Shop All RNAi and RNA Reagents

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Purification Target


Silencer™ Custom Designed siRNA Invitrogen™

Silencer® custom siRNAs (unmodified 21-bp duplexes) are cost-effective RNA interference (RNAi) tools ideal for knocking down gene expression in order to study protein function in a wide range of cell types. Use our GeneAssist™ Custom siRNA Builder to design and order a custom siRNA.

mirVana™ miRNA Inhibitor, let-7c positive control Invitrogen™

miRNA inhibitors are small, chemically modified single-stranded RNA molecules designed to specifically bind to and inhibit endogenous miRNA molecules and enable miRNA functional analysis by down-regulation of miRNA activity.

We have now released the second generation of miRNA inhibitors, mirVana™ miRNA Inhibitors, which:
Display better potency than lead competitor's product
• Offer maximum and consistent effect in vitro at low miRNA inhibitor concentration
• Are non toxic
• Target the most updated Sanger content
• Can be used in vitro and in vivo, offering consistency throughout your entire research project


Positive and negative controls are also available for use along with mirVana™ miRNA Inhibitors in miRNA down-regulation experiments.

mirVana™ miRNA Inhibitor let-7c Positive Control
The mirVana™ miRNA Inhibitor let-7c Positive Control is intended for use as a positive control for mammalian cell culture experiments using mirVana™ miRNA Inhibitors. Endogenous let-7c miRNA has been shown to negatively regulate HMGA2 mRNA in cultured cells. HMGA2 is a ubiquitously expressed, nonhistone, chromatin protein that can modulate gene expression through changes in chromatin architecture. let-7c miRNA down-regulates levels of HMGA2 mRNA. When transfected into human and mouse cell lines, let-7c miRNA inhibitor blocks endogenous let-7c miRNA, resulting in increased levels of HMGA2 mRNA. Thus, let-7c miRNA inhibitor activity can be monitored in human or mouse cells using real-time reverse transcription PCR (RT-PCR) to detect HMGA2 mRNA.

First Generation Inhibitor Controls
Our first-generation miRNA inhibitors (and controls), Ambion® Anti-miR™ miRNA Inhibitors, have lower specificity and potency, plus a lower strand specificity compared to the new mirVana™ miRNA Inhibitors. These first-generation inhibitors are recommended for completing ongoing in vitro miRNA studies. For new studies or in vivo studies, we highly recommend our new mirVana™ miRNA Inhibitors and their corresponding controls.

Silencer™ Select Human Long Non-coding RNA (lncRNA) siRNA Library (384 well) Invitrogen™

Long noncoding RNAs (lncRNAs) have gained interest in recent years as they have been implicated in genomic regulation, cellular housekeeping functions, developmental processes and disease. The Silencer™ Select Human Long Noncoding RNA (lncRNA) siRNA Library contains 15,081 Ambion™ Silencer Select siRNAs targeting 5,027 lncRNAs as identified in GENCODE v22. The Silencer Select Human Long Noncoding RNA (lncRNA) siRNA Library is designed against targeted transcripts aligned to the entire genome, maximizing prediction and coverage across alternatively spliced transcripts. Silencer Select siRNAs are designed with Thermo Fisher Scientific’s leading design algorithms and locked nucleic acid (LNA) chemical modifications to help ensure efficacy, specificity and potency. This in turn provides a powerful platform for achieving accurate and consistent phenotype data from RNAi screens in the discovery and elucidation of lncRNAs.

