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Tumor necrosis factor-alpha activation of the c-Jun N-terminal kinase pathway in human neutrophils. Integrin involvement in a pathway leading from cytoplasmic tyrosine kinases apoptosis. Citations & References

  • Authors: Avdi NJ, Nick JA, Whitlock BB, Billstrom MA, Henson PM, Johnson GL, Worthen GS
  • Journal: J Biol Chem (2001) 276:2189-2199
  • PubMed ID: 11053415
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Rho and Rho-associated kinase modulate the tyrosine kinase PYK2 in T-cells through regulation of the activity of the integrin LFA-1. Citations & References

  • Authors: Rodríguez-Fernández JL, Sánchez-Martín L, Rey M, Vicente-Manzanares M, Narumiya S, Teixidó J, Sánchez-Madrid F, Cabañas C
  • Journal: J Biol Chem (2001) 276:40518-40527
  • PubMed ID: 11489881
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The Bmx tyrosine kinase induces activation of the Stat signaling pathway, which is specifically inhibited by protein kinase Cdelta. Citations & References

  • Authors: Saharinen P, Ekman N, Sarvas K, Parker P, Alitalo K, Silvennoinen O
  • Journal: Blood (1997) 90:4341-4353
  • PubMed ID: 9373245
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Bruton's Tyrosine Kinase Btk-PH Redistribution Assay - Instructions Product Literature

Tyrosine phosphorylation of the novel protein-tyrosine kinase RAFTK during an early phase of platelet activation by an integrin glycoprotein IIb-IIIa-independent mechanism. Citations & References

  • Authors: Raja S, Avraham S, Avraham H
  • Journal: J Biol Chem (1997) 272:10941-10947
  • PubMed ID: 9099753
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Expression of the human epidermal growth factor receptor in a murine T-cell hybridoma. A transmembrane protein tyrosine kinase can synergize with the T-cell antigen receptor. Citations & References

  • Authors: Kennedy IC, June CH, O'Shea JJ
  • Journal: J Biol Chem (1992) 267:4924-4929
  • PubMed ID: 1537871
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Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Citations & References

  • Authors: Baxter EJ, Scott LM, Campbell PJ, East C, Fourouclas N, Swanton S, Vassiliou GS, Bench AJ, Boyd EM, Curtin N, Scott MA, Erber WN, Green AR
  • Journal: Lancet ; (365):9464 1054-1061
  • PubMed ID: 15781101

The interaction of activated integrin lymphocyte function-associated antigen 1 with ligand intercellular adhesion molecule 1 induces activation and redistribution of focal adhesion kinase and proline-rich tyrosine kinase 2 in T lymphocytes. Citations & References

  • Authors: Rodríguez-Fernández JL, Gómez M, Luque A, Hogg N, Sánchez-Madrid F, Cabañas C
  • Journal: Mol Biol Cell (1999) 10:1891-1907
  • PubMed ID: 10359604
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Regulation of JAK2 by miR-135a: prognostic impact in classic Hodgkin lymphoma. Citations & References

  • Authors: Navarro A, Diaz T, Martinez A, Gaya A, Pons A, Gel B, Codony C, Ferrer G, Martinez C, Montserrat E, Monzo M
  • Journal: Blood 2009 14:2945-2951
  • PubMed ID: 19666866
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Galangin inhibits tumour growth and metastasis of B16F10 melanoma. Citations & References

  • Authors: Zhang W, Tang B, Huang Q, Hua Z,
  • Journal: J Cell Biochem (2012) -
  • PubMed ID: 22887049
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(AHR0361) TDS Manual / Product Insert

  • Version: 10/08
Catalog # AHR0361(Discontinued)

HER-2/c-erbB-2/neu Ab-6, Mouse Monoclonal Antibody Product Literature

Btk expression is controlled by Oct and BOB.1/OBF.1. Citations & References

  • Authors: Brunner C, Wirth T
  • Journal: Nucleic Acids Res 2006 6:1807-1815
  • PubMed ID: 16582106
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HER-2/c-erbB-2/neu Ab-1, Rabbit Polyclonal Antibody Product Literature

Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor. Citations & References

  • Authors: Novick D, Cohen B, Tal N, Rubinstein M
  • Journal: J Leukoc Biol 1995; (57):5 712-718
  • PubMed ID: 7759950
Catalog # 10359MM07FAB(Discontinued)

B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading. Citations & References

  • Authors: Tse KW, Dang-Lawson M, Lee RL, Vong D, Bulic A, Buckbinder L, Gold MR
  • Journal: J Biol Chem 2009 34:22865-22877
  • PubMed ID: 19561089

KHO0501 - Protocol Manual / Product Insert

  • Version: A7
Catalog # KHO0501(Discontinued)

B Cell Receptor-induced Phosphorylation of Pyk2 and Focal Adhesion Kinase Involves Integrins and the Rap GTPases and Is Required for B Cell Spreading Citations & References

  • Authors: Tse, KWK; Dang-Lawson, M; Lee, RL; Vong, D; Bulic, A; Buckbinder, L; Gold, MR
  • Journal: JOURNAL OF BIOLOGICAL CHEMISTRY 2009 34:22865-22877

CXCL12 signaling is independent of Jak2 and Jak3. Citations & References

  • Authors: Moriguchi M, Hissong BD, Gadina M, Yamaoka K, Tiffany HL, Murphy PM, Candotti F, O'Shea JJ,
  • Journal: J Biol Chem (2005) 280:17408-17414
  • PubMed ID: 15611059
Catalog # 336000

Expression profiling of chicken DT40 lymphoma cells indicates clonal selection of knockout and gene reconstituted cells. Citations & References

  • Authors: Nawaz HM, Blomberg KE, Lindvall JM, Kurosaki T, Smith CI
  • Journal: Biochem Biophys Res Commun 2008; (377):2 584-588
  • PubMed ID: 18930021

Caveolar and lipid raft localization of the growth hormone receptor and its signaling elements: impact on growth hormone signaling. Citations & References

  • Authors: Yang N, Huang Y, Jiang J, Frank SJ,
  • Journal: J Biol Chem (2004) 279:20898-20905
  • PubMed ID: 15010456
Catalog # 716900

Rabbit (polyclonal) Anti-IRS-2 pS731) Phosphospecific Antibody Manual / Product Insert

  • Version: 11/08
Catalog # 44828(Discontinued)

Rabbit anti-phospho-FAK-1 (Tyr397) Manual / Product Insert

  • Version: 11/06
Catalog # 367900(Discontinued)

HER-2/c-erbB-2/neu Ab-8, Mouse Monoclonal Antibody Product Literature

Cholecystokinin activates PYK2/CAKbeta by a phospholipase C-dependent mechanism and its association with the mitogen-activated protein kinase signaling pathway in pancreatic acinar cells. Citations & References

  • Authors: Tapia JA, Ferris HA, Jensen RT, García LJ
  • Journal: J Biol Chem (1999) 274:31261-31271
  • PubMed ID: 10531323
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Neuropilin 1 directly interacts with Fer kinase to mediate semaphorin 3A-induced death of cortical neurons. Citations & References

  • Authors: Jiang SX, Whitehead S, Aylsworth A, Slinn J, Zurakowski B, Chan K, Li J, Hou ST
  • Journal: J Biol Chem 2010 13:9908-9918
  • PubMed ID: 20133938

HER-2/c-erbB-2/neu Ab-2, Mouse Monoclonal Antibody Product Literature

KHO0281 - Protocol Manual / Product Insert

  • Version: A4
Catalog # KHO0281(Discontinued)

AHO1532 Mouse (monoclonal) Anti-IRS-2 unconjugated Manual / Product Insert

  • Version: 10/08
Catalog # AHO1532(Discontinued)

AHR0351 Manual / Product Insert

  • Version: 10/08
Catalog # AHR0351(Discontinued)

HER-2/c-erbB-2/neu Ab-5, Mouse Monoclonal Antibody Product Literature

Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. Citations & References

  • Authors: Kim B, Feldman EL,
  • Journal: J Biol Chem (2002) 277:27393-27400
  • PubMed ID: 12011046
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HER-2/c-erbB-2/neu Ab-4, Mouse Monoclonal Antibody Product Literature

Distinct gene expression signature in Btk-defective T1 B-cells. Citations & References

