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GeneMapper™ ID-X Software v1.4, Client Upgrade Thermo Scientific™

This product includes a GeneMapper ID-X v1.4 Client Upgrade DVD (no database) to upgrade previous Client Installation versions of GeneMapper ID-X. Documentation is not included.

GeneMapper ID-X Software is an automated genotyping software solution for all data analysis needs, including forensic casework, databasing, and paternity testing. GeneMapper ID-X Software supports a multi-user database configuration and provides a set of data analysis and sample review tools that streamline sizing, allele calling, mixture analysis, and statistical calculations. The software offers a comprehensive quality value system that can be optimized and validated for use in both Expert System and traditional data analysis workflows. The software supports genotyping applications on the ABI PRISM 310, 3100, 3100-Avant, Applied Biosystems 3130, 3130xl, 3500, 3500xL genetic analyzers and Applied Biosystems 3730 DNA Analyzer.

Learn more about GeneMapper ID-X Software

Features in the latest GeneMapper ID-X Software, Version 1.4, include:

• Microsoft Windows 7 and XP compatibility
• Analysis of data generated with the GlobalFiler or GlobalFiler Express PCR amplification kits, as well as all AmpFℓSTR PCR amplification kits
• Enhanced data assessment functionality (Expert System and Expert Assistant features)
--Spike detection disable/enable—Automated spike detection functionality has been enhanced to allow you to disable or enable spike detection for samples and controls.
--Y-marker analysis—In addition to the ability to analyze autosomal STR and Y-STR data separately, GeneMapper ID-X Software v1.4 can analyze autosomal and Y-STR markers in one multiplexed sample. To evaluate the quality of Y-marker data, several new data quality assessment tools have been added including: a sample-level PQV, Amelogenin Cross Check (ACC), and a maximum Y-marker Allele Number (AN) PQV.

• Define new sample path for .hid files—Allows you to view raw data, view EPT data, or reanalyze samples when .hid sample files (generated on 3500 Series Genetic Analyzers) have been moved from their original location

Overview of GeneMapper ID-X Software:
• Powerful, easy to use data analysis tool designed to increase lab productivity
• Comprehensive Expert System capability for analysis of forensic databasing samples delivered by automated data assessment functionality and efficient manual review tools
• Complete Expert Assistant solution for analysis of forensic casework samples combining an efficient suite of manual review features with an integrated mixture analysis tool
• Quality control functionality allows rapid allele match comparisons and concordance searches within a data set
• Extensive security, auditing, and e-signature capabilities help protect data integrity and control technical records
• Multi-user database configuration stores your projects in a central location and facilitates information exchange
• Command Line Interface—the ability to access GeneMapper ID-X Software automatically (without human intervention) streamlines its integration with LIMS installations and other applications in an existing laboratory infrastructure

Automated Data Assessment
GeneMapper ID-X Software was designed specifically to fulfill the requirements of both Expert System and Expert Assistant software. A combination of sophisticated automated data assessment processes and efficient manual review tools deliver comprehensive expert system capability. This provides optimal interaction between the analyst and the data, significantly reducing the amount of analysis time required for single source samples. New features such as the Analysis Requirements check, Allelic Ladder Quality Assessment, Improved Quality Value System, and the Analysis Summary analyze samples and segregate them into pass or review categories based on your thresholds. Once segregated, you can easily conduct any necessary manual review of samples.

Despite its capabilities to automate and streamline the analysis of single source samples, an Expert System is as yet unable to make the final analysis decision for most forensic casework samples and in particular for those containing mixtures. GeneMapper ID-X Software harnesses the automated, rule-based, subject-specific knowledge to act as an Expert Assistant to the forensic analyst, simplifying much of the analysis process and empowering the analyst to make key interpretation decisions. A mixture analysis tool determines the number of contributors to a mixture and efficiently manages the resulting possible genotypes. This enables the forensic analyst to interpret mixtures and generate accurate statistical calculations.

Manual Tools Improve Data Review
Data analysis efficiencies offered by the automated data review processes have been further enhanced through the introduction of a new suite of manual review tools. These developments focus around the plot window providing quick and easy access to all aspects of the data, thus simplifying the data review process. Colored marker header bars indicate which markers within a sample have failed to meet the user defined thresholds and the new Process Quality Value (PQV) Details window details which flags have been fired and how much the observed value differs from the threshold. In addition, expanded labeling options are available to distinguish alleles from artifacts and reviewers can directly access raw data for further troubleshooting. Electronic/peer review of the data is enhanced with the review and manual acceptance of marker and sample level PQVs along with a detailed label edit table display.

For further troubleshooting, reviewers can also directly access raw data. The ability to review and manually accept markers and sample-level PQVs in a detailed label edit table display enhances electronic/peer data review.

A Complete, Verified System
GeneMapper ID-X Software is an integral component of our complete system of instruments, reagents, software, and services for human-identity applications. It has undergone extensive verification testing to ensure robust design features, performance, and reproducibility. When you partner with us, you gain access to the most extensive Human Identification resource network in the industry. Our dedicated team of industry-leading experts—with extensive forensic product development experience—worked closely with the forensic community to develop GeneMapper ID-X Software. The software is part of a system that is supported by on-site technical assistance from skilled Field Applications Support Scientists and Field Service Engineers.

