Extruders & Pharmaceutical Applications

Pharma 11 Twin-screw Extruder Thermo Scientific™

Perform material- and labor-effective extrusion with Thermo Scientific™ Pharma 11 Twin-screw Extruder, which requires only a small amount of active pharmaceutical ingredient, operating at throughput levels as low as 20g/h.

The parallel 11mm twin screws and compact design of the Pharma 11 Twin-screw Extruder is fully scalable with the Thermo Scientific stand-alone pharmaceutical compounding systems. Together, you can obtain process relevant results or even perform small scale production.

If you need a complete extrusion solution, a wide range of accessories are available for the Pharma 11 Twin-screw Extruder, including volumetric and gravimetric feeders, a conveyor belt and a pelletizer.

Pharma mini HME Micro Compounder Accessories Thermo Scientific™

Accessories for the Pharma miniHME Micro Compounder used for Hot Melt Extrusion in research and development in the pharmaceutical industry.

Pharma mini HME Micro Compounder Thermo Scientific™

The Thermo Scientific™ Pharma mini HME is a GMP compliant conical micro compounder for Hot Melt Extrusion in research and development in the pharmaceutical industry. When developing new drugs, shortening time-to-market and reducing waste of expensive API's and overall development costs provide a distinct competitive advantage. Hence, quick and early assessment of new API/excipient formulations is critical. Hot melt extrusion and continuous processing can lead to speedier formulation development and cost efficient production. The Thermo Scientific Pharma mini HME allows users to identify the right drug candidates for hot melt extrusion by compounding as little as three grams of material.

Pharma 24 Twin-Screw Granulator Thermo Scientific™

The Thermo Scientific™ Pharma 24 Twin-Screw Granulator (TSG) is a dedicated system for wet and dry granulation processes. It can be used as a stand-alone instrument or integrated into a modular, continuous manufacturing line that spans from raw materials to final tableting. Such flexibility minimizes scale-up risks.

The Pharma 24 TSG provides consistent and controllable processing, on-demand production, and reduced clean room space and ATEX risk. It is also suitable for process analytical technology (PAT).

Pharma 24 Twin-Screw Extruder

The Thermo Scientific™ Pharma 24 Twin-Screw Extruder, with avaialble HME and Twin-Screw Granulation (TSG) Application Sets, is ideal for continuous processing in research, development or production in the pharmaceutical industry. The Pharma 24 extruder drives reduced clean room area, consistent and controllable processing, reduced product changeover time, on-demand production, minimized scale-up risk and reliable cleaning. It is suitable for process analytical technology (PAT).

Pharma mini Implant Line

Produce high-quality, injectable drug delivery systems with the Thermo Scientific™ Pharma mini Implant Line. This automated end-to-end solution meets cGMP and FDA requirements. Accurate dosing of pre-blended material enters the extruder, which moves material through a die to produce a filament. A closed-loop filament control system ensures that the implant strand has minimal diameter variability. The strand is cut to the required implant diameter and length. Out-of-specification implants are automatically discarded, assuring 100% quality.

Pharma 16 Twin-Screw Extruder Thermo Scientific™

Rapidly develop pharmaceutical formulations and adopt continuous processing methods using the Thermo Scientific™ Pharma 16 Twin-Screw Extruder.  The Pharma 16 Twin-Screw Extruder can switch between continuous hot melt extrusion (HME) or wet granulation (TSG) with ease. Optimize drug process development parameters with less time and effort than batch processes and easily scale-up to larger Thermo Scientific™ extruders with using minimal amounts of expensive APIs and excipients.