Crosslinking, Labeling and Protein Modification

Crosslinking, Labeling and Protein Modification

Browse through our collection of crosslinking, labeling, and protein modification reagents designed for various protein analysis and bioconjugation applications. This category includes protein labeling reagents, crosslinking reagents, protein modification reagents, protein and antibody labeling kits, and tandem mass tag reagents. These chemical tools are used to study protein structure, interactions, and functions by attaching functional groups, creating covalent bonds between molecules, or introducing specific modifications. Protein labeling reagents allow for the attachment of fluorescent dyes, biotin, or other detectable molecules to proteins for visualization and tracking. Crosslinking reagents facilitate the formation of chemical bonds between proteins or other molecules, enabling the study of protein-protein interactions and complex formation. Protein modification reagents are used to alter specific amino acid residues or introduce new functional groups. Labeling kits provide convenient all-in-one solutions for protein and antibody conjugation. Tandem mass tag reagents are specialized tools for quantitative proteomics using mass spectrometry. Learn more about protein labeling, crosslinking, and modification products and methods.

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  • Protein Labeling Reagents (297)
    Crosslinking Reagents (85)
    Protein Modification Reagents (74)
    Protein and Antibody Labeling Kits (52)
    Tandem Mass Tag Reagents (21)
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Alexa Fluor™ 546 is a bright, orange fluorescent dye that can be excited using the 488 nm or 532 nm laser lines.
Thermo Scientific™ EZ-Link Hydrazide-Biotin is the shortest and simplest hydrazide-activated biotinylation reagent for labeling glycoproteins and other carbohydrate-containing compounds having oxidizable sugars or aldehydes.
The far red-fluorescent Alexa Fluor™ 647 azide is reactive with terminal alkynes via a copper-catalyzed click reaction.
As part of the LanthaScreen™ TR-FRET toolbox of assay reagents, LanthaScreen™ Amine Reactive Tb Chelate labeling reagent is available for assay development.
LanthaScreen™ Thiol Reactive Tb Chelate
Optimize applications where product integrity and risk minimization are paramount with the specially characterized Thermo Scientific™ Pierce™ Premium Grade Sulfo-SMCC, our highest quality formulation of this popular amine-to-sulfhydryl crosslinker.
Label intracellular proteins for affinity purification with streptavidin beads
TMTpro label reagents are the next generation of tandem mass tags, designed to increase the level of sample multiplexing without compromising on protein identification and quantitation. The Thermo Scientific TMTpro 18plex Label Reagent Set enables multiplexing up to 18 samples, enabling even greater...
Thermo Scientific™ EZ-Link Sulfo-NHS-LC-Biotin is an intermediate-length, water-soluble biotinylation reagent for labeling antibodies, proteins and other molecules that have primary amines.
Kinase Tracer 222 is an Alexa Fluor™ 647 dye-labeled, ATP-competitive kinase inhibitor scaffold for use in the LanthaScreen™ Eu Kinase Binding Assay.
Thermo Scientific™ FITC and Fluorescein Labeling Reagents and Kits are high-performance derivatives of fluorescein dye, activated for easy and reliable labeling of antibodies, proteins and other molecules for use as fluorescent probes.
Alexa Fluor™ 488 Hydrazide is useful as a cell tracer and as a reactive dye for labeling aldehydes or ketones in polysaccharides or glycoproteins.
Invitrogen Dylight Antibody Labeling kits provide everything needed to label 1 mg of antibody or protein with amine-reactive Dylight dye and subsequent free dye removal. Choose from a variety of Dylight fluorophores across the spectrum to covalently label your antibody or protein.
Thermo Scientific™ Amine-Reactive DyLight Dyes are NHS ester-activated DyLight Fluors for fluorescent labeling of antibodies and other proteins to be used as molecular probes for cellular imaging and other fluorescence detection methods.
Invitrogen Dylight Microscale Antibody Labeling kits provide everything needed to label 100 μg of antibody or protein with amine-reactive Dylight dye and subsequent free dye removal. Choose from a variety of Dylight fluorophores across the spectrum to covalently label your antibody or protein.
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A number of techniques for studying the structure and interaction of proteins, as well as for manipulating proteins for use in affinity purification or detection procedures, depend on methods for chemically crosslinking, modifying or labeling proteins.
We offer a wide range of reagents to modify proteins by crosslinking, fragmenting, cleaving, denaturing, reducing disulfides, or attaching functional groups to study protein function and interactions. Use our helpful Bioconjugation Technical Handbook to help improve your protein modification...
Documents & Support (126)
What is a protein modification reagent?
What functional groups are available on proteins for crosslinking/labeling?