Oncomine™ Immune Response Research Assay - Automated Ion Torrent™

The Oncomine™ Immune Response Research Assay is a targeted gene expression assay designed for the Ion™ next-generation sequencing (NGS) platform. This pan-cancer gene expression assay is designed to interrogate the tumor microenvironment to enable mechanistic studies and identification of predictive biomarkers for immunotherapy in retrospective or prospective clinical trial research cohorts. The assay is optimized to measure the expression of genes involved in tumor-immune interactions, including the low-expressing genes involved in inflammatory signaling.

This assay contains the reagents for automated library construction using the Ion Chef™ System and a single pool of primers used to perform multiplex PCR for preparation of amplicon libraries from formalin-fixed paraffin-embedded (FFPE) samples. The assay enables quantitative evaluation of the expression of markers associated with different leukocyte subsets, antigen presentation, checkpoint pathways, and tumor progression. This 400-gene assay is supported with a user-friendly informatics workflow and demonstrates high sensitivity for low-expressing transcripts derived from FFPE samples (request a gene list). The Oncomine Immune Response Research Assay leverages Ion AmpliSeq™ technology to deliver results from as little as 10 ng of total RNA, enabling robust performance from challenging FFPE samples.

Assay workflow
The Oncomine Immune Response Research Assay automated workflow features high sample multiplexing on Ion S5™ sequencing systems. The entire workflow, from sample extraction to results, can be completed in less than 48 hours with less than 45 minutes of hands-on time from DNA to data, and only two pipetting steps per sample. Note: An alternate assay is available (Cat. No. A32881) for the preparation of Ion AmpliSeq libraries in manual mode without use of an Ion Chef System.

Assay performance
• High repeatability and sensitive detection of gene expression across different types of solid tumors
• Low sample input requirement (10 ng of total RNA material)
• High sensitivity detection of low-expressing signaling molecules such as interleukins and interferon gamma
• High sample multiplexing with flexibility to sequence 4, 8, or 32 samples per single run
• Automated workflow that offers sample-to-results in less than 48 hours, with less than 45 minutes hands-on time and only two pipetting steps
• Automated and seamlessly integrated analysis solution
• Interpretation of immune surveillance and tumor progression mechanism with functional annotation of genes and pathways

Informatics
The Oncomine Immune Response Research Assay comes with optimized informatics and visualization software that minimizes the complexity of data analysis. The analysis workflow consists of a data exploration component automated by the Immune Response Torrent Suite™ Plug-in and a two-group differential analysis provided by the Affymetrix™ Transcriptome Analysis Console (TAC). Together these tools offer a streamlined process for common gene expression analyses and exportable data files that are amenable to further exploration with other third-party software. Specifically, these tools provide:
• QC metrics and expression of housekeeping genes to qualify data
• Hierarchical clustering of samples with user-defined gene sets or by all genes on the panel
• Visualization with PCA, heatmaps, and gene expression distribution plots
• Sample correlation using rich correlation plots
• Fold-change estimates in easy-to-use tabular data format (TAC)
• Volcano plots to visualize differentially genes (TAC)

GeneMapper™ ID-X Software v1.4, Client Installation Thermo Scientific™

This product includes a single GeneMapper ID-X Software v1.4 Client Installation (no database) and license. Documentation is included.

GeneMapper ID-X Software is an automated genotyping software solution for all data analysis needs, including forensic casework, databasing, and paternity testing. GeneMapper ID-X Software supports a multi-user database configuration and provides a set of data analysis and sample review tools that streamline sizing, allele calling, mixture analysis, and statistical calculations. The software offers a comprehensive quality value system that can be optimized and validated for use in both Expert System and traditional data analysis workflows. The software supports genotyping applications on the ABI PRISM 310, 3100, 3100-Avant, Applied Biosystems 3130, 3130xl, 3500, 3500xL genetic analyzers and Applied Biosystems 3730 DNA Analyzer.

Learn more about GeneMapper ID-X Software

Features in the latest GeneMapper ID-X Software, Version 1.4, include:

• Microsoft Windows 7 and XP compatibility
• Analysis of data generated with the GlobalFiler or GlobalFiler Express PCR amplification kits, as well as all AmpFℓSTR PCR amplification kits
• Enhanced data assessment functionality (Expert System and Expert Assistant features)
--Spike detection disable/enable—Automated spike detection functionality has been enhanced to allow you to disable or enable spike detection for samples and controls.
--Y-marker analysis—In addition to the ability to analyze autosomal STR and Y-STR data separately, GeneMapper ID-X Software v1.4 can analyze autosomal and Y-STR markers in one multiplexed sample. To evaluate the quality of Y-marker data, several new data quality assessment tools have been added including: a sample-level PQV, Amelogenin Cross Check (ACC), and a maximum Y-marker Allele Number (AN) PQV.