  • Authors: Lindvall JM, Blomberg KE, Berglöf A, Smith CI
  • Journal: Biochem Biophys Res Commun 2006; (346):2 461-469
  • PubMed ID: 16764821

Mutation of Y925F in focal adhesion kinase (FAK) suppresses melanoma cell proliferation and metastasis Citations & References

  • Authors: Kaneda, T; Sonoda, Y; Ando, K; Suzuki, T; Sasaki, Y; Oshio, T; Tago, M; Kasahara, T
  • Journal: CANCER LETTERS 2008 2:354-361

Distinct involvement of the Gab1 and Grb2 adaptor proteins in signal transduction by the related receptor tyrosine kinases RON and MET. Citations & References

  • Authors: Chaudhuri A, Xie MH, Yang B, Mahapatra K, Liu J, Marsters S, Bodepudi S, Ashkenazi A
  • Journal: J Biol Chem 2011; (286):37 32762-32774
  • PubMed ID: 21784853

Signal transduction through a biomolecular receptor tyrosine protein kinase composed of a platelet-derived growth factor receptor-CD4 chimera and the nonreceptor tyrosine protein kinase Lck. Citations & References

  • Authors: Adam D, Klages S, Bishop P, Mahajan S, Escobedo JA, Bolen JB
  • Journal: J Biol Chem (1993) 268:19882-19888
  • PubMed ID: 8366126
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PECAM-1 (CD31) regulates a hydrogen peroxide-activated nonselective cation channel in endothelial cells. Citations & References

  • Authors: Ji G, O'Brien CD, Feldman M, Manevich Y, Lim P, Sun J, Albelda SM, Kotlikoff MI
  • Journal: J Cell Biol (2002) 157:173-184
  • PubMed ID: 11927609

Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain. Citations & References

  • Authors: Nishiya N; Iwabuchi Y; Shibanuma M; Côté J F; Tremblay M L; Nose K;
  • Journal: J Biol Chem (1999) 274:9847-9900
  • PubMed ID: 10092676
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Tec protein-tyrosine kinase is involved in interleukin-3 signaling pathway. Citations & References

  • Authors: Mano H; Yamashita Y; Sato K; Yazaki Y; Hirai H
  • Journal: Blood 1995 2:343-350
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Protein kinase A-mediated inhibition of gamma interferon-induced tyrosine phosphorylation of Janus kinases and latent cytoplasmic transcription factors in human monocytes by Ehrlichia chaffeensis. Citations & References

  • Authors: Lee EH, Rikihisa Y
  • Journal: Infect Immun (1998) 66:2514-2520
  • PubMed ID: 9596710
Catalog # D113(Discontinued)

RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6. Citations & References

  • Authors: Trivier Elisabeth; Ganesan Trivadi S;
  • Journal: J Biol Chem (2002) 277:23037-43
  • PubMed ID: 11956217
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  • R96025
  • 136500(Discontinued)
  • V37520(Discontinued)
  • V88501(Discontinued)

Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases. Citations & References

  • Authors: Brdicka T, Kadlecek TA, Roose JP, Pastuszak AW, Weiss A,
  • Journal: Mol Cell Biol (2005) 25:4924-4933
  • PubMed ID: 15923611
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Dectin-1-mediated signaling leads to characteristic gene expressions and cytokine secretion via spleen tyrosine kinase (Syk) in rat mast cells. Citations & References

  • Authors: Kimura Y, Chihara K, Honjoh C, Takeuchi K, Yamauchi S, Yoshiki H, Fujieda S, Sada K
  • Journal: J Biol Chem 2014; (289):45 31565-31575
  • PubMed ID: 25246527

Src-dependent phosphorylation of membrane type I matrix metalloproteinase on cytoplasmic tyrosine 573: role in endothelial and tumor cell migration. Citations & References

  • Authors: Nyalendo C, Michaud M, Beaulieu E, Roghi C, Murphy G, Gingras D, Béliveau R
  • Journal: J Biol Chem (2007) 282:15690-15699
  • PubMed ID: 17389600
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Immunofluorescent localization of a 39,000-dalton substrate of tyrosine protein kinases to the cytoplasmic surface of the plasma membrane. Citations & References

