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Genomics and proteomics search results
CCL4 (MIP-1 beta) Monoclonal Antibody (FL34Z3L), APC, eBioscience™ (Invitrogen™)
CCL4 (MIP-1 beta) Monoclonal Antibody for Flow
CCL4 (MIP-1 beta) Monoclonal Antibody (FL34Z3L), PerCP-eFluor 710, eBioscience™ (Invitrogen™)
CCL4 (MIP-1 beta) Monoclonal Antibody for Flow
CCL4 Human Uncoated ELISA Kit with Plates (Invitrogen™)
This Human CCL4 (MIP-1 beta) Uncoated ELISA Kit with Plates contains the necessary reagents, standards, buffers and diluents for performing quantitative enzyme-linked immunosorbent assays (ELISA). This ELISA kit is specifically engineered for accurate and precise measurement of protein levels from samples including serum, plasma, and supernatants from cell cultures.
CCL4, also known as MIP-1 beta (Macrophage Inflammatory Protein-1 beta), is a member of the CC-subfamily of chemokines and is most closely related to CCL3, or MIP-1 alpha. These proteins play critical roles in the recruitment of leukocytes to the site of inflammation. While both CCL3 and CCL4 are chemoattractant for monocytes, macrophages, and dendritic cells, CCL4 preferentially attracts CD4+ T cells, while CD8+ T cells are more responsive to CCL3. In addition to its chemotactic functions, CCL4 induces the release of proinflammatory cytokine, mast cells degranulation, and NK cell activation.
CCL4 signaling is mediated by the G protein-coupled receptors CCR1, CCR4, and CCR5, which are shared with CCL3 and CCL5 (RANTES). CCR5 is the primary co-receptor for HIV entry, which the virus binds through the gp120 envelope protein. All CCR5 ligands demonstrate potent inhibition of virus entry into the cell, both through steric hindrance of gp120-CCR5 interaction, and ligand-mediated receptor internalization.
Reported Application
ELISA
CCL4, also known as MIP-1 beta (Macrophage Inflammatory Protein-1 beta), is a member of the CC-subfamily of chemokines and is most closely related to CCL3, or MIP-1 alpha. These proteins play critical roles in the recruitment of leukocytes to the site of inflammation. While both CCL3 and CCL4 are chemoattractant for monocytes, macrophages, and dendritic cells, CCL4 preferentially attracts CD4+ T cells, while CD8+ T cells are more responsive to CCL3. In addition to its chemotactic functions, CCL4 induces the release of proinflammatory cytokine, mast cells degranulation, and NK cell activation.
CCL4 signaling is mediated by the G protein-coupled receptors CCR1, CCR4, and CCR5, which are shared with CCL3 and CCL5 (RANTES). CCR5 is the primary co-receptor for HIV entry, which the virus binds through the gp120 envelope protein. All CCR5 ligands demonstrate potent inhibition of virus entry into the cell, both through steric hindrance of gp120-CCR5 interaction, and ligand-mediated receptor internalization.
Reported Application
ELISA
CCL4 Human Uncoated ELISA Kit with Plates (Invitrogen™)
CCL4 (MIP-1 beta) Human Uncoated ELISA Kit with Plates for ELISA
CCL4 Human ProcartaPlex™ Simplex Kit, Platinum (Invitrogen™)
Platinum ProcartaPlex™ Immunoassays are our are highest validated bead based Multiplexing assay system for quantificaton of multiple protein biomarkers in a single sample.
Newly developed matrix type specific diluents for plasma and serum enable to overcome matrix effects and assure high performance specifications (e.g spike and dilution recovery results between 70-130%).
Our Platinum ProcartaPlex assays use Luminex™ xMAP technology for the multi-analyte detection of secreted proteins including cytokines, chemokines, growth factors and other proteins. Platinum ProcartaPlex™ assays are subject to the same stringent and robust development and manufacturing as are our extensively validated Platinum and Instant ELISA assays.
Platinum ProcartaPlex Simplex kits can only be combined with one another.
Reactivity/Species
Human
Suitable Sample Types
Serum, Plasma
Sample Volume
Serum, Plasma: 25 µL
Reported Application
Multiplex Immunoassay
Newly developed matrix type specific diluents for plasma and serum enable to overcome matrix effects and assure high performance specifications (e.g spike and dilution recovery results between 70-130%).
Our Platinum ProcartaPlex assays use Luminex™ xMAP technology for the multi-analyte detection of secreted proteins including cytokines, chemokines, growth factors and other proteins. Platinum ProcartaPlex™ assays are subject to the same stringent and robust development and manufacturing as are our extensively validated Platinum and Instant ELISA assays.
Platinum ProcartaPlex Simplex kits can only be combined with one another.
Reactivity/Species
Human
Suitable Sample Types
Serum, Plasma
Sample Volume
Serum, Plasma: 25 µL
Reported Application
Multiplex Immunoassay
CCL4 Antibody (C4HCLC), ABfinity™ Rabbit Oligoclonal (Invitrogen™)
CCL4 Oligoclonal Antibody for Western Blot
CCL4 Antibody (6HCLC), ABfinity™ Rabbit Oligoclonal (Invitrogen™)
CCL4 Oligoclonal Antibody for Western Blot, IHC (P)
Human CCL4 (MIP-1 beta) ELISA Standard Recombinant Protein, eBioscience™ (Invitrogen™)
Human CCL4 (MIP-1 beta) ELISA Standard Recombinant Protein for ELISA, Ctrl