• Define new sample path for .hid files—Allows you to view raw data, view EPT data, or reanalyze samples when .hid sample files (generated on 3500 Series Genetic Analyzers) have been moved from their original location

Overview of GeneMapper ID-X Software:
• Powerful, easy to use data analysis tool designed to increase lab productivity
• Comprehensive Expert System capability for analysis of forensic databasing samples delivered by automated data assessment functionality and efficient manual review tools
• Complete Expert Assistant solution for analysis of forensic casework samples combining an efficient suite of manual review features with an integrated mixture analysis tool
• Quality control functionality allows rapid allele match comparisons and concordance searches within a data set
• Extensive security, auditing, and e-signature capabilities help protect data integrity and control technical records
• Multi-user database configuration stores your projects in a central location and facilitates information exchange
• Command Line Interface—the ability to access GeneMapper ID-X Software automatically (without human intervention) streamlines its integration with LIMS installations and other applications in an existing laboratory infrastructure

Automated Data Assessment
GeneMapper ID-X Software was designed specifically to fulfill the requirements of both Expert System and Expert Assistant software. A combination of sophisticated automated data assessment processes and efficient manual review tools deliver comprehensive expert system capability. This provides optimal interaction between the analyst and the data, significantly reducing the amount of analysis time required for single source samples. New features such as the Analysis Requirements check, Allelic Ladder Quality Assessment, Improved Quality Value System, and the Analysis Summary analyze samples and segregate them into pass or review categories based on your thresholds. Once segregated, you can easily conduct any necessary manual review of samples.

Despite its capabilities to automate and streamline the analysis of single source samples, an Expert System is as yet unable to make the final analysis decision for most forensic casework samples and in particular for those containing mixtures. GeneMapper ID-X Software harnesses the automated, rule-based, subject-specific knowledge to act as an Expert Assistant to the forensic analyst, simplifying much of the analysis process and empowering the analyst to make key interpretation decisions. A mixture analysis tool determines the number of contributors to a mixture and efficiently manages the resulting possible genotypes. This enables the forensic analyst to interpret mixtures and generate accurate statistical calculations.

Manual Tools Improve Data Review
Data analysis efficiencies offered by the automated data review processes have been further enhanced through the introduction of a new suite of manual review tools. These developments focus around the plot window providing quick and easy access to all aspects of the data, thus simplifying the data review process. Colored marker header bars indicate which markers within a sample have failed to meet the user defined thresholds and the new Process Quality Value (PQV) Details window details which flags have been fired and how much the observed value differs from the threshold. In addition, expanded labeling options are available to distinguish alleles from artifacts and reviewers can directly access raw data for further troubleshooting. Electronic/peer review of the data is enhanced with the review and manual acceptance of marker and sample level PQVs along with a detailed label edit table display.

For further troubleshooting, reviewers can also directly access raw data. The ability to review and manually accept markers and sample-level PQVs in a detailed label edit table display enhances electronic/peer data review.

A Complete, Verified System
GeneMapper ID-X Software is an integral component of our complete system of instruments, reagents, software, and services for human-identity applications. It has undergone extensive verification testing to ensure robust design features, performance, and reproducibility. When you partner with us, you gain access to the most extensive Human Identification resource network in the industry. Our dedicated team of industry-leading experts—with extensive forensic product development experience—worked closely with the forensic community to develop GeneMapper ID-X Software. The software is part of a system that is supported by on-site technical assistance from skilled Field Applications Support Scientists and Field Service Engineers.

ASSY, Sample Collector .50LD Z Applied Biosystems™

This is a spare part for the 310 Genetic Analyzer.

For Research Use Only. Not for use in diagnostics procedures.

Ion GeneStudio™ S5 System with SmartStart Ion Torrent™

The Ion GeneStudio S5 System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows. The Ion GeneStudio S5 System is optimized to provide affordability for labs focused on smaller panels and lower sequencing throughput requirements. With cartridge-based reagents, the system is simple to use and offers scalability and flexibility. It uses Ion 5 Series chips to support a broad range of high-throughput sequencing for clinical research and research applications from microbial genomes and gene panels to exomes and transcriptomes.

Key features:
• Select the chip (Ion 510–540 chip) that fits your application and throughput needs to achieve from 2–80 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments

The Ion GeneStudio S5 Series
The Ion GeneStudio S5 Series sequencers share the same foundational technology and fluidic architecture across all three instruments: this Ion GeneStudio S5 System, the Ion GeneStudio S5 Plus System, and Ion GeneStudio S5 Prime System. The primary difference across the three instruments is on-sequencer analysis time.

Speed
The Ion GeneStudio S5 Series leverages the speed of semiconductor sequencing to enable the production of high quality sequencing data in a few hours and enables you to go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time when paired with the Ion Chef System.

Simplicity
With single-day installation, a straightforward user interface, and cartridge-based reagents, the Ion GeneStudio S5 Series sequencers are easy to use. Combined with Ion AmpliSeq technology for target selection, the Ion Chef System for automated library and template preparation, and Ion Reporter Software for automated variant annotation, targeted sequencing is simpler than ever.

Small sample input
Low input DNA from challenging samples types such as formalin-fixed paraffin-embedded (FFPE) tissue, retrospective samples from fine needle aspirates, and cell-free DNA extracted from blood (cfDNA) can be difficult to sequence on competitor next-generation sequencers. However, with Ion AmpliSeq technology and the Ion GeneStudio S5 Series, you can use as little as 1 ng input DNA or RNA.

Scalability
Why buy multiple systems for your lab when you can run all of your targeted sequencing or microbial applications on a single next-generation sequencer? The Ion 5 Series chips that run on the Ion GeneStudio S5 Series provide several throughput options, so your lab has the flexibility to scale from small to large projects, enabling multiple targeted sequencing applications on a single system.

Simple analysis and storage solutions
Torrent Suite Software and Ion Reporter Software make NGS easy for beginners and experts alike. Plan, monitor, track, and analyze your runs using Torrent Suite Software (pre-installed on the Torrent Server). Integrate, annotate, and interpret variants using Ion Reporter Software (Thermo Fisher Cloud or local options available based on your needs).