  • Authors: Nigg EA, Cooper JA, Hunter T
  • Journal: J Cell Biol (1983) 96:1601-1609
  • PubMed ID: 6304112
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CD66 family members are associated with tyrosine kinase activity in human neutrophils. Citations & References

  • Authors: Skubitz KM, Campbell KD, Ahmed K, Skubitz AP
  • Journal: J Immunol (1995) 155:5382-5390
  • PubMed ID: 7594554
Catalog # B6353(Discontinued)

Characterization of receptor tyrosine-specific protein kinases by the use of inhibitors. Staurosporine is a 100-times more potent inhibitor of insulin receptor than IGF-I receptor. Citations & References

  • Authors: Fujita-Yamaguchi Y, Kathuria S
  • Journal: Biochem Biophys Res Commun (1988) 157:955-962
  • PubMed ID: 2974700

Integrin α9β1 mediates enhanced cell migration through nitric oxide synthase activity regulated by Src tyrosine kinase Citations & References

  • Authors: Gupta, SK; Vlahakis, NE
  • Journal: JOURNAL OF CELL SCIENCE 2009 12:2043-2054

Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases. Citations & References

  • Authors: Kawabuchi M, Satomi Y, Takao T, Shimonishi Y, Nada S, Nagai K, Tarakhovsky A, Okada M
  • Journal: Nature (2000) 404:999-1003
  • PubMed ID: 10801129
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Distinct functions of the Fc epsilon R1 gamma and beta subunits in the control of Fc epsilon R1-mediated tyrosine kinase activation and signaling responses in RBL-2H3 mast cells. Citations & References

  • Authors: Wilson BS, Kapp N, Lee RJ, Pfeiffer JR, Martinez AM, Platt Y, Letourneur F, Oliver JM
  • Journal: J Biol Chem (1995) 270:4013-4022
  • PubMed ID: 7876149
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Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-ß-catenin signaling. Citations & References

  • Authors: Zhang B, Li M, McDonald T, Holyoake TL, Moon RT, Campana D, Shultz L, Bhatia R
  • Journal: Blood 2013; (121):10 1824-1838
  • PubMed ID: 23299311

Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein. Citations & References

  • Authors: Liu W, Quinto I, Chen X, Palmieri C, Rabin RL, Schwartz OM, Nelson DL, Scala G
  • Journal: Nat Immunol (2001) 2:939-946
  • PubMed ID: 11577348

Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases. Citations & References

  • Authors: Poghosyan Z, Robbins SM, Houslay MD, Webster A, Murphy G, Edwards DR
  • Journal: J Biol Chem 2002; (277):7 4999-5007
  • PubMed ID: 11741929
Catalog # 10517R007AB(Discontinued)

Intracellular calcium regulates the tyrosine kinase receptor encoded by the MET oncogene. Citations & References

  • Authors: Gandino L, Munaron L, Naldini L, Ferracini R, Magni M, Comoglio PM
  • Journal: J Biol Chem (1991) 266:16098-16104
  • PubMed ID: 1651934
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The nonreceptor tyrosine kinase fer mediates cross-talk between N-cadherin and beta1-integrins. Citations & References

  • Authors: Arregui C, Pathre P, Lilien J, Balsamo J
  • Journal: J Cell Biol (2000) 149:1263-1274
  • PubMed ID: 10851023
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Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase. Citations & References

  • Authors: Besset V, Scott RP, Ibáñez CF
  • Journal: J Biol Chem (2000) 275:39159-39166
  • PubMed ID: 10995764
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Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways. Citations & References

  • Authors: Takata M, Sabe H, Hata A, Inazu T, Homma Y, Nukada T, Yamamura H, Kurosaki T
  • Journal: EMBO J (1994) 13:1341-1349
  • PubMed ID: 8137818
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Inhibition of receptor tyrosine kinase signalling by small molecule agonist of T-cell protein tyrosine phosphatase. Citations & References

  • Authors: Mattila E, Marttila H, Sahlberg N, Kohonen P, Tähtinen S, Halonen P, Perälä M, Ivaska J,
  • Journal: BMC Cancer (2010) 10:7-7
  • PubMed ID: 20055993
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