Genomics and proteomics search results

JAK3 Recombinant Human Protein

Janus kinase 3 (JAK3) phosphorylates members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to activation of interleukin receptors. ...

Specifications

Gene ID
3718
Species
Human
Target Gene
Janus kinase 3
Gene Aliases
JAK3, LJAK, JAKL
Protein Form
Catalytic
Cytoplasmic
Recombinant
Protein Family
Kinases & Inhibitors
Protein Subtype
Cytoplasmic Tyrosine Kinases
Accession Number
NP_000206
Molecular Weight
67.4 kDa
Research Category
Signal Transduction
System Compatibility
LanthaScreen® Substrate
Z'-LYTE™
Omnia® Bulk Substrate
LanthaScreen® Antibody
Validated Application
Kinase Assay
Protein Length or Portion (a.a.)
aa 781-1124
Protein Tag or Fusion
GST Tag
Expression
Baculovirus
Kinase Family
JAK Kinase Family
Kinase Group
Tyrosine Kinases
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PV3855
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Novex™ JAK3 Antibody (515R6) (Novex™)

JAK 3 (also designated L JAK) is a member of the Janus family of protein tyrosine kinases along with JAK 1, JAK 2, or Tyk 2. Subsequent to activation, these kinases function to activate various members of the Stat family of transcription factors by phosphorylation on critical tyr ...

Specifications

Reactivity
Human
Validated Application
Western Blot
Host
Mouse
Clonality
Monoclonal
Clone ID
515R6
Target Gene
JAK3
Gene ID
3718
Label or Dye
Unconjugated
Purification
Affinity Purified
Research Category
Signal Transduction
Shipping Condition
Approved for shipment on Wet or Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

AHO1572
6cac7a3b2e2d79dcd2847a01bee34e1b_CmgtBuyProduct

Pierce™ JAK3 Antibody (5H2) (Thermo Scientific™)

MA5-15561 targets JAK3 in FACS, IF, and WB applications and shows reactivity with Human and mouse samples. ...

Specifications

Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.
MA515561
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Novex™ Phospho-JAK2 pTyr1007 / pTyr1008 Antibody (Novex™)

Janus Activating Kinase 2 (JAK2) is one of a number of related tyrosine kinases involved in cytoplasmic signal transduction. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine re ...

Specifications

Reactivity
Human
Rat
Mouse
Validated Application
Western Blot
Host
Rabbit
SubClass (Isotype)
IgG
Clonality
Polyclonal
Target Gene
JAK2 [pYpY1007/1008]
Gene ID
3717
Label or Dye
Unconjugated
Target Modification State
Phospho
Research Category
Signal Transduction
Shipping Condition
Approved for shipment on Wet or Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

44426G
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LanthaScreen® Tb-PY20 Antibody Kit

A general reagent to monitor tyrosine kinase activity, the pY20 antibody binds to phosphorylated tyrosines within a peptide or physiological protein substrate. ...

Specifications

Format
384-well plate
Readout
End Point
Technique
TR-FRET
Label or Dye
Tb (Terbium)
FITC (Fluorescein)
Target Enzyme
Tyrosine Kinases
Validated Kinases
ABL1, ABL2, AXL, BLK, BMX, BTK, CSF1R, CSK, DDR2, EGFR, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, ERBB2, ERBB4, FER, FGFR1, FGFR2, FGFR3, FGFR4, FGR, FLT1, FLT3, FLT4, FRK, FYN, HCK, IGF1R, INSR, KDR, KIT, LCK, LTK, LYNA, LYNB, MATK, MERTK, MET, MST1R, MUSK, NTRK1, NTRK2, NTRK3, PDGFRA, PDGFRB, PTK2, PTK2B, PTK6, RET, ROS1, SRC, SRCN1, SRMS, SYK, TEC, TEK, TNK2, TTK, TYRO3, YES1, ZAP70
Antibody Molecular Weight
150000 Da
Excitation⁄Emission (nm)
340⁄490, 520
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PV3552
74a2597eb8313d2f2861ebaf055d5433_CmgtBuyProduct

LanthaScreen® Tb-anti-pSTAT1 [pTyr701] Antibody Kit

A part of the JAK/STAT Pathway, STAT1 (Signal Transducer and Activator of Transcription 1) is phosphorylated at Tyr701 by the Janus family of tyrosine kinases. ...

Specifications

Format
384-well plate
Readout
End Point
Technique
TR-FRET
Reactivity
Human
Label or Dye
Tb (Terbium)
GFP (EmGFP)
Target Enzyme
Tyrosine Kinases
Validated Kinases
JAK1, JAK2, JAK3, TYK2
Antibody Molecular Weight
150000 Da
Excitation⁄Emission (nm)
340⁄490, 520
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PV4844
2a334e63a4ff9ead83fb18b5248485a5_CmgtBuyProduct

LanthaScreen® Tb-pSTAT3 [pTyr705] Antibody Kit

A part of the JAK/STAT Pathway, STAT3 (Signal Transducer and Activator of Transcription 3) is phosphorylated at Tyr705 by the Janus family of tyrosine kinases. ...