Services and support
With more than 2,000 field personnel, Thermo Fisher Scientific has the most extensive network of dedicated Field Application Specialists and Service Engineers to work with you, so you can be confident that we will be there when and where you need us most.

Service and support plans—comprehensive plans to maximize instrument performance and ensure availability of critical systems
Qualification services—document and ensure instrument is installed, operating, and performing to manufacturer’s specifications
Training—courses for experimental design, data analysis, troubleshooting, applications, and instrument operation
Bioinformatics—tailored support for NGS informatics execution, software use, data analysis, and downstream applications
DataSafe Solution—storage and back-up strategy, design, hardware, and support for all lab data

Ion GeneStudio™ S5 Food Protection System Thermo Scientific™

Identify meat, fish or plant species present in all food types using the Ion Genestudio™ S5 Food Protection System - a semiconductor-based next-generation sequencing (NGS) system which, when used as part of the Thermo Scientific™ Next Generation Sequencing Food Authenticity Workflow allows identification of the species present in even the most challenging sample types.

The Ion GeneStudio S5 Food Protection System is optimized to provide flexibility and affordability for laboratories who have a food application focus and comes with a laptop suitable for use with the SGS™ All Species ID Software.

GeneMapper™ ID-X Software v1.4, Full Upgrade Thermo Scientific™

This product includes a GeneMapper ID-X v1.4 Full Upgrade DVD to upgrade previous Full Installation versions of GeneMapper ID-X. Documentation is not included.

GeneMapper ID-X Software is an automated genotyping software solution for all data analysis needs, including forensic casework, databasing, and paternity testing. GeneMapper ID-X Software supports a multi-user database configuration and provides a set of data analysis and sample review tools that streamline sizing, allele calling, mixture analysis, and statistical calculations. The software offers a comprehensive quality value system that can be optimized and validated for use in both Expert System and traditional data analysis workflows. The software supports genotyping applications on the ABI PRISM 310, 3100, 3100-Avant, Applied Biosystems 3130, 3130xl, 3500, 3500xL genetic analyzers and Applied Biosystems 3730 DNA Analyzer.

Learn more about GeneMapper ID-X Software

Features in the latest GeneMapper ID-X Software, Version 1.4, include:

• Microsoft Windows 7 and XP compatibility
• Analysis of data generated with the GlobalFiler or GlobalFiler Express PCR amplification kits, as well as all AmpFℓSTR PCR amplification kits
• Enhanced data assessment functionality (Expert System and Expert Assistant features)
--Spike detection disable/enable—Automated spike detection functionality has been enhanced to allow you to disable or enable spike detection for samples and controls.
--Y-marker analysis—In addition to the ability to analyze autosomal STR and Y-STR data separately, GeneMapper ID-X Software v1.4 can analyze autosomal and Y-STR markers in one multiplexed sample. To evaluate the quality of Y-marker data, several new data quality assessment tools have been added including: a sample-level PQV, Amelogenin Cross Check (ACC), and a maximum Y-marker Allele Number (AN) PQV.

• Define new sample path for .hid files—Allows you to view raw data, view EPT data, or reanalyze samples when .hid sample files (generated on 3500 Series Genetic Analyzers) have been moved from their original location

Overview of GeneMapper ID-X Software:
• Powerful, easy to use data analysis tool designed to increase lab productivity
• Comprehensive Expert System capability for analysis of forensic databasing samples delivered by automated data assessment functionality and efficient manual review tools
• Complete Expert Assistant solution for analysis of forensic casework samples combining an efficient suite of manual review features with an integrated mixture analysis tool
• Quality control functionality allows rapid allele match comparisons and concordance searches within a data set
• Extensive security, auditing, and e-signature capabilities help protect data integrity and control technical records
• Multi-user database configuration stores your projects in a central location and facilitates information exchange
• Command Line Interface—the ability to access GeneMapper ID-X Software automatically (without human intervention) streamlines its integration with LIMS installations and other applications in an existing laboratory infrastructure

Automated Data Assessment
GeneMapper ID-X Software was designed specifically to fulfill the requirements of both Expert System and Expert Assistant software. A combination of sophisticated automated data assessment processes and efficient manual review tools deliver comprehensive expert system capability. This provides optimal interaction between the analyst and the data, significantly reducing the amount of analysis time required for single source samples. New features such as the Analysis Requirements check, Allelic Ladder Quality Assessment, Improved Quality Value System, and the Analysis Summary analyze samples and segregate them into pass or review categories based on your thresholds. Once segregated, you can easily conduct any necessary manual review of samples.

Despite its capabilities to automate and streamline the analysis of single source samples, an Expert System is as yet unable to make the final analysis decision for most forensic casework samples and in particular for those containing mixtures. GeneMapper ID-X Software harnesses the automated, rule-based, subject-specific knowledge to act as an Expert Assistant to the forensic analyst, simplifying much of the analysis process and empowering the analyst to make key interpretation decisions. A mixture analysis tool determines the number of contributors to a mixture and efficiently manages the resulting possible genotypes. This enables the forensic analyst to interpret mixtures and generate accurate statistical calculations.

