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How is NIR spectroscopy used in pharmaceutical manufacturing? Product FAQ

Answer

Traditional laboratory material verification workflows require moving materials into a sampling room, opening and sampling them, documenting samples for tracking purposes, sending samples to the lab, and moving materials into quarantine while awaiting lab results. With handheld NIR spectroscopy, pharmaceutical and dietary supplement manufacturers can verify the identity of incoming materials in the warehouse in minutes and avoid the time and costs of lab testing. Supplied materials such as API, bulking agents, lubricants, and solvents must be qualified at the point of entry into the factory to ensure finished product integrity. Portable NIR analyzers such as microPHAZIR RX Analyzer take NIR spectroscopy out of the lab and into the plant. Handheld NIR instruments allow non-expert users to obtain reliable material identity verification in the warehouse.

Answer Id: E20668

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What factors influence the ROI (Return on Investment) of using an IonicX Portable XRF Analyzer? Product FAQ

Answer

Each year, plant personnel spend considerable resources moving materials to be sampled in a controlled location, performing analysis with trained personnel in a laboratory setting, documenting samples, and moving materials into a quarantine area to await laboratory results. With the IonicX Portable XRF Analyzer, incoming materials may be verified in the warehouse, by-passing all the traditional central laboratory testing steps, thus saving time and manufacturing resources such as personnel, plant space, and inventory costs.

QC laboratory testing is also resource intensive. Highly qualified lab personnel spend numerous hours preparing and analyzing samples, reviewing data, and documenting procedures and results. Identity testing occupies valuable instrument time that could be used for other analyses. Chemical disposal fees add to laboratory costs. By using non-destructive, portable XRF analyzers like the IonicX Portable XRF Analyzer, pharmaceutical manufacturers minimize these costs.

Answer Id: E20741

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How long can POP-7 polymer stay on the Applied Biosystems 3730 Series DNA Analyzer? Product FAQ

Answer

POP-7 polymer can maintain its performance for seven days on the Applied Biosystems 3730 Series DNA Analyzer at standard lab conditions. After seven days, perform all required maintenance (including the Water Wash Wizard) and replace with fresh polymer. Do not "top off" the polymer bottle (add fresh polymer to old polymer), which can adversely affect data quality and consumable lifespan.

Find additional tips, troubleshooting help, and resources within our Capillary Electrophoresis Instruments Support Center.

Answer Id: E2528

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What is the ROI of using the TruScan RM Handheld Raman Analyzer? Product FAQ

Answer

The TruScan RM Handheld Raman Analyzer can save manufacturing resources. Each year, plant personnel spend hours moving materials into the sampling room, sampling them, documenting samples for tracking purposes and sending them to the lab, then moving materials into a quarantine area to await laboratory results. With the TruScan RM Handheld Raman Analyzer, incoming materials may be verified in the warehouse, by-passing all the traditional central laboratory testing steps, saving time and manufacturing resources such as personnel, plant space, and inventory costs.

QC laboratory testing is also resource intensive. Highly qualified lab personnel spend numerous hours preparing and analyzing samples, reviewing data, and documenting procedures and results. Identity testing uses up valuable instrument time that could be used for other analyses. Consumables like sample vials and reagents along with chemical disposal fees add to laboratory costs. Pharmaceutical manufacturers can avoid all these costs by using non-destructive, no-contact Raman handheld analyzers like the TruScan RM Handheld Raman Analyzer.

Traditional sampling and laboratory testing introduces production risks that have the potential to impact product quality, yield, and production schedule. Opening a container to extract a sample increases its chance of material contamination and rejection of the final product. Sampling and lab analysis adds variability to material release times. Samples may be accidentally contaminated, destroyed, lost, or mislabeled in a traditional central laboratory testing workflow. The variabilities of turnaround time for material inspection may impair the ability to forecast production equipment and personnel scheduling, a direct stress on plant productivity. Non-contact, non-destructive analysis using the TruScan RM Handheld Raman Analyzer reduces contamination risks and production uncertainties.

Answer Id: E20648

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I am performing fragment analysis, and my fragments have shifted in size. Why is this? Product FAQ

Answer

If the fragments have shifted in size and the same capillary electrophoresis (CE) instrument, dyes, and run module are being used, the polymer should be checked to see how long it has been on the instrument and whether it has expired. The polymer can be kept on most CE instruments for 7 days, with the exception of the 3500/3500xL Genetic Analyzers where the polymer may be on the instrument for up to 14 days if the lab temperature is below 25 degrees C.

Find additional tips, troubleshooting help, and resources within our Capillary Electrophoresis Applications Support Center.

Answer Id: E15294

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Using Portable XRF instruments for analyzing ore concentrates and grade control Product Literature

Ta-Nb (Coltan), Sn, and W Exploration and Mining Using Portable XRF Instruments Product Literature

Flyer: Instrument service plans Product Literature

Determination of Tantalum and Tin Ore with XRF Product Literature

Orion Laboratory Products Catalog Product Literature

Protein Quantitation in Solution—Section 9.2 Molecular Probes Handbook

Viability and Cytotoxicity Assay Kits for Diverse Cell Types—Section 15.3 Molecular Probes Handbook

Effectiveness of gene expression profiling for response prediction of rectal adenocarcinomas to preoperative chemoradiotherapy. Citations & References

  • Authors: Ghadimi BM, Grade M, Difilippantonio MJ, Varma S, Simon R, Montagna C, Fuzesi L, Langer C, Becker H, Liersch T, Ried T
  • Journal: J Clin Oncol
  • PubMed ID: 15774776
Catalog #

Nucleic Acid Detection on Gels, Blots and Arrays—Section 8.4 Molecular Probes Handbook

Reagents for Analysis of Low Molecular Weight Amines—Section 1.8 Molecular Probes Handbook

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