• Superior efficacy—Reduce off target effects by up to 90% due to latest design algorithms and LNA chemical modifications
• Highest efficiency—Perform knockdown studies with 100-fold more potent siRNAs than currently available siRNAs
• Dependable—Achieve faster discoveries via consistency of gene knockdown and reliability of phenotypic results
• Convenient—Reduce data de-convolution and accelerate target validation with our 96- and 384-well arrayed format
• Customizable—Choose the best option for your workflow demands, including additional siRNA scales and pooled formats

Why use the Silencer Select Human Long Noncoding RNA (lncRNA) siRNA Library?
Together with careful bioinformatics selection of gene targets, Silencer Select siRNAs are optimized with latest design algorithms, proprietary chemical modifications and high quality synthesis to help ensure desired RNAi outcomes (learn more). The Silencer Select Human Long Noncoding RNA (lncRNA) siRNA Library contains our pre-designed and when available, validated siRNAs generated with highest potency and specificity in mind so you can focus on the highest data quality backed by the best in industry guarantee (learn more about the guarantee).

Silencer Select siRNA libraries empower you with highly potent siRNAs to maximize discovery with even less
Ambion Silencer Select siRNAs are designed with the highest potency of available siRNAs, resulting in 100-fold more potent siRNAs and allowing gene knockdowns at the lowest concentrations (see figure below). The highly potent Silencer Select siRNAs allow you to use even lower concentrations of siRNAs, which helps to minimize off target effects, reduce false negative data and maximize siRNA library output for additional screens and data validation. The Silencer Select Human Long Noncoding RNA (lncRNA) siRNA Library contains 0.25 nmol of each highly potent siRNA, sufficient for at least 500 transfections (at 5 nM siRNA, 100 µL transfection volume).

Flexibility to meet your workflow needs
Thermo Fisher Scientific offers a comprehensive list of pre-defined or custom siRNA libraries to human, mouse or rat genes with 1, 2, or 5 nmol of each siRNA or larger sizes. For a complete gene list, additional information or to discuss your research with one of our technical experts, contact your local sales representative or e-mail us at RNAilibraries@lifetech.com.

Silencer™ Human Membrane Trafficking siRNA Library Invitrogen™

The Silencer™ Human Membrane Trafficking siRNA Library is designed for researchers targeting proteins known or predicted to participate in membrane trafficking or remodeling. This library is designed with an aim to understand gene expression in critical cellular functions including biosynthesis, secretion, endocytosis, lysosomal and proteasomal protein degradation, and phagocytosis. The Silencer Human Membrane Trafficking siRNA Library contains 426 Ambion™ Silencer siRNAs targeting 142 genes. The library was designed using the most up-to-date genome databases, including the NCBI RefSeq database and cross-referenced to the Gene Ontology Consortium (GO) database and/or the HUGO Gene Nomenclature Committee (HGNC). Utilizing Ambion Silencer technology built on stringent bioinformatics to ensure high target specificity and siRNA potency, the Silencer Human Membrane Trafficking siRNA Library is an ideal solution for focused and cost-effective RNAi screens against genes integral to membrane trafficking.

• Comprehensive—Expedite your cell membrane trafficking RNAi functional screens with pre-defined Silencer Human Membrane Trafficking siRNA Library
• Reliable—Increase target screening accuracy with three individual siRNAs per gene target
• Effective—Reduce off target impacts at low concentrations with proven Ambion Silencer siRNA design
• Convenient—Reduce data de-convolution and accelerate target validation with our arrayed format
• Customizable—Choose the best option for your workflow demands, including additional siRNA scales and pooled formats

Why use the Silencer Human Membrane Trafficking siRNA Library?
Together with careful bioinformatics selection of gene targets, Silencer siRNAs are optimized with design and high quality synthesis with guaranteed silencing (learn more about the guarantee). The Silencer Human Membrane Trafficking siRNA Library contains our pre-designed and when available, validated siRNAs generated with maximum potency and specificity in mind so you can focus on data quality (learn more about the design). All Silencer libraries are selected against the latest available databases and resources for up-to-date content. Full siRNA sequence information, as well as the exon targeted and each targeted gene's symbol, full name, aliases, RefSeq number, and Locus ID, plus results from any validation experiments performed using the included siRNAs is provided. Please contact us for the complete list of targets.

