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CellSensor™ NFkB-bla ME-180 Cell Line

The CellSensor® NFκB-bla ME-180 cell line contains a beta-lactamase reporter gene under control of the Nuclear Factor Kappa B (NFκB) response element stably integrated into ME-180 cells. The cell line was created through fluorescence activated cell sorting (FACS) of cells responsive to stimulation of the NFκB pathway with tumor necrosis factor alpha (TNFα). The cell line was validated for DMSO tolerance, incubation time with stimulant, and substrate loading conditions. The CellSensor® NFκB-bla ME-180 cell line responds to agonist treatment as expected from literature and can be adapted for high-throughput screening for agonists or antagonists of the NFκB pathway with compound libraries. Candidate drugs can also be tested for dose response against this cell line. Academic and non-profit customers, please inquire for special pricing.

CHUK (IKK α) Recombinant Human Protein

CHUK (IKK alpha) is a serine⁄threonine kinase involved in signal transduction and cellular communication. It belongs to the cytokine activated protein complex that is an inhibitor of the NF-kappa B complex.

LanthaScreen™ Tb-IKBa pSer32 Antibody Kit

An essential component of the canonical NF-kB pathway, phosphorylation of IkappaBalpha at Ser32 by IKK preceedes the transactivation of NF-kappaB.

For use in combination with the Fluorescein-IKK peptide substrate (PV3507) to evaluate inhibitors in medium to high throughput screening applications.

Adapta™ Universal Kinase Assay Kit

The Adapta™ Universal Kinase Assay Kit is a homogenous, fluorescence-based immunoassay for the detection of ADP produced by kinases or other ATP dependent enzymes.

For more information, please visit www.invitrogen.com/adapta.

Phospho-IKK alpha (Ser176, Ser180) Polyclonal Antibody (Invitrogen™)

Phospho-IKK alpha (Ser176, Ser180) Polyclonal Antibody for Western Blot, IF, ICC, ChIP

Fluorescein-IKK Substrate

A fluorescein-labeled peptide substrate that is primarily used with the IkappaB kinase (IKK) family.

For use in combination with the LanthaScreen® Tb-IkappaBalpha [pSer32] antibody (PV3562) to evaluate inhibitors in medium to high throughput screening applications.

IKK alpha Polyclonal Antibody (Invitrogen™)

IKK alpha Polyclonal Antibody for Western Blot, IF, ICC

IKK alpha Polyclonal Antibody (Invitrogen™)

IKK alpha Polyclonal Antibody for Western Blot, ICC

IKK alpha Polyclonal Antibody (Invitrogen™)

IKK alpha Polyclonal Antibody for Western Blot, IF, ICC

IKK alpha Monoclonal Antibody (3G12H9) (Invitrogen™)

IKK alpha Monoclonal Antibody for Western Blot, IF, ICC, Flow

IKK alpha Monoclonal Antibody (3G12) (Invitrogen™)

IKK alpha Monoclonal Antibody for Western Blot

Phospho-IKK alpha (Thr23) Polyclonal Antibody (Invitrogen™)

Phospho-IKK alpha (Thr23) Polyclonal Antibody for Western Blot, IHC (P)

IKK alpha Monoclonal Antibody (7C10B6, 1A10A10) (Invitrogen™)

IKK alpha Monoclonal Antibody for Western Blot

Phospho-IKK alpha (Thr23) Polyclonal Antibody (Invitrogen™)

Phospho-IKK alpha (Thr23) Polyclonal Antibody for Western Blot, IHC (P)

Phospho-IKK alpha/beta (Ser180, Ser181) Polyclonal Antibody (Invitrogen™)

Phospho-IKK alpha/beta (Ser180, Ser181) Polyclonal Antibody for Western Blot, IHC (P)