Bioactive Small Molecules

Bioactive Small Molecules

These products include a vast array of non-peptide, small bioactive molecules and organic compounds, including receptor antagonists, molecular probes, fluorophores, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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1-15 of 142 Products

Nile Red Invitrogen™

Nile red is used to localize and quantitate lipids, particularly neutral lipid droplets within cells. Nile red is almost nonfluorescent in water and other polar solvents but undergoes fluorescence enhancement and large absorption and emission blue shifts in nonpolar environments (Excitation/emission...

eBioscience™ Brefeldin A Solution (1000X) Invitrogen™

Brefeldin A is an inhibitor of intracellular protein transport. Incubation of cells in culture with Brefeldin A leads to blockade of protein transport to the Golgi complex (GC) and accumulation of proteins in the endoplasmic reticulum (ER).

Pepstatin A, BODIPY™ FL Conjugate Invitrogen™

For the study of cathepsin D trafficking in cells by fluorescence microscopy, try our BODIPY FL pepstatin A. This green-fluorescent probe, which inhibits cathepsin D in vitro (IC50 ∼50 nM), targets cathepsin D within lysosomes of live cells.

BODIPY™ 505/515 (4,4-Difluoro-1,3,5,7-Tetramethyl-4-Bora-3a,4a-Diaza-s-Indacene) Invitrogen™

With its nonpolar structure and long-wavelength absorption and fluorescence, BODIPY™ 505/515 can be used as a stain for netural lipids and as a tracer for oil and other nonpolar lipids. To make a concentrated stock solution from 1–5 mM, dissolve in either high quality anhydrous DMSO or 100% ethanol.

BODIPY™ 493/503 (4,4-Difluoro-1,3,5,7,8-Pentamethyl-4-Bora-3a,4a-Diaza-s-Indacene) Invitrogen™

With its nonpolar structure and long-wavelength absorption and fluorescence, BODIPY™ 493/503 can be used as a stain for neutral lipds and as a tracer for oil and other nonpolar lipids. We recommend dissolving in high-quality anhydrous DMSO to attain a stock concentration of 1 to 10 mM.

Tolvaptan Thermo Scientific Chemicals

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to...

Fluorescein-5-(and-6)-Sulfonic Acid, Trisodium Salt Invitrogen™

The cell-impermeant fluorescein-5-(and-6)-sulfonic acid can be used as a non-fixable polar tracer to investigate fusion, lysis and gap-junctional communication.

ANTS (8-Aminonaphthalene-1,3,6-Trisulfonic Acid, Disodium Salt) Invitrogen™

The polyanionic dye ANTS is often used in combination with the cationic quencher DPX (X1525) for membrane fusion or permeability assays, including complement-mediated immune lysis. The unusually high Stokes shift of ANTS in water (>150 nm) separates this from much of the autofluorescence of...

Latrunculin A Invitrogen™

Latrunculin A disrupts microfilament organization in cultured cells by binding to monomeric G-actin in a 1:1 complex at submicromolar concentrations. Its physiological effects include inhibition of fertilization, early embryological development and phagocytic internalization of immune complexes.

Muscimol, BODIPY™ TMR-X Conjugate Invitrogen™

Muscimol is a powerful agonist of the GABAA receptor and has been widely used to reversibly inactivate localized groups of neurons. The BODIPY TMR-X muscimol conjugate, can be used, in place of radioactive reagents and methods, to map the distribution of muscimol in the nervous system, as well as to...

Ionomycin, Calcium Salt Invitrogen™

Ionomycin is an effective Ca2+ ionopohre that is commonly used to both modify intracellular Ca2+ concentrations and to calibrate fluorescent Ca2+ indicators when studying the regulatory properties of Ca2+ in cellular processes.

Nigericin, Free Acid Invitrogen™

Intracellular calibration of the fluorescence response of cytosolic pH indicators is typically performed using the K+/H+ ionophore nigericin, which causes equilibration of intracellular and extracellular pH in the presence of a depolarizing concentration of extracellular K+.

Vancomycin, BODIPY™ FL Conjugate (BODIPY™ FL Vancomycin) Invitrogen™

BODIPY™ FL vancomycin, which contains a single BODIPY™ dye per vancoymycin molecule, is a green-fluorescent analog of this important antibiotic, which is active against gram-positive bacteria, including entereococci.

Bis-ANS (4,4'-Dianilino-1,1'-Binaphthyl-5,5'-Disulfonic Acid, Dipotassium Salt) Invitrogen™

Bis-ANS is superior to 1-8-ANS as a probe for nonpolar cavities in proteins, often binding with an affinity that is orders-of-magnitude higher. Anilinonaphthalene sulfonates (ANS) are essentially nonfluorescent in water, only becoming appreciably fluorescent when bound to membranes.

Remdesivir Thermo Scientific Chemicals

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to...
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