Signal Transduction Reagents and Kits | Thermo Fisher Scientific

BAY 11-7085, 99% Thermo Scientific Chemicals

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo...

N-Acetyl-D-sphingosine, 98% Thermo Scientific Chemicals

Inhibits cell proliferation and induces monocytic differentiation of HL-60 cells. Activates protein phosphatases This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand.

Vincamine, 98% Thermo Scientific Chemicals

A vasodilator This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition...

SKF-96365 hydrochloride, 99+% Thermo Scientific™

Inhibits receptor-mediated calcium influx This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand.

U0126, ≥99% Thermo Scientific Chemicals

U0126, is used as a selective MAP Kinase Kinase (MKK, MEK) inhibitor. U-0126 has been observed to inhibit promoters containing an AP-1 response element, while in contrast having no effect on promoters that lack an AP-1 response group.

Amrinone, 98% Thermo Scientific Chemicals

Phosphodiesterase III inhibitor and inhibits platelet aggregation This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand.

U-73122, 95% Thermo Scientific Chemicals

It is used as a phospholipase C, phospholipase A2, and 5-LO inhibitor. It is also determined that in SK-N-SH neuroblastoma cells, U-73122 inhibits agonist-induced down-regulation of muscarinic receptors.

Sulindac Sulfide Thermo Scientific Chemicals

It is also shown to inhibit growth and induce apoptosis in human prostate cancer cells through a COX-1 and COX-2 independent mechanism. Sulindac sulfide is an analgesic that has antiproliferative and apoptotic effects.

Ionomycin, 96% Thermo Scientific Chemicals

Ionomycin free acid is a beneficial tool in research to raise intracellular calcium levels. Also this antibiotic can be used to study the calcium transport across the plasma membrane. It has been shown to induce central demyelination , inhibit adrenal bovine TREK-1 channels , and to regulate cell...

Evodiamine Thermo Scientific Chemicals

A vanilloid receptor agonist that induces apoptosis in leukemia U937 cells This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand.

Caspase-3 Inhibitor III Thermo Scientific Chemicals

A potent, cell-permeable, and irreversible inhibitor of caspase-3; also inhibits caspases -6, -7, -8, and -10. Commonly used at concentrations up to 100 -M to examine the role of caspase-3-dependent apoptosis This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar...

MIF Antagonist, ISO-1 Thermo Scientific Chemicals

MIF Antagonist, ISO-1 inhibits MIF dopachrome tautomerase activity by binding to its catalytic active site (IC50 = 7 μM for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE2 and COX-2 in human monocytes and arachidonic acid in RAW 264.7 macrophages.

IKK-2 Inhibitor V Thermo Scientific Chemicals

A selective IKK-2 inhibitor This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand.

SB 225002 Thermo Scientific Chemicals

SB 225002 is a selective non-peptide CXCR2 inhibitor which suppresses IL-8 induced neutrophil chemotaxis and margination. In addition, SB 225002 reduces MPO activity, IL-1β, MIP-2, and keratinocyte-derived chemokine (KC) levels.

CP-31398, 98% Thermo Scientific Chemicals

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo...