of POROS Benzyl HIC Resin are a major improvement to the performance of traditional HIC resins, setting the standard for hydrophobic interaction chromatography. POROS Benzyl HIC Resin combines superior and consistent performance, exceptional customer support, strong operational excellence, and a strong legacy based on proven technology from a well-established chromatography resin supplier. This resin comes with complete technical and regulatory support. POROS Benzyl HIC Resin is available in various bulk package sizes for large-scale purification, as well as pre-packed columns for initial process development.

Main characteristics

Support matrix: cross-linked poly(styrene-divinylbenzene)
Average particle size: 50 µm
Ligand: benzyl/aromatic
pH range: 1–14
Ionic strength range: 0 to 5 M, all common salts
Mechanical resistance: 100 bar (1,450 psi; 10 MPa)
Shipping solution: 18% (v/v) ethanol

POROS™ GoPure™ Benzyl Pre-packed Column, 0.8 x 10 cm, 5 mL Thermo Scientific™

POROS GoPure 0.8 cmD pre-packed columns are intended for the screening of POROS affinity, ion exchange, and hydrophobic interaction chromatography (HIC) and hydrophobic interaction chromatography (HIC) resins or for small-scale purification. These pre-packed columns are ready to connect and have the following features:

• Dimensions of 0.8 cmD x 10 cmL, with a nominal bed volume of 5 mL, providing a uniform screening platform
• Direct connection to standard chromatography systems
>• Convenient—ready-to-run columns simplify and speed POROS resin evaluations
• The 10-cm bed height and 5-mL bed volume allow initial process development at a bench scale
• Packed with POROS high performance resins that offer high dynamic binding capacity and high resolution over a wide range of flow rates

The POROS Benzyl HIC resin in this GoPure column has an aromatic hydrophobic benzyl ligand, suited for hydrophobic interaction chromatography (HIC) for both bind/elute and flow-through purifications.

Other POROS hydrophobic interaction and ion exchange resins are also available in this column format. All POROS High Performance Chromatography resins have a unique pore structure that provides excellent mass transport for high capacity and resolution over a wide range of flow rates.

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