Manual Tools Improve Data Review
Data analysis efficiencies offered by the automated data review processes have been further enhanced through the introduction of a new suite of manual review tools. These developments focus around the plot window providing quick and easy access to all aspects of the data, thus simplifying the data review process. Colored marker header bars indicate which markers within a sample have failed to meet the user defined thresholds and the new Process Quality Value (PQV) Details window details which flags have been fired and how much the observed value differs from the threshold. In addition, expanded labeling options are available to distinguish alleles from artifacts and reviewers can directly access raw data for further troubleshooting. Electronic/peer review of the data is enhanced with the review and manual acceptance of marker and sample level PQVs along with a detailed label edit table display.

For further troubleshooting, reviewers can also directly access raw data. The ability to review and manually accept markers and sample-level PQVs in a detailed label edit table display enhances electronic/peer data review.

A Complete, Verified System
GeneMapper ID-X Software is an integral component of our complete system of instruments, reagents, software, and services for human-identity applications. It has undergone extensive verification testing to ensure robust design features, performance, and reproducibility. When you partner with us, you gain access to the most extensive Human Identification resource network in the industry. Our dedicated team of industry-leading experts—with extensive forensic product development experience—worked closely with the forensic community to develop GeneMapper ID-X Software. The software is part of a system that is supported by on-site technical assistance from skilled Field Applications Support Scientists and Field Service Engineers.

DS37 Matrix Standard Kit (Dye Set J6-T) Applied Biosystems™

The DS-37 Matrix Standard Kit (Dye Set J6-T) is used to perform the spectral calibration required to analyze 6-FAM, VIC, TED, SID, TAZ, and LIZ dye-labeled DNA fragments on the Applied Biosystems SeqStudio, 3130, and 3500 series systems. The data collection software for these instruments uses the multi-component matrix to automatically analyze the 6 differently colored fluorescent dye-labeled samples in a single capillary. The DS-37 Matrix Standard Kit (Dye Set J6-T) contains 6 specific sizes of a unique fluorescent dye label.

AmpFLSTR™ Identifiler™ Direct PCR Amplification Kit Applied Biosystems™

The AmpFLSTR Identifiler Direct PCR Amplification Kit enables direct amplification of the 16 loci included in the Identifiler Kit, eliminating the need to perform DNA extraction or purification steps for DNA database and other single source reference samples. Blood or buccal samples on FTA Cards can be punched into PCR plates or tubes, and taken directly to PCR amplification, without reduction in data quality. Samples collected with the Buccal DNA Collector and other non-FTA substrates can be processed without the need for heat incubation or additional workflow steps using the Applied Biosystems Prep-n-Go Buffer.

Key Features of the AmpFLSTR Identifiler Direct PCR Amplification Kit:

• Enables the direct amplification of blood and buccal samples without the need for extraction or purification
• Facilitates high throughput & automated sample processing
• Minimizes the risk of contamination and procedural errors by reducing the number of processing steps
• Helps accelerate time to result with minimal reduction in data quality
• Minimizes extraction/purification costs and helps reduce the cost of labor and consumables

In addition, the Identifiler Direct kit uses the same dye set, allelic ladder and primer sequences as the standard Identifiler kit, which:
• Maximizes concordance with STR profiles generated with other AmpFLSTR kits including the Identifiler, Identifiler Plus, Profiler Plus, Profiler Plus ID, SGM Plus and COfiler Kits
• Facilitates comparison with casework data and legacy databases
• Streamlines validation and implementation

Sample typeSuccess Rate
(50 rfu Threshold)
Success Rate
(150 rfu Threshold)
Number of Samples Tested
Blood on FTA Card99.4-100%
Mean: 99.5%
95.7-98.8%
Mean: 97.3%
414
Buccal on FTA Card91.8-99.4%
Mean: 97.1%
84.2-95.5%
Mean: 90.9%
643
Buccal on Bode Buccal
DNA Collector Card
97.5-98.8%
Mean: 97.8%
88.1-98.8%
Mean: 94.0%
582


Table 1: As part of its rigorous development, the Identifiler Direct Kit was field tested by several medium to high-throughput DNA databasing laboratories to assess "first pass" success rate. Combined results from external test site laboratories are shown below. 1.2 mm punches from blood and buccal samples on FTA Cards and Buccal DNA Collectors were amplified with the Identifiler Direct Kit, and the resulting data was analyzed using GeneMapper ID-X, at two different minimum peak amplitude thresholds.

The Confidence to Do More
The Identifiler Direct Kit is part of a new generation of AmpFLSTR Kits that harnesses significant advances in PCR amplification technology to enable recovery of more results from more samples with increased confidence.

Ultimately, laboratories using the Identifiler Direct Kit will be able to significantly expand their throughput capabilities, while also maximizing sample integrity and quality assurance for the entire process.

Complete Validated Solution
We offer a complete solution to meet the needs of the human identification community. Our system includes DNA extraction and quantification kits, a range of AmpFLSTR STR Kits, instrumentation, software, and consumables.

The Identifiler Direct Kit is part of a comprehensively validated system for STR-based Human Identification. The PCR reaction components, primer sequences, and amplification protocols have been developed, optimized and validated together with Applied Biosystems instrumentation and software to provide specific, robust amplification. Validation experiments for the Identifiler Direct Kit were performed by our scientists according to the DNA Advisory Board (DAB) Quality Assurance Standards for Forensic DNA Testing Laboratories and the Scientific Working Group on DNA Analysis Methods (SWGDAM) Revised Validation Guidelines. However, each laboratory using the Identifiler Direct Kit should perform its own internal validation studies.

