Shandon™ Finesse™ E+ and ME+ Microtome Accessories Thermo Scientific™
Support and expand the functionality of Thermo Scientific™ Shandon™ Finesse™ E+ and ME+ Microtomes with the Thermo Scientific Shandon Finesse E+ and ME+ Microtome Accessories.
Quick Release Clamp Thermo Scientific™
Fix cassettes or embedding rings both longitudinally and horizontally, with orientation on X-, Y-, and Z-axes using the Thermo Scientific™ Quick Release Clamp.
Specimen Clamp and Accessories Thermo Scientific™
Get the most out of your Thermo Scientific™ microtome with this Thermo Scientific™ Specimen Clamp and Accessories.
Round Specimen Clamps Thermo Scientific™
Ensure easy insertion and removal of round specimens with Thermo Scientific™ Round Specimen Clamps.
Shandon™ Finesse™ Vises and Clamps Thermo Scientific™
Designed for use with Thermo Scientific™ Shandon™ and Microm™ Microtomes, the Thermo Scientific™ Shandon™ Finesse™ Vises and Clamps meets the needs of most laboratories.
Fixed Specimen Head Adapter Thermo Scientific™
Designed for adaptation on the Thermo Scientific microtome with fixed head, the non-orienting version Thermo Scientific™ Fixed Specimen Head Adapter meets the needs of most laboratories.
Miscellaneous Microtome Accessories Thermo Scientific™
Support and expand the functionality of Thermo Scientific™ 200 and 300 series of microtomes with Thermo Scientific Miscellaneous Microtome Accessories.
HM 430, HM 450 and 440 E Sliding Microtomes Accessories Thermo Scientific™
Maintain Thermo Scientific™ HM 430 and HM 450 Sliding Microtomes with Thermo Scientific HM 430, HM 450 and 440 E Sliding Microtomes Accessories.
Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE). This enzyme is synthesized as a propeptide that must be modified to the mature and active form by the prohormone convertase, furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP and a membrane-bound remnant. This remnant is then processed by another protease termed gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide. Gamma-secretase is believed to be a multi-subunit complex containing presenilin-1 and 2 as central components. Found associated with the presenilins is the transmembrane glycoprotein nicastrin. Nicastrin has been found to bind to the carboxyl-terminus of betaAPP and helps to modulate the production of the amyloid beta peptide.
HM Microtome Instrumentation Accessories Thermo Scientific™
Choose from multiple Thermo Scientific™ HM Microtome Instrumentation Accessories for use with Thermo Scientific™ HM Microtomes.
HM 650V Vibrating Blade Microtome Accessories Thermo Scientific™
Use these Thermo Scientific™ HM 650V Vibrating Blade Microtome Accessories with the Thermo Scientific™ HM650V Vibrating Blade Microtome.
Shandon™ Finesse™ Cold Point Light Source Thermo Scientific™
Direct two powerful beams of light to the specimen with the Thermo Scientific™ Shandon™ Finesse™ Cold Point Light Source.
Shandon™ Finesse™ Fixed Orienting Head, Thermo Scientific™
Designed for the Thermo Scientific Shandon™ Finesse ME/E Series only, the Thermo Scientific™ Finesse Fixed Orienting Head is of excellent quality.
Blade Carriers Thermo Scientific™
Insert a variety of Thermo Scientific™ blades in Thermo Scientific™ Blade Carriers.
Microm™ Clamps for Sectioning Paraffin Thermo Scientific™
Designed for use with Thermo Scientific™ HM 500 Series Cryostats, the Thermo Scientific™ Microm™ Clamps for Sectioning Paraffin meets the needs of most laboratories.