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Imject™ Freund's Incomplete Adjuvant (FIA) Thermo Scientific™

Thermo Scientific Imject Freund's Incomplete Adjuvant is a popular nonspecific stimulator of the immune response for use in antibody production immunization protocols.

This product comes in 10 mL ampules that are convenient and ready-to-use. The water-and-oil emulsion greatly enhances immune responses to immunogens when mixed and injected with the prepared antigen, and is typically used for booster injections. The ampules comprise conveniently sized aliquots that provide long shelf life.

Highlights of Freund's Incomplete Adjuvant (FIA):
• Also called Incomplete Freund's Adjuvant (IFA)
• Water-in-oil emulsion without Mycobacterium
• Enhances immune response in booster injections
• Typically used for subsequent boosts after initial injection with FCA
• Disadvantage: difficult to mix with immunogen

Adjuvants are nonspecific stimulators of the immune response. When mixed with an antigen or immunogen, adjuvants help to deposit or sequester the injected material thereby helping to increase antibody response. Adjuvants enhance the immune response to compounds that are already immunogenic; they do not confer immunogenicity to non-immunogenic haptens. To make prospective antigens more immunogenic, it is necessary to conjugate them to a carrier protein or some other complex, immunogenic molecule.

For added safety when opening glass ampules, consider using our Ampule Breakers, which are disposable safety devices that protect the fingers when breaking open a glass ampule.

Related Products
Imject™ Alum Adjuvant
Imject™ Freund's Complete Adjuvant (FCA)

Imject™ Freund's Complete Adjuvant (FCA) Thermo Scientific™

Thermo Scientific Imject Freund's Complete Adjuvant is a popular nonspecific stimulator of the immune response for use in antibody production immunization protocols.

This product comes in 10 mL ampules that are convenient and ready to use. The water-and-oil emulsion greatly enhances immune responses to immunogens when mixed and injected with the prepared antigen, and is typically used for initial injections. The ampules comprise conveniently sized aliquots that provide long shelf life.

Features of Freund's Complete Adjuvant (FCA):
• Also called Complete Freund's Adjuvant (CFA)
• Water-in-oil emulsion containing killed Mycobacterium
• Greatly enhances immune response to immunogen
• Typically used for initial injections
• Disadvantages: difficult to mix with immunogen and can cause tissue necrosis at injection site

Adjuvants are nonspecific stimulators of the immune response. When mixed with an antigen or immunogen, adjuvants help to deposit or sequester the injected material thereby helping to increase antibody response. Adjuvants enhance the immune response to compounds that are already immunogenic; they do not confer immunogenicity to non-immunogenic haptens. To make prospective antigens more immunogenic, it is necessary to conjugate them to a carrier protein or some other complex, immunogenic molecule.

For added safety when opening glass ampules, consider using our Ampule Breakers, which are disposable safety devices that protect the fingers when breaking open a glass ampule.

Related Products
Imject™ Alum Adjuvant
Imject™ Freund's Incomplete Adjuvant (FIA)

Imject™ Alum Adjuvant Thermo Scientific™

Thermo Scientific Imject Alum Adjuvant is a formulation of aluminum hydroxide and magnesium hydroxide that effectively stimulates the immune response for antibody production procedures when mixed and injected with prepared immunogens.

Alum is considerably easier to mix with immunogens than Freund's adjuvants, as it does not require laborious emulsification. Although its effects are less pronounced compared to Freund's complete adjuvant (CFA), Imject Alum produces sufficient stimulation when used with complex immunogens (i.e., those that have been prepared as conjugates with KLH or other immunogenic carrier proteins).

Features of Pierce Imject Alum Adjuvant:

• Suspension of aluminum hydroxide and magnesium hydroxide
• Mild but effective adjuvant for substantial immunogens
• Ready to use: mix antigen directly with Imject Alum and inject
• The adjuvant of choice for allergy and immunogenicity testing with or without sensitization and challenge with fraction V ovalbumin (OVA) (see Moisan and Pongratz references)
• Disadvantage: does not elicit as strong an immune response as CFA; requires a strong immunogen

Adjuvants are nonspecific stimulators of the immune response. When mixed with an antigen or immunogen, adjuvants help to deposit or sequester the injected material thereby helping to increase antibody response. Adjuvants enhance the immune response to compounds that are already immunogenic; they do not confer immunogenicity to non-immunogenic haptens. To make prospective antigens more immunogenic, it is necessary to conjugate them to a carrier protein or some other complex, immunogenic molecule.

Related Products
Imject™ Freund's Incomplete Adjuvant (FIA)
Imject™ Freund's Complete Adjuvant (FCA)
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