Silencer siRNA libraries allow you to screen efficiently and maximize data output
Ambion Silencer siRNAs are designed with potency in mind to help ensure gene knockdown at minimum concentrations. This not only helps ensure less potential for off target effects and false positive data but also minimizes false negative outcomes of siRNA screening. The Silencer Human Membrane Trafficking siRNA Library contains 0.25 nmol of each siRNA, sufficient for 100 transfections (at 25 nM siRNA, 100 µL transfection volume).

Flexibility to meet your workflow needs
Thermo Fisher Scientific offers a comprehensive list of pre-defined or custom siRNA libraries to human, mouse or rat genes with 1, 2, or 5 nmol of each siRNA or larger sizes. For a complete gene list, additional information or to discuss your research with one of our technical experts, contact your local sales representative or e-mail us at RNAilibraries@lifetech.

LentiArray™ Human Tumor Suppressor CRISPR Library Invitrogen™

The award-winning Invitrogen™ LentiArray™ Human Tumor Suppressor Library targets 716 genes with up to 4 gRNA per gene target (pooled in a single well) for a total of 2,864 gRNAs. Libraries are delivered as 100 μL of ready to use lentiviral particles per gene target with an average titer of 1x108 TU/mL (functional titer determined by antibiotic resistance) and are also available as glycerol stocks.

Tumor suppressors are negative regulators cell cycle progression. Loss or mutation of tumor suppressor genes is often involved in the development of cancer.The gene targets within this library were selected using the most up-to-date genome databases, including the NCBI RefSeq database, and cross-referenced to the Gene Ontology Consortium (GO) database and/or the HUGO Gene Nomenclature Committee (HGNC), as well as the Tumor Suppressor Gene Database (TSGene).

Built to bring you success
LentiArray CRISPR libraries are constructed using gRNA designs produced using Thermo Fisher Scientific’s proprietary CRISPR gRNA design algorithm. This algorithm incorporates the latest gRNA design research, as well as our extensive in-house experience, to produce the highest quality designs. The gRNA designs included in the LentiArray CRISPR libraries are selected for maximal editing efficiency and specificity and are designed to knock out all known isoforms of the target gene. For each gene target, up to four high-quality gRNAs are included to help ensure highly efficient knockout of the target gene in a wide array of cell types.

Design and execute your experiments without limitations
LentiArray CRISPR libraries are designed and constructed to give you complete control over your experimental design. They utilize a two-vector design, expressing the Cas9 nuclease and the gRNA off of separate lentiviral constructs, enabling you to dictate when and how the genome editing tools are delivered to your cells.

The LentiArray Cas9 lentivirus construct expresses a human, codon-optimized Cas9 nuclease with a blasticidin-resistance gene under the control of the EF-1α (EFS) promoter. You can choose to co-infect your cells with both the LentiArray gRNA lentiviruses and the Cas9 lentivirus or just the LentiArray Cas9 lentivirus to establish a stable Cas9 expressing cell line. With LentiArray CRISPR libraries you have the freedom to design the experimental approach that best suits your model system and your screening goals.

Furthermore, to minimize restrictions to your experimental design, the gRNA lentiviruses that make up the LentiArray CRISPR libraries do not contain fluorescent markers. This allows reporters of any wavelength to be used with the libraries and expands your ability to perform multiplexed experiments. For challenging cell lines, the LentiArray gRNA lentiviruses contain a puromycin resistance gene that allows enrichment of the population of edited cells and drives stronger phenotypes.

Learn more about LentiArray CRISPR libraries >

Optimize your assay design and have full confidence in your results with LentiArray controls
High quality controls are the cornerstone of a successful screen. The LentiArray CRISPR libraries product line includes a suite of controls to help you quickly develop your assay and give you confidence in defining your hit criteria.