The Identifiler Direct Kit is subjected to rigorous quality control testing to ensure consistent performance. We develop and manufacture our products in accordance with ISO 9001 quality system requirements. Additionally, a Certificate of Analysis is available upon request that confirms that the specific combination of components within each lot meets quality assurance testing specifications.

Experience Matters
We are the only company in the world that designs and validates its reagents, instruments, and data analysis software together as an integrated system for DNA testing. Technical Service Scientists and Field Application Specialists are available to answer your technical questions, review data, and make recommendations on how to perform assays and troubleshoot results. All of these resources help ensure success when using Applied Biosystems Human Identification solutions in your laboratory.

Note: For Forensic or Paternity Use Only.

Important Notice

The purchase of this product conveys to the buyer the non-transferable license to use the purchased amount of the product only for forensic or paternity testing conducted by the buyer. This license does not include, as ruled by a U.S. Court, a license to use this product in chimerism determination or analysis, molar specimens classification, cell line authentication, determination of fetal sex, cancer analysis, genetic research, non-casework-related forensic applications (such as general research in forensics or teaching and training persons not employed in a forensic laboratory), identifying or determining maternal cell contamination, or sample tracking. Further rights can be obtained by contacting Promega Corp., 2800 Woods Hollow Rd., Madison, WI 53711 USA.

Ion 530™ Chip Kit-4 Reactions for Agrigenomics Ion Torrent™

The Ion 530™ Chip Kit-4 Reactions contains 4 barcoded chips for sample tracking and sequencing of 400-600 bp fragments. The kit is intended for use with the Ion 520™ & Ion 530™ ExT Kit-Chef and the Ion S5™ and Ion S5™ XL Sequencing Systems. The Ion 530 Chip electronically detects polymerase-driven base incorporation without the use of fluorescence. By eliminating the use of an optical detection system, this advance in next-generation sequencing technology allows for rapid sequencing times of as little as 4.5 hours for 600 bp sequencing.

The Ion 530 Chip Kit-4 Reactions offers:
• Sample tracking functionality from an integrated barcode
• Read lengths of 400-600 bp to support a variety of research applications, including microbial sequencing and metagenomics
• A rapid sequencing run time of as little as 4.5 hours, generating up to 12 million reads with ExT chemistry
• Automated handling and loading of templated products for sequencing
• Compatibility with current library preparation methods

Notes:
This kit is only compatible with the Ion S5 and Ion S5 XL Systems.
Use this kit with the Ion 520 & Ion 530 ExT Kit-Chef and Torrent Suite™ Software 5.2 or higher.

GeneMapper™ ID-X Software v1.5, Client Installation Applied Biosystems™

This product includes a single GeneMapper ID-X Software v1.5 Client Installation (no database) and license.

GeneMapper ID-X Software is an automated genotyping software solution designed for all human identification data analysis needs, including forensic casework, databasing, and paternity testing. GeneMapper ID-X Software supports a multi-user database configuration and provides a set of data analysis and sample review tools that help streamline sizing, allele calling, mixture analysis, and statistical calculations. The software offers a comprehensive quality value system that can be optimized and validated for use in both Expert System and traditional data analysis workflows. The software supports genotyping applications on the Applied Biosystems 310, 3100, 3100-Avant; Applied Biosystems 3130, 3130xl, 3500, 3500xL genetic analyzers; and Applied Biosystems 3730 DNA Analyzer.

Learn more about GeneMapper ID-X Software >

Features of GeneMapper ID-X Software v1.5 include:
• Microsoft Windows 7 64-bit compatibility
• Enhanced Profile Manager
     --Allows import of reference or custom profiles from text files
     --Enables export of comparison results for analysis and reporting
• Expanded capabilities to integrate with third party systems and manage data archiving
     --Additional command line interface to automate exporting of all key data objects, opening of a project, splitting one project into multiple projects, and filtering of samples for selected commands
     --Allows user to generate sample plots in individual PDFs using a single command
• Support of CODIS CMFv3.2 R13 specification
     --Allows export of CODIS XML with latest list of specimen categories, markers, and kits accepted by CODIS
     --Support of expanded CODIS ORI
     --Enables user to define kit/panel names and locus names that can be exported
• An updated and consolidated set of panel, bin, and stutter files to support analysis with all existing AmpFlSTR kits, including GlobalFiler, GlobalFiler Express, and Yfiler Plus, is pre-installed with the software
• The addition of GlobalFiler Population Database to support statistical analysis of GlobalFiler kit data

Overview of GeneMapper ID-X Software:
• Powerful, easy-to-use data analysis tool designed to increase lab productivity
• Comprehensive Expert System capability enables analysis of forensic databasing samples delivered by automated data assessment functionality and efficient manual review tools
• Complete Expert Assistant solution for analysis of forensic casework samples combines an efficient suite of manual review features with an integrated mixture analysis tool
• Quality control functionality allows rapid allele match comparisons and concordance searches within a data set
• Extensive security, auditing, and e-signature capabilities help protect data integrity and control technical records
• Multi-user database configuration stores your projects in a central location and facilitates information exchange
• Command Line Interface—offers the ability to access GeneMapper ID-X Software automatically (without human intervention) and helps streamline its integration with LIMS installations and other applications in an existing laboratory infrastructure

Automated data assessment
GeneMapper ID-X Software was designed specifically to fulfill the requirements of both Expert System and Expert Assistant software. A combination of sophisticated automated data assessment processes and efficient manual review tools deliver comprehensive Expert System capability. This facilitates optimal interaction between the analyst and the data, helping to significantly reduce the amount of analysis time required for single source samples. Features such as the Analysis Requirements check, Allelic Ladder Quality Assessment, Improved Quality Value System, and the Analysis Summary analyze samples and segregate them into pass or review categories based on your thresholds. Once segregated, you are enables to easily conduct manual review of samples.

