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In 1980, the Japanese Nobel prize-winning chemist Ryoji Noyori reported that BINAP (2,2'-bis(diphenylphosphino)-1,1'-binaphthyl) complexed with ruthenium [BINAP-Ru(II)] catalyzed the asymmetric hydrogenation of alpha-(acylamino)acrylic acids or esters to give the corresponding amino acid derivatives...

Oxygen-containing compounds include alcohols, aldehydes, ketones, ethers, and carboxylic acids and derivatives. Thermo Fisher Scientific offers a range of oxygen-containing compounds and derivatives suitable for various research applications.

In 1946, E.R.H. Jones and colleagues reported the synthesis of alkynyl ketones from their corresponding carbinols using chromic acid (chromic trioxide mixed with diluted sulfuric acid) without oxidizing their sensitive triple bond.

Our application specific columns utilize novel and unique chemistries to provide superior resolution and ease of use for your key pharmaceutical, environmental, and food/beverage applications. These columns were developed for specialized workflows and can effectively perform complex separations of a...

To inorganic chemists, hydrides are compounds or ions made up of hydrogen bonded to an electropositive (or a less electronegative) element. Hydrides can be formed with almost all main-group elements, but inorganic hydrides are usually classified iinto four main groups: covalent, ionic, transition...

In 1887, L. Claisen discovered the formation of benzyl benzoate from the reaction of benzaldehyde in the presence of sodium alkoxides. Almost thirty years later, W.E. Tishchenko found that both enolizable and non-enolizable aldehydes could be converted to their corresponding esters in the presence...

Introduction Hydrazides Alkoxyamines (aminooxy compounds) Reductive amination, Sulfhydryl-to-Carbohydrate Crosslinkers Hydrazide Biotinylation Reagents Carbohydrate Oxidant Aniline (GlycoLink coupling catalyst) Crosslinker Selection Tool Crosslinkers at a Glance, Aldehydes (RCHO) and ketones (RCOR')...

The “semivolatile” contaminant grouping is composed of compounds with broad chemical properties and structural features. Examples of semivolatiles compounds include hydrocarbons, aldehydes, ethers, esters, phenols, organic acids, ketones, amines, amides, nitroaromatics, PCBs (also known as...

Radioactive metabolic labeling Stable isotope labeling using SILAC Photoreactive amino acids Bioorthogonal labeling reagents Fluorescent probes used in live cells Recommended reading, Protein Interaction Analysis Protein Crosslinking In Vivo, Radioactive analogs are the most commonly used compounds...

Activation of caspase enzymes, which participate in the cleavage of protein substrates and in the subsequent disassembly of the cell, plays an important role in apoptosis. Thermo Fisher Scientific offers reagents and kits for imaging caspase activity in real-time or as an end-point assay.

Heterocyclic compounds, or heterocycles, are cyclic compounds that have atoms of at least two different elements as members of the ring structure.Organic heterocycles contain one or more carbon atoms and, based on their electronic structure, are classified as saturated, unsaturated, and aromatic.

Explore protein crosslinking products Crosslinking Technical Handbook, Despite the complexity of protein structure, including composition and sequence of 20 different amino acids, only a small number of protein functional groups comprise selectable targets for practical bioconjugation methods.

Optimize your protein labeling, crosslinking, and modification experiments to get the best results. We’ve compiled a detailed knowledge base of the top tips and tricks to meet your research needs. View the relevant questions below:, Browse our FAQ database for more information ›, Having problems...

Krishna Vattem, Ph.D., In vitro translation (IVT) systems have been used for rapid expression of functional proteins, including enzymes. Typically, proteins expressed in mammalian cells have higher activity compared to those expressed in bacteria, because slower translational rates in the mammalian...

Introduction Methods to detect and analyze glycoproteins N-glycosylation O-glycosylation Glypiation C-glycosylation Phosphoglycosylation Post-glycosylation modifications Recommended reading, Protein Enrichment Amino Acid Analysis Reagents Pierce Glycoprotein Staining Kit Pierce Glycoprotein...