Learn more about LentiArray controls >

Custom Select siRNA, In Vivo Ready Invitrogen™

Silencer® Select custom siRNAs (LNA-modified 21-bp duplex with overhangs) are RNA interference (RNAi) tools ideal for knocking down gene expression in order to study protein function in a wide range of cell types. These siRNAs provide high knock-down efficiencies and specificities.

Breast Adenocaricinoma (MCF-7) Total RNA Invitrogen™

Breast Adenocarcinoma (MCF-7) Total RNA is a total RNA sample extracted from MCF-7 cells for use as a positive control in QuantiGene assays.

Ambion™ In Vivo Pre-Designed siRNA Invitrogen™

Ambion® siRNAs are classic 21-mers which incorporate the latest improvements in siRNA design, off-target effect prediction algorithms, and chemistry. These siRNAs are guaranteed-to-silence based on their proven design.

Custom RT Pools Thermo Scientific™

Custom miRNA array designs can hold from 12 to 380 assays, and 1 to 8 samples on each array design. Ten formats are offered, available only with microfluidics card design.

LentiArray™ Human Protease CRISPR Library Invitrogen™

The award-winning Invitrogen™ LentiArray™ Human Protease Library targets 475 genes with up to 4 gRNA per gene target (pooled in a single well) for a total of 1,900 gRNAs. Libraries are delivered as 200 μL of ready to use lentiviral particles per gene target with an average titer of 1x108 TU/mL (functional titer determined by antibiotic resistance) and are also available as glycerol stocks.

Proteases degrade proteins but are also integral signaling molecules, and the deregulation of protease signaling pathways has been implicated in the development of cardiovascular disease, neurological disorders, cancer, and inflammatory disease. The gene targets within this library were selected using the most up-to-date genome databases, including the NCBI RefSeq database, and cross-referenced to the Gene Ontology Consortium (GO) database and/or the HUGO Gene Nomenclature Committee (HGNC).

Built to bring you success
LentiArray CRISPR libraries are constructed using gRNA designs produced using Thermo Fisher Scientific’s proprietary CRISPR gRNA design algorithm. This algorithm incorporates the latest gRNA design research, as well as our extensive in-house experience, to produce the highest quality designs. The gRNA designs included in the LentiArray CRISPR libraries are selected for maximal editing efficiency and specificity and are designed to knock out all known isoforms of the target gene. For each gene target, up to four high-quality gRNAs are included to help ensure highly efficient knockout of the target gene in a wide array of cell types.

Design and execute your experiments without limitations
LentiArray CRISPR libraries are designed and constructed to give you complete control over your experimental design. They utilize a two-vector design, expressing the Cas9 nuclease and the gRNA off of separate lentiviral constructs, enabling you to dictate when and how the genome editing tools are delivered to your cells.

The LentiArray Cas9 lentivirus construct expresses a human, codon-optimized Cas9 nuclease with a blasticidin-resistance gene under the control of the EF-1α (EFS) promoter. You can choose to co-infect your cells with both the LentiArray gRNA lentiviruses and the Cas9 lentivirus or just the LentiArray Cas9 lentivirus to establish a stable Cas9 expressing cell line. With LentiArray CRISPR libraries you have the freedom to design the experimental approach that best suits your model system and your screening goals.

Furthermore, to minimize restrictions to your experimental design, the gRNA lentiviruses that make up the LentiArray CRISPR libraries do not contain fluorescent markers. This allows reporters of any wavelength to be used with the libraries and expands your ability to perform multiplexed experiments. For challenging cell lines, the LentiArray gRNA lentiviruses contain a puromycin resistance gene that allows enrichment of the population of edited cells and drives stronger phenotypes.

Learn more about LentiArray CRISPR libraries >

Optimize your assay design and have full confidence in your results with LentiArray controls
High quality controls are the cornerstone of a successful screen. The LentiArray CRISPR libraries product line includes a suite of controls to help you quickly develop your assay and give you confidence in defining your hit criteria.

