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Case Study: Empowering Success by Adopting New LC Instruments within an Existing Network Product Literature

Technical Note: Flexible HPLC Instrument Setups for Double Usage as One Heart-Cut-2D-LC System or Two Independent 1D-LC Systems Product Literature

Application Note: The Importance of Correct UHPLC Instrument Setup for Protein Aggregate Analysis by Size-Exclusion Chromatography Product Literature

Technical Note: Long-term Robustness of Thiopental Ph. Eur. Method Performance on Modern HPLC Instrumentation Product Literature

Flyer: SureSTART collection - SureSTART vial, cap, insert, well plate and mat for every HPLC/UHPLC instrument, application and budget Product Literature

Application Note: The Importance of Correct UHPLC Instrument Setup for Protein Aggregate Analysis by Size-Exclusion Chromatography [JA] Product Literature

Application Note: Simultaneous Analysis of Monoclonal Antibodies Using a Novel Dual-Channel UHPLC Instrument and Orthogonal Chromatography Product Literature

Application Note: High-Throughput Protein Aggregate Analysis of Monoclonal Antibodies Using a Novel Dual-Channel UHPLC Instrument Product Literature

Application Note: Out-of-the-box usability of Thermo Scientific UltiMate 3000 and Vanquish Core HPLC instruments for the compendial analysis of commonly prescribed drugs Product Literature

After running the Pierce TMT11plex Yeast Digest Standard, I observe low signal to noise ratio and poor quantitation accuracy for the Tandem Mass Tag (TMT) reporter ions. What do you recommend? Product FAQ

Answer

Here are some recommendations:

- Clean and recalibrate the mass spectrometry instrument using one of our Pierce Calibration Solutions (https://www.thermofisher.com/search/browse/category/us/en/600654).
- Verify settings for liquid chromatography (LC) acquisition methods.
- Fractionate TMT-labeled samples using the Pierce High pH Reversed-Phase Peptide Fractionation Kit (Cat. No. 84868) to reduce sample complexity.

Find additional tips, troubleshooting help, and resources within our Mass Spectrometry Support Center.

Answer Id: E18824

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Installation Instructions: EASY-nLC Series Preinstallation Requirements Guide Revision G Product Literature

Installation Instructions: EASY-nLC Series Preinstallation Requirements Guide Revision A [ZH] Product Literature

Installation Instructions: EASY-nLC Series Preinstallation Requirements Guide Revision F Product Literature

How does mzLogic work on the Orbitrap ID-X Tribrid Mass Spectrometer? Product FAQ

Answer

Watch this video.

Find additional tips, troubleshooting help, and resources within our Mass Spectrometry Support Center.

Answer Id: E16896

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How does AcquireX data acquisition tool work on the Orbitrap Tribrid mass spectrometry instruments? Product FAQ

Answer

Watch this video.

Find additional tips, troubleshooting help, and resources within our Mass Spectrometry Support Center.

Answer Id: E16889

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