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MCP-4 Polyclonal Antibody (Invitrogen™)

MCP-4 Polyclonal Antibody for Western Blot, ELISA

MCP-4/CCL13 Human ELISA Kit (Invitrogen™)

MCP-4/CCL13 Human ELISA Kit for ELISA

MCP-4 Monoclonal Antibody (3G4) (Invitrogen™)

MCP-4 Monoclonal Antibody for Western Blot, ELISA

MCP-4 Monoclonal Antibody (8C12) (Invitrogen™)

MCP-4 Monoclonal Antibody for ELISA

MCP-4 Recombinant Human Protein (Gibco™)

Recombinant MCP-4 is a bioactive protein intended for use in cell culture applications. MCP-4 displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues.

Human MCP-4 Recombinant Protein (Invitrogen™)

Human MCP-4 Recombinant Protein for Ctrl

RANTES Recombinant Human Protein (Gibco™)

Recombinant RANTES is a bioactive protein intended for use in cell culture applications. RANTES functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. RANTES is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.

CCL4 Human Uncoated ELISA Kit with Plates (Invitrogen™)

This Human CCL4 (MIP-1 beta) Uncoated ELISA Kit with Plates contains the necessary reagents, standards, buffers and diluents for performing quantitative enzyme-linked immunosorbent assays (ELISA). This ELISA kit is specifically engineered for accurate and precise measurement of protein levels from samples including serum, plasma, and supernatants from cell cultures.

CCL4, also known as MIP-1 beta (Macrophage Inflammatory Protein-1 beta), is a member of the CC-subfamily of chemokines and is most closely related to CCL3, or MIP-1 alpha. These proteins play critical roles in the recruitment of leukocytes to the site of inflammation. While both CCL3 and CCL4 are chemoattractant for monocytes, macrophages, and dendritic cells, CCL4 preferentially attracts CD4+ T cells, while CD8+ T cells are more responsive to CCL3. In addition to its chemotactic functions, CCL4 induces the release of proinflammatory cytokine, mast cells degranulation, and NK cell activation.

CCL4 signaling is mediated by the G protein-coupled receptors CCR1, CCR4, and CCR5, which are shared with CCL3 and CCL5 (RANTES). CCR5 is the primary co-receptor for HIV entry, which the virus binds through the gp120 envelope protein. All CCR5 ligands demonstrate potent inhibition of virus entry into the cell, both through steric hindrance of gp120-CCR5 interaction, and ligand-mediated receptor internalization.

Reported Application
ELISA

Eotaxin Recombinant Human Protein (Gibco™)

Recombinant human eotaxin is a bioactive protein intended for use in cell culture applications. Eotaxin is a member of the PF-4 family of chemokines. Eotaxin plays a role in inducing calcium flux in eosinophils.

CCL4 (MIP-1 beta) Human Uncoated ELISA Kit (Invitrogen™)

CCL4 (MIP-1 beta) Human Uncoated ELISA Kit for ELISA

CCL3 (MIP-1 alpha) Human Uncoated ELISA Kit with Plates (Invitrogen™)

CCL3 (MIP-1 alpha) Human Uncoated ELISA Kit with Plates for ELISA

Eotaxin-2 Recombinant Mouse Protein (Gibco™)

Recombinant mouse eotaxin is a bioactive protein intended for use in cell culture applications. Eotaxin is a member of the PF-4 family of chemokines. Eotaxin plays a role in inducing calcium flux in eosinophils.

CCL3 (MIP-1 alpha) Human Uncoated ELISA Kit (Invitrogen™)

CCL3 (MIP-1 alpha) Human Uncoated ELISA Kit for ELISA

MCP-1/CCL2 Human Uncoated ELISA Kit with Plates (Invitrogen™)

MCP-1/CCL2 Human Uncoated ELISA Kit with Plates for ELISA

MIP-3 beta Human Uncoated ELISA Kit with Plates (Invitrogen™)

MIP-3 beta Human Uncoated ELISA Kit with Plates for ELISA