Learn more about LentiArray controls >

FAM3™ Dye-Labeled Pre-miR Negative Control #1 Invitrogen™

Ambion® FAM™ dye-labeled synthetic miRNA mimic for miRNA functional analysis. 5 nmol is supplied.

• Optimized design results in correct strand utilization by RISC
• Purified and ready to transfect

Ambion® Pre-miR™ miRNA Precursor Molecules are small, chemically modified, double-stranded RNA molecules designed to mimic endogenous mature miRNAs. This ready-to-use miRNA mimic can be introduced into cells using transfection or electroporation parameters similar to those used for siRNAs. They enable detailed study of miRNA biological effects via gain-of-function experiments. The FAM™ Dye-Labeled Pre-miR™ Negative Control #1 is a random sequence Pre-miR™ molecule that has been extensively tested in human cell lines and tissues and validated to produce no identifiable effects on known miRNA function. It is ideal for monitoring transfection efficiency, as the fluorescent label enables direct observation of the cellular uptake, distribution, and localization of the control. The label is on the 5' end of the molecule, and the oligonucleotide sequence is the same as the Pre-miR™ miRNA Precursor Molecule Negative Control #1 (SKU #AM17110). NOTE: Pre-miR™ miRNA Precursors are not hairpin constructs and should not be confused with pre-miRNAs.

Human Pancreas Total RNA Invitrogen™

Human Pancreatic Total RNA is a total RNA sample extracted from human pancreatic tissue for use as a positive control in tQuantiGene assays.

Custom PreAmp Pools Applied Biosystems™

Custom miRNA array designs can hold from 12 to 380 assays, and 1 to 8 samples on each array design. Ten formats are offered, available only with microfluidics card design. Use Custom PreAmp pools for samples with limited miRNA amounts.

LentiArray™ Human Nuclear Hormone Receptor CRISPR Library Invitrogen™

The award-winning Invitrogen™ LentiArray™ Human Nuclear Hormone Receptor Library targets 47 genes with up to 4 gRNA per gene target (pooled in a single well) for a total of 188 gRNAs. Libraries are delivered as 200 μL of ready to use lentiviral particles per gene target with an average titer of 1x108 TU/mL (functional titer determined by antibiotic resistance) and are also available as glycerol stocks.

Nuclear hormone receptors are a family of ligand-activated transcription factors that are activated by lipid-soluble ligands such as steroid hormones, thyroid hormone, vitamin D, and retinoic acid. Nuclear hormone receptors regulate a range of biological processes, including metabolism, development, proliferation, and reproduction. The gene targets within this library were selected using the most up-to-date genome databases, including the NCBI RefSeq database, and cross-referenced to the Gene Ontology Consortium (GO) database and/or the HUGO Gene Nomenclature Committee (HGNC).

Built to bring you success
LentiArray CRISPR libraries are constructed using gRNA designs produced using Thermo Fisher Scientific’s proprietary CRISPR gRNA design algorithm. This algorithm incorporates the latest gRNA design research, as well as our extensive in-house experience, to produce the highest quality designs. The gRNA designs included in the LentiArray CRISPR libraries are selected for maximal editing efficiency and specificity and are designed to knock out all known isoforms of the target gene. For each gene target, up to four high-quality gRNAs are included to help ensure highly efficient knockout of the target gene in a wide array of cell types.

Design and execute your experiments without limitations
LentiArray CRISPR libraries are designed and constructed to give you complete control over your experimental design. They utilize a two-vector design, expressing the Cas9 nuclease and the gRNA off of separate lentiviral constructs, enabling you to dictate when and how the genome editing tools are delivered to your cells.

The LentiArray Cas9 lentivirus construct expresses a human, codon-optimized Cas9 nuclease with a blasticidin-resistance gene under the control of the EF-1α (EFS) promoter. You can choose to co-infect your cells with both the LentiArray gRNA lentiviruses and the Cas9 lentivirus or just the LentiArray Cas9 lentivirus to establish a stable Cas9 expressing cell line. With LentiArray CRISPR libraries you have the freedom to design the experimental approach that best suits your model system and your screening goals.