Despite its capabilities to automate and streamline the analysis of single source samples, an Expert System is unable to make the final analysis decision for most forensic casework samples and in particular for those containing mixtures. GeneMapper ID-X Software is designed to harness the automated, rule-based, subject-specific knowledge to act as an Expert Assistant to the forensic analyst, to help simplify much of the analysis process and empower the analyst to make key interpretation decisions. A mixture analysis tool determines the number of contributors to a mixture and help efficiently manage the resulting possible genotypes. This enables the forensic analyst to interpret mixtures and generate accurate statistical calculations.

Manual tools help improve data review
Data analysis efficiencies offered by the automated data review processes have been further enhanced through the introduction of a suite of manual review tools. These developments focus around the plot window, enabling quick and easy access to all aspects of the data, thus helping to simplify the data review process. Colored marker header bars indicate which markers within a sample have failed to meet the user defined thresholds and the Process Quality Value (PQV) Details window details which flags have been fired and how much the observed value differs from the threshold. In addition, expanded labeling options are available to distinguish alleles from artifacts and reviewers can directly access raw data for further troubleshooting. Electronic/peer review of the data is enhanced with the review and manual acceptance of marker and sample level PQVs along with a detailed label edit table display.

For further troubleshooting, reviewers can also directly access raw data. The ability to review and manually accept markers and sample-level PQVs in a detailed label edit table display enhances electronic/peer data review.

A complete, verified system
GeneMapper ID-X Software is an integral component of the Thermo Fisher Scientific complete system of instruments, reagents, software, and services for human-identity applications. It has undergone extensive verification testing to help ensure robust design features, performance, and reproducibility. When you partner with Thermo Fisher, you gain access to one of the most extensive human identification resource networks in the industry. Our dedicated team of experienced forensic professionals—with extensive forensic product development experience—worked closely with the forensic community to develop GeneMapper ID-X Software. The software is part of a system that is supported by on-site technical assistance from skilled Field Applications Support Scientists and Field Service Engineers.

Ion GeneStudio™ S5 System Extended Warranty Package Ion Torrent™

The Ion GeneStudio S5 System is a semiconductor-based next-generation sequencing (NGS) system that enables simple targeted sequencing workflows. It is optimized to provide affordability for labs focused on smaller panels and lower sequencing throughput requirements. Combining an extended warranty with your system purchase helps extend the life of your investment.

This package includes the Ion GeneStudio S5 System, SmartStart orientation, and an extended warranty. Key features include:
• Select the chip (Ion 510–540 chip) that fits your application and throughput needs to achieve from 2–80 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete run and analysis in hours and move forward with your experiments
• Increase efficiency and become operational faster with SmartStart orientation
• Receive fast repair from certified service engineers
• Minimize instrument downtime by troubleshooting with experienced Technical Support teams

For detailed instrument information and specifications, see the Ion GeneStudio S5 System.

Get up and running quickly with SmartStart
SmartStart orientation is carried out by a Field Application Scientist (FAS) to get you up and running quickly in your lab and reduce downtime. SmartStart is the first step of your education journey and is designed to help you work smarter and with greater efficiency. It includes:
• 1-day technology overview and instrument workflow
• 1-day hands-on application workflow training
• 10 hours bioinformatics consultancy

Content will vary depending on your level of knowledge and experience.

Extended warranty plan
Add coverage to your existing manufacturer’s limited warranty with an extended warranty. Each extended warranty includes a planned maintenance visit. Should your instrument require a repair, the extended warranty coverage includes parts, labor, and travel at no additional cost. In addition, you’ll receive:
• On-site guaranteed 2-day response time*
• Scheduled on-site planned maintenance (PM)
• Priority access to Remote Service Engineers

Certain exclusions apply. Contact your Services and Support Representative for details at service.sales@thermofisher.com.

*Availability limited in some geographical areas.

Ion Chef™ Food Protection Instrument Thermo Scientific™

Simplify your workflow with automated template preparation and chip loading, with the Ion Chef™ Food Protection Instrument - a part of the Thermo Scientific™ Next Generation Sequencing (NGS) Food Authenticity Workflow. 

The Thermo Scientific NGS Food Authenticity Workflow allows identification of meat, plant and fish species present in even the most challenging sample types; protecting your business from food fraud by verifying the authenticity of any sample type.

This simple, automated instrument makes your workflow suitable for users at any experience level.

NGM Detect™ PCR Amplification Kit Applied Biosystems™

The Applied Biosystems NGM Detect PCR Amplification Kit is the first 6-dye STR kit designed specifically for those laboratories using the European Standard Set (ESS) of loci. The kit offers excellent sensitivity and provides an alternate marker configuration to the well-established NGM SElect PCR Amplification Kit format to maximize information recovery, even from degraded casework samples.

As with all Applied Biosystems STR kits, the NGM Detect kit is ISO18385 Forensic DNA Grade, giving you piece of mind when choosing this kit for your casework samples.