Specifications

Format
384-well plate
Readout
End Point
Technique
TR-FRET
Reactivity
Human
Label or Dye
Tb (Terbium)
GFP (EmGFP)
Target Enzyme
Tyrosine Kinases
Validated Kinases
JAK1, JAK2, JAK3, TYK2
Antibody Molecular Weight
150000 Da
Excitation⁄Emission (nm)
340⁄490, 520
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PV4846
74be8d39f8505a11268dcd3d7f307770_CmgtBuyProduct

Fluorescein-Poly GAT

A general fluorescein peptide substrate consisting of a polymer of glutamate, alanine, and tyrosine that is used to monitor tyrosine kinase activity. ...

Specifications

Substrate
Fluorescein-Poly GAT
Label or Dye
FITC (Fluorescein)
Target Enzyme
Tyrosine Kinases
Substrate Type
Kinase Substrate
Detection Method
Fluorescent
Validated Kinases
ABL1, ABL2, AXL, BLK, BMX, BTK, CSF1R, CSK, DDR2, EGFR, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, ERBB2, ERBB4, FER, FGFR1, FGFR2, FGFR3, FGFR4, FGR, FLT1, FLT3, FLT4, FRK, FYN, HCK, IGF1R, INSR, KDR, KIT, LCK, LTK, LYNA, LYNB, MATK, MERTK, MET, MST1R, MUSK, NTRK1, NTRK2, NTRK3, PDGFRA, PDGFRB, PTK2, PTK2B, PTK6, RET, ROS1, SRC, SRCN1, SRMS, SYK, TEC, TEK, TNK2, TTK, TYRO3, YES1, ZAP70
Amino Acid Sequence
Fluorescein- Poly Glu:Ala:Tyr (6:3:1)
Substrate Properties
Peptide-Based Substrate
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PV3611
2f7ff130727e71fa4314b503cfd9db47_CmgtBuyProduct

Pierce™ Phospho-JAK3 pTyr785 Antibody (Thermo Scientific™)

JAK 3 (also designated L JAK) is a member of the Janus family of protein tyrosine kinases along with JAK 1, JAK 2, or Tyk 2. Subsequent to activation, these kinases function to activate various members of the Stat family of transcription factors by phosphorylation on critical tyr ...

Specifications

Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.
f35fde2978fb9bf5145541b00f939f74_CmgtBuyProduct

Novex™ JAK2 Antibody (691R5) (Novex™)

Janus Activating Kinase 2 (JAK2) is one of a number of related tyrosine kinases involved in cytoplasmic signal transduction. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine re ...

Specifications

Reactivity
Human
Rat
Mouse
Validated Application
Western Blot
Host
Mouse
Clonality
Monoclonal
Clone ID
691R5
Target Gene
JAK2
Gene ID
16452, 24514, 3717
Label or Dye
Unconjugated
Research Category
Signal Transduction
Shipping Condition
Approved for shipment on Wet or Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

AHO1352
6e1a421bbb44214d253af264e6b257b9_CmgtBuyProduct

Novex™ JAK2 Antibody (Novex™)

Janus Activating Kinase 2 (JAK2) is one of a number of related tyrosine kinases involved in cytoplasmic signal transduction. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine re ...

Specifications

Reactivity
Human
Mouse
Validated Application
Western Blot
Host
Rabbit
SubClass (Isotype)
IgG
Clonality
Polyclonal
Target Gene
JAK2
Gene ID
3717
Label or Dye
Unconjugated
Research Category
Signal Transduction
Shipping Condition
Approved for shipment on Wet or Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

44406G
d62f7f973d5c1d43adc48f04059259c6_CmgtBuyProduct

CellSensor® STAT6-bla RA-1 Cell Line

The CellSensor® STAT6-bla RA-1 Cell Line contains a beta-lactamase reporter gene under control of the STAT6 response element stably integrated into Ramos-1 (RA-1) cells. This cell line is a clonal population isolated by flow cytometry in response to interleukin-4 (IL-4). This ce ...

Specifications

System
CellSensor™
Cell State
Dividing Cells
Druggable Target
Signaling Pathway
Cytokines
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

K1646
262dce2016e04a8461d19f8c88752daa_CmgtBuyProduct

AcroMetrix® Oncology Hotspot Control

The AcroMetrix® Oncology Hotspot Control is a highly multiplexed quality control used to assess the performance of next-generation sequencing (NGS) assays that detect somatic mutations. ...

Specifications

Target Gene
PTEN
EZH2
FBXW7
AKT1
FLT3
CTNNB1
RET
MAP2K1
ERBB2
MLH1
ALK
KRAS
KIT
JAK3
JAK2
RB1
STK11
PDGFRA
SMARCB1
CSF1R
PTPN11
FGFR2
BRAF
EGFR
SRC
FGFR1
ERBB4
APC
HNF1A
HRAS
VHL
GNAQ
FOXL2
CDKN2A
IDH2
MPL
CDH1
GNAS
IDH1
SMO
SMAD4
TP53
NRAS
ATM
NPM1
GNA11
FGFR3
PIK3CA
NOTCH1
KDR
ABL1
MSH6
MET
Control Type
Molecular Control
Positive Control
Test Category
Oncology
Regulatory Statement
For In Vitro Diagnostic Use.
969056
42e3b689ba0e0d7c97cb0e5fd9948c44_CmgtBuyProduct

Phospho-JAK3 pTyr785 Antibody (Thermo Scientific™)

This antibody is predicted to react with mouse and rat based on sequence homology. ...

Specifications

Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.
PA540264
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