Furthermore, to minimize restrictions to your experimental design, the gRNA lentiviruses that make up the LentiArray CRISPR libraries do not contain fluorescent markers. This allows reporters of any wavelength to be used with the libraries and expands your ability to perform multiplexed experiments. For challenging cell lines, the LentiArray gRNA lentiviruses contain a puromycin resistance gene that allows enrichment of the population of edited cells and drives stronger phenotypes.

Learn more about LentiArray CRISPR libraries >

Optimize your assay design and have full confidence in your results with LentiArray controls
High quality controls are the cornerstone of a successful screen. The LentiArray CRISPR libraries product line includes a suite of controls to help you quickly develop your assay and give you confidence in defining your hit criteria.

Learn more about LentiArray controls >

LentiArray™ Human DNA Damage Response CRISPR Library Invitrogen™

The award-winning Invitrogen™ LentiArray™ Human DNA Damage Response Library targets 561 genes with up to 4 gRNA per gene target (pooled in a single well) for a total of 2,244 gRNAs. Libraries are delivered as 100 μL of ready to use lentiviral particles per gene target with an average titer of 1x108 TU/mL (functional titer determined by antibiotic resistance) and are also available as glycerol stocks.

DNA surveillance proteins continuously monitor DNA integrity and activate cell cycle checkpoints and DNA repair pathways in response to DNA damage. The gene targets within this library were selected using the most up-to-date genome databases, including the NCBI RefSeq database, and cross-referenced to the Gene Ontology Consortium (GO) database and/or the HUGO Gene Nomenclature Committee (HGNC).

Built to bring you success
LentiArray CRISPR libraries are constructed using gRNA designs produced using Thermo Fisher Scientific’s proprietary CRISPR gRNA design algorithm. This algorithm incorporates the latest gRNA design research, as well as our extensive in-house experience, to produce the highest quality designs. The gRNA designs included in the LentiArray CRISPR libraries are selected for maximal editing efficiency and specificity and are designed to knock out all known isoforms of the target gene. For each gene target, up to four high-quality gRNAs are included to help ensure highly efficient knockout of the target gene in a wide array of cell types.

Design and execute your experiments without limitations
LentiArray CRISPR libraries are designed and constructed to give you complete control over your experimental design. They utilize a two-vector design, expressing the Cas9 nuclease and the gRNA off of separate lentiviral constructs, enabling you to dictate when and how the genome editing tools are delivered to your cells.

The LentiArray Cas9 lentivirus construct expresses a human, codon-optimized Cas9 nuclease with a blasticidin-resistance gene under the control of the EF-1α (EFS) promoter. You can choose to co-infect your cells with both the LentiArray gRNA lentiviruses and the Cas9 lentivirus or just the LentiArray Cas9 lentivirus to establish a stable Cas9 expressing cell line. With LentiArray CRISPR libraries you have the freedom to design the experimental approach that best suits your model system and your screening goals.

Furthermore, to minimize restrictions to your experimental design, the gRNA lentiviruses that make up the LentiArray CRISPR libraries do not contain fluorescent markers. This allows reporters of any wavelength to be used with the libraries and expands your ability to perform multiplexed experiments. For challenging cell lines, the LentiArray gRNA lentiviruses contain a puromycin resistance gene that allows enrichment of the population of edited cells and drives stronger phenotypes.

Learn more about LentiArray CRISPR libraries >

Optimize your assay design and have full confidence in your results with LentiArray controls
High quality controls are the cornerstone of a successful screen. The LentiArray CRISPR libraries product line includes a suite of controls to help you quickly develop your assay and give you confidence in defining your hit criteria.

Learn more about LentiArray controls >

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