The key features of NGM Detect kit are:
Increased database searches by virtue of prioritization of markers with the highest representation in historic databases
Optimized positioning of SE33 in the sub-350 bp range to support mixture analysis
Dual amplification compatibility when partnered with the NGM SElect kit
High sensitivity through a new master mix formulation coupled with the ability to add up to 15 μL of sample to the reaction
Fast PCR cycle time—<60 min
Additional Y marker enabling gender confirmation
Integrated Quality Control System to verify reaction set up and assess the presence of inhibition in the sample

Increased database searches
The European Standard Set (ESS) of loci was established to enable cross-border information sharing and was composed of seven SGM/SEFiler Plus markers. The ESS was expanded to 12 loci in 2009 to include more markers to enable wider compatibility between neighboring countries.

Because of this, a large number of historic crime-scene profiles contained in databases consist of SGM/SEFiler Plus marker data. When dealing with challenging casework, such as cases involving degraded samples, the information recovery is limited. In this situation, recovering the SGM/SEFiler Plus markers is key for producing a partial DNA profile that has maximum overlap with older data contained in databases, giving a higher probability of a match and providing valuable investigative leads.

The NGM Detect kit takes full advantage of the space afforded by 6 dyes and features optimized marker positioning, placing the SGM/SEFiler Plus markers in the low molecular weight (LMW) range to help ensure the highest compatibility with historic datasets and the possibility of a higher chance of generating investigative leads.

Optimized positioning of SE33
The highly polymorphic SE33 marker is useful for mixture analysis but extends up to 500 bp in most STR kits. As a result, it is one of the first markers to drop out in degraded samples. In the NGM Detect kit, SE33 extends to a maximum of 351 bp to help to significantly increase the chances of recovery of this highly informative marker in challenging samples.

Dual amplification compatibility
Dual amplification, where two different STR kits are used to amplify a sample, is a strategy that can be used to confirm or extend a DNA profile result for increased confidence in the final result in the former and to obtain additional information in the latter.The NGM Detect kit is an advanced partner for the NGM SElect kit, featuring the same loci, but with different primer sequences and different marker placement. When using the two kits in combination, different primer sequences provide confidence that the consensus profile generated reflects the ‘true’ genotype of the sample. The complimentary marker positioning places mini-STR loci in the NGM Detect kit in the high molecular weight (HMW) range in the NGM Select kit and vice versa, meaning that additional alleles can be recovered from degraded samples when using the two kits in combination. Together the NGM Detect and NGM Select system delivers 12 independent mini-STRs.

Integrated Quality Control System
The IQC assay consists of two synthetic sequences not found in nature with primers specific for each of the targets. It provides positive confirmation that the assay is functioning as expected in a given run.

This system is particularly useful to confirm the validity of negative results and can also be used to distinguish samples that are degraded versus those that contain PCR inhibitors, supplementing data analysis and informing downstream processing decisions.

Experience matters
The NGM Detect kit is part of a fully integrated and validated forensic DNA workflow backed by superior global training, service, and support. Technical support scientists and field application specialists are available to answer your technical questions, review data, and make recommendations on how to perform assays and troubleshoot results. All of these resources help ensure success when using Applied Biosystems human identification solutions in your laboratory.

We also offer a range of Human Identification Professional Services (HPS) to assist with bringing new kits and workflows online. Since 2007, the HPS team has completed over 400 successful validation projects worldwide with a staff of more than 20 technical support specialists, each averaging 8 years of real-world forensic experience, providing customers with in-depth training and support on our instruments, chemistries, and software.

For licensing and limited use restrictions visit thermofisher.com/HIDlicensing.

Ion PI™ Hi-Q™ Chef Kit Ion Torrent™

The Ion PI™ Hi-Q™ Chef Kit enables robust and reproducible template preparation, chip loading, and sequencing of 200 base-read libraries on the Ion Chef™ System as part of the Ion Proton™ System sequencing workflow. The plug & play, pre-packaged, single-use reagent cartridges for template and chip preparation enables an automated workflow for processing single and dual samples. The reagent and sample barcodes interact with the Ion Chef™ System to validate user-defined run plans and offer complete run traceability.

The Ion PI™ Hi-Q™ Chef kit offers:
• The latest advancements in data quality and accuracy using the Ion Proton™ System
• Improved specificity for SNP and insertion/deletion variant calls
• Increased sensitivity with improved target coverage and representation
• A simplified workflow with ready-to-use Ion PI™ chips v3
• Over 60% reduction of library input amount when compared to PI™ IC 200 workflow
• Less than 15 minutes hands-on time
• Protocols for the preparation of one or two Ion PI™ chips per run
• Planned run sharing between different Ion Chef™ systems

The Ion PI™ Hi-Q™ Chef Kit is an integral component of the Ion Torrent™ next-generation sequencing workflow, designed to simplify and streamline the overall workflow with minimal hands-on-time for users with any experience level. This easy-to-use kit delivers high-quality and reproducible templated products for semiconductor sequencing.

The Ion PI™ Hi-Q™ Chef Kit contains sufficient reagents and consumables for 8 template preparation and sequencing runs, and should be used in conjunction with Ion PI™ chips v3 for sample tracking purposes.

Notes:
• This kit supports 200 base-read libraries for a variety of applications.
• This kit is only compatible with the Ion Chef™ and Ion Proton™ systems.
• Components of this kit have been optimized for use on the Ion Chef™ and Ion Proton™ systems specifically and should NOT be replaced or interchanged with